PDB: 80 resultsInfo pagesStatus searchChemie searchBIRD

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2YXR	The plug domain of the SecY protein stablizes the closed state of the translocation channel and maintains a membrane seal Descriptor: Preprotein translocase secG subunit, Preprotein translocase subunit secE, Preprotein translocase subunit secY Authors: Li, W, Schulman, S. Deposit date: 2007-04-27 Release date: 2007-08-14 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (3.6 Å) Cite: The plug domain of the SecY protein stabilizes the closed state of the translocation channel and maintains a membrane seal Mol.Cell, 26, 2007
2YXQ	The plug domain of the SecY protein stablizes the closed state of the translocation channel and maintains a membrane seal Descriptor: Preprotein translocase secG subunit, Preprotein translocase subunit secE, Preprotein translocase subunit secY Authors: Li, W, Schulman, S. Deposit date: 2007-04-27 Release date: 2007-08-14 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (3.5 Å) Cite: The plug domain of the SecY protein stabilizes the closed state of the translocation channel and maintains a membrane seal Mol.Cell, 26, 2007
2ZJS	Crystal Structure of SecYE translocon from Thermus thermophilus with a Fab fragment Descriptor: Fab56 (heavy chain), Fab56 (light chain), Preprotein translocase SecE subunit, ... Authors: Tsukazaki, T, Mori, H, Fukai, S, Ishitani, R, Perederina, A, Vassylyev, D.G, Ito, K, Nureki, O. Deposit date: 2008-03-08 Release date: 2008-10-14 Last modified: 2021-11-10 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Conformational transition of Sec machinery inferred from bacterial SecYE structures Nature, 455, 2008
2ZQP	Crystal Structure of SecYE translocon from Thermus thermophilus Descriptor: Preprotein translocase SecE subunit, Preprotein translocase SecY subunit Authors: Tsukazaki, T, Nureki, O. Deposit date: 2008-08-14 Release date: 2008-10-14 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (6 Å) Cite: Conformational transition of Sec machinery inferred from bacterial SecYE structures Nature, 455, 2008
3BO0	Ribosome-SecY complex Descriptor: 23S RIBOSOMAL RNA, PREPROTEIN TRANSLOCASE SecE SUBUNIT, PREPROTEIN TRANSLOCASE SecY SUBUNIT, ... Authors: Akey, C.W, Menetret, J.F. Deposit date: 2007-12-15 Release date: 2008-12-09 Last modified: 2024-02-21 Method: ELECTRON MICROSCOPY (9.6 Å) Cite: Ribosome binding of a single copy of the SecY complex: implications for protein translocation Mol.Cell, 28, 2007
8B6L	Subtomogram average of the human Sec61-TRAP-OSTA-translocon Descriptor: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit, Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1, Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2, ... Authors: Gemmer, M, Fedry, J.M.M, Forster, F.G. Deposit date: 2022-09-27 Release date: 2022-12-07 Last modified: 2023-02-08 Method: ELECTRON MICROSCOPY (7.6 Å) Cite: Visualization of translation and protein biogenesis at the ER membrane. Nature, 614, 2023
7ZL3	Signal peptide mimicry primes Sec61 for client-selective inhibition Descriptor: Cyclic depsipeptide signal peptide mimic, Protein transport protein Sec61 subunit alpha, Protein transport protein Sec61 subunit beta, ... Authors: Rehan, S, Paavilainen O, V. Deposit date: 2022-04-13 Release date: 2023-03-22 Last modified: 2023-11-15 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Signal peptide mimicry primes Sec61 for client-selective inhibition. Nat.Chem.Biol., 19, 2023
8DNX	Cryo-EM structure of the human Sec61 complex inhibited by cotransin Descriptor: Cotransin analogue peptide inhibitor, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ... Authors: Park, E, Itskanov, S. Deposit date: 2022-07-12 Release date: 2023-05-24 Last modified: 2023-11-15 Method: ELECTRON MICROSCOPY (2.98 Å) Cite: A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8DNY	Cryo-EM structure of the human Sec61 complex inhibited by decatransin Descriptor: Decatransin peptide inhibitor, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ... Authors: Park, E, Itskanov, S. Deposit date: 2022-07-12 Release date: 2023-05-24 Last modified: 2023-11-15 Method: ELECTRON MICROSCOPY (2.85 Å) Cite: A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8DNZ	Cryo-EM structure of the human Sec61 complex inhibited by apratoxin F Descriptor: Apratoxin F peptide inhibitor, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ... Authors: Park, E, Itskanov, S. Deposit date: 2022-07-12 Release date: 2023-05-24 Last modified: 2023-11-15 Method: ELECTRON MICROSCOPY (2.57 Å) Cite: A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8DO3	Cryo-EM structure of the human Sec61 complex inhibited by eeyarestatin I Descriptor: N'-(4-chlorophenyl)-N-[(4R)-3-(4-chlorophenyl)-5,5-dimethyl-1-(2-{(2E)-2-[(2E)-3-(5-nitrofuran-2-yl)prop-2-en-1-ylidene]hydrazinyl}-2-oxoethyl)-2-oxoimidazolidin-4-yl]-N-hydroxyurea, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ... Authors: Park, E, Itskanov, S. Deposit date: 2022-07-12 Release date: 2023-05-24 Last modified: 2023-09-06 Method: ELECTRON MICROSCOPY (3.22 Å) Cite: A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8DNV	Cryo-EM structure of the human Sec61 complex in a partially-open apo state (Class 1) Descriptor: Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, Protein transport protein Sec61 subunit gamma Authors: Park, E, Itskanov, S. Deposit date: 2022-07-12 Release date: 