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7ZID
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BU of 7zid by Molmil
Crystal Structure of truncated aspartate transcarbamoylase from Plasmodium falciparum in complex with BDA-14
Descriptor: Aspartate carbamoyltransferase, GLYCEROL, SULFATE ION, ...
Authors:Wang, C, Zhang, B.
Deposit date:2022-04-07
Release date:2022-08-31
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Discovery of Small-Molecule Allosteric Inhibitors of Pf ATC as Antimalarials.
J.Am.Chem.Soc., 144, 2022
1EP9
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BU of 1ep9 by Molmil
HUMAN ORNITHINE TRANSCARBAMYLASE: CRYSTALLOGRAPHIC INSIGHTS INTO SUBSTRATE RECOGNITION AND CONFORMATIONAL CHANGE
Descriptor: ORNITHINE TRANSCARBAMYLASE, PHOSPHORIC ACID MONO(FORMAMIDE)ESTER
Authors:Shi, D, Morizono, H, Yu, X, Allewell, N.M, Tuchman, M.
Deposit date:2000-03-28
Release date:2001-04-04
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Human ornithine transcarbamylase: crystallographic insights into substrate recognition and conformational changes.
Biochem.J., 354, 2001
1EKX
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BU of 1ekx by Molmil
THE ISOLATED, UNREGULATED CATALYTIC TRIMER OF ASPARTATE TRANSCARBAMOYLASE COMPLEXED WITH BISUBSTRATE ANALOG PALA (N-(PHOSPHONACETYL)-L-ASPARTATE)
Descriptor: ASPARTATE TRANSCARBAMOYLASE, CALCIUM ION, N-(PHOSPHONACETYL)-L-ASPARTIC ACID
Authors:Endrizzi, J.A, Beernink, P.T, Alber, T, Schachman, H.K.
Deposit date:2000-03-09
Release date:2000-05-12
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Binding of bisubstrate analog promotes large structural changes in the unregulated catalytic trimer of aspartate transcarbamoylase: implications for allosteric regulation induced cell migration.
Proc.Natl.Acad.Sci.USA, 97, 2000
2I6U
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BU of 2i6u by Molmil
Crystal Structure of Ornithine Carbamoyltransferase complexed with Carbamoyl Phosphate and L-Norvaline from Mycobacterium tuberculosis (Rv1656) at 2.2 A
Descriptor: NORVALINE, Ornithine carbamoyltransferase, PHOSPHORIC ACID MONO(FORMAMIDE)ESTER, ...
Authors:Sankaranarayanan, R, Moradian, F, Cherney, L.T, Garen, C, Cherney, M.M, James, M.N.G, TB Structural Genomics Consortium (TBSGC)
Deposit date:2006-08-29
Release date:2007-06-26
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The crystal structures of ornithine carbamoyltransferase from Mycobacterium tuberculosis and its ternary complex with carbamoyl phosphate and L-norvaline reveal the enzyme's catalytic mechanism
J.Mol.Biol., 375, 2008
1DUV
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BU of 1duv by Molmil
CRYSTAL STRUCTURE OF E. COLI ORNITHINE TRANSCARBAMOYLASE COMPLEXED WITH NDELTA-L-ORNITHINE-DIAMINOPHOSPHINYL-N-SULPHONIC ACID (PSORN)
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, NDELTA-(N'-SULPHODIAMINOPHOSPHINYL)-L-ORNITHINE, ORNITHINE TRANSCARBAMOYLASE
Authors:Langley, D.B, Templeton, M.D, Fields, B.A, Mitchell, R.E, Collyer, C.A.
Deposit date:2000-01-18
Release date:2000-07-04
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Mechanism of inactivation of ornithine transcarbamoylase by Ndelta -(N'-Sulfodiaminophosphinyl)-L-ornithine, a true transition state analogue? Crystal structure and implications for catalytic mechanism.
J.Biol.Chem., 275, 2000
8AT1
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BU of 8at1 by Molmil
CRYSTAL STRUCTURES OF ASPARTATE CARBAMOYLTRANSFERASE LIGATED WITH PHOSPHONOACETAMIDE, MALONATE, AND CTP OR ATP AT 2.8-ANGSTROMS RESOLUTION AND NEUTRAL P*H
Descriptor: ASPARTATE CARBAMOYLTRANSFERASE (R STATE), CATALYTIC CHAIN, ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN, ...
