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7TUR
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BU of 7tur by Molmil
Joint X-ray/neutron structure of aspastate aminotransferase (AAT) in complex with pyridoxamine 5'-phosphate (PMP)
Descriptor: 2-[(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL)-AMINO]-2-METHYL-SUCCINIC ACID, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, Aspartate aminotransferase, ...
Authors:Drago, V.N, Kovalevsky, A.Y, Dajnowicz, S, Mueser, T.C.
Deposit date:2022-02-03
Release date:2022-09-28
Last modified:2023-10-25
Method:NEUTRON DIFFRACTION (1.7 Å), X-RAY DIFFRACTION
Cite:An N⋯H⋯N low-barrier hydrogen bond preorganizes the catalytic site of aspartate aminotransferase to facilitate the second half-reaction.
Chem Sci, 13, 2022
3MEB
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BU of 3meb by Molmil
Structure of cytoplasmic aspartate aminotransferase from giardia lamblia
Descriptor: 1,2-ETHANEDIOL, Aspartate aminotransferase, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2010-03-31
Release date:2010-04-21
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of aspartate aminotransferases from Trypanosoma brucei, Leishmania major and Giardia lamblia.
Acta Crystallogr F Struct Biol Commun, 71, 2015
8KDL
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BU of 8kdl by Molmil
Crystal structure of LmbF in complex with PLP
Descriptor: Aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme, GLYCEROL
Authors:Mori, T, Lyu, S, Kadlcik, S, Abe, I.
Deposit date:2023-08-09
Release date:2024-08-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of LmbF in complex with PLP
To Be Published
8GUH
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BU of 8guh by Molmil
Serine Palmitoyltransferase from Sphingobacterium multivorum complexed with Tris
Descriptor: 1,2-ETHANEDIOL, Serine palmitoyltransferase, [4-[[[2-(hydroxymethyl)-1,3-bis(oxidanyl)propan-2-yl]amino]methyl]-6-methyl-5-oxidanyl-pyridin-3-yl]methyl dihydrogen phosphate
Authors:Murakami, T, Takahashi, A, Katayama, A, Miyahara, I, Kamiya, N, Ikushiro, H, Yano, T.
Deposit date:2022-09-12
Release date:2023-07-19
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal structure of Sphingobacterium multivorum serine palmitoyltransferase complexed with tris(hydroxymethyl)aminomethane.
Acta Crystallogr.,Sect.F, 78, 2022
4WBT
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BU of 4wbt by Molmil
Crystal structure of histidinol-phosphate aminotransferase from Sinorhizobium meliloti in complex with pyridoxal-5'-phosphate
Descriptor: 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Shabalin, I.G, Bacal, P, Kowalska, A.K, Cooper, D.R, Stead, M, Hammonds, J, Ahmed, M, Hillerich, B.S, Bonanno, J, Seidel, R, Almo, S.C, Minor, W, New York Structural Genomics Research Consortium (NYSGRC)
Deposit date:2014-09-03
Release date:2014-09-24
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of histidinol-phosphate aminotransferase from Sinorhizobium meliloti in complex with pyridoxal-5'-phosphate
to be published
6EZL
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BU of 6ezl by Molmil
Crystal structure of aspartate aminotransferase from Trypanosoma cruzi at 2.07 Angstrom resolution
Descriptor: Aspartate aminotransferase, PYRIDOXAL-5'-PHOSPHATE
Authors:Jagoe, W.N, Khan, A.R.
Deposit date:2017-11-15
Release date:2018-12-12
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Structure of aspartate aminotransferase from Trypanosoma Cruzi at 2.07 Angstrom resolution
To Be Published
6F35
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BU of 6f35 by Molmil
Crystal structure of the aspartate aminotranferase from Rhizobium meliloti
Descriptor: ACETATE ION, Aspartate aminotransferase B, GLYCEROL, ...
Authors:Cobessi, D, Graindorge, M, Giustini, C, Matringe, M.
