2ZFJ
| Crystal Structure of the Kif1A Motor Domain during Mg release: Mg-releasing Transition-1 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF1A, Kinesin heavy chain isoform 5C, ... | Authors: | Nitta, R, Okada, Y, Hirokawa, N. | Deposit date: | 2008-01-08 | Release date: | 2008-09-23 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural model for strain-dependent microtubule activation of Mg-ADP release from kinesin. Nat.Struct.Mol.Biol., 15, 2008
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2ZFL
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2ZFM
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2ZFK
| Crystal Structure of the Kif1A Motor Domain during Mg release: Mg-releasing Transition-2 | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF1A, ... | Authors: | Nitta, R, Okada, Y, Hirokawa, N. | Deposit date: | 2008-01-08 | Release date: | 2008-09-23 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.61 Å) | Cite: | Structural model for strain-dependent microtubule activation of Mg-ADP release from kinesin. Nat.Struct.Mol.Biol., 15, 2008
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3CJO
| Crystal structure of KSP in complex with inhibitor 30 | Descriptor: | (2S)-4-(2,5-difluorophenyl)-N-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide, ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF11, ... | Authors: | Yan, Y. | Deposit date: | 2008-03-13 | Release date: | 2008-07-01 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Kinesin spindle protein (KSP) inhibitors. 9. Discovery of (2S)-4-(2,5-difluorophenyl)-n-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the treatment of taxane-refractory cancer. J.Med.Chem., 51, 2008
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3CNZ
| Structural dynamics of the microtubule binding and regulatory elements in the kinesin-like calmodulin binding protein | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Kinesin heavy chain-like protein, MAGNESIUM ION | Authors: | Vinogradova, M.V, Malanina, G.G, Reddy, V, Reddy, A.S.N, Fletterick, R.J. | Deposit date: | 2008-03-26 | Release date: | 2008-06-17 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural dynamics of the microtubule binding and regulatory elements in the kinesin-like calmodulin binding protein. J.Struct.Biol., 163, 2008
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3COB
| Structural Dynamics of the Microtubule binding and regulatory elements in the Kinesin-like Calmodulin binding protein | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Kinesin heavy chain-like protein, MAGNESIUM ION | Authors: | Vinogradova, M.V, Malanina, G.G, Reddy, V, Reddy, A.S.N, Fletterick, R.J. | Deposit date: | 2008-03-27 | Release date: | 2008-06-24 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural dynamics of the microtubule binding and regulatory elements in the kinesin-like calmodulin binding protein. J.Struct.Biol., 163, 2008
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3DC4
| Crystal structure of the Drosophila kinesin family member NOD in complex with ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein Nod, MAGNESIUM ION | Authors: | Cochran, J.C, Mulko, N.K, Kull, F.J. | Deposit date: | 2008-06-03 | Release date: | 2009-02-10 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | ATPase cycle of the nonmotile kinesin NOD allows microtubule end tracking and drives chromosome movement. Cell(Cambridge,Mass.), 136, 2009
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3DCB
| Crystal structure of the Drosophila kinesin family member NOD in complex with AMPPNP | Descriptor: | Kinesin-like protein Nod, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | Authors: | Cochran, J.C, Mulko, N.K, Kull, F.J. | Deposit date: | 2008-06-03 | Release date: | 2009-02-10 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | ATPase cycle of the nonmotile kinesin NOD allows microtubule end tracking and drives chromosome movement. Cell(Cambridge,Mass.), 136, 2009
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3DCO
| Drosophila NOD (3DC4) and Bovine Tubulin (1JFF) Docked into the 11-Angstrom Cryo-EM Map of Nucleotide-Free NOD Complexed to the Microtubule | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Bovine Alpha Tubulin, Bovine Beta Tubulin, ... | Authors: | Sindelar, C.V, Cochran, J.C, Kull, F.J. | Deposit date: | 2008-06-04 | Release date: | 2009-02-10 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (11 Å) | Cite: | ATPase cycle of the nonmotile kinesin NOD allows microtubule end tracking and drives chromosome movement. Cell(Cambridge,Mass.), 136, 2009
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2VVG
| Crystal Structure of the G.intestinalis Kinesin 2 GiKIN2a Motor Domain | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, KINESIN-2, MAGNESIUM ION | Authors: | Hoeng, J.C, Loewe, J, Dawson, S.C, Cande, W.Z, Sagolla, M.S, Mancuso, J.J. | Deposit date: | 2008-06-08 | Release date: | 2008-07-08 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | High-Resolution Crystal Structure and in Vivo Function of a Kinesin-2 Homologue in Giardia Intestinalis. Mol.Biol.Cell, 19, 2008
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3EDL
| Kinesin13-Microtubule Ring complex | Descriptor: | 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE, Beta tubulin, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Tan, D, Rice, W.J, Sosa, H. | Deposit date: | 2008-09-03 | Release date: | 2009-01-20 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (28 Å) | Cite: | Structure of the kinesin13-microtubule ring complex. Structure, 16, 2008
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3GBJ
