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2G9H
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Crystal Structure of Staphylococcal Enterotoxin I (SEI) in Complex with a Human MHC class II Molecule
Descriptor: 1,4-DIETHYLENE DIOXIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, HLA class II histocompatibility antigen, ...
Authors:Fernandez, M.M, Guan, R, Malchiodi, E.L, Mariuzza, R.A.
Deposit date:2006-03-06
Release date:2006-07-11
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of staphylococcal enterotoxin I (SEI) in complex with a human major histocompatibility complex class II molecule.
J.Biol.Chem., 281, 2006
3R8B
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Crystal structure of Staphylococcal Enterotoxin B in complex with an affinity matured mouse TCR VBeta8.2 protein, G5-8
Descriptor: CHLORIDE ION, Enterotoxin type B, G5-8, ...
Authors:Bonsor, D.A, Sundberg, E.J.
Deposit date:2011-03-23
Release date:2011-04-06
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Molecular basis of a million-fold affinity maturation process in a protein-protein interaction.
J.Mol.Biol., 411, 2011
4RGO
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Structure of Staphylococcal Enterotoxin B bound to the neutralizing antibody 14G8
Descriptor: 14G8 heavy chain, 14G8 light chain, ACETATE ION, ...
Authors:Franklin, M.C, Dutta, K, Varshney, A.K, Goger, M.J, Fries, B.C.
Deposit date:2014-09-30
Release date:2015-01-21
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mechanisms mediating enhanced neutralization efficacy of staphylococcal enterotoxin B by combinations of monoclonal antibodies.
J.Biol.Chem., 290, 2015
4RGM
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Structure of Staphylococcal Enterotoxin B bound to the neutralizing antibody 20B1
Descriptor: 20B1 heavy chain, 20B1 light chain, Enterotoxin type B
Authors:Franklin, M.C, Dutta, K, Varshney, A.K, Goger, M.J, Fries, B.C.
Deposit date:2014-09-30
Release date:2015-01-21
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.689 Å)
Cite:Mechanisms mediating enhanced neutralization efficacy of staphylococcal enterotoxin B by combinations of monoclonal antibodies.
J.Biol.Chem., 290, 2015
4RGN
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Structure of Staphylococcal Enterotoxin B bound to two neutralizing antibodies, 14G8 and 6D3
Descriptor: 14G8 heavy chain, 14G8 light chain, 6D3 heavy chain, ...
Authors:Franklin, M.C, Dutta, K, Varshney, A.K, Goger, M.J, Fries, B.C.
Deposit date:2014-09-30
Release date:2015-01-21
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.698 Å)
Cite:Mechanisms mediating enhanced neutralization efficacy of staphylococcal enterotoxin B by combinations of monoclonal antibodies.
J.Biol.Chem., 290, 2015
4UDU
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Crystal structure of staphylococcal enterotoxin E in complex with a T cell receptor
Descriptor: ENTEROTOXIN TYPE E, PROTEIN TRBV7-9, T-CELL RECEPTOR BETA-2 CHAIN C REGION, ...
Authors:Rodstrom, K.E.J, Regenthal, P, Lindkvist-Petersson, K.
Deposit date:2014-12-11
Release date:2015-06-24
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of Staphylococcal Enterotoxin E in Complex with Tcr Defines the Role of Tcr Loop Positioning in Superantigen Recognition.
Plos One, 10, 2015
1HQR
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CRYSTAL STRUCTURE OF A SUPERANTIGEN BOUND TO THE HIGH-AFFINITY, ZINC-DEPENDENT SITE ON MHC CLASS II
Descriptor: HLA-DR ALPHA CHAIN, HLA-DR BETA CHAIN, MYELIN BASIC PROTEIN, ...
Authors:Li, Y, Li, H, Dimasi, N, Schlievert, P, Mariuzza, R.
Deposit date:2000-12-19
Release date:2001-01-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of a superantigen bound to the high-affinity, zinc-dependent site on MHC class II.
Immunity, 14, 2001
1I4P
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CRYSTAL STRUCTURE OF STAPHYLOCOCCAL ENTEROTOXIN C2 AT 100K CRYSTALLIZED AT PH 5.5
Descriptor: ENTEROTOXIN TYPE C-2, ZINC ION
Authors:Kumaran, D, Swaminathan, S.
Deposit date:2001-02-22
Release date:2001-03-14
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of staphylococcal enterotoxin C2 at various pH levels.
Acta Crystallogr.,Sect.D, 57, 2001
1JWM
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Crystal Structure of the Complex of the MHC Class II Molecule HLA-DR1(HA peptide 306-318) with the Superantigen SEC3
Descriptor: Enterotoxin type C-3, HA peptide, HLA class II histocompatibility antigen, ...
