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4PXO
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BU of 4pxo by Molmil
Crystal structure of Maleylacetoacetate isomerase from Methylobacteriu extorquens AM1 WITH BOUND MALONATE AND GSH (TARGET EFI-507068)
Descriptor: 1,2-ETHANEDIOL, GLUTATHIONE, MALONIC ACID, ...
Authors:Patskovsky, Y, Toro, R, Bhosle, R, Hillerich, B, Seidel, R.D, Washington, E, Scott Glenn, A, Chowdhury, S, Evans, B, Hammonds, J, Imker, H.J, Al Obaidi, N, Stead, M, Love, J, Gerlt, J.A, Armstrong, R.N, Almo, S.C, Enzyme Function Initiative (EFI)
Deposit date:2014-03-24
Release date:2014-04-09
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of glutathione s-transferase zeta from Methylobacterium extorquens (TARGET EFI-507068)
To be Published
4PX1
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BU of 4px1 by Molmil
CRYSTAL STRUCTURE OF Maleylacetoacetate isomerase from Methylobacteriu extorquens AM1 WITH BOUND MALONATE (TARGET EFI-507068)
Descriptor: CHLORIDE ION, MALONIC ACID, Maleylacetoacetate isomerase (Glutathione S-transferase)
Authors:Patskovsky, Y, Toro, R, Bhosle, R, Hillerich, B, Seidel, R.D, Washington, E, Scott Glenn, A, Chowdhury, S, Evans, B, Hammonds, J, Imker, H.J, