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4WBB
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BU of 4wbb by Molmil
Single Turnover Autophosphorylation Cycle of the PKA RIIb Holoenzyme
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, cAMP-dependent protein kinase catalytic subunit alpha, ...
Authors:Zhang, P, Knape, M.J, Ahuja, L.G, Keshwani, M.M, King, C.C, Sastri, M, Herberg, F.W, Taylor, S.S.
Deposit date:2014-09-02
Release date:2015-05-20
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Single Turnover Autophosphorylation Cycle of the PKA RII beta Holoenzyme.
Plos Biol., 13, 2015
3KCC
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BU of 3kcc by Molmil
Crystal structure of D138L mutant of Catabolite Gene Activator Protein
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Catabolite gene activator
Authors:Tao, W.B, Gao, Z.Q, Zhou, J.H, Dong, Y.H, Yu, S.N.
Deposit date:2009-10-21
Release date:2009-11-17
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:The 1.6A resolution structure of activated D138L mutant of catabolite gene activator protein with two cAMP bound in each monomer
Int.J.Biol.Macromol., 48, 2011
5FET
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BU of 5fet by Molmil
Crystal Structure of PVX_084705 in presence of Compound 2
Descriptor: 4-[7-[(dimethylamino)methyl]-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-2-amine, cGMP-dependent protein kinase, putative
Authors:Wernimont, A.K, Tempel, W, Walker, J.R, He, H, Seitova, A, Hills, T, Neculai, A.M, Baker, D.A, Flueck, C, Kettleborough, C.A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Hui, R, Hutchinson, A, El Bakkouri, M, Structural Genomics Consortium (SGC)
Deposit date:2015-12-17
Release date:2016-01-13
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (3.07 Å)
Cite:Crystal Structure of PVX_084705 in presence of Compound 2
To be published
8BX7
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BU of 8bx7 by Molmil
Structure of the rod CNG channel bound to calmodulin
Descriptor: Cyclic nucleotide-gated cation channel beta-1, cGMP-gated cation channel alpha-1, calmodulin-1
Authors:Marino, J.
Deposit date:2022-12-08
Release date:2023-04-12
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (2.76 Å)
Cite:Structural basis of calmodulin modulation of the rod cyclic nucleotide-gated channel.
Proc.Natl.Acad.Sci.USA, 120, 2023
7O4H
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BU of 7o4h by Molmil
The structure of the native CNGA1/CNGB1 CNG channel from retinal rods
Descriptor: Cyclic nucleotide-gated cation channel beta-1, cGMP-gated cation channel alpha-1
Authors:Barret, D.C.A, Marino, J.
Deposit date:2021-04-06
Release date:2022-01-12
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:The structure of the native CNGA1/CNGB1 CNG channel from bovine retinal rods.
Nat.Struct.Mol.Biol., 29, 2022
7CAL
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BU of 7cal by Molmil
Cryo-EM Structure of the Hyperpolarization-Activated Inwardly Rectifying Potassium Channel KAT1 from Arabidopsis
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, Potassium channel KAT1
Authors:Li, S.Y, Yang, F, Sun, D.M, Zhang, Y, Zhang, M.G, Zhou, P, Liu, S.L, Zhang, Y.N, Zhang, L.H, Tian, C.L.
Deposit date:2020-06-09
Release date:2020-07-29
Last modified:2020-11-18
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structure of the hyperpolarization-activated inwardly rectifying potassium channel KAT1 from Arabidopsis.
Cell Res., 30, 2020
6M63
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BU of 6m63 by Molmil
Crystal structure of a cAMP sensor G-Flamp1.
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Chimera of Cyclic nucleotide-gated potassium channel mll3241 and Yellow fluorescent protein
Authors:Zhou, Z, Chen, S, Wang, L, Chu, J.
Deposit date:2020-03-12
Release date:2021-09-22
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:A high-performance genetically encoded fluorescent indicator for in vivo cAMP imaging.
Nat Commun, 13, 2022
6B6H
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BU of 6b6h by Molmil
The cryo-EM structure of a bacterial class I transcription activation complex
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Liu, B, Hong, C, Huang, R, Yu, Z, Steitz, T.A.