Authors:Gouaux, J.E, Stevens, R.C, Lipscomb, W.N.
Deposit date:1989-09-22
Release date:1990-10-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of aspartate carbamoyltransferase ligated with phosphonoacetamide, malonate, and CTP or ATP at 2.8-A resolution and neutral pH.
Biochemistry, 29, 1990
8ATC
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BU of 8atc by Molmil
COMPLEX OF N-PHOSPHONACETYL-L-ASPARTATE WITH ASPARTATE CARBAMOYLTRANSFERASE. X-RAY REFINEMENT, ANALYSIS OF CONFORMATIONAL CHANGES AND CATALYTIC AND ALLOSTERIC MECHANISMS
Descriptor: ASPARTATE CARBAMOYLTRANSFERASE (R STATE), CATALYTIC CHAIN, ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN, ...
Authors:Ke, H, Lipscomb, W.N, Cho, Y, Honzatko, R.B.
Deposit date:1989-08-25
Release date:1990-10-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Complex of N-phosphonacetyl-L-aspartate with aspartate carbamoyltransferase. X-ray refinement, analysis of conformational changes and catalytic and allosteric mechanisms.
J.Mol.Biol., 204, 1988
2IPO
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BU of 2ipo by Molmil
E. coli Aspartate Transcarbamoylase complexed with N-phosphonacetyl-L-asparagine
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, ...
Authors:Cardia, J.P, Eldo, J, Xia, J, O'Day, E.M, Tsuruta, H, Kantrowitz, E.R.
Deposit date:2006-10-12
Release date:2007-08-28
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Use of L-asparagine and N-phosphonacetyl-L-asparagine to investigate the linkage of catalysis and homotropic cooperativity in E. coli aspartate transcarbomoylase.
Proteins, 71, 2008
1DXH
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BU of 1dxh by Molmil
Catabolic ornithine carbamoyltransferase from Pseudomonas aeruginosa
Descriptor: ORNITHINE CARBAMOYLTRANSFERASE, SULFATE ION
Authors:Sainz, G, Vicat, J, Kahn, R, Duee, E, Tricot, C, Stalon, V, Dideberg, O.
Deposit date:2000-01-05
Release date:2001-01-12
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of the Allosteric Active Form of Catabolic Ornithine Carbamoyltransferase from Pseudomonas Aeruginosa
To be Published
1FB5
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BU of 1fb5 by Molmil
LOW RESOLUTION STRUCTURE OF OVINE ORNITHINE TRANSCARBMOYLASE IN THE UNLIGANDED STATE
Descriptor: NORVALINE, ORNITHINE TRANSCARBAMOYLASE
Authors:Zanotti, G, Battistutta, R, Panzalorto, M, Francescato, P, Bruno, G, De Gregorio, A.
Deposit date:2000-07-14
Release date:2003-08-26
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Functional and structural characterization of ovine ornithine transcarbamoylase.
Org.Biomol.Chem., 1, 2003
1D09
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BU of 1d09 by Molmil
ASPARTATE TRANSCARBAMOYLASE COMPLEXED WITH N-PHOSPHONACETYL-L-ASPARTATE (PALA)
Descriptor: ASPARTATE CARBAMOYLTRANSFERASE CATALYTIC CHAIN, ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN, N-(PHOSPHONACETYL)-L-ASPARTIC ACID, ...
Authors:Jin, L, Stec, B, Lipscomb, W.N, Kantrowitz, E.R.
Deposit date:1999-09-09
Release date:2000-01-28
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Insights into the mechanisms of catalysis and heterotropic regulation of Escherichia coli aspartate transcarbamoylase based upon a structure of the enzyme complexed with the bisubstrate analogue N-phosphonacetyl-L-aspartate at 2.1 A.
Proteins, 37, 1999
2FZK
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BU of 2fzk by Molmil
The Structure of Wild-Type E. Coli Aspartate Transcarbamoylase in Complex with Novel T State Inhibitors at 2.50 Resolution
Descriptor: 3,5-BIS[(PHOSPHONOACETYL)AMINO]BENZOIC ACID, Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, ...
