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1M9D
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X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) O-type chimera Complex.
Descriptor: Cyclophilin A, HIV-1 Capsid
Authors:Howard, B.R, Vajdos, F.F, Li, S, Sundquist, W.I, Hill, C.P.
Deposit date:2002-07-28
Release date:2003-05-27
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural insights into the catalytic mechanism of cyclophilin A
Nat.Struct.Biol., 10, 2003
1AK4
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BU of 1ak4 by Molmil
HUMAN CYCLOPHILIN A BOUND TO THE AMINO-TERMINAL DOMAIN OF HIV-1 CAPSID
Descriptor: CYCLOPHILIN A, HIV-1 CAPSID
Authors:Hill, C.P, Gamble, T.R, Vajdos, F.F, Worthylake, D.K, Sundquist, W.I.
Deposit date:1997-05-28
Release date:1997-10-15
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Crystal structure of human cyclophilin A bound to the amino-terminal domain of HIV-1 capsid.
Cell(Cambridge,Mass.), 87, 1996
6ZDJ
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BU of 6zdj by Molmil
Structure of the native full-length HIV-1 capsid protein in complex with Cyclophilin A from helical assembly (-13,10)
Descriptor: Gag protein, Peptidyl-prolyl cis-trans isomerase A
Authors:Ni, T, Gerard, S, Zhao, G, Ning, J, Zhang, P.
Deposit date:2020-06-14
Release date:2020-08-19
Last modified:2021-02-10
Method:ELECTRON MICROSCOPY (5.8 Å)
Cite:Intrinsic curvature of the HIV-1 CA hexamer underlies capsid topology and interaction with cyclophilin A.
Nat.Struct.Mol.Biol., 27, 2020
3R63
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BU of 3r63 by Molmil
Structure of ERK2 (SPE) mutant (S246E)
Descriptor: Mitogen-activated protein kinase 1
Authors:Livnah, O, Karamansha, Y.
Deposit date:2011-03-21
Release date:2011-08-17
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Nuclear ERK translocation is mediated by protein kinase CK2 and accelerated by autophosphorylation.
Mol.Cell.Biol., 31, 2011
3R90
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BU of 3r90 by Molmil
Crystal structure of Malignant T cell-amplified sequence 1 protein
Descriptor: GLYCEROL, Malignant T cell-amplified sequence 1, SULFATE ION, ...
Authors:Hong, B, Dimov, S, Tempel, W, Tong, Y, Wernimont, A.K, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2011-03-24
Release date:2011-04-13
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of Malignant T cell-amplified sequence 1 protein
to be published
1WKW
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Crystal structure of the ternary complex of eIF4E-m7GpppA-4EBP1 peptide
Descriptor: Eukaryotic translation initiation factor 4E, Eukaryotic translation initiation factor 4E binding protein 1, P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE
Authors:Tomoo, K, Matsushita, Y, Fujisaki, H, Shen, X, Miyagawa, H, Kitamura, K, Miura, K, Ishida, T.
Deposit date:2004-06-10
Release date:2005-06-10
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for mRNA Cap-Binding regulation of eukaryotic initiation factor 4E by 4E-binding protein, studied by spectroscopic, X-ray crystal structural, and molecular dynamics simulation methods
Biochim.Biophys.Acta, 1753, 2005
2Z7L
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Unphosphorylated Mitogen Activated Protein Kinase ERK2 in Complex with (4-{[5-Carbamoyl-4-(3-Methylanilino)Pyrimidin 2-Yl]Amino}Phenyl)Acetic Acid
Descriptor: BETA-MERCAPTOETHANOL, Mitogen-activated protein kinase 1, SULFATE ION, ...
Authors:Katayama, N, Kurihara, H.
Deposit date:2007-08-27
Release date:2008-08-12
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Identification of a key element for hydrogen-bonding patterns between protein kinases and their inhibitors
Proteins, 73, 2008
8D3B
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BU of 8d3b by Molmil
Hexameric HIV-1 (M-group) Q50Y/R120 mutant
Descriptor: Capsid protein p24
Authors:Jacques, D.A, Govasli, M.L, Pinotsis, N, James, L.C.
Deposit date:2022-06-01
Release date:2022-10-19
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Evasion of cGAS and TRIM5 defines pandemic HIV.
Nat Microbiol, 7, 2022
2XDE
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Crystal structure of the complex of PF-3450074 with an engineered HIV capsid N terminal domain
Descriptor: GAG POLYPROTEIN, N-METHYL-NALPHA-[(2-METHYL-1H-INDOL-3-YL)ACETYL]-N-PHENYL-L-PHENYLALANINAMIDE
Authors:Brown, D.G, Irving, S.L, Anderson, M, Bazin, R.
