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8DCK
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BU of 8dck by Molmil
Structure of hemolysin A secretion system HlyB/D complex, ATP-bound
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Alpha-hemolysin translocation ATP-binding protein HlyB, MAGNESIUM ION, ...
Authors:Zhao, H, Chen, J.
Deposit date:2022-06-16
Release date:2022-09-14
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:The hemolysin A secretion system is a multi-engine pump containing three ABC transporters.
Cell, 185, 2022
5EG1
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BU of 5eg1 by Molmil
Antibacterial peptide ABC transporter McjD with a resolved lipid
Descriptor: (2S)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(6E)-HEXADEC-6-ENOYLOXY]PROPYL (8E)-OCTADEC-8-ENOATE, MAGNESIUM ION, Microcin-J25 export ATP-binding/permease protein McjD, ...
Authors:Choudhury, H.G, Beis, K.
Deposit date:2015-10-26
Release date:2016-08-31
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.42 Å)
Cite:Structural and Functional Basis for Lipid Synergy on the Activity of the Antibacterial Peptide ABC Transporter McjD.
J.Biol.Chem., 291, 2016
8DMO
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BU of 8dmo by Molmil
Structure of open, inward-facing MsbA from E. coli
Descriptor: ATP-binding transport protein MsbA
Authors:Liu, C, Lyu, J, Laganowsky, A.D, Zhao, M.
Deposit date:2022-07-08
Release date:2022-12-14
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural basis for lipid and copper regulation of the ABC transporter MsbA.
Nat Commun, 13, 2022
8DMM
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BU of 8dmm by Molmil
Structure of the vanadate-trapped MsbA bound to KDL
Descriptor: (2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-[(2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-carboxy-2-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-5-[[(3~{R})-3-dodecanoyloxytetradecanoyl]amino]-6-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-3-oxidanyl-5-[[(3~{R})-3-oxidanyltetradecanoyl]amino]-4-[(3~{R})-3-oxidanyltetradecanoyl]oxy-6-phosphonooxy-oxan-2-yl]methoxy]-3-phosphonooxy-4-[(3~{R})-3-tetradecanoyloxytetradecanoyl]oxy-oxan-2-yl]methoxy]-5-oxidanyl-oxan-4-yl]oxy-4,5-bis(oxidanyl)oxane-2-carboxylic acid, ADP ORTHOVANADATE, ATP-binding transport protein MsbA
Authors:Liu, C, Lyu, J, Laganowsky, A.D, Zhao, M.
Deposit date:2022-07-08
Release date:2022-12-14
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.47 Å)
Cite:Structural basis for lipid and copper regulation of the ABC transporter MsbA.
Nat Commun, 13, 2022
6GDI
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BU of 6gdi by Molmil
Structure of P-glycoprotein(ABCB1) in the post-hydrolytic state
Descriptor: Multidrug resistance protein 1A
Authors:Ford, R.C, Thonghin, N, Collins, R.F, Barbieri, A, Shafi, T, Siebert, A.
Deposit date:2018-04-23
Release date:2018-05-23
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (7.9 Å)
Cite:Novel features in the structure of P-glycoprotein (ABCB1) in the post-hydrolytic state as determined at 7.9 angstrom resolution.
Bmc Struct.Biol., 18, 2018
6LR0
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BU of 6lr0 by Molmil
structure of human bile salt exporter ABCB11
Descriptor: Bile salt export pump
Authors:Wang, L, Hou, W.T, Chen, L, Jiang, Y.L, Xu, D, Sun, L.F, Zhou, C.Z, Chen, Y.
Deposit date:2020-01-15
Release date:2020-04-15
Last modified:2023-01-18
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Cryo-EM structure of human bile salts exporter ABCB11.
Cell Res., 30, 2020
6HRC
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BU of 6hrc by Molmil
Outward-facing PglK with ATPgammaS bound
Descriptor: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, WlaB protein
Authors:Perez, C, Locher, K.P.
Deposit date:2018-09-26
Release date:2019-03-06
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structure of Outward-Facing PglK and Molecular Dynamics of Lipid-Linked Oligosaccharide Recognition and Translocation.
Structure, 27, 2019
5C76
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BU of 5c76 by Molmil
ATP-driven lipid-linked oligosaccharide flippase PglK in apo-inward facing state (2)
Descriptor: WlaB protein
Authors:Perez, C, Gerber, S, Locher, K.P.