2023-05-24 Last modified: 2023-09-06 Method: ELECTRON MICROSCOPY (3.03 Å) Cite: A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8DNW	Cryo-EM structure of the human Sec61 complex in a partially-open apo state (Class 2) Descriptor: Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, Protein transport protein Sec61 subunit gamma Authors: Park, E, Itskanov, S. Deposit date: 2022-07-12 Release date: 2023-05-24 Last modified: 2023-09-06 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8DO2	Cryo-EM structure of the human Sec61 complex inhibited by cyclotriazadisulfonamide (CADA) Descriptor: 9-benzyl-1,5-bis(4-methylbenzene-1-sulfonyl)-3-methylidene-1,5,9-triazacyclododecane, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ... Authors: Park, E, Itskanov, S. Deposit date: 2022-07-12 Release date: 2023-05-24 Last modified: 2023-09-06 Method: ELECTRON MICROSCOPY (2.95 Å) Cite: A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8DO0	Cryo-EM structure of the human Sec61 complex inhibited by mycolactone Descriptor: Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, Protein transport protein Sec61 subunit gamma, ... Authors: Park, E, Itskanov, S. Deposit date: 2022-07-12 Release date: 2023-05-24 Last modified: 2023-09-06 Method: ELECTRON MICROSCOPY (2.86 Å) Cite: A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8DO1	Cryo-EM structure of the human Sec61 complex inhibited by ipomoeassin F Descriptor: Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, Protein transport protein Sec61 subunit gamma, ... Authors: Park, E, Itskanov, S. Deposit date: 2022-07-12 Release date: 2023-05-24 Last modified: 2023-09-06 Method: ELECTRON MICROSCOPY (3.01 Å) Cite: A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
6W6L	Cryo-EM structure of the human ribosome-TMCO1 translocon Descriptor: 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... Authors: Keenan, R.J, McGilvray, P.T. Deposit date: 2020-03-17 Release date: 2020-09-02 Method: ELECTRON MICROSCOPY (3.84 Å) Cite: An ER translocon for multi-pass membrane protein biogenesis. Elife, 9, 2020
7AFT	Cryo-EM structure of the signal sequence-engaged post-translational Sec translocon Descriptor: Mating factor alpha-1,Mating factor alpha-1, Protein translocation protein SEC63, Protein transport protein SBH1, ... Authors: Weng, T.-H, Beatrix, B, Berninghausen, O, Becker, T, Cheng, J, Beckmann, R. Deposit date: 2020-09-20 Release date: 2020-12-02 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (4.4 Å) Cite: Architecture of the active post-translational Sec translocon. Embo J., 40, 2021
5GAE	RNC in complex with a translocating SecYEG Descriptor: 23S rRNA, 50S ribosomal protein L10, 50S ribosomal protein L11, ... Authors: Jomaa, A, Boehringer, D, Leibundgut, M, Ban, N. Deposit date: 2015-11-25 Release date: 2016-01-27 Last modified: 2019-12-11 Method: ELECTRON MICROSCOPY (3.33 Å) Cite: Structures of the E. coli translating ribosome with SRP and its receptor and with the translocon. Nat Commun, 7, 2016
5NCO	Quaternary complex between SRP, SR, and SecYEG bound to the translating ribosome Descriptor: 23S rRNA, 4.5S SRP RNA (Ffs), 50S ribosomal protein L10, ... Authors: Jomaa, A, Hwang Fu, Y, Boerhinger, D, Leibundgut, M, Shan, S.O, Ban, N. Deposit date: 2017-03-06 Release date: 2017-05-24 Last modified: 2018-03-28 Method: ELECTRON MICROSCOPY (4.8 Å) Cite: Structure of the quaternary complex between SRP, SR, and translocon bound to the translating ribosome. Nat Commun, 8, 2017
6N3Q	Cryo-EM structure of the yeast Sec complex Descriptor: Protein translocation protein SEC63, Protein transport protein SBH1, Protein transport protein SEC61, ... Authors: Park, E, Itskanov, S. Deposit date: 2018-11-16 Release date: 2018-12-19 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (3.68 Å) Cite: Structure of the posttranslational Sec protein-translocation channel complex from yeast. Science, 363, 2019
6ND1	CryoEM structure of the Sec Complex from yeast Descriptor: Protein translocation protein SEC63, Protein transport protein SBH1, Protein transport protein SEC61, ... Authors: Wu, X, Cabanos, C, Rapoport, T.A. Deposit date: 2018-12-13 Release date: 2019-01-09 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (4.1 Å) Cite: Structure of the post-translational protein translocation machinery of the ER membrane. Nature, 566, 2019
8OJ8	60S ribosomal subunit bound to the E3-UFM1 complex - state 1 (native) Descriptor: 28S rRNA, 5.8S rRNA, 5S rRNA, ... Authors: Penchev, I, DaRosa, P.A, Becker, T, Beckmann, R, Kopito, R. Deposit date: 2023-03-24 Release date: 2024-02-21 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER. Nature, 627, 2024
8OJ0	60S ribosomal subunit bound to the E3-UFM1 complex - state 2 (native) Descriptor: 28S rRNA, 5.8S rRNA, 5S rRNA, ... Authors: Penchev, I, DaRosa, P.A, Becker, T, Beckmann, R, Kopito, R. Deposit date: 2023-03-23 Release date: 2024-02-21 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER. Nature, 627, 2024
6R7Q	Structure of XBP1u-paused ribosome nascent chain complex with Sec61. Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... Authors: Shanmuganathan, V, Cheng, J, Braunger, K, Berninghausen, O, Beatrix, B, Beckmann, R. Deposit date: 2019-03-29 Release date: 2019-07-10 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Structural and mutational analysis of the ribosome-arresting human XBP1u. Elife, 8, 2019

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