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2YXR
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BU of 2yxr by Molmil
The plug domain of the SecY protein stablizes the closed state of the translocation channel and maintains a membrane seal
Descriptor: Preprotein translocase secG subunit, Preprotein translocase subunit secE, Preprotein translocase subunit secY
Authors:Li, W, Schulman, S.
Deposit date:2007-04-27
Release date:2007-08-14
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:The plug domain of the SecY protein stabilizes the closed state of the translocation channel and maintains a membrane seal
Mol.Cell, 26, 2007
2YXQ
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BU of 2yxq by Molmil
The plug domain of the SecY protein stablizes the closed state of the translocation channel and maintains a membrane seal
Descriptor: Preprotein translocase secG subunit, Preprotein translocase subunit secE, Preprotein translocase subunit secY
Authors:Li, W, Schulman, S.
Deposit date:2007-04-27
Release date:2007-08-14
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:The plug domain of the SecY protein stabilizes the closed state of the translocation channel and maintains a membrane seal
Mol.Cell, 26, 2007
2ZJS
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BU of 2zjs by Molmil
Crystal Structure of SecYE translocon from Thermus thermophilus with a Fab fragment
Descriptor: Fab56 (heavy chain), Fab56 (light chain), Preprotein translocase SecE subunit, ...
Authors:Tsukazaki, T, Mori, H, Fukai, S, Ishitani, R, Perederina, A, Vassylyev, D.G, Ito, K, Nureki, O.
Deposit date:2008-03-08
Release date:2008-10-14
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Conformational transition of Sec machinery inferred from bacterial SecYE structures
Nature, 455, 2008
2ZQP
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BU of 2zqp by Molmil
Crystal Structure of SecYE translocon from Thermus thermophilus
Descriptor: Preprotein translocase SecE subunit, Preprotein translocase SecY subunit
Authors:Tsukazaki, T, Nureki, O.
Deposit date:2008-08-14
Release date:2008-10-14
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (6 Å)
Cite:Conformational transition of Sec machinery inferred from bacterial SecYE structures
Nature, 455, 2008
3BO0
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BU of 3bo0 by Molmil
Ribosome-SecY complex
Descriptor: 23S RIBOSOMAL RNA, PREPROTEIN TRANSLOCASE SecE SUBUNIT, PREPROTEIN TRANSLOCASE SecY SUBUNIT, ...
Authors:Akey, C.W, Menetret, J.F.
Deposit date:2007-12-15
Release date:2008-12-09
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (9.6 Å)
Cite:Ribosome binding of a single copy of the SecY complex: implications for protein translocation
Mol.Cell, 28, 2007
8B6L
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BU of 8b6l by Molmil
Subtomogram average of the human Sec61-TRAP-OSTA-translocon
Descriptor: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit, Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1, Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2, ...
Authors:Gemmer, M, Fedry, J.M.M, Forster, F.G.
Deposit date:2022-09-27
Release date:2022-12-07
Last modified:2023-02-08
Method:ELECTRON MICROSCOPY (7.6 Å)
Cite:Visualization of translation and protein biogenesis at the ER membrane.
Nature, 614, 2023
7ZL3
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BU of 7zl3 by Molmil
Signal peptide mimicry primes Sec61 for client-selective inhibition
Descriptor: Cyclic depsipeptide signal peptide mimic, Protein transport protein Sec61 subunit alpha, Protein transport protein Sec61 subunit beta, ...
Authors:Rehan, S, Paavilainen O, V.
Deposit date:2022-04-13
Release date:2023-03-22
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Signal peptide mimicry primes Sec61 for client-selective inhibition.
Nat.Chem.Biol., 19, 2023
8DNX
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BU of 8dnx by Molmil
Cryo-EM structure of the human Sec61 complex inhibited by cotransin
Descriptor: Cotransin analogue peptide inhibitor, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ...
Authors:Park, E, Itskanov, S.
Deposit date:2022-07-12
Release date:2023-05-24
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.98 Å)
Cite:A common mechanism of Sec61 translocon inhibition by small molecules.
Nat.Chem.Biol., 19, 2023
8DNY
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BU of 8dny by Molmil
Cryo-EM structure of the human Sec61 complex inhibited by decatransin
Descriptor: Decatransin peptide inhibitor, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ...