Deposit date:2015-06-24
Release date:2015-08-19
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.94 Å)
Cite:Structure and mechanism of an active lipid-linked oligosaccharide flippase.
Nature, 524, 2015
6MSM
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BU of 6msm by Molmil
Phosphorylated, ATP-bound human cystic fibrosis transmembrane conductance regulator (CFTR)
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL, ...
Authors:Zhang, Z, Liu, F, Chen, J.
Deposit date:2018-10-16
Release date:2018-11-21
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Molecular structure of the ATP-bound, phosphorylated human CFTR.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6PAM
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BU of 6pam by Molmil
Structure of a bacterial Atm1-family ABC transporter with MgADP bound
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATM1-type heavy metal exporter, MAGNESIUM ION
Authors:Fan, C, Kaiser, J.T, Rees, D.C.
Deposit date:2019-06-11
Release date:2020-06-24
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:A structural framework for unidirectional transport by a bacterial ABC exporter.
Proc.Natl.Acad.Sci.USA, 117, 2020
6P6J
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BU of 6p6j by Molmil
Structure of YbtPQ importer with substrate Ybt-Fe bound
Descriptor: ABC transporter protein, FE (III) ION, inner membrane ABC-transporter, ...
Authors:Wang, Z, Hu, W, Zheng, H.
Deposit date:2019-06-04
Release date:2020-03-04
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Pathogenic siderophore ABC importer YbtPQ adopts a surprising fold of exporter.
Sci Adv, 6, 2020
6PAN
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BU of 6pan by Molmil
Structure of a bacterial Atm1-family ABC exporter with ATP bound
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, ATM1-type heavy metal exporter
Authors:Fan, C, Kaiser, J.T, Rees, D.C.
Deposit date:2019-06-11
Release date:2020-06-24
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:A structural framework for unidirectional transport by a bacterial ABC exporter.
Proc.Natl.Acad.Sci.USA, 117, 2020
7O9W
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BU of 7o9w by Molmil
Encequidar-bound human P-glycoprotein in complex with UIC2-Fab
Descriptor: Multidrug resistance protein 1, UIC2 Fab-fragment heavy chain, UIC2 Fab-fragment light chain, ...
Authors:Nosol, K, Locher, K.P.
Deposit date:2021-04-17
Release date:2022-01-12
Last modified:2022-01-26
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Discovery and Characterization of Potent Dual P-Glycoprotein and CYP3A4 Inhibitors: Design, Synthesis, Cryo-EM Analysis, and Biological Evaluations.
J.Med.Chem., 65, 2022
6PAQ
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BU of 6paq by Molmil
Structure of a bacterial Atm1-family ABC exporter with ATP bound
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, ATM1-type heavy metal exporter
Authors:Fan, C, Kaiser, J.T, Rees, D.C.
Deposit date:2019-06-11
Release date:2020-06-24
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.301 Å)
Cite:A structural framework for unidirectional transport by a bacterial ABC exporter.
Proc.Natl.Acad.Sci.USA, 117, 2020
5NBD
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BU of 5nbd by Molmil
PglK flippase in complex with inhibitory nanobody
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Nanobody, WlaB protein
Authors:Perez, C, Pardon, E, Steyaert, J, Locher, K.P.
Deposit date:2017-03-01
Release date:2017-05-03
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Structural basis of inhibition of lipid-linked oligosaccharide flippase PglK by a conformational nanobody.
Sci Rep, 7, 2017
7OCY
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BU of 7ocy by Molmil
Enterococcus faecalis EfrCD in complex with a nanobody
Descriptor: ABC transporter ATP-binding protein, Nanobody
Authors:Ehrenbolger, K, Hutter, C.A.J, Meier, G, Seeger, M.A, Barandun, J.
Deposit date:2021-04-28
Release date:2022-05-18
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (4.25 Å)
Cite:Deep mutational scan of a drug efflux pump reveals its structure-function landscape.
Nat.Chem.Biol., 19, 2023
6P6I
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BU of 6p6i by Molmil
Structure of YbtPQ importer
Descriptor: ABC transporter protein, inner membrane ABC-transporter
Authors:Wang, Z, Hu, W, Zheng, H.
Deposit date:2019-06-04
Release date:2020-03-04
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.67 Å)
Cite:Pathogenic siderophore ABC importer YbtPQ adopts a surprising fold of exporter.