Deposit date:2017-11-28
Release date:2019-03-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Tyrosine metabolism: identification of a key residue in the acquisition of prephenate aminotransferase activity by 1 beta aspartate aminotransferase.
Febs J., 286, 2019
6F5V
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BU of 6f5v by Molmil
Crystal structure of the prephenate aminotransferase from Arabidopsis thaliana
Descriptor: Bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase, CITRIC ACID, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Cobessi, D, Robin, A, Giustini, C, Graindorge, M, Matringe, M.
Deposit date:2017-12-03
Release date:2019-03-13
Last modified:2019-06-12
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Tyrosine metabolism: identification of a key residue in the acquisition of prephenate aminotransferase activity by 1 beta aspartate aminotransferase.
Febs J., 286, 2019
6F77
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Crystal structure of the prephenate aminotransferase from Rhizobium meliloti
Descriptor: Aspartate aminotransferase A, PYRIDOXAL-5'-PHOSPHATE
Authors:Cobessi, D, Giustini, C, Graindorge, M, Matringe, M.
Deposit date:2017-12-07
Release date:2019-03-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.794 Å)
Cite:Tyrosine metabolism: identification of a key residue in the acquisition of prephenate aminotransferase activity by 1 beta aspartate aminotransferase.
Febs J., 286, 2019
4WLJ
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BU of 4wlj by Molmil
High resolution crystal structure of human kynurenine aminotransferase-I in complex with aminooxyacetate
Descriptor: 4'-DEOXY-4'-ACETYLYAMINO-PYRIDOXAL-5'-PHOSPHATE, Kynurenine--oxoglutarate transaminase 1
Authors:Nadvi, N.A, Salam, N.K, Park, J, Akladios, F.N, Kapoor, V, Collyer, C.A, Gorrell, M.D, Church, W.B.
Deposit date:2014-10-07
Release date:2014-12-03
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:High resolution crystal structures of human kynurenine aminotransferase-I bound to PLP cofactor, and in complex with aminooxyacetate.
Protein Sci., 26, 2017
4WP0
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Crystal structure of human kynurenine aminotransferase-I with a C-terminal V5-hexahistidine tag
Descriptor: Kynurenine--oxoglutarate transaminase 1
Authors:Nadvi, N.A, Salam, N.K, Park, J, Akladios, F.N, Kapoor, V, Collyer, C.A, Gorrell, M.D, Church, W.B.
Deposit date:2014-10-17
Release date:2014-11-19
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of human kynurenine aminotransferase-I in a novel space group
To be published
6T8P
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BU of 6t8p by Molmil
HKATII IN COMPLEX WITH LIGAND (2R)-N-benzyl-1-[6-methyl-5-(oxan-4-yl)-7-oxo-6H,7H-[1,3]thiazolo[5,4-d]pyrimidin-2-yl]pyrrolidine-2-carboxamide
Descriptor: 1,2-ETHANEDIOL, 3,5-bis(fluoranyl)-~{N}-[5-[(2~{R})-2-(3-fluorophenyl)-3-methyl-butyl]-1,3,4-thiadiazol-2-yl]benzenesulfonamide, IODIDE ION, ...
Authors:Blaesse, M, Venalainen, J.
Deposit date:2019-10-24
Release date:2020-03-04
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Discovery of sulfonamides and 9-oxo-2,8-diazaspiro[5,5]undecane-2-carboxamides as human kynurenine aminotransferase 2 (KAT2) inhibitors.
Bioorg.Med.Chem.Lett., 30, 2020
6T3V
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BU of 6t3v by Molmil
Psychrophilic aromatic amino acids aminotransferase from Psychrobacter sp. B6 cocrystalized with substrate analog - malic acid
Descriptor: (2S)-2-hydroxybutanedioic acid, Aminotransferase, PYRIDOXAL-5'-PHOSPHATE
Authors:Rutkiewicz, M, Bujacz, A, Rum, J, Bujacz, G.