Authors:Park, E, Itskanov, S.
Deposit date:2022-07-12
Release date:2023-05-24
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.85 Å)
Cite:A common mechanism of Sec61 translocon inhibition by small molecules.
Nat.Chem.Biol., 19, 2023
8DNZ
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BU of 8dnz by Molmil
Cryo-EM structure of the human Sec61 complex inhibited by apratoxin F
Descriptor: Apratoxin F peptide inhibitor, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ...
Authors:Park, E, Itskanov, S.
Deposit date:2022-07-12
Release date:2023-05-24
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.57 Å)
Cite:A common mechanism of Sec61 translocon inhibition by small molecules.
Nat.Chem.Biol., 19, 2023
8DO3
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BU of 8do3 by Molmil
Cryo-EM structure of the human Sec61 complex inhibited by eeyarestatin I
Descriptor: N'-(4-chlorophenyl)-N-[(4R)-3-(4-chlorophenyl)-5,5-dimethyl-1-(2-{(2E)-2-[(2E)-3-(5-nitrofuran-2-yl)prop-2-en-1-ylidene]hydrazinyl}-2-oxoethyl)-2-oxoimidazolidin-4-yl]-N-hydroxyurea, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ...
Authors:Park, E, Itskanov, S.
Deposit date:2022-07-12
Release date:2023-05-24
Last modified:2023-09-06
Method:ELECTRON MICROSCOPY (3.22 Å)
Cite:A common mechanism of Sec61 translocon inhibition by small molecules.
Nat.Chem.Biol., 19, 2023
8DNV
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BU of 8dnv by Molmil
Cryo-EM structure of the human Sec61 complex in a partially-open apo state (Class 1)
Descriptor: Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, Protein transport protein Sec61 subunit gamma
Authors:Park, E, Itskanov, S.
Deposit date:2022-07-12
Release date:2023-05-24
Last modified:2023-09-06
Method:ELECTRON MICROSCOPY (3.03 Å)
Cite:A common mechanism of Sec61 translocon inhibition by small molecules.
Nat.Chem.Biol., 19, 2023
8DNW
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BU of 8dnw by Molmil
Cryo-EM structure of the human Sec61 complex in a partially-open apo state (Class 2)
Descriptor: Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, Protein transport protein Sec61 subunit gamma
Authors:Park, E, Itskanov, S.
Deposit date:2022-07-12
Release date:2023-05-24
Last modified:2023-09-06
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:A common mechanism of Sec61 translocon inhibition by small molecules.
Nat.Chem.Biol., 19, 2023
8DO2
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BU of 8do2 by Molmil
Cryo-EM structure of the human Sec61 complex inhibited by cyclotriazadisulfonamide (CADA)
Descriptor: 9-benzyl-1,5-bis(4-methylbenzene-1-sulfonyl)-3-methylidene-1,5,9-triazacyclododecane, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ...
Authors:Park, E, Itskanov, S.
Deposit date:2022-07-12
Release date:2023-05-24
Last modified:2023-09-06
Method:ELECTRON MICROSCOPY (2.95 Å)
Cite:A common mechanism of Sec61 translocon inhibition by small molecules.
Nat.Chem.Biol., 19, 2023
8DO0
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BU of 8do0 by Molmil
Cryo-EM structure of the human Sec61 complex inhibited by mycolactone
Descriptor: Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, Protein transport protein Sec61 subunit gamma, ...
Authors:Park, E, Itskanov, S.
Deposit date:2022-07-12
Release date:2023-05-24
Last modified:2023-09-06
Method:ELECTRON MICROSCOPY (2.86 Å)
Cite:A common mechanism of Sec61 translocon inhibition by small molecules.
Nat.Chem.Biol., 19, 2023
8DO1
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BU of 8do1 by Molmil
Cryo-EM structure of the human Sec61 complex inhibited by ipomoeassin F
Descriptor: Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, Protein transport protein Sec61 subunit gamma, ...
Authors:Park, E, Itskanov, S.
Deposit date:2022-07-12
Release date:2023-05-24
Last modified:2023-09-06
Method:ELECTRON MICROSCOPY (3.01 Å)
Cite:A common mechanism of Sec61 translocon inhibition by small molecules.