Authors:Heng, S, Stieglitz, K.A, Eldo, J, Xia, J, Cardia, J.P, Kantrowitz, E.R.
Deposit date:2006-02-09
Release date:2006-08-29
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:T-state Inhibitors of E. coli Aspartate Transcarbamoylase that Prevent the Allosteric Transition.
Biochemistry, 45, 2006
8BPS
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BU of 8bps by Molmil
Aspartate transcarbamoylase mutant (N2045C, R2238C) from Chaetomium thermophilum CAD-like in apo form
Descriptor: Carbamoyl-phosphate synthase (glutamine-hydrolyzing), GLYCEROL
Authors:del Cano-Ochoa, F, Ramon-Maiques, S.
Deposit date:2022-11-25
Release date:2023-02-01
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:A Tailored Strategy to Crosslink the Aspartate Transcarbamoylase Domain of the Multienzymatic Protein CAD.
Molecules, 28, 2023
8BPL
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BU of 8bpl by Molmil
Aspartate transcarbamoylase mutant (N2045C, R2238C) from Chaetomium thermophilum CAD-like bound to carbamoyl phosphate
Descriptor: Carbamoyl-phosphate synthase (glutamine-hydrolyzing), GLYCEROL, PHOSPHORIC ACID MONO(FORMAMIDE)ESTER, ...
Authors:del Cano-Ochoa, F, Ramon-Maiques, S.
Deposit date:2022-11-16
Release date:2023-02-01
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:A Tailored Strategy to Crosslink the Aspartate Transcarbamoylase Domain of the Multienzymatic Protein CAD.
Molecules, 28, 2023
2FZG
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BU of 2fzg by Molmil
The Structure of Wild-Type E. Coli Aspartate Transcarbamoylase in Complex with Novel T State Inhibitors at 2.25 Resolution
Descriptor: Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, CYTIDINE-5'-TRIPHOSPHATE, ...
Authors:Heng, S, Stieglitz, K.A, Eldo, J, Xia, J, Cardia, J.P, Kantrowitz, E.R.
Deposit date:2006-02-09
Release date:2006-08-29
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:T-state Inhibitors of E. coli Aspartate Transcarbamoylase that Prevent the Allosteric Transition.
Biochemistry, 45, 2006
1FVO
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BU of 1fvo by Molmil
CRYSTAL STRUCTURE OF HUMAN ORNITHINE TRANSCARBAMYLASE COMPLEXED WITH CARBAMOYL PHOSPHATE
Descriptor: ORNITHINE TRANSCARBAMYLASE, PHOSPHORIC ACID MONO(FORMAMIDE)ESTER
Authors:Shi, D, Morizono, H, Yu, X, Allewell, N.M, Tuchman, M.
Deposit date:2000-09-20
Release date:2001-04-04
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Human ornithine transcarbamylase: crystallographic insights into substrate recognition and conformational changes.
Biochem.J., 354, 2001
2H3E
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BU of 2h3e by Molmil
Structure of wild-type E. coli Aspartate Transcarbamoylase in the presence of N-phosphonacetyl-L-isoasparagine at 2.3A resolution
Descriptor: (S)-4-AMINO-4-OXO-3-(2-PHOSPHONOACETAMIDO)BUTANOIC ACID, Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, ...
Authors:Eldo, J, Cardia, J.P, O'Day, E.M, Xia, J, Tsuruta, H, Kantrowitz, E.R.
Deposit date:2006-05-22
Release date:2006-10-17
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:N-Phosphonacetyl-l-isoasparagine a Potent and Specific Inhibitor of Escherichia coli Aspartate Transcarbamoylase.
J.Med.Chem., 49, 2006
1F1B
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BU of 1f1b by Molmil
CRYSTAL STRUCTURE OF E. COLI ASPARTATE TRANSCARBAMOYLASE P268A MUTANT IN THE R-STATE IN THE PRESENCE OF N-PHOSPHONACETYL-L-ASPARTATE
Descriptor: ASPARTATE CARBAMOYLTRANSFERASE CATALYTIC CHAIN, ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN, N-(PHOSPHONACETYL)-L-ASPARTIC ACID, ...
Authors:Jin, L, Stec, B, Kantrowitz, E.R.
