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4QL1
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BU of 4ql1 by Molmil
Crystal structure of human WDR5 in complex with compound OICR-9429
Descriptor: 1,2-ETHANEDIOL, GLYCEROL, N-(4-(4-methylpiperazin-1-yl)-3'-(morpholinomethyl)-[1,1'-biphenyl]-3-yl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide, ...
Authors:Dong, A, Dombrovski, L, Walker, J.R, Getlik, M, Kuznetsova, E, Smil, D, Barsyte, D, Li, F, Poda, G, Senisterra, G, Marcellus, R, Al-Awar, R, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Schapira, M, Vedadi, M, Wu, H, Structural Genomics Consortium (SGC)
Deposit date:2014-06-10
Release date:2014-12-17
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Pharmacological targeting of the Wdr5-MLL interaction in C/EBP alpha N-terminal leukemia.
Nat.Chem.Biol., 11, 2015
4QQE
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Crystal structure of WDR5, WD repeat domain 5 in complex with compound SGC-DS-MT-0345
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, N-[2-(4-methylpiperazin-1-yl)-5-(quinolin-3-yl)phenyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide, ...
Authors:Dong, A, Dombrovski, L, Wernimont, A, Smil, D, Getlik, M, Senisterra, G, Poda, G, Al-Awar, R, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Schapira, M, Vedadi, M, Wu, H, Structural Genomics Consortium (SGC)
Deposit date:2014-06-27
Release date:2014-07-30
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of WDR5, WD repeat domain 5 in complex with compound SGC-DS-MT-0345
To be Published
4ES0
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BU of 4es0 by Molmil
X-ray structure of WDR5-SETd1b Win motif peptide binary complex
Descriptor: Histone-lysine N-methyltransferase SETD1B, WD repeat-containing protein 5
Authors:Dharmarajan, V, Lee, J.-H, Patel, A, Skalnik, D.G, Cosgrove, M.S.
Deposit date:2012-04-21
Release date:2012-05-30
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.817 Å)
Cite:Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.
J.Biol.Chem., 287, 2012
5MWJ
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BU of 5mwj by Molmil
Structure Enabled Discovery of a Stapled Peptide Inhibitor to Target the Oncogenic Transcriptional Repressor TLE1
Descriptor: DIMETHYL SULFOXIDE, Transducin-like enhancer protein 1, pepide inhibtor
Authors:McGrath, S, Tortorici, M, Vidler, L, Drouin, L, Westwood, I, Gimeson, P, Van Montfort, R, Hoelder, S.
Deposit date:2017-01-18
Release date:2017-04-05
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Structure-Enabled Discovery of a Stapled Peptide Inhibitor to Target the Oncogenic Transcriptional Repressor TLE1.
Chemistry, 23, 2017
5N4A
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BU of 5n4a by Molmil
Crystal structure of Chlamydomonas IFT80
Descriptor: GLYCEROL, Intraflagellar transport protein 80, OXALATE ION
Authors:Taschner, M, Mourao, A.
Deposit date:2017-02-10
Release date:2018-02-28
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Crystal structure of intraflagellar transport protein 80 reveals a homo-dimer required for ciliogenesis.
Elife, 7, 2018
4ERQ
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BU of 4erq by Molmil
X-ray structure of WDR5-MLL2 Win motif peptide binary complex
Descriptor: Histone-lysine N-methyltransferase MLL2, WD repeat-containing protein 5
Authors:Dharmarajan, V, Lee, J.-H, Patel, A, Skalnik, D.G, Cosgrove, M.S.
Deposit date:2012-04-20
Release date:2012-05-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.906 Å)
Cite:Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.
J.Biol.Chem., 287, 2012
5NAF
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BU of 5naf by Molmil
Co-crystal structure of an MeCP2 peptide with TBLR1 WD40 domain
Descriptor: F-box-like/WD repeat-containing protein TBL1XR1, GLYCEROL, Methyl-CpG-binding protein 2
Authors:Kruusvee, V, Cook, A.G.
Deposit date:2017-02-27
Release date:2017-03-29
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.493 Å)
Cite:Structure of the MeCP2-TBLR1 complex reveals a molecular basis for Rett syndrome and related disorders.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5NNZ
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BU of 5nnz by Molmil
Crystal structure of human ODA16
Descriptor: Dynein assembly factor with WDR repeat domains 1
Authors:Lorentzen, E, Taschner, T, Basquin, J.