Sci Adv, 6, 2020
7OTI
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BU of 7oti by Molmil
Structure of ABCB1/P-glycoprotein in apo state
Descriptor: Multidrug resistance protein 1A
Authors:Ford, R.C, Barbieri, A, Thonghin, N, Shafi, T, Prince, S.M, Collins, R.F.
Deposit date:2021-06-10
Release date:2021-12-08
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structure of ABCB1/P-Glycoprotein in the Presence of the CFTR Potentiator Ivacaftor.
Membranes (Basel), 11, 2021
7OTG
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BU of 7otg by Molmil
Structure of ABCB1/P-glycoprotein in the presence of the CFTR potentiator ivacaftor
Descriptor: Multidrug resistance protein 1A, N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide
Authors:Ford, R.C, Barbieri, A, Thonghin, N, Shafi, T, Prince, S.M, Collins, R.F.
Deposit date:2021-06-10
Release date:2021-12-08
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (5.4 Å)
Cite:Structure of ABCB1/P-Glycoprotein in the Presence of the CFTR Potentiator Ivacaftor.
Membranes (Basel), 11, 2021
7OW8
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BU of 7ow8 by Molmil
CryoEM structure of the ABC transporter BmrA E504A mutant in complex with ATP-Mg
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Multidrug resistance ABC transporter ATP-binding/permease protein BmrA
Authors:Gobet, A, Schoehn, G, Falson, P, Chaptal, V.
Deposit date:2021-06-17
Release date:2022-01-19
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Substrate-bound and substrate-free outward-facing structures of a multidrug ABC exporter.
Sci Adv, 8, 2022
5OFR
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BU of 5ofr by Molmil
Structure of the antibacterial peptide ABC transporter McjD in a high energy outward occluded intermediate state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Microcin-J25 export ATP-binding/permease protein McjD, ...
Authors:Beis, K, Bountra, K.
Deposit date:2017-07-11
Release date:2017-09-06
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structural basis for antibacterial peptide self-immunity by the bacterial ABC transporter McjD.
EMBO J., 36, 2017
5OCH
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BU of 5och by Molmil
The crystal structure of human ABCB8 in an outward-facing state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATP-binding cassette sub-family B member 8, mitochondrial, ...
Authors:Faust, B, Pike, A.C.W, Shintre, C.A, Quiqley, A.M, Chu, A, Barr, A, Shrestha, L, Mukhopadhyay, S, Borkowska, O, Chalk, R, Burgess-Brown, N.A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC)
Deposit date:2017-06-30
Release date:2018-07-25
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:The crystal structure of human ABCB8 in an outward-facing state
To Be Published
5OFP
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BU of 5ofp by Molmil
Structure of the antibacterial peptide ABC transporter McjD in an apo inward occluded conformation
Descriptor: Microcin-J25 export ATP-binding/permease protein McjD
Authors:Beis, K, Choudhury, H.G.
Deposit date:2017-07-11
Release date:2017-09-06
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (4.71 Å)
Cite:Structural basis for antibacterial peptide self-immunity by the bacterial ABC transporter McjD.
EMBO J., 36, 2017
7A65
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BU of 7a65 by Molmil
Nanodisc reconstituted, drug-free human ABCB1 in complex with MRK16 Fab
Descriptor: CHOLESTEROL, MRK16 Fab-fragment heavy chain, MRK16 Fab-fragment light chain, ...
Authors:Nosol, K, Locher, K.P.
Deposit date:2020-08-25
Release date:2020-10-14
Last modified:2020-10-28
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Cryo-EM structures reveal distinct mechanisms of inhibition of the human multidrug transporter ABCB1.
Proc.Natl.Acad.Sci.USA, 117, 2020
7A6E
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BU of 7a6e by Molmil
Nanodisc reconstituted human ABCB1 in complex with MRK16 Fab and tariquidar
Descriptor: CHOLESTEROL, MRK16 Fab-fragment heavy chain, MRK16 Fab-fragment light chain, ...
Authors:Nosol, K, Locher, K.P.
Deposit date:2020-08-25
Release date:2020-10-14
Last modified:2020-10-28
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cryo-EM structures reveal distinct mechanisms of inhibition of the human multidrug transporter ABCB1.
Proc.Natl.Acad.Sci.USA, 117, 2020

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