Deposit date:2000-05-18
Release date:2000-11-22
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A cis-proline to alanine mutant of E. coli aspartate transcarbamoylase: kinetic studies and three-dimensional crystal structures.
Biochemistry, 39, 2000
2FZC
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BU of 2fzc by Molmil
The Structure of Wild-Type E. Coli Aspartate Transcarbamoylase in Complex with Novel T State Inhibitors at 2.10 Resolution
Descriptor: Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, CYTIDINE-5'-TRIPHOSPHATE, ...
Authors:Heng, S, Stieglitz, K.A, Eldo, J, Xia, J, Cardia, J.P, Kantrowitz, E.R.
Deposit date:2006-02-09
Release date:2006-08-29
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:T-state Inhibitors of E. coli Aspartate Transcarbamoylase that Prevent the Allosteric Transition.
Biochemistry, 45, 2006
2G7M
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BU of 2g7m by Molmil
Crystal structure of B. fragilis N-succinylornithine transcarbamylase P90E mutant complexed with carbamoyl phosphate and N-acetylnorvaline
Descriptor: N-ACETYL-L-NORVALINE, PHOSPHORIC ACID MONO(FORMAMIDE)ESTER, SULFATE ION, ...
Authors:Shi, D, Yu, X, Roth, L, Morizono, H, Allewell, N.M, Tuchman, M.
Deposit date:2006-02-28
Release date:2007-03-06
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A single mutation in the active site swaps the substrate specificity of N-acetyl-L-ornithine transcarbamylase and N-succinyl-L-ornithine transcarbamylase.
Protein Sci., 16, 2007
1EZZ
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BU of 1ezz by Molmil
CRYSTAL STRUCTURE OF E. COLI ASPARTATE TRANSCARBAMOYLASE P268A MUTANT IN THE T-STATE
Descriptor: ASPARTATE CARBAMOYLTRANSFERASE CATALYTIC CHAIN, ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN, ZINC ION
Authors:Jin, L, Stec, B, Kantrowitz, E.R.
Deposit date:2000-05-12
Release date:2000-11-22
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A cis-proline to alanine mutant of E. coli aspartate transcarbamoylase: kinetic studies and three-dimensional crystal structures.
Biochemistry, 39, 2000
4EP1
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BU of 4ep1 by Molmil
Crystal structure of anabolic ornithine carbamoyltransferase from Bacillus anthracis
Descriptor: Ornithine carbamoyltransferase
Authors:Shabalin, I.G, Mikolajczak, K, Stam, J, Winsor, J, Shuvalova, L, Anderson, W.F, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2012-04-16
Release date:2012-04-25
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Crystal structures of anabolic ornithine carbamoyltransferase from Bacillus anthracis
To be Published
4F04
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BU of 4f04 by Molmil
A Second Allosteric site in E. coli Aspartate Transcarbamoylase: R-state ATCase with UTP bound
Descriptor: Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, N-(PHOSPHONACETYL)-L-ASPARTIC ACID, ...
Authors:Peterson, A.W, Cockrell, G.M, Kantrowitz, E.R.
Deposit date:2012-05-03
Release date:2012-07-11
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A second allosteric site in Escherichia coli aspartate transcarbamoylase.
Biochemistry, 51, 2012
4E2F
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BU of 4e2f by Molmil
Crystal Structure of E. coli Aspartate Transcarbamoylase K164E/E239K Mutant in an intermediate state
Descriptor: Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, ZINC ION
Authors:Guo, W, Kantrowitz, E.R.
Deposit date:2012-03-08
Release date:2012-05-02
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Trapping and structure determination of an intermediate in the allosteric transition of aspartate transcarbamoylase.
Proc.Natl.Acad.Sci.USA, 109, 2012
4FYX
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BU of 4fyx by Molmil
E. coli Aspartate Transcarbamoylase complexed with dCTP, UTP, and Mg2+
Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, ...
Authors:Cockrell, G.M, Kantrowitz, E.R.
Deposit date:2012-07-05
Release date:2012-10-10
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.0889 Å)
Cite:Metal Ion Involvement in the Allosteric Mechanism of Escherichia coli Aspartate Transcarbamoylase.
Biochemistry, 51, 2012

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