6T8P
HKATII IN COMPLEX WITH LIGAND (2R)-N-benzyl-1-[6-methyl-5-(oxan-4-yl)-7-oxo-6H,7H-[1,3]thiazolo[5,4-d]pyrimidin-2-yl]pyrrolidine-2-carboxamide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0006103 | biological_process | 2-oxoglutarate metabolic process |
| A | 0006536 | biological_process | glutamate metabolic process |
| A | 0008483 | molecular_function | transaminase activity |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0016212 | molecular_function | kynurenine-oxoglutarate transaminase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0033512 | biological_process | L-lysine catabolic process to acetyl-CoA via saccharopine |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0047315 | molecular_function | kynurenine-glyoxylate transaminase activity |
| A | 0047536 | molecular_function | 2-aminoadipate transaminase activity |
| A | 0047958 | molecular_function | glycine:2-oxoglutarate aminotransferase activity |
| A | 0050094 | molecular_function | methionine-glyoxylate transaminase activity |
| A | 0070189 | biological_process | kynurenine metabolic process |
| A | 1901605 | biological_process | alpha-amino acid metabolic process |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0006103 | biological_process | 2-oxoglutarate metabolic process |
| B | 0006536 | biological_process | glutamate metabolic process |
| B | 0008483 | molecular_function | transaminase activity |
| B | 0009058 | biological_process | biosynthetic process |
| B | 0016212 | molecular_function | kynurenine-oxoglutarate transaminase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0033512 | biological_process | L-lysine catabolic process to acetyl-CoA via saccharopine |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0047315 | molecular_function | kynurenine-glyoxylate transaminase activity |
| B | 0047536 | molecular_function | 2-aminoadipate transaminase activity |
| B | 0047958 | molecular_function | glycine:2-oxoglutarate aminotransferase activity |
| B | 0050094 | molecular_function | methionine-glyoxylate transaminase activity |
| B | 0070189 | biological_process | kynurenine metabolic process |
| B | 1901605 | biological_process | alpha-amino acid metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | binding site for residue MVT A 501 |
| Chain | Residue |
| A | GLN118 |
| A | HOH684 |
| A | HOH771 |
| B | ILE19 |
| B | MET33 |
| B | LEU36 |
| B | LEU40 |
| B | TYR74 |
| B | LEU293 |
| B | MVT501 |
| B | HOH663 |
| A | TYR142 |
| A | ASN202 |
| A | LLP263 |
| A | MET354 |
| A | MET377 |
| A | LEU380 |
| A | ARG399 |
| A | HOH625 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | binding site for residue MVT A 502 |
| Chain | Residue |
| A | GLY38 |
| A | GLY39 |
| A | TYR74 |
| A | SER75 |
| A | LEU293 |
| A | HOH786 |
| B | GLN118 |
| B | TYR142 |
| B | ASN202 |
| B | LLP263 |
| B | MET354 |
| B | ARG399 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | binding site for residue MVT A 503 |
| Chain | Residue |
| A | LEU90 |
| A | LYS93 |
| A | LEU94 |
| A | GLN237 |
| A | LYS240 |
| A | ARG242 |
| A | GLU312 |
| A | MET316 |
| A | VAL319 |
| A | ASP320 |
| A | HOH728 |
| B | PRO81 |
| B | GLU82 |
| B | SER85 |
| B | EDO507 |
| B | HOH646 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue IOD A 504 |
| Chain | Residue |
| A | LYS123 |
| B | GLN119 |
| B | LYS123 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | binding site for residue IOD A 505 |
| Chain | Residue |
| A | SER304 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue IOD A 506 |
| Chain | Residue |
| A | TRP86 |
| B | GLY29 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | binding site for residue IOD A 507 |
| Chain | Residue |
| A | SER77 |
| site_id | AC8 |
| Number of Residues | 15 |
| Details | binding site for residue MVT B 501 |
| Chain | Residue |
| A | LYS93 |
| A | MVT501 |
| A | HOH714 |
| B | SER17 |
| B | ILE19 |
| B | LYS31 |
| B | SER32 |
| B | MET33 |
| B | TYR74 |
| B | SER75 |
| B | PRO76 |
| B | SER77 |
| B | GLN289 |
| B | HOH666 |
| B | HOH739 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue IOD B 502 |
| Chain | Residue |
| B | MET33 |
| B | PRO81 |
| site_id | AD1 |
| Number of Residues | 1 |
| Details | binding site for residue IOD B 504 |
| Chain | Residue |
| B | ARG321 |
| site_id | AD2 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 505 |
| Chain | Residue |
| A | HOH711 |
| B | LYS59 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 506 |
| Chain | Residue |
| A | ASN44 |
| A | MET45 |
| B | GLU56 |
| B | HIS318 |
| B | ARG321 |
| B | HOH667 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 507 |
| Chain | Residue |
| A | MET316 |
| A | MVT503 |
| B | SER85 |
| B | HOH693 |
| B | HOH736 |
| B | HOH777 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 54 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | Compositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 9 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9WVM8","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 5 |
| Details | Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q9WVM8","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
