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6AOB	Crystal structure of non-canonical dimeric guanylyl cyclase domain of RhoGC fusion protein from the aquatic fungus Blastocladiella emersonii Descriptor: Bacterio-rhodopsin/guanylyl cyclase 1 fusion protein, L(+)-TARTARIC ACID, MANGANESE (II) ION Authors: Prem Kumar, R, Oprian, D.D. Deposit date: 2017-08-15 Release date: 2017-11-22 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structure and monomer/dimer equilibrium for the guanylyl cyclase domain of the optogenetics protein RhoGC. J. Biol. Chem., 292, 2017
7YZ9	Structure of catalytic domain of Rv1625c bound to nanobody NB4 Descriptor: 3'-O-(N-METHYLANTHRANILOYL)-GUANOSINE-5'-TRIPHOSPHATE, Adenylate cyclase, GLYCEROL, ... Authors: Khanppnavar, B, Mehta, V.J, Iype, T, Korkhov, V.M. Deposit date: 2022-02-19 Release date: 2022-08-31 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.97 Å) Cite: Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane adenylyl cyclases. Elife, 11, 2022
8CNH	Crystal structure of human soluble adenylyl cyclase (sAC) in complex with inhibitor TDI-10512 Descriptor: 1,2-ETHANEDIOL, ACETATE ION, Adenylate cyclase type 10, ... Authors: Steegborn, C. Deposit date: 2023-02-23 Release date: 2023-04-26 Last modified: 2023-05-17 Method: X-RAY DIFFRACTION (2 Å) Cite: Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation. J.Chem.Inf.Model., 63, 2023
8COJ	Crystal structure of human soluble adenylyl cyclase catalytic domain in complex with the inhibitor TDI-10228 Descriptor: 1,2-ETHANEDIOL, 4-chloranyl-6-[4-[(3-fluorophenyl)methyl]-1-methyl-pyrazol-3-yl]pyrimidin-2-amine, ACETATE ION, ... Authors: Steegborn, C, Fushimi, M. Deposit date: 2023-02-28 Release date: 2023-04-26 Last modified: 2023-05-17 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation. J.Chem.Inf.Model., 63, 2023
8COT	Complex of human soluble adenylyl cyclase 10 catalytic core with inhibitor TDI-10962 Descriptor: 1,2-ETHANEDIOL, 2-(dimethylamino)ethyl 5-(2-azanyl-6-chloranyl-pyrimidin-4-yl)-2-methyl-4-(phenylmethyl)pyrazole-3-carboxylate, ACETATE ION, ... Authors: Steegborn, C, Fushimi, M. Deposit date: 2023-02-28 Release date: 2023-04-26 Last modified: 2023-05-17 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation. J.Chem.Inf.Model., 63, 2023
8IL7	Structure of human soluble Adenylyl Cyclase in complex with lactate Descriptor: (2S)-2-HYDROXYPROPANOIC ACID, Adenylate cyclase type 10, GLYCEROL Authors: Li, Q.J, Li, Z.L, Gao, P. Deposit date: 2023-03-02 Release date: 2023-07-26 Last modified: 2024-08-14 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Lactate modulates iron metabolism by binding soluble adenylyl cyclase. Cell Metab., 35, 2023
4USU	Crystal structure of human soluble Adenylyl Cyclase in complex with alpha,beta-methyleneadenosine-5'-triphosphate Descriptor: 1,2-ETHANEDIOL, ADENYLATE CYCLASE TYPE 10, CALCIUM ION, ... Authors: Kleinboelting, S, Steegborn, C. Deposit date: 2014-07-13 Release date: 2014-07-30 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Structural Analysis of Human Soluble Adenylyl Cyclase and Crystal Structures of its Nucleotide Complexes -Implications for Cyclase Catalysis and Evolution. FEBS J., 281, 2014
4WP9	Crystal structure of Adenylyl cyclase MA1120 from Mycobacterium Avium bound to 2'5'-DD-3'-ATP, Calcium and Magnesium ion Descriptor: 2',5'-dideoxyadenosine 3'-(tetrahydrogen triphosphate), CALCIUM ION, MAGNESIUM ION, ... Authors: Bharambe, N.G, Barathy, D.V, Suguna, K. Deposit date: 2014-10-17 Release date: 2015-09-02 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.382 Å) Cite: Autoinhibitory mechanism and activity-related structural changes in a mycobacterial adenylyl cyclase J.Struct.Biol., 190, 2015
