6T8P

HKATII IN COMPLEX WITH LIGAND (2R)-N-benzyl-1-[6-methyl-5-(oxan-4-yl)-7-oxo-6H,7H-[1,3]thiazolo[5,4-d]pyrimidin-2-yl]pyrrolidine-2-carboxamide

Summary for 6T8P

• Entry DOI: 10.2210/pdb6t8p/pdb
• Descriptor: Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial, 3,5-bis(fluoranyl)-~{N}-[5-[(2~{R})-2-(3-fluorophenyl)-3-methyl-butyl]-1,3,4-thiadiazol-2-yl]benzenesulfonamide, IODIDE ION, ... (5 entities in total)
• Functional Keywords: alpha & beta protein, plp-dependent transferase, kat ii, kynurenine am, proteros biostructures gmbh, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 104822.79

Authors

Blaesse, M.,Venalainen, J. (deposition date: 2019-10-24, release date: 2020-03-04, Last modification date: 2024-01-24)

• Primary citation: Kalliokoski, T.,Rummakko, P.,Rantanen, M.,Blaesse, M.,Augustin, M.,Ummenthala, G.R.,Choudhary, S.,Venalainen, J.; Discovery of sulfonamides and 9-oxo-2,8-diazaspiro[5,5]undecane-2-carboxamides as human kynurenine aminotransferase 2 (KAT2) inhibitors.; Bioorg.Med.Chem.Lett., 30:127060-127060, 2020; PubMed: 32113843; DOI: 10.1016/j.bmcl.2020.127060

Experimental method

X-RAY DIFFRACTION (2.02 Å)