Authors:Sundberg, E.J, Andersen, P.S, Schlievert, P.M, Karjalainen, K, Mariuzza, R.A.
Deposit date:2001-09-04
Release date:2003-07-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural, energetic, and functional analysis of a protein-protein interface at distinct stages of affinity maturation
Structure, 11, 2003
1I4R
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CRYSTAL STRUCTURE OF STAPHYLOCOCCAL ENTEROTOXIN C2 AT 100K CRYSTALLIZED AT PH 6.5
Descriptor: ENTEROTOXIN TYPE C-2, ZINC ION
Authors:Kumaran, D, Swaminathan, S.
Deposit date:2001-02-22
Release date:2001-03-14
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of staphylococcal enterotoxin C2 at various pH levels.
Acta Crystallogr.,Sect.D, 57, 2001
1I4X
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STAPHYLOCOCCAL ENTEROTOXIN C2, MONOCLINIC FORM CRYSTALLIZED AT PH 8.0
Descriptor: ENTEROTOXIN TYPE C-2, ZINC ION
Authors:Swaminathan, S, Sax, M.
Deposit date:2001-02-23
Release date:2001-03-14
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of staphylococcal enterotoxin C2 at various pH levels.
Acta Crystallogr.,Sect.D, 57, 2001
1KLU
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Crystal structure of HLA-DR1/TPI(23-37) complexed with staphylococcal enterotoxin C3 variant 3B2 (SEC3-3B2)
Descriptor: ENTEROTOXIN TYPE C-3, HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN, ...
Authors:Sundberg, E.J, Sawicki, M.W, Andersen, P.S, Sidney, J, Sette, A, Mariuzza, R.A.
Deposit date:2001-12-12
Release date:2002-08-02
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Minor structural changes in a mutated human melanoma antigen correspond to dramatically enhanced stimulation of a CD4+ tumor-infiltrating lymphocyte line.
J.Mol.Biol., 319, 2002
1I4H
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Crystal structure of Zn2+ soaked Staphylococcal enterotoxin A mutant H187A
Descriptor: ENTEROTOXIN TYPE A, ZINC ION
Authors:Hakansson, M, Antonsson, P, Bjork, P, Svensson, L.A.
Deposit date:2001-02-21
Release date:2001-02-28
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Cooperative zinc binding in a staphylococcal enterotoxin A mutant mimics the SEA-MHC class II interaction
J.Biol.Inorg.Chem., 6, 2001
1I4Q
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CRYSTAL STRUCTURE OF STAPHYLOCOCCAL ENTEROTOXIN C2 AT 100K CRYSTALLIZED AT PH 6.0
Descriptor: ENTEROTOXIN TYPE C-2, ZINC ION
Authors:Kumaran, D, Swaminathan, S.
Deposit date:2001-02-22
Release date:2001-03-14
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of staphylococcal enterotoxin C2 at various pH levels.
Acta Crystallogr.,Sect.D, 57, 2001
1I4G
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Crystal structure of Staphylococcal enterotoxin A mutant H187A with reduced Zn2+ affinity
Descriptor: ENTEROTOXIN TYPE A, SULFATE ION, ZINC ION
Authors:Hakansson, M, Antonsson, P, Bjork, P, Svensson, L.A.
Deposit date:2001-02-21
Release date:2001-02-28
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Cooperative zinc binding in a staphylococcal enterotoxin A mutant mimics the SEA-MHC class II interaction
J.Biol.Inorg.Chem., 6, 2001
1KLG
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Crystal structure of HLA-DR1/TPI(23-37, Thr28-->Ile mutant) complexed with staphylococcal enterotoxin C3 variant 3B2 (SEC3-3B2)
Descriptor: ENTEROTOXIN TYPE C-3, HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN, ...
Authors:Sundberg, E.J, Sawicki, M.W, Andersen, P.S, Sidney, J, Sette, A, Mariuzza, R.A.
Deposit date:2001-12-11
Release date:2002-08-02
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Minor structural changes in a mutated human melanoma antigen correspond to dramatically enhanced stimulation of a CD4+ tumor-infiltrating lymphocyte line.
J.Mol.Biol., 319, 2002
1JWU
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Crystal Structure of the Complex of the MHC Class II Molecule HLA-DR1 (HA peptide 306-318) with the superantigen SEC3 Variant 3B2
Descriptor: Enterotoxin type C-3, HA peptide, HLA class II histocompatibility antigen, ...
Authors:Sundberg, E.J, Andersen, P.S, Schlievert, P.M, Karjalainen, K, Mariuzza, R.A.