Deposit date:2017-04-10
Release date:2017-06-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.651 Å)
Cite:Purification and crystal structure of human ODA16: Implications for ciliary import of outer dynein arms by the intraflagellar transport machinery.
Protein Sci., 29, 2020
5NUV
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Structure of the WD40-domain of human ATG16L1
Descriptor: (R,R)-2,3-BUTANEDIOL, Autophagy-related protein 16-1
Authors:Bajagic, M, Scrima, A.
Deposit date:2017-05-02
Release date:2017-07-19
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structure of the WD40-domain of human ATG16L1.
Protein Sci., 26, 2017
4FHL
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BU of 4fhl by Molmil
Nucleoporin Nup37 from Schizosaccharomyces pombe
Descriptor: 1,2-ETHANEDIOL, 1,4-BUTANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ...
Authors:Bilokapic, S, Schwartz, T.U.
Deposit date:2012-06-06
Release date:2012-09-26
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular basis for Nup37 and ELY5/ELYS recruitment to the nuclear pore complex.
Proc.Natl.Acad.Sci.USA, 109, 2012
4CY3
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BU of 4cy3 by Molmil
Crystal structure of the NSL1-WDS complex.
Descriptor: CG4699, ISOFORM D, GLYCEROL, ...
Authors:Dias, J, Brettschneider, J, Cusack, S, Kadlec, J.
Deposit date:2014-04-10
Release date:2014-05-14
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural Analysis of the Kansl1/Wdr5/Kansl2 Complex Reveals that Wdr5 is Required for Efficient Assembly and Chromatin Targeting of the Nsl Complex.
Genes Dev., 28, 2014
4D6V
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BU of 4d6v by Molmil
Crystal structure of signal transducing protein
Descriptor: G PROTEIN BETA SUBUNIT GIB2
Authors:Ero, R, Dimitrova, V.T, Chen, Y, Bu, W, Feng, S, Liu, T, Wang, P, Xue, C, Tan, S.M, Gao, Y.G.
Deposit date:2014-11-17
Release date:2015-03-18
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of Gib2, a Signal-Transducing Protein Scaffold Associated with Ribosomes in Cryptococcus Neoformans.
Sci.Rep., 5, 2015
4GM8
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BU of 4gm8 by Molmil
Crystal structure of human WD repeat domain 5 with compound MM-102
Descriptor: MM-102, WD repeat-containing protein 5
Authors:Karatas, H, Townsend, E.C, Chen, Y, Bernard, D, Cao, F, Liu, L, Lei, M, Dou, Y, Wang, S.
Deposit date:2012-08-15
Release date:2013-07-31
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction.
J.Am.Chem.Soc., 135, 2013
5MZH
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BU of 5mzh by Molmil
Crystal structure of ODA16 from Chlamydomonas reinhardtii
Descriptor: Dynein assembly factor with WDR repeat domains 1, SULFATE ION
Authors:Lorentzen, E, Taschner, M, Basquin, J, Mourao, A.
Deposit date:2017-01-31
Release date:2017-03-22
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.398 Å)
Cite:Structural basis of outer dynein arm intraflagellar transport by the transport adaptor protein ODA16 and the intraflagellar transport protein IFT46.
J. Biol. Chem., 292, 2017
5N1A
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BU of 5n1a by Molmil
Crystal structure of Utp4 from Chaetomium thermophilum
Descriptor: utp4
Authors:Calvino, F.R, Ahmed, Y.L, Wild, K, Sinning, I.
Deposit date:2017-02-05
Release date:2017-06-14
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural basis for 5'-ETS recognition by Utp4 at the early stages of ribosome biogenesis.
PLoS ONE, 12, 2017
4GM9
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BU of 4gm9 by Molmil
Crystal structure of human WD repeat domain 5 with compound MM-401
Descriptor: MM-401, WD repeat-containing protein 5
Authors:Karatas, H, Townsend, E.C, Chen, Y, Bernard, D, Liu, L, Dou, Y, Lei, M, Wang, S.