Deposit date:2019-10-11
Release date:2020-11-18
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Structural Evidence of Active Site Adaptability towards Different Sized Substrates of Aromatic Amino Acid Aminotransferase from Psychrobacter Sp. B6.
Materials, 14, 2021
6T8Q
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BU of 6t8q by Molmil
HKATII IN COMPLEX WITH LIGAND (2R)-N-benzyl-1-[6-methyl-5-(oxan-4-yl)-7-oxo-6H,7H-[1,3]thiazolo[5,4-d]pyrimidin-2-yl]pyrrolidine-2-carboxamide
Descriptor: (2~{R})-1-[6-methyl-5-(oxan-4-yl)-7-oxidanylidene-[1,3]thiazolo[5,4-d]pyrimidin-2-yl]-~{N}-(phenylmethyl)pyrrolidine-2-carboxamide, ACETATE ION, CADMIUM ION, ...
Authors:Blaesse, M, Venalainen, J.
Deposit date:2019-10-24
Release date:2020-03-04
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Discovery of sulfonamides and 9-oxo-2,8-diazaspiro[5,5]undecane-2-carboxamides as human kynurenine aminotransferase 2 (KAT2) inhibitors.
Bioorg.Med.Chem.Lett., 30, 2020
4WLH
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BU of 4wlh by Molmil
High resolution crystal structure of human kynurenine aminotransferase-I bound to PLP cofactor
Descriptor: Kynurenine--oxoglutarate transaminase 1
Authors:Nadvi, N.A, Salam, N.K, Park, J, Akladios, F.N, Kapoor, V, Collyer, C.A, Gorrell, M.D, Church, W.B.
Deposit date:2014-10-07
Release date:2014-12-03
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:High resolution crystal structures of human kynurenine aminotransferase-I bound to PLP cofactor, and in complex with aminooxyacetate.
Protein Sci., 26, 2017
4JE5
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BU of 4je5 by Molmil
Crystal structure of the aromatic aminotransferase Aro8, a putative alpha-aminoadipate aminotransferase in Saccharomyces cerevisiae
Descriptor: 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Aromatic/aminoadipate aminotransferase 1, ...
Authors:Bulfer, S.L, Brunzelle, J.S, Trievel, R.C.
Deposit date:2013-02-26
Release date:2013-09-11
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.909 Å)
Cite:Crystal structure of Saccharomyces cerevisiae Aro8, a putative alpha-aminoadipate aminotransferase.
Protein Sci., 22, 2013
7AAT
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BU of 7aat by Molmil
X-RAY STRUCTURE REFINEMENT AND COMPARISON OF THREE FORMS OF MITOCHONDRIAL ASPARTATE AMINOTRANSFERASE
Descriptor: ASPARTATE AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE
Authors:Mcphalen, C.A, Vincent, M.G, Jansonius, J.N.
Deposit date:1991-12-02
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:X-ray structure refinement and comparison of three forms of mitochondrial aspartate aminotransferase.
J.Mol.Biol., 225, 1992
2O0R
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BU of 2o0r by Molmil
The three-dimensional structure of N-Succinyldiaminopimelate aminotransferase from Mycobacterium tuberculosis
Descriptor: CHLORIDE ION, GLYCEROL, Rv0858c (N-Succinyldiaminopimelate aminotransferase), ...
Authors:Weyand, S, Kefala, G, Weiss, M.S, TB Structural Genomics Consortium (TBSGC)
Deposit date:2006-11-28
Release date:2007-02-27
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Three-dimensional Structure of N-Succinyldiaminopimelate Aminotransferase from Mycobacterium tuberculosis
J.Mol.Biol., 367, 2007
2O1B
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BU of 2o1b by Molmil
Structure of aminotransferase from Staphylococcus aureus
Descriptor: Aminotransferase, class I, PYRIDOXAL-5'-PHOSPHATE
Authors:McGrath, T.E, Dharamsi, A, Thambipillai, D, Edwards, A.M, Pai, E.F, Chirgadze, N.Y.