4WP8	Crystal structure of Adenylyl cyclase Ma1120 from Mycobacterium Avium in complex with 2'5'-DD-3'-ATP and Manganese ion Descriptor: 2',5'-dideoxyadenosine 3'-(tetrahydrogen triphosphate), CHLORIDE ION, MANGANESE (II) ION, ... Authors: Barathy, D.V, Bharambe, N.G, Suguna, K. Deposit date: 2014-10-17 Release date: 2015-09-02 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Autoinhibitory mechanism and activity-related structural changes in a mycobacterial adenylyl cyclase J.Struct.Biol., 190, 2015
4WP3	Crystal Structure of Adenylyl cyclase from Mycobacterium avium Ma1120 wild type Descriptor: CHLORIDE ION, Ma1120 Authors: Barathy, D.V, Bharambe, N.G, Suguna, K. Deposit date: 2014-10-17 Release date: 2015-09-02 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Autoinhibitory mechanism and activity-related structural changes in a mycobacterial adenylyl cyclase J.Struct.Biol., 190, 2015
4WPA	Crystal structure of Adenylyl cyclase Ma1120 from Mycobacterium Avium bound to Pyrophosphate and Calcium Descriptor: CALCIUM ION, Ma1120, PYROPHOSPHATE Authors: Bharambe, N.G, Barathy, D.V, Suguna, K. Deposit date: 2014-10-17 Release date: 2015-09-02 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Autoinhibitory mechanism and activity-related structural changes in a mycobacterial adenylyl cyclase J.Struct.Biol., 190, 2015
7PD4	structure of Adenylyl cyclase 9 in complex with MANT-GTP Descriptor: Adenylate cyclase 9 Authors: Qi, C, Korkhov, V.M. Deposit date: 2021-08-04 Release date: 2022-01-19 Last modified: 2024-07-17 Method: ELECTRON MICROSCOPY (4.9 Å) Cite: Structural basis of adenylyl cyclase 9 activation. Nat Commun, 13, 2022
7PD8	Structure of Adenylyl cyclase 9 in complex with DARPin C4 and MANT-GTP Descriptor: Adenylate cyclase 9, DARPin C4 Authors: Qi, C, Korkhov, V.M. Deposit date: 2021-08-04 Release date: 2022-01-19 Last modified: 2024-07-17 Method: ELECTRON MICROSCOPY (4.2 Å) Cite: Structural basis of adenylyl cyclase 9 activation. Nat Commun, 13, 2022
7PDH	structure of adenylyl cyclase 9 in complex with DARPin C4 and ATP-aS Descriptor: Adenylate cyclase 9, DARPin C4 Authors: Qi, C, Korkhov, V.M. Deposit date: 2021-08-05 Release date: 2022-01-19 Last modified: 2024-07-17 Method: ELECTRON MICROSCOPY (4 Å) Cite: Structural basis of adenylyl cyclase 9 activation. Nat Commun, 13, 2022
7PDD	Focus refinement of soluble domain of Adenylyl cyclase 9 in complex with DARPin C4 and MANT-GTP Descriptor: Adenylate cyclase 9, DARPin C4 Authors: Qi, C, Korkhov, V.M. Deposit date: 2021-08-05 Release date: 2022-01-19 Last modified: 2024-07-17 Method: ELECTRON MICROSCOPY (4.2 Å) Cite: Structural basis of adenylyl cyclase 9 activation. Nat Commun, 13, 2022
7PDG	structure of adenylyl cyclase 9 in complex with DARPin C4 and ATP-aS Descriptor: Adenylate cyclase 9, DARPin C4 Authors: Qi, C, Korkhov, V.M. Deposit date: 2021-08-05 Release date: 2022-01-19 Last modified: 2024-07-17 Method: ELECTRON MICROSCOPY (4.3 Å) Cite: Structural basis of adenylyl cyclase 9 activation. Nat Commun, 13, 2022
7R65	Crystal structure of a bacterial cyclic UMP synthase from Burkholderia cepacia LK29 Descriptor: Adenylate/guanylate cyclase Authors: Morehouse, B.R, Kranzusch, P.J. Deposit date: 2021-06-22 Release date: 2021-10-13 Last modified: 2021-11-24 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Cyclic CMP and cyclic UMP mediate bacterial immunity against phages. Cell, 184, 2021
1FX4	STRUCTURE ANALYSIS OF ADENYLATE CYCLASES FROM TRYPANOSOMA BRUCEI IN THEIR MONOMERIC STATE Descriptor: MAGNESIUM ION, RECEPTOR-TYPE ADENYLATE CYCLASE GRESAG 4.3 Authors: Bieger, B, Essen, L.O. Deposit date: 2000-09-25 Release date: 2001-02-28 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural analysis of adenylate cyclases from Trypanosoma brucei in their monomeric state. EMBO J., 20, 2001