Deposit date:2017-10-02
Release date:2017-11-15
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural basis of bacterial transcription activation.
Science, 358, 2017
9CHQ
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BU of 9chq by Molmil
Cryo-EM structure of the human ether-a-go-go related K+ channel (hERG) in 3 mM K+
Descriptor: Potassium voltage-gated channel subfamily H member 2
Authors:Lau, C.H.Y, Hunter, M.J, Vandenberg, J.I.
Deposit date:2024-07-01
Release date:2024-08-21
Last modified:2024-09-11
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Potassium dependent structural changes in the selectivity filter of HERG potassium channels.
Nat Commun, 15, 2024
9CHS
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BU of 9chs by Molmil
Cryo-EM structure of the human ether-a-go-go related K+ channel (hERG) in 3 mM K+ without symmetry
Descriptor: Potassium voltage-gated channel subfamily H member 2
Authors:Lau, C.H.Y, Hunter, M.J, Vandenberg, J.I.
Deposit date:2024-07-01
Release date:2024-08-21
Last modified:2024-09-11
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Potassium dependent structural changes in the selectivity filter of HERG potassium channels.
Nat Commun, 15, 2024
3RDI
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BU of 3rdi by Molmil
Domain-domain flexibility leads to allostery within the camp receptor protein (CRP)
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Catabolite gene activator
Authors:Knapp, J, White, M.A, Lee, J.C.
Deposit date:2011-04-01
Release date:2012-05-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Domain-Domain Flexibility Leads to Allostery within the Cam Receptor Protein (Crp)
To be Published
6I9D
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BU of 6i9d by Molmil
MloK1 consensus structure from single particle analysis of 2D crystals
Descriptor: Cyclic nucleotide-gated potassium channel mll3241, POTASSIUM ION
Authors:Righetto, R, Biyani, N, Kowal, J, Chami, M, Stahlberg, H.
Deposit date:2018-11-23
Release date:2019-04-24
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Retrieving high-resolution information from disordered 2D crystals by single-particle cryo-EM.
Nat Commun, 10, 2019
2XGX
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BU of 2xgx by Molmil
Crystal structure of transcription factor NtcA from Synechococcus elongatus (mercury derivative)
Descriptor: 2-OXOGLUTARIC ACID, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLOBAL NITROGEN REGULATOR, ...
Authors:Llacer, J.L, Castells, M.A, Rubio, V.
Deposit date:2010-06-08
Release date:2010-08-18
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural Basis for the Regulation of Ntca-Dependent Transcription by Proteins Pipx and Pii.
Proc.Natl.Acad.Sci.USA, 107, 2010
6VXZ
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BU of 6vxz by Molmil
SthK P300A cyclic nucleotide-gated potassium channel in the closed state, in complex with cAMP
Descriptor: (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, SthK
Authors:Schmidpeter, P.A.M, Rheinberger, J, Nimigean, C.M.
Deposit date:2020-02-25
Release date:2020-11-11
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.42 Å)
Cite:Prolyl isomerization controls activation kinetics of a cyclic nucleotide-gated ion channel.
Nat Commun, 11, 2020
6VY0
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BU of 6vy0 by Molmil
SthK P300A cyclic nucleotide-gated potassium channel in a putative active state, in complex with cAMP
Descriptor: SthK
Authors:Schmidpeter, P.A.M, Rheinberger, J, Nimigean, C.M.
Deposit date:2020-02-25
Release date:2020-11-11
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (6.68 Å)
Cite:Prolyl isomerization controls activation kinetics of a cyclic nucleotide-gated ion channel.
Nat Commun, 11, 2020
3RYP
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BU of 3ryp by Molmil
Domain-domain flexibility leads to allostery within the camp receptor protein (CRP)
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Catabolite gene activator, GLYCEROL
Authors:Knapp, J, White, M.A, Lee, J.C.
