Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4EU1
DownloadVisualize
BU of 4eu1 by Molmil
Structure of a mitochondrial aspartate aminotransferase from Trypanosoma brucei
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Mitochondrial aspartate aminotransferase
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2012-04-25
Release date:2012-05-16
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of aspartate aminotransferases from Trypanosoma brucei, Leishmania major and Giardia lamblia.
Acta Crystallogr F Struct Biol Commun, 71, 2015
4F5J
DownloadVisualize
BU of 4f5j by Molmil
Rational Design and Directed Evolution for Conversion of Substrate Specificity from E.coli Aspartate Aminotransferase to Tyrosine Aminotransferase: Mutant P5.
Descriptor: Aspartate aminotransferase
Authors:Addington, T.A, Fisher, A.J, Toney, M.D.
Deposit date:2012-05-13
Release date:2013-02-13
Last modified:2013-04-24
Method:X-RAY DIFFRACTION (1.954 Å)
Cite:Janus: prediction and ranking of mutations required for functional interconversion of enzymes.
J.Mol.Biol., 425, 2013
4F5F
DownloadVisualize
BU of 4f5f by Molmil
Structure of Aspartate Aminotransferase Conversion to Tyrosine Aminotransferase: Chimera P1.
Descriptor: Aspartate aminotransferase
Authors:Addington, T.A, Fisher, A.J, Toney, M.D.
Deposit date:2012-05-13
Release date:2013-02-13
Last modified:2013-04-24
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Janus: prediction and ranking of mutations required for functional interconversion of enzymes.
J.Mol.Biol., 425, 2013
4F5M
DownloadVisualize
BU of 4f5m by Molmil
Wild-Type E. coli Aspartate Aminotransferase: A Template For The Interconversion of Substrate Specificity and Activity To Tyrosine Aminotransferase By The JANUS Algorithm.
Descriptor: 1,2-ETHANEDIOL, Aspartate aminotransferase
Authors:Addington, T.A, Fisher, A.J, Toney, M.D.
Deposit date:2012-05-13
Release date:2013-02-13
Last modified:2013-04-24
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Janus: prediction and ranking of mutations required for functional interconversion of enzymes.
J.Mol.Biol., 425, 2013
4F5I
DownloadVisualize
BU of 4f5i by Molmil
Substrate Specificity Conversion of E. coli Pyridoxal-5'-Phosphate Dependent Aspartate Aminotransferase to Tyrosine Aminotransferase: Chimera P4.
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Aspartate aminotransferase
Authors:Addington, T.A, Fisher, A.J, Toney, M.D.
Deposit date:2012-05-13
Release date:2013-02-13
Last modified:2013-04-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Janus: prediction and ranking of mutations required for functional interconversion of enzymes.
J.Mol.Biol., 425, 2013
4DQ6
DownloadVisualize
BU of 4dq6 by Molmil
Crystal structure of PLP-bound putative aminotransferase from Clostridium difficile 630
Descriptor: CHLORIDE ION, PYRIDOXAL-5'-PHOSPHATE, Putative pyridoxal phosphate-dependent transferase
Authors:Shabalin, I.G, Onopriyenko, O, Kudritska, M, Chruszcz, M, Grimshaw, S, Porebski, P.J, Cooper, D.R, Savchenko, A, Anderson, W.F, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2012-02-15
Release date:2012-02-29
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structures of putative aminotransferase from Clostridium difficile 630
to be published
4DBC
DownloadVisualize
BU of 4dbc by Molmil
Substrate Activation in Aspartate Aminotransferase
Descriptor: (E)-N-{2-hydroxy-3-methyl-6-[(phosphonooxy)methyl]benzylidene}-L-aspartic acid, 1,2-ETHANEDIOL, Aspartate aminotransferase, ...
Authors:Toney, M.D, Fisher, A.J, Griswold, W.R.
Deposit date:2012-01-14
Release date:2012-12-05
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Ground-state electronic destabilization via hyperconjugation in aspartate aminotransferase.
J.Am.Chem.Soc., 134, 2012
4DGT
DownloadVisualize
BU of 4dgt by Molmil
Crystal structure of PLP-bound putative aminotransferase from Clostridium difficile 630 crystallized with magnesium formate
Descriptor: CHLORIDE ION, MAGNESIUM ION, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Shabalin, I.G, Onopriyenko, O, Kudritska, M, Chruszcz, M, Grimshaw, S, Porebski, P.J, Cooper, D.R, Savchenko, A, Anderson, W.F, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2012-01-26
Release date:2012-02-08
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structures of putative aminotransferase from Clostridium difficile 630
to be published
4GEB
DownloadVisualize
BU of 4geb by Molmil
Kynurenine Aminotransferase II Inhibitors
Descriptor: (5-hydroxy-4-{[(7-hydroxy-6-oxo-2-phenyl-6,7-dihydro-2H-pyrazolo[3,4-b]pyridin-5-yl)amino]methyl}-6-methylpyridin-3-yl)methyl dihydrogen phosphate, Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial, ...