Deposit date:2010-04-30
Release date:2010-12-22
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:HIV Capsid is a Tractable Target for Small Molecule Therapeutic Intervention.
Plos Pathog., 6, 2010
5EYM
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BU of 5eym by Molmil
MEK1 IN COMPLEX WITH BI 847325
Descriptor: 3-[(3~{Z})-3-[[[4-[(dimethylamino)methyl]phenyl]amino]-phenyl-methylidene]-2-oxidanylidene-1~{H}-indol-6-yl]-~{N}-ethyl-prop-2-ynamide, CALCIUM ION, Dual specificity mitogen-activated protein kinase kinase 1
Authors:Bader, G, Reiser, U, Zahn, S.K, Treu, M.
Deposit date:2015-11-25
Release date:2016-08-17
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Pharmacological Profile of BI 847325, an Orally Bioavailable, ATP-Competitive Inhibitor of MEK and Aurora Kinases.
Mol.Cancer Ther., 15, 2016
5BXV
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eIF4E complex
Descriptor: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, Eukaryotic translation initiation factor 4E, Eukaryotic translation initiation factor 4E-binding protein 1
Authors:Sekiyama, N, Arthanari, H, Papdopoulos, E, Rodriguez-Mias, R.A, Wagner, G, Leger-Abraham, M.
Deposit date:2015-06-09
Release date:2015-07-15
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Molecular mechanism of the dual activity of 4EGI-1: Dissociating eIF4G from eIF4E but stabilizing the binding of unphosphorylated 4E-BP1.
Proc.Natl.Acad.Sci.USA, 112, 2015
1Y19
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BU of 1y19 by Molmil
Structural basis for phosphatidylinositol phosphate kinase type I-gamma binding to talin at focal adhesions
Descriptor: Phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma, Talin 1
Authors:de Pereda, J.M, Wegener, K, Santelli, E, Bate, N, Ginsberg, M.H, Critchley, D.R, Campbell, I.D, Liddington, R.C.
Deposit date:2004-11-17
Release date:2005-01-04
Last modified:2016-11-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural bases for phosphatidylinositol phosphate kinase type I-gamma binding to talin at focal adhesions
J.Biol.Chem., 280, 2005
6KZJ
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BU of 6kzj by Molmil
Crystal structure of Ankyrin B/NdeL1 complex
Descriptor: Ankyrin-2, Nuclear distribution protein nudE-like 1
Authors:Ye, J, Li, J, Ye, F, Zhang, M, Zhang, Y, Wang, C.
Deposit date:2019-09-24
Release date:2020-01-15
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Mechanistic insights into the interactions of dynein regulator Ndel1 with neuronal ankyrins and implications in polarity maintenance.
Proc.Natl.Acad.Sci.USA, 117, 2020
6MS4
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BU of 6ms4 by Molmil
Crystal structure of the DENR-MCT-1 complex
Descriptor: Density-regulated protein, GLYCEROL, Malignant T-cell-amplified sequence 1, ...
Authors:Lomakin, I.B, Steitz, T.A, Dmitriev, S.E.
Deposit date:2018-10-16
Release date:2019-01-02
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:Crystal structure of the DENR-MCT-1 complex revealed zinc-binding site essential for heterodimer formation.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
1EJH
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BU of 1ejh by Molmil
EIF4E/EIF4G PEPTIDE/7-METHYL-GDP
Descriptor: 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, EUKARYOTIC INITIATION FACTOR 4E, EUKARYOTIC INITIATION FACTOR 4GII
Authors:Marcotrigiano, J, Gingras, A.-C, Sonenberg, N, Burley, S.K.
Deposit date:2000-03-02
Release date:2000-03-10
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G.
Mol.Cell, 3, 1999
1E6J
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BU of 1e6j by Molmil
Crystal structure of HIV-1 capsid protein (p24) in complex with Fab13B5
Descriptor: CAPSID PROTEIN P24, IMMUNOGLOBULIN
Authors:Berthet-Colominas, C, Monaco, S, Novelli, A, Sibai, G, Mallet, F, Cusack, S.
Deposit date:2000-08-18
Release date:2000-11-27
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Mutual Conformational Adaptations in Antigen and Antibody Upon Complex Formation between an Fab and HIV-1 Capsid Protein P24
Structure, 8, 2000
1CMZ
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BU of 1cmz by Molmil
SOLUTION STRUCTURE OF GAIP (GALPHA INTERACTING PROTEIN): A REGULATOR OF G PROTEIN SIGNALING
Descriptor: PROTEIN (GAIP (G-ALPHA INTERACTING) PROTEIN)
Authors:De Alba, E, De Vries, L, Farquhar, M.G, Tjandra, N.