Nat.Chem.Biol., 19, 2023
6W6L
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BU of 6w6l by Molmil
Cryo-EM structure of the human ribosome-TMCO1 translocon
Descriptor: 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ...
Authors:Keenan, R.J, McGilvray, P.T.
Deposit date:2020-03-17
Release date:2020-09-02
Method:ELECTRON MICROSCOPY (3.84 Å)
Cite:An ER translocon for multi-pass membrane protein biogenesis.
Elife, 9, 2020
7AFT
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BU of 7aft by Molmil
Cryo-EM structure of the signal sequence-engaged post-translational Sec translocon
Descriptor: Mating factor alpha-1,Mating factor alpha-1, Protein translocation protein SEC63, Protein transport protein SBH1, ...
Authors:Weng, T.-H, Beatrix, B, Berninghausen, O, Becker, T, Cheng, J, Beckmann, R.
Deposit date:2020-09-20
Release date:2020-12-02
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Architecture of the active post-translational Sec translocon.
Embo J., 40, 2021
5GAE
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BU of 5gae by Molmil
RNC in complex with a translocating SecYEG
Descriptor: 23S rRNA, 50S ribosomal protein L10, 50S ribosomal protein L11, ...
Authors:Jomaa, A, Boehringer, D, Leibundgut, M, Ban, N.
Deposit date:2015-11-25
Release date:2016-01-27
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.33 Å)
Cite:Structures of the E. coli translating ribosome with SRP and its receptor and with the translocon.
Nat Commun, 7, 2016
5NCO
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BU of 5nco by Molmil
Quaternary complex between SRP, SR, and SecYEG bound to the translating ribosome
Descriptor: 23S rRNA, 4.5S SRP RNA (Ffs), 50S ribosomal protein L10, ...
Authors:Jomaa, A, Hwang Fu, Y, Boerhinger, D, Leibundgut, M, Shan, S.O, Ban, N.
Deposit date:2017-03-06
Release date:2017-05-24
Last modified:2018-03-28
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:Structure of the quaternary complex between SRP, SR, and translocon bound to the translating ribosome.
Nat Commun, 8, 2017
6N3Q
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BU of 6n3q by Molmil
Cryo-EM structure of the yeast Sec complex
Descriptor: Protein translocation protein SEC63, Protein transport protein SBH1, Protein transport protein SEC61, ...
Authors:Park, E, Itskanov, S.
Deposit date:2018-11-16
Release date:2018-12-19
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.68 Å)
Cite:Structure of the posttranslational Sec protein-translocation channel complex from yeast.
Science, 363, 2019
6ND1
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BU of 6nd1 by Molmil
CryoEM structure of the Sec Complex from yeast
Descriptor: Protein translocation protein SEC63, Protein transport protein SBH1, Protein transport protein SEC61, ...
Authors:Wu, X, Cabanos, C, Rapoport, T.A.
Deposit date:2018-12-13
Release date:2019-01-09
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structure of the post-translational protein translocation machinery of the ER membrane.
Nature, 566, 2019
8OJ8
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BU of 8oj8 by Molmil
60S ribosomal subunit bound to the E3-UFM1 complex - state 1 (native)
Descriptor: 28S rRNA, 5.8S rRNA, 5S rRNA, ...
Authors:Penchev, I, DaRosa, P.A, Becker, T, Beckmann, R, Kopito, R.
Deposit date:2023-03-24
Release date:2024-02-21
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER.
Nature, 627, 2024
8OJ0
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BU of 8oj0 by Molmil
60S ribosomal subunit bound to the E3-UFM1 complex - state 2 (native)
Descriptor: 28S rRNA, 5.8S rRNA, 5S rRNA, ...
Authors:Penchev, I, DaRosa, P.A, Becker, T, Beckmann, R, Kopito, R.
Deposit date:2023-03-23
Release date:2024-02-21
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER.
Nature, 627, 2024
6R7Q
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BU of 6r7q by Molmil
Structure of XBP1u-paused ribosome nascent chain complex with Sec61.
Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ...
Authors:Shanmuganathan, V, Cheng, J, Braunger, K, Berninghausen, O, Beatrix, B, Beckmann, R.
Deposit date:2019-03-29
Release date:2019-07-10
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural and mutational analysis of the ribosome-arresting human XBP1u.
Elife, 8, 2019

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