Deposit date:2001-09-05
Release date:2003-07-08
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural, energetic, and functional analysis of a protein-protein interface at distinct stages of affinity maturation
Structure, 11, 2003
1KTK
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Complex of Streptococcal pyrogenic enterotoxin C (SpeC) with a human T cell receptor beta chain (Vbeta2.1)
Descriptor: Exotoxin type C, T-cell receptor beta chain
Authors:Sundberg, E.J, Li, H, Llera, A.S, McCormick, J.K, Tormo, J, Karjalainen, K, Schlievert, P.M, Mariuzza, R.A.
Deposit date:2002-01-16
Release date:2002-06-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structures of two streptococcal superantigens bound to TCR beta chains reveal diversity in the architecture of T cell signaling complexes.
Structure, 10, 2002
1HXY
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CRYSTAL STRUCTURE OF STAPHYLOCOCCAL ENTEROTOXIN H IN COMPLEX WITH HUMAN MHC CLASS II
Descriptor: ENTEROTOXIN H, HEMAGGLUTININ, HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, ...
Authors:Petersson, K, Hakansson, M, Nilsson, H, Forsberg, G, Svensson, L.A, Liljas, A, Walse, B.
Deposit date:2001-01-17
Release date:2001-06-27
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of a Superantigen Bound to MHC Class II Displays Zinc and Peptide Dependence
Embo J., 20, 2001
1JCK
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T-CELL RECEPTOR BETA CHAIN COMPLEXED WITH SEC3 SUPERANTIGEN
Descriptor: 14.3.D T CELL ANTIGEN RECEPTOR, STAPHYLOCOCCAL ENTEROTOXIN C3
Authors:Fields, B.A, Mariuzza, R.A.
Deposit date:1996-10-22
Release date:1997-11-12
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Crystal structure of a T-cell receptor beta-chain complexed with a superantigen.
Nature, 384, 1996
1JWS
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Crystal Structure of the Complex of the MHC Class II Molecule HLA-DR1 (HA peptide 306-318) with the Superantigen SEC3 Variant 3B1
Descriptor: Enterotoxin type C-3, HA peptide, HLA class II histocompatibility antigen, ...
Authors:Sundberg, E.J, Andersen, P.S, Schlievert, P.M, Karjalainen, K, Mariuzza, R.A.
Deposit date:2001-09-05
Release date:2003-07-08
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural, energetic, and functional analysis of a protein-protein interface at distinct stages of affinity maturation
Structure, 11, 2003
1L0Y
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T cell receptor beta chain complexed with superantigen SpeA soaked with zinc
Descriptor: 14.3.d T cell receptor beta chain, Exotoxin type A, GLYCEROL, ...
Authors:Li, H, Sundberg, E.J, Mariuzza, R.A.
Deposit date:2002-02-14
Release date:2002-04-03
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of two streptococcal superantigens bound to TCR beta chains reveal diversity in the architecture of T cell signaling complexes.
Structure, 10, 2002
1LO5
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Crystal structure of the D227A variant of Staphylococcal enterotoxin A in complex with human MHC class II
Descriptor: HLA class II histocompatibility antigen, DR alpha chain, DR-1 beta chain, ...
Authors:Petersson, K, Thunnissen, M, Forsberg, G, Walse, B.
Deposit date:2002-05-06
Release date:2002-12-18
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal Structure of a SEA Variant in Complex with MHC Class II Reveals the Ability of SEA to Crosslink MHC Molecules
Structure, 10, 2002
1L0X
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TCR beta chain complexed with streptococcal superantigen SpeA
Descriptor: 14.3.d T cell receptor beta chain, Exotoxin type A, GLYCEROL
Authors:Li, H, Sundberg, E.J, Mariuzza, R.A.
Deposit date:2002-02-14
Release date:2002-04-03
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structures of two streptococcal superantigens bound to TCR beta chains reveal diversity in the architecture of T cell signaling complexes.
Structure, 10, 2002
1D5X
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X-RAY CRYSTAL STRUCTURE OF HLA-DR4 COMPLEXED WITH DIPEPTIDE MIMETIC AND SEB
Descriptor: DIPEPTIDE MIMETIC INHIBITOR, ENTEROTOXIN TYPE B, HLA CLASS II HISTOCOMPATIBILITY ANTIGEN
Authors:Swain, A, Crowther, R, Kammlott, U.
Deposit date:1999-10-12
Release date:2000-06-28
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Peptide and peptide mimetic inhibitors of antigen presentation by HLA-DR class II MHC molecules. Design, structure-activity relationships, and X-ray crystal structures.
J.Med.Chem., 43, 2000

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