1FX2	STRUCTURAL ANALYSIS OF ADENYLATE CYCLASES FROM TRYPANOSOMA BRUCEI IN THEIR MONOMERIC STATE Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, RECEPTOR-TYPE ADENYLATE CYCLASE GRESAG 4.1, SULFATE ION Authors: Bieger, B, Essen, L.-O. Deposit date: 2000-09-25 Release date: 2001-02-28 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.46 Å) Cite: Structural analysis of adenylate cyclases from Trypanosoma brucei in their monomeric state. EMBO J., 20, 2001
4CLW	Crystal structure of human soluble Adenylyl Cyclase in complex with alpha,beta-methyleneadenosine-5'-triphosphate soaked with bisulfite Descriptor: 1,2-ETHANEDIOL, ADENYLATE CYCLASE TYPE 10, CALCIUM ION, ... Authors: Kleinboelting, S, Weyand, M, Steegborn, C. Deposit date: 2014-01-15 Release date: 2014-03-05 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Crystal Structures of Human Soluble Adenylyl Cyclase Reveal Mechanisms of Catalysis and of its Activation Through Bicarbonate. Proc.Natl.Acad.Sci.USA, 111, 2014
4CLP	Crystal structure of human soluble Adenylyl Cyclase complex with adenosine-3',5'-cyclic-monophosphate Descriptor: 1,2-ETHANEDIOL, ACETATE ION, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, ... Authors: Kleinboelting, S, Weyand, M, Steegborn, C. Deposit date: 2014-01-15 Release date: 2014-03-05 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal Structures of Human Soluble Adenylyl Cyclase Reveal Mechanisms of Catalysis and of its Activation Through Bicarbonate. Proc.Natl.Acad.Sci.USA, 111, 2014
4CLT	Crystal structure of human soluble Adenylyl Cyclase with adenosine-3', 5'-cyclic-monophosphate and pyrophosphate Descriptor: 1,2-ETHANEDIOL, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, ADENYLATE CYCLASE TYPE 10, ... Authors: Kleinboelting, S, Weyand, M, Steegborn, C. Deposit date: 2014-01-15 Release date: 2014-03-05 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Crystal Structures of Human Soluble Adenylyl Cyclase Reveal Mechanisms of Catalysis and of its Activation Through Bicarbonate. Proc.Natl.Acad.Sci.USA, 111, 2014
4CLZ	Crystal structure of human soluble Adenylyl Cyclase with Inhibitor 4, 4'-Diisothiocyano-2,2'-stilbenedisulfonic acid Descriptor: 1,2-ETHANEDIOL, 4,4'-Diisothiocyano-2,2'-stilbenedisulfonic acid, ACETATE ION, ... Authors: Kleinboelting, S, Weyand, M, Steegborn, C. Deposit date: 2014-01-15 Release date: 2014-03-05 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal Structures of Human Soluble Adenylyl Cyclase Reveal Mechanisms of Catalysis and of its Activation Through Bicarbonate. Proc.Natl.Acad.Sci.USA, 111, 2014
4CM0	Crystal structure of human soluble Adenylyl Cyclase with alpha,beta- methyleneadenosine-5'-triphosphate soaked with bicarbonate Descriptor: CALCIUM ION, CHLORIDE ION, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ... Authors: Kleinboelting, S, Weyand, M, Steegborn, C. Deposit date: 2014-01-15 Release date: 2014-03-05 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Crystal Structures of Human Soluble Adenylyl Cyclase Reveal Mechanisms of Catalysis and of its Activation Through Bicarbonate. Proc.Natl.Acad.Sci.USA, 111, 2014
4CLK	Crystal structure of human soluble Adenylyl Cyclase in complex with alpha,beta-methyleneadenosine-5'-triphosphate Descriptor: 1,2-ETHANEDIOL, ADENYLATE CYCLASE TYPE 10, CALCIUM ION, ... Authors: Kleinboelting, S, Weyand, M, Steegborn, C. Deposit date: 2014-01-15 Release date: 2014-03-05 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal Structures of Human Soluble Adenylyl Cyclase Reveal Mechanisms of Catalysis and of its Activation Through Bicarbonate. Proc.Natl.Acad.Sci.USA, 111, 2014

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