| Crystal structure of the motor domain of kinesin KIF13B bound with ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, KIF13B protein, MAGNESIUM ION, ... | Authors: | Tong, Y, Shen, L, Shen, Y, Tempel, W, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2009-02-19 | Release date: | 2009-03-03 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.102 Å) | Cite: | Crystal structure of the motor domain of kinesin KIF13B bound with ADP To be Published
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2WBE
| Kinesin-5-Tubulin Complex with AMPPNP | Descriptor: | BIPOLAR KINESIN KRP-130, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Bodey, A.J, Kikkawa, M, Moores, C.A. | Deposit date: | 2009-02-26 | Release date: | 2009-03-24 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (9.4 Å) | Cite: | 9-Angstrom Structure of a Microtubule-Bound Mitotic Motor. J.Mol.Biol., 388, 2009
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3H4S
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3HQD
| Human kinesin Eg5 motor domain in complex with AMPPNP and Mg2+ | Descriptor: | Kinesin-like protein KIF11, MAGNESIUM ION, PHOSPHATE ION, ... | Authors: | Parke, C.L, Wojcik, E.J, Kim, S, Worthylake, D.K. | Deposit date: | 2009-06-05 | Release date: | 2009-12-08 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.19 Å) | Cite: | ATP Hydrolysis in Eg5 Kinesin Involves a Catalytic Two-water Mechanism. J.Biol.Chem., 285, 2010
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2WOG
| Intermediate and final states of human kinesin Eg5 in complex with S-trityl-L-cysteine | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KIF11, MAGNESIUM ION, ... | Authors: | Kaan, H.Y.K, Ulaganathan, V, Hackney, D.D, Kozielski, F. | Deposit date: | 2009-07-23 | Release date: | 2010-08-04 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | An Allosteric Transition Trapped in an Intermediate State of a New Kinesin-Inhibitor Complex. Biochem.J., 425, 2010
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3K3B
| Co-crystal structure of the human kinesin Eg5 with a novel tetrahydro-beta-carboline | Descriptor: | 3-[(1R)-2-acetyl-6-methyl-2,3,4,9-tetrahydro-1H-beta-carbolin-1-yl]phenol, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ... | Authors: | Bussiere, D.E, Bellamacina, C, Le, V. | Deposit date: | 2009-10-02 | Release date: | 2009-12-15 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | The discovery of tetrahydro-beta-carbolines as inhibitors of the kinesin Eg5. Bioorg.Med.Chem.Lett., 20, 2010
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3K5E
| The structure of human kinesin-like motor protein Kif11/KSP/Eg5 in complex with ADP and enastrol. | Descriptor: | (4S,5R)-5-hydroxy-4-(3-hydroxyphenyl)-3,4,5,6,7,8-hexahydroquinazoline-2(1H)-thione, ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF11, ... | Authors: | Crawley, L, Cheng, R.K.Y, Wood, M, Barker, J, Felicetti, B, Whittaker, M. | Deposit date: | 2009-10-07 | Release date: | 2009-10-20 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | The structure of human kinesin-like motor protein Kif11/KSP/Eg5 in complex with ADP and enastrol. To be Published
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3KEN
| Human Eg5 in complex with S-trityl-L-cysteine | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF11, MAGNESIUM ION, ... | Authors: | Parke, C.L, Wojcik, E.J, Kim, S, Worthylake, D.K. | Deposit date: | 2009-10-26 | Release date: | 2010-03-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Allosteric drug discrimination is coupled to mechanochemical changes in the kinesin-5 motor core. J.Biol.Chem., 285, 2010
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3L1C
| Kinesin-14 Protein Ncd, T436S Mutant | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Protein claret segregational | Authors: | Kull, F.J. | Deposit date: | 2009-12-11 | Release date: | 2010-08-18 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | A kinesin motor in a force-producing conformation. Bmc Struct.Biol., 10, 2010
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3L9H
| X-ray structure of mitotic kinesin-5 (KSP, KIF11, Eg5)in complex with the hexahydro-2H-pyrano[3,2-c]quinoline EMD 534085 | Descriptor: | 1-[2-(dimethylamino)ethyl]-3-{[(2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl]methyl}urea, ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF11 | Authors: | Knoechel, T. | Deposit date: | 2010-01-05 | Release date: | 2010-03-02 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The discovery and optimization of hexahydro-2H-pyrano[3,2-c]quinolines (HHPQs) as potent and selective inhibitors of the mitotic kinesin-5. Bioorg.Med.Chem.Lett., 20, 2010
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2X2R
| Crystal structure of human kinesin Eg5 in complex with (R)-2-amino-3-((4-chlorophenyl)diphenylmethylthio)propanoic acid | Descriptor: | (2R)-2-AMINO-3-[(2R)-2-METHYL-1,1-DIPHENYL-BUTYL]SULFANYL-PROPANOIC ACID, ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KIF11, ... | Authors: | Kaan, H.Y.K, Weiss, J, Menger, D, Ulaganathan, V, Laggner, C, Popowycz, F, Joseph, B, Kozielski, F. | Deposit date: | 2010-01-15 | Release date: | 2011-01-26 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure-Activity Relationship and Multidrug Resistance Study of New S-Trityl-L-Cysteine Derivatives as Inhibitors of Eg5. J.Med.Chem., 54, 2011
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3LRE
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2X7E
| Crystal structure of human kinesin Eg5 in complex with (R)-fluorastrol | Descriptor: | (4R)-5-[(S)-(3,4-DIFLUOROPHENYL)(HYDROXY)METHYL]-4-(3-HYDROXYPHENYL)-1,6-DIMETHYL-3,4-DIHYDROPYRIMIDINE-2(1H)-THIONE, ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KIF11, ... | Authors: | Kaan, H.Y.K, Ulaganathan, V, Rath, O, Laggner, C, Prokopcova, H, Dallinger, D, Kappe, C.O, Kozielski, F. | Deposit date: | 2010-02-26 | Release date: | 2010-07-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol. J.Med.Chem., 53, 2010
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