6T8P
HKATII IN COMPLEX WITH LIGAND (2R)-N-benzyl-1-[6-methyl-5-(oxan-4-yl)-7-oxo-6H,7H-[1,3]thiazolo[5,4-d]pyrimidin-2-yl]pyrrolidine-2-carboxamide
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005739 | cellular_component | mitochondrion |
A | 0005759 | cellular_component | mitochondrial matrix |
A | 0006103 | biological_process | 2-oxoglutarate metabolic process |
A | 0006536 | biological_process | glutamate metabolic process |
A | 0008483 | molecular_function | transaminase activity |
A | 0009058 | biological_process | biosynthetic process |
A | 0016212 | molecular_function | kynurenine-oxoglutarate transaminase activity |
A | 0030170 | molecular_function | pyridoxal phosphate binding |
A | 0033512 | biological_process | L-lysine catabolic process to acetyl-CoA via saccharopine |
A | 0042803 | molecular_function | protein homodimerization activity |
A | 0047315 | molecular_function | kynurenine-glyoxylate transaminase activity |
A | 0047536 | molecular_function | 2-aminoadipate transaminase activity |
A | 0047958 | molecular_function | glycine:2-oxoglutarate aminotransferase activity |
A | 0050094 | molecular_function | methionine-glyoxylate transaminase activity |
A | 0070189 | biological_process | kynurenine metabolic process |
A | 0097052 | biological_process | L-kynurenine metabolic process |
A | 1901605 | biological_process | alpha-amino acid metabolic process |
B | 0005739 | cellular_component | mitochondrion |
B | 0005759 | cellular_component | mitochondrial matrix |
B | 0006103 | biological_process | 2-oxoglutarate metabolic process |
B | 0006536 | biological_process | glutamate metabolic process |
B | 0008483 | molecular_function | transaminase activity |
B | 0009058 | biological_process | biosynthetic process |
B | 0016212 | molecular_function | kynurenine-oxoglutarate transaminase activity |
B | 0030170 | molecular_function | pyridoxal phosphate binding |
B | 0033512 | biological_process | L-lysine catabolic process to acetyl-CoA via saccharopine |
B | 0042803 | molecular_function | protein homodimerization activity |
B | 0047315 | molecular_function | kynurenine-glyoxylate transaminase activity |
B | 0047536 | molecular_function | 2-aminoadipate transaminase activity |
B | 0047958 | molecular_function | glycine:2-oxoglutarate aminotransferase activity |
B | 0050094 | molecular_function | methionine-glyoxylate transaminase activity |
B | 0070189 | biological_process | kynurenine metabolic process |
B | 0097052 | biological_process | L-kynurenine metabolic process |
B | 1901605 | biological_process | alpha-amino acid metabolic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 19 |
Details | binding site for residue MVT A 501 |
Chain | Residue |
A | GLN118 |
A | HOH684 |
A | HOH771 |
B | ILE19 |
B | MET33 |
B | LEU36 |
B | LEU40 |
B | TYR74 |
B | LEU293 |
B | MVT501 |
B | HOH663 |
A | TYR142 |
A | ASN202 |
A | LLP263 |
A | MET354 |
A | MET377 |
A | LEU380 |
A | ARG399 |
A | HOH625 |
site_id | AC2 |
Number of Residues | 12 |
Details | binding site for residue MVT A 502 |
Chain | Residue |
A | GLY38 |
A | GLY39 |
A | TYR74 |
A | SER75 |
A | LEU293 |
A | HOH786 |
B | GLN118 |
B | TYR142 |
B | ASN202 |
B | LLP263 |
B | MET354 |
B | ARG399 |
site_id | AC3 |
Number of Residues | 16 |
Details | binding site for residue MVT A 503 |
Chain | Residue |
A | LEU90 |
A | LYS93 |
A | LEU94 |
A | GLN237 |
A | LYS240 |
A | ARG242 |
A | GLU312 |
A | MET316 |
A | VAL319 |
A | ASP320 |
A | HOH728 |
B | PRO81 |
B | GLU82 |
B | SER85 |
B | EDO507 |
B | HOH646 |
site_id | AC4 |
Number of Residues | 3 |
Details | binding site for residue IOD A 504 |
Chain | Residue |
A | LYS123 |
B | GLN119 |
B | LYS123 |
site_id | AC5 |
Number of Residues | 1 |
Details | binding site for residue IOD A 505 |
Chain | Residue |
A | SER304 |
site_id | AC6 |
Number of Residues | 2 |
Details | binding site for residue IOD A 506 |
Chain | Residue |
A | TRP86 |
B | GLY29 |
site_id | AC7 |
Number of Residues | 1 |
Details | binding site for residue IOD A 507 |
Chain | Residue |
A | SER77 |
site_id | AC8 |
Number of Residues | 15 |
Details | binding site for residue MVT B 501 |
Chain | Residue |
A | LYS93 |
A | MVT501 |
A | HOH714 |
B | SER17 |
B | ILE19 |
B | LYS31 |
B | SER32 |
B | MET33 |
B | TYR74 |
B | SER75 |
B | PRO76 |
B | SER77 |
B | GLN289 |
B | HOH666 |
B | HOH739 |
site_id | AC9 |
Number of Residues | 2 |
Details | binding site for residue IOD B 502 |
Chain | Residue |
B | MET33 |
B | PRO81 |
site_id | AD1 |
Number of Residues | 1 |
Details | binding site for residue IOD B 504 |
Chain | Residue |
B | ARG321 |
site_id | AD2 |
Number of Residues | 2 |
Details | binding site for residue EDO B 505 |
Chain | Residue |
A | HOH711 |
B | LYS59 |
site_id | AD3 |
Number of Residues | 6 |
Details | binding site for residue EDO B 506 |
Chain | Residue |
A | ASN44 |
A | MET45 |
B | GLU56 |
B | HIS318 |
B | ARG321 |
B | HOH667 |
site_id | AD4 |
Number of Residues | 6 |
Details | binding site for residue EDO B 507 |
Chain | Residue |
A | MET316 |
A | MVT503 |
B | SER85 |
B | HOH693 |
B | HOH736 |
B | HOH777 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 10 |
Details | BINDING: |
Chain | Residue | Details |
A | ARG20 | |
B | ARG399 | |
A | TYR74 | |
A | TYR142 | |
A | ASN202 | |
A | ARG399 | |
B | ARG20 | |
B | TYR74 | |
B | TYR142 | |
B | ASN202 |
site_id | SWS_FT_FI2 |
Number of Residues | 6 |
Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9WVM8 |
Chain | Residue | Details |
A | LYS69 | |
A | LYS179 | |
A | LYS422 | |
B | LYS69 | |
B | LYS179 | |
B | LYS422 |
site_id | SWS_FT_FI3 |
Number of Residues | 6 |
Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q9WVM8 |
Chain | Residue | Details |
A | LLP263 | |
A | LYS339 | |
A | LYS367 | |
B | LLP263 | |
B | LYS339 | |
B | LYS367 |