Authors:Pandit, J.
Deposit date:2012-08-01
Release date:2013-03-20
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:PF-04859989 as a template for structure-based drug design: identification of new pyrazole series of irreversible KAT II inhibitors with improved lipophilic efficiency.
Bioorg.Med.Chem.Lett., 23, 2013
4F5G
DownloadVisualize
BU of 4f5g by Molmil
Rational Design and Directed Evolution of E. coli Apartate Aminotransferase to Tyrosine Aminotransferase: Mutant P2.
Descriptor: Aspartate aminotransferase
Authors:Addington, T.A, Fisher, A.J, Toney, M.D.
Deposit date:2012-05-13
Release date:2013-02-13
Last modified:2013-04-24
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Janus: prediction and ranking of mutations required for functional interconversion of enzymes.
J.Mol.Biol., 425, 2013
4GE7
DownloadVisualize
BU of 4ge7 by Molmil
Kynurenine Aminotransferase II Inhibitors
Descriptor: (5-hydroxy-4-{[(1-hydroxy-2-oxo-6-phenoxy-1,2-dihydroquinolin-3-yl)amino]methyl}-6-methylpyridin-3-yl)methyl dihydrogen phosphate, Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Authors:Pandit, J.
Deposit date:2012-08-01
Release date:2012-11-07
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-Based Design of Irreversible Human KAT II Inhibitors: Discovery of New Potency-Enhancing Interactions.
ACS Med Chem Lett, 4, 2013
4GE4
DownloadVisualize
BU of 4ge4 by Molmil
Kynurenine Aminotransferase II Inhibitors
Descriptor: (5-hydroxy-4-{[(1-hydroxy-7-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)amino]methyl}-6-methylpyridin-3-yl)methyl dihydrogen phosphate, Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Authors:Pandit, J.
Deposit date:2012-08-01
Release date:2012-11-07
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Structure-Based Design of Irreversible Human KAT II Inhibitors: Discovery of New Potency-Enhancing Interactions.
ACS Med Chem Lett, 4, 2013
4GDY
DownloadVisualize
BU of 4gdy by Molmil
Kynurenine Aminotransferase II inhibitors
Descriptor: (5-hydroxy-6-methyl-4-{[(1-oxo-7-phenoxy-1,2-dihydro[1,2,4]triazolo[4,3-a]quinolin-4-yl)amino]methyl}pyridin-3-yl)methyl dihydrogen phosphate, Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Authors:Pandit, J.
Deposit date:2012-08-01
Release date:2012-08-29
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Discovery of Hydroxamate Bioisosteres as KATII Inhibitors with Improved Oral Bioavailability and Pharmacokinetics
MEDCHEMCOMM, 2012
4GE9
DownloadVisualize
BU of 4ge9 by Molmil
Kynurenine Aminotransferase II Inhibitors
Descriptor: (4-{[(6-benzyl-1-hydroxy-7-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)amino]methyl}-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate, Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Authors:Pandit, J.
Deposit date:2012-08-01
Release date:2012-11-07
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Structure-Based Design of Irreversible Human KAT II Inhibitors: Discovery of New Potency-Enhancing Interactions.
ACS Med Chem Lett, 4, 2013
4F5H
DownloadVisualize
BU of 4f5h by Molmil
Intercoversion of Substrate Specificity: E. coli Aspatate Aminotransferase to Tyrosine Aminotransferase: Chimera P3.
Descriptor: Aspartate aminotransferase
Authors:Addington, T.A, Fisher, A.J, Toney, M.D.
Deposit date:2012-05-13
Release date:2013-02-13
Last modified:2013-04-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Janus: prediction and ranking of mutations required for functional interconversion of enzymes.
J.Mol.Biol., 425, 2013
4F5L
DownloadVisualize
BU of 4f5l by Molmil
A Theoretical Optimized Mutant for the Conversion of Substrate Specificity and Activity of Aspartate Aminotransferase to Tyrosine Aminotransferase: Chimera P7.
Descriptor: 1,2-ETHANEDIOL, Aspartate aminotransferase
Authors:Addington, T.A, Fisher, A.J, Toney, M.D.
Deposit date:2012-05-13
Release date:2013-05-15
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Janus: an algorithm for ranking functional importance of residues from protein sequence alignments.
To be Published
4FL0
DownloadVisualize
BU of 4fl0 by Molmil
Crystal structure of ALD1 from Arabidopsis thaliana
Descriptor: Aminotransferase ALD1, PYRIDOXAL-5'-PHOSPHATE
Authors:Sobolev, V, Edelman, M, Dym, O, Unger, T, Albeck, S, Kirma, M, Galili, G, Israel Structural Proteomics Center (ISPC)
Deposit date:2012-06-14
Release date:2013-02-20
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of ALD1, a plant-specific homologue of the universal diaminopimelate aminotransferase enzyme of lysine biosynthesis.