Deposit date:2006-11-28
Release date:2006-12-12
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure of aminotransferase from Staphylococcus aureus
To be Published
6ZUP
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BU of 6zup by Molmil
Psychrophilic aromatic amino acids aminotransferase from Psychrobacter sp. B6 cocrystalized with substrate analog - L-(-)-3-phenyllactic acid
Descriptor: ALPHA-HYDROXY-BETA-PHENYL-PROPIONIC ACID, Aminotransferase, MAGNESIUM ION, ...
Authors:Bujacz, A, Rum, J, Rutkiewicz, M, Pietrzyk-Brzezinska, A.J, Bujacz, G.
Deposit date:2020-07-23
Release date:2021-07-14
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Evidence of Active Site Adaptability towards Different Sized Substrates of Aromatic Amino Acid Aminotransferase from Psychrobacter Sp. B6.
Materials (Basel), 14, 2021
5BK7
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BU of 5bk7 by Molmil
The structure of MppP E15A mutant soaked with the substrate L-arginine
Descriptor: (E)-N~2~-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-arginine, PLP-Dependent L-Arginine Hydroxylase MppP
Authors:Han, L, Silvaggi, N.R.
Deposit date:2018-01-27
Release date:2018-09-05
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.196 Å)
Cite:Streptomyces wadayamensis MppP is a PLP-Dependent Oxidase, Not an Oxygenase.
Biochemistry, 57, 2018
6ZUR
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BU of 6zur by Molmil
Psychrophilic aromatic amino acids aminotransferase from Psychrobacter sp. B6 cocrystalized with substrate analog - L-p-hydroxyphenyllactic acid
Descriptor: (2S)-2-hydroxy-3-(4-hydroxyphenyl)propanoic acid, Aminotransferase, MAGNESIUM ION, ...
Authors:Bujacz, A, Rum, J, Rutkiewicz, M, Pietrzyk-Brzezinska, A.J, Bujacz, G.
Deposit date:2020-07-23
Release date:2021-07-14
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Structural Evidence of Active Site Adaptability towards Different Sized Substrates of Aromatic Amino Acid Aminotransferase from Psychrobacter Sp. B6.
Materials (Basel), 14, 2021
6ZVG
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BU of 6zvg by Molmil
Psychrophilic aromatic amino acids aminotransferase from Psychrobacter sp. B6 cocrystalized with substrate analog - L-indole-3-lactic acid
Descriptor: 3-(INDOL-3-YL) LACTATE, Aminotransferase, MAGNESIUM ION, ...
Authors:Rum, J, Rutkiewicz, M, Pruska, A, Bujacz, A, Pietrzyk-Brzezinska, A.J, Bujacz, G.
Deposit date:2020-07-24
Release date:2021-07-14
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Structural Evidence of Active Site Adaptability towards Different Sized Substrates of Aromatic Amino Acid Aminotransferase from Psychrobacter Sp. B6.
Materials (Basel), 14, 2021
6UXZ
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BU of 6uxz by Molmil
(S)-4-Amino-5-phenoxypentanoate as a Selective Agonist of the Transcription Factor GabR
Descriptor: (4S)-4-[(E)-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)amino]-5-phenoxypentanoic acid, HTH-type transcriptional regulatory protein GabR, SULFATE ION
Authors:Catlin, D.S, Liu, D.
Deposit date:2019-11-09
Release date:2020-10-07
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:(S)-4-Amino-5-phenoxypentanoate designed as a potential selective agonist of the bacterial transcription factor GabR.
Protein Sci., 29, 2020
5AX8
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Recombinant expression, purification and preliminary crystallographic studies of the mature form of human mitochondrial aspartate aminotransferase
Descriptor: Aspartate aminotransferase, mitochondrial
Authors:Jiang, X, Wang, J, Chang, H, Zhou, Y.
Deposit date:2015-07-20
Release date:2016-03-16
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.989 Å)
Cite:Recombinant expression, purification and crystallographic studies of the mature form of human mitochondrial aspartate aminotransferase
Biosci Trends, 10, 2016

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