Deposit date:2012-08-15
Release date:2014-02-19
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of human WD repeat domain 5 with compound MM-401
To be Published
4EWR
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BU of 4ewr by Molmil
X-ray structure of WDR5-SETd1a Win motif peptide binary complex
Descriptor: Histone-lysine N-methyltransferase SETD1A, WD repeat-containing protein 5
Authors:Dharmarajan, V, Lee, J.-H, Patel, A, Skalnik, D.G, Cosgrove, M.S.
Deposit date:2012-04-27
Release date:2012-05-30
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.503 Å)
Cite:Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.
J.Biol.Chem., 287, 2012
5OV3
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BU of 5ov3 by Molmil
Structure of the RbBP5 beta-propeller domain
Descriptor: Retinoblastoma-binding protein 5, TETRAETHYLENE GLYCOL, TRIETHYLENE GLYCOL
Authors:Mittal, A, Zhang, Y, Gamblin, S.J, Wilson, J.R.
Deposit date:2017-08-27
Release date:2018-03-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:The structure of the RbBP5 beta-propeller domain reveals a surface with potential nucleic acid binding sites.
Nucleic Acids Res., 46, 2018
4ESG
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BU of 4esg by Molmil
X-ray structure of WDR5-MLL1 Win motif peptide binary complex
Descriptor: Histone-lysine N-methyltransferase MLL, WD repeat-containing protein 5
Authors:Dharmarajan, V, Lee, J.-H, Patel, A, Skalnik, D.G, Cosgrove, M.S.
Deposit date:2012-04-23
Release date:2012-05-30
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.
J.Biol.Chem., 287, 2012
4ERY
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BU of 4ery by Molmil
X-ray structure of WDR5-MLL3 Win motif peptide binary complex
Descriptor: Histone-lysine N-methyltransferase MLL3, WD repeat-containing protein 5
Authors:Dharmarajan, V, Lee, J.-H, Patel, A, Skalnik, D.G, Cosgrove, M.S.
Deposit date:2012-04-21
Release date:2012-05-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.
J.Biol.Chem., 287, 2012
4GM3
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BU of 4gm3 by Molmil
Crystal structure of human WD repeat domain 5 with compound MM-101
Descriptor: MM-101, WD repeat-containing protein 5
Authors:Karatas, H, Townsend, E.C, Chen, Y, Bernard, D, Cao, F, Liu, L, Lei, M, Dou, Y, Wang, S.
Deposit date:2012-08-15
Release date:2013-07-31
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.393 Å)
Cite:High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction.
J.Am.Chem.Soc., 135, 2013
4GMB
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BU of 4gmb by Molmil
Crystal structure of human WD repeat domain 5 with compound MM-402
Descriptor: MM-402, WD repeat-containing protein 5
Authors:Karatas, H, Townsend, E.C, Chen, Y, Bernard, D, Cao, F, Liu, L, Lei, M, Dou, Y, Wang, S.
Deposit date:2012-08-15
Release date:2014-02-19
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.781 Å)
Cite:Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction.
J.Med.Chem., 60, 2017
4ERZ
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BU of 4erz by Molmil
X-ray structure of WDR5-MLL4 Win motif peptide binary complex
Descriptor: Histone-lysine N-methyltransferase MLL4, WD repeat-containing protein 5
Authors:Dharmarajan, V, Lee, J.-H, Patel, A, Skalnik, D.G, Cosgrove, M.S.
Deposit date:2012-04-21
Release date:2012-05-30
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.
J.Biol.Chem., 287, 2012
4GQ1
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Nup37 of S. pombe
Descriptor: Nup37, SULFATE ION
Authors:Liu, X, Mitchell, J, Wozniak, R, Blobel, G, Fan, J.
Deposit date:2012-08-22
Release date:2012-10-03
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural evolution of the membrane-coating module of the nuclear pore complex.
Proc.Natl.Acad.Sci.USA, 109, 2012
4H5J
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BU of 4h5j by Molmil
Crystal Structure of the Guanine Nucleotide Exchange Factor Sec12 (P64 form)
Descriptor: Guanine nucleotide-exchange factor SEC12, POTASSIUM ION
Authors:McMahon, C, Jeffrey, P.D, Hughson, F.M.
Deposit date:2012-09-18
Release date:2012-11-07
Last modified:2013-01-09
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:The structure of sec12 implicates potassium ion coordination in sar1 activation.
J.Biol.Chem., 287, 2012

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