Acta Crystallogr.,Sect.F, 69, 2013
4F4E
DownloadVisualize
BU of 4f4e by Molmil
Crystal structure of Aromatic-amino-acid aminotransferase from Burkholderia pseudomallei covalently bound to pyridoxal phosphate
Descriptor: 1,2-ETHANEDIOL, Aromatic-amino-acid aminotransferase
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2012-05-10
Release date:2012-05-23
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of Aromatic-amino-acid aminotransferase from Burkholderia pseudomallei covalently bound to pyridoxal phosphate
To be Published
4F5K
DownloadVisualize
BU of 4f5k by Molmil
Substrate Specificity Conversion of Aspartate Aminotransferase to Tyrosine Aminotransferase By The JANUS Algorithm: Chimera P6.
Descriptor: Aspartate aminotransferase
Authors:Addington, T.A, Fisher, A.J, Toney, M.D.
Deposit date:2012-05-13
Release date:2013-02-13
Last modified:2013-04-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Janus: prediction and ranking of mutations required for functional interconversion of enzymes.
J.Mol.Biol., 425, 2013
4H51
DownloadVisualize
BU of 4h51 by Molmil
Crystal structure of a putative Aspartate Aminotransferase from Leishmania major Friedlin
Descriptor: 1,2-ETHANEDIOL, Aspartate aminotransferase
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2012-09-18
Release date:2012-10-10
Last modified:2015-05-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structures of aspartate aminotransferases from Trypanosoma brucei, Leishmania major and Giardia lamblia.
Acta Crystallogr F Struct Biol Commun, 71, 2015
2CST
DownloadVisualize
BU of 2cst by Molmil
CRYSTAL STRUCTURE OF THE CLOSED FORM OF CHICKEN CYTOSOLIC ASPARTATE AMINOTRANSFERASE AT 1.9 ANGSTROMS RESOLUTION
Descriptor: ASPARTATE AMINOTRANSFERASE, MALEIC ACID, PYRIDOXAL-5'-PHOSPHATE
Authors:Malashkevich, V.N, Strokopytov, B.V, Borisov, V.V.
Deposit date:1994-09-06
Release date:1994-11-30
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the closed form of chicken cytosolic aspartate aminotransferase at 1.9 A resolution.
J.Mol.Biol., 247, 1995
2D65
DownloadVisualize
BU of 2d65 by Molmil
Aspartate Aminotransferase Mutant MABC
Descriptor: Aspartate aminotransferase, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION
Authors:Tanaka, Y, Nakagawa, N, Tada, H, Yano, T, Masui, R, Kuramitsu, S.
Deposit date:2005-11-09
Release date:2006-11-14
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Structures of Aspartate Aminotransferase with Mutations of Non-Active-Site Residues
To be Published
2D7Z
DownloadVisualize
BU of 2d7z by Molmil
Aspartate Aminotransferase Mutant MAB Complexed with Maleic Acid
Descriptor: Aspartate aminotransferase, MALEIC ACID, PYRIDOXAL-5'-PHOSPHATE
Authors:Tanaka, Y, Nakagawa, N, Tada, H, Yano, T, Masui, R, Kuramitsu, S.
Deposit date:2005-11-30
Release date:2006-11-14
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:The Structures of Aspartate Aminotransferase with Mutations of Non-Active-Site Residues
To be Published
2D66
DownloadVisualize
BU of 2d66 by Molmil
Aspartate Aminotransferase Mutant MAB
Descriptor: Aspartate aminotransferase, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION
Authors:Tanaka, Y, Nakagawa, N, Tada, H, Yano, T, Masui, R, Kuramitsu, S.
Deposit date:2005-11-09
Release date:2006-11-14
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:The Structures of Aspartate Aminotransferase with Mutations of Non-Active-Site Residues
To be Published
2BWP
DownloadVisualize
BU of 2bwp by Molmil
5-Aminolevulinate Synthase from Rhodobacter capsulatus in complex with glycine
Descriptor: 5-AMINOLEVULINATE SYNTHASE, ACETIC ACID, N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE]
Authors:Astner, I, Schulze, J.O, Van Den Heuvel, J.J, Jahn, D, Schubert, W.-D, Heinz, D.W.
Deposit date:2005-07-15
Release date:2005-09-27
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structure of 5-Aminolevulinate Synthase, the First Enzyme of Heme Biosynthesis, and its Link to Xlsa in Humans.
Embo J., 24, 2005

225158

PDB entries from 2024-09-18

PDB statisticsPDBj update infoContact PDBjnumon