Deposit date:2011-05-11
Release date:2012-05-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Domain-Domain Flexibility Leads to Allostery within the Cam Receptor Protein (Crp)
To be Published
2XKO
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BU of 2xko by Molmil
Crystal structure of the complex of NtcA with its transcriptional co- activator PipX
Descriptor: 2-OXOGLUTARIC ACID, GLOBAL NITROGEN REGULATOR, PIPX
Authors:Llacer, J.L, Castells, M.A, Rubio, V.
Deposit date:2010-07-11
Release date:2010-08-18
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural Basis for the Regulation of Ntca-Dependent Transcription by Proteins Pipx and Pii.
Proc.Natl.Acad.Sci.USA, 107, 2010
6IAX
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BU of 6iax by Molmil
MloK1 model from single particle analysis of 2D crystals, class 1 (extended conformation)
Descriptor: Cyclic nucleotide-gated potassium channel mll3241, POTASSIUM ION
Authors:Righetto, R, Biyani, N, Kowal, J, Chami, M, Stahlberg, H.
Deposit date:2018-11-27
Release date:2019-04-24
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (5.2 Å)
Cite:Retrieving high-resolution information from disordered 2D crystals by single-particle cryo-EM.
Nat Commun, 10, 2019
6NO7
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BU of 6no7 by Molmil
Crystal Structure of the full-length wild-type PKA RIa Holoenzyme
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, cAMP-dependent protein kinase catalytic subunit alpha, ...
Authors:Lu, T, Wu, J, Taylor, S.S.
Deposit date:2019-01-15
Release date:2019-07-24
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.55 Å)
Cite:Two PKA RI alpha holoenzyme states define ATP as an isoform-specific orthosteric inhibitor that competes with the allosteric activator, cAMP.
Proc.Natl.Acad.Sci.USA, 116, 2019
4X6R
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BU of 4x6r by Molmil
An Isoform-specific Myristylation Switch Targets RIIb PKA Holoenzymes to Membranes
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ...
Authors:Zhang, P, Ye, F, Bastidas, A.C, Kornev, A.P, Ginsberg, M.H, Wu, J, Taylor, S.S.
Deposit date:2014-12-09
Release date:2015-07-22
Last modified:2020-06-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes.
Structure, 23, 2015
4X6Q
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BU of 4x6q by Molmil
An Isoform-specific Myristylation Switch Targets RIIb PKA Holoenzymes to Membranes
Descriptor: cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase type II-beta regulatory subunit
Authors:Zhang, P, Ye, F, Bastidas, A.C, Kornev, A.P, Ginsberg, M.H, Taylor, S.S.
Deposit date:2014-12-08
Release date:2015-07-22
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes.
Structure, 23, 2015
2QCS
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BU of 2qcs by Molmil
A complex structure between the Catalytic and Regulatory subunit of Protein Kinase A that represents the inhibited state
Descriptor: ACETATE ION, GLYCEROL, MANGANESE (II) ION, ...
Authors:Kim, C, Cheng, C.Y, Saldanha, A.S, Taylor, S.S.
Deposit date:2007-06-19
Release date:2007-11-06
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation.
Cell(Cambridge,Mass.), 130, 2007
6PB4
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BU of 6pb4 by Molmil
The E. coli class-II CAP-dependent transcription activation complex with de novo RNA transcript at the state 2
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Liu, B, Shi, W.
Deposit date:2019-06-13
Release date:2020-03-18
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (4.35 Å)
Cite:Visualization of two architectures in class-II CAP-dependent transcription activation
Plos Biol., 18, 2020
2BYV
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BU of 2byv by Molmil
Structure of the cAMP responsive exchange factor Epac2 in its auto- inhibited state
Descriptor: RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 4
Authors:Rehmann, H, Wittinghofer, A, Bos, J.L.
Deposit date:2005-08-08
Release date:2006-02-02
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of the Cyclic-AMP Responsive Exchange Factor Epac2 in its Auto-Inhibited State
Nature, 439, 2006
6PB5
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BU of 6pb5 by Molmil
The E. coli class-II CAP-dependent transcription activation complex at the state 1 architecture
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Liu, B, Shi, W.
Deposit date:2019-06-13
Release date:2020-03-18
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (4.52 Å)
Cite:Visualization of two architectures in class-II CAP-dependent transcription activation
Plos Biol., 18, 2020

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