5W2S
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3LRF
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5W2Q
| Crystal structure of Mycobacterium tuberculosis KasA in complex with 6U5 | Descriptor: | 3,3',3''-phosphanetriyltripropanoic acid, 3-oxoacyl-[acyl-carrier-protein] synthase 1, GLYCEROL, ... | Authors: | Capodagli, G.C, Neiditch, M.B. | Deposit date: | 2017-06-06 | Release date: | 2018-12-05 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Synergistic Lethality of a Binary Inhibitor of Mycobacterium tuberculosis KasA. MBio, 9, 2018
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3MQD
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5W2P
| Crystal structure of Mycobacterium tuberculosis KasA in complex with 6U5 | Descriptor: | 3,3',3''-phosphanetriyltripropanoic acid, 3-oxoacyl-[acyl-carrier-protein] synthase 1, GLYCEROL, ... | Authors: | Capodagli, G.C, Neiditch, M.B. | Deposit date: | 2017-06-06 | Release date: | 2018-12-05 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Synergistic Lethality of a Binary Inhibitor of Mycobacterium tuberculosis KasA. MBio, 9, 2018
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3KZU
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3O04
| Crystal structure of the beta-keto-acyl carrier protein synthase II (lmo2201) from Listeria monocytogenes | Descriptor: | beta-keto-acyl carrier protein synthase II | Authors: | Anderson, S.M, Wawrzak, Z, Onopriyenko, O, Anderson, W.F, Savchenko, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2010-07-19 | Release date: | 2010-08-04 | Last modified: | 2021-10-06 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Crystal structure of the beta-keto-acyl carrier protein synthase II (lmo2201) from Listeria monocytogenes To be Published
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6U5T
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6U5U
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7CPY
| Lovastatin nonaketide synthase with LovC | Descriptor: | Lovastatin nonaketide synthase, enoyl reductase component lovC, polyketide synthase component, ... | Authors: | Wang, J, Wang, Z. | Deposit date: | 2020-08-08 | Release date: | 2021-01-13 | Last modified: | 2021-12-15 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural basis for the biosynthesis of lovastatin. Nat Commun, 12, 2021
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6U5V
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6U5W
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7CPX
| Lovastatin nonaketide synthase | Descriptor: | Lovastatin nonaketide synthase, polyketide synthase component, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Wang, J, Wang, Z. | Deposit date: | 2020-08-08 | Release date: | 2021-01-13 | Last modified: | 2021-12-15 | Method: | ELECTRON MICROSCOPY (2.91 Å) | Cite: | Structural basis for the biosynthesis of lovastatin. Nat Commun, 12, 2021
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7S6B
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7S6C
| CryoEM structure of modular PKS holo-Lsd14 stalled at the condensation step and bound to antibody fragment 1B2, composite structure | Descriptor: | 2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHATE, 4'-PHOSPHOPANTETHEINE, 6-deoxyerythronolide-B synthase EryA2, ... | Authors: | Bagde, S.R, Kim, C.-Y, Fromme, J.C. | Deposit date: | 2021-09-13 | Release date: | 2021-11-03 | Last modified: | 2021-11-17 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Modular polyketide synthase contains two reaction chambers that operate asynchronously. Science, 374, 2021
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7S6D
| CryoEM structure of modular PKS holo-Lsd14 bound to antibody fragment 1B2, composite structure | Descriptor: | 2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHATE, 6-deoxyerythronolide-B synthase EryA2, modules 3 and 4, ... | Authors: | Bagde, S.R, Kim, C.-Y, Fromme, J.C. | Deposit date: | 2021-09-13 | Release date: | 2021-11-03 | Last modified: | 2021-11-17 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Modular polyketide synthase contains two reaction chambers that operate asynchronously. Science, 374, 2021
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7S2X
| Structure of SalC, a gamma-lactam-beta-lactone bicyclase for salinosporamide biosynthesis | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, POTASSIUM ION, SalC | Authors: | Chen, P.Y.-T, Trivella, D.B.B, Bauman, K.D, Moore, B.S. | Deposit date: | 2021-09-04 | Release date: | 2022-04-06 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Enzymatic assembly of the salinosporamide gamma-lactam-beta-lactone anticancer warhead. Nat.Chem.Biol., 18, 2022
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7ZMD
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7ZMC
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7ZMA
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7ZM9
| Ketosynthase domain 3 of Brevibacillus Brevis orphan BGC11 | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Putative polyketide synthase | Authors: | Tittes, Y.U, Herbst, D.A, Jakob, R.P, Maier, T. | Deposit date: | 2022-04-19 | Release date: | 2022-09-21 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.62 Å) | Cite: | The structure of a polyketide synthase bimodule core. Sci Adv, 8, 2022
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6WC7
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7SQI
| Crosslinked Crystal Structure of Type II Fatty Acid Synthase Ketosynthase, FabB, and C14-crypto Acyl Carrier Protein, AcpP | Descriptor: | Acyl carrier protein, Beta-ketoacyl-ACP synthase I, N-{2-[(2Z)-3-chlorotetradec-2-enamido]ethyl}-N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alaninamide, ... | Authors: | Chen, A, Mindrebo, J.T, Davis, T.D, Noel, J.P, Burkart, M.D. | Deposit date: | 2021-11-05 | Release date: | 2022-08-03 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Mechanism-based cross-linking probes capture the Escherichia coli ketosynthase FabB in conformationally distinct catalytic states. Acta Crystallogr D Struct Biol, 78, 2022
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7ZSK
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7F27
| Crystal structure of polyketide ketosynthase | Descriptor: | 3-oxoacyl-(Acyl-carrier-protein) synthase | Authors: | Kim, Y, Lee, W.C. | Deposit date: | 2021-06-10 | Release date: | 2022-06-15 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.806 Å) | Cite: | Structural basis of the complementary activity of two ketosynthases in aryl polyene biosynthesis. Sci Rep, 11, 2021
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