Deposit date:1999-05-12
Release date:1999-11-10
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Solution structure of human GAIP (Galpha interacting protein): a regulator of G protein signaling.
J.Mol.Biol., 291, 1999
1GWP
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BU of 1gwp by Molmil
STRUCTURE OF THE N-TERMINAL DOMAIN OF THE MATURE HIV-1 CAPSID PROTEIN
Descriptor: GAG POLYPROTEIN
Authors:Tang, C, Gitti, R.K, Lee, B.M, Walker, J, Summers, M.F, Yoo, S, Sundquist, W.I.
Deposit date:2002-03-22
Release date:2002-06-21
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Structure of the N-Terminal 283-Residue Fragment of the Immature HIV-1 Gag Polyprotein
Nat.Struct.Biol., 9, 2002
6VWS
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BU of 6vws by Molmil
Hexamer of Helical HIV capsid by RASTR method
Descriptor: HIV capsid protein
Authors:Zhao, H, Iqbal, N, Asturias, F, Kvaratskhelia, M, Vanblerkom, P.
Deposit date:2020-02-20
Release date:2020-10-21
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (6.08 Å)
Cite:Structural and mechanistic bases for a potent HIV-1 capsid inhibitor.
Science, 370, 2020
6WAP
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BU of 6wap by Molmil
Atomic-Resolution Structure of HIV-1 Capsid Tubes by Magic Angle Spinning NMR
Descriptor: HIV-1 capsid protein
Authors:Lu, M, Russell, R.W, Bryer, A, Quinn, C.M, Hou, G, Zhang, H, Schwieters, C.D, Perilla, J.R, Gronenborn, A.M, Polenova, T.
Deposit date:2020-03-25
Release date:2020-09-02
Last modified:2024-05-15
Method:SOLID-STATE NMR
Cite:Atomic-resolution structure of HIV-1 capsid tubes by magic-angle spinning NMR.
Nat.Struct.Mol.Biol., 27, 2020
6X63
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Atomic-Resolution Structure of HIV-1 Capsid Tubes by Magic Angle Spinning NMR
Descriptor: HIV-1 capsid protein
Authors:Lu, M, Russell, R.W, Bryer, A, Quinn, C.M, Hou, G, Zhang, H, Schwieters, C.D, Perilla, J.R, Gronenborn, A.M, Polenova, T.
Deposit date:2020-05-27
Release date:2020-09-02
Last modified:2024-05-15
Method:SOLID-STATE NMR
Cite:Atomic-resolution structure of HIV-1 capsid tubes by magic-angle spinning NMR.
Nat.Struct.Mol.Biol., 27, 2020
4WYM
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BU of 4wym by Molmil
Structural basis of HIV-1 capsid recognition by CPSF6
Descriptor: Capsid protein p24, ISOFORM 2 OF CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 6
Authors:Battacharya, A, Taylor, A.B, Hart, P.J, Ivanov, D.N.
Deposit date:2014-11-17
Release date:2014-12-17
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis of HIV-1 capsid recognition by PF74 and CPSF6.
Proc.Natl.Acad.Sci.USA, 111, 2014
4XFZ
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Structure of the native full-length HIV-1 capsid protein in complex with PF-3450074 (PF74)
Descriptor: CHLORIDE ION, HIV-1 capsid protein, IODIDE ION, ...
Authors:Gres, A.T, Kirby, K.A, Sarafianos, S.G.
Deposit date:2014-12-29
Release date:2015-06-10
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:STRUCTURAL VIROLOGY. X-ray crystal structures of native HIV-1 capsid protein reveal conformational variability.
Science, 349, 2015
4XP3
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BU of 4xp3 by Molmil
Crystal structure of ERK2 in complex with an inhibitor
Descriptor: 2-amino-1,9-dihydro-6H-purine-6-thione, DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, ...
Authors:Gelin, M, Allemand, F, Labesse, G, Guichou, J.F.
Deposit date:2015-01-16
Release date:2015-08-12
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.782 Å)
Cite:Combining `dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography.
Acta Crystallogr.,Sect.D, 71, 2015
4XNE
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Crystal structure of ERK2 in complex with an inhibitor
Descriptor: 1-phenyl-1H-1,2,4-triazole-3,5-diamine, Mitogen-activated protein kinase 1, SULFATE ION
Authors:Gelin, M, Allemand, F, Labesse, G, Guichou, J.F.
Deposit date:2015-01-15
Release date:2015-08-12
Last modified:2015-08-19
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Combining `dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography.
Acta Crystallogr.,Sect.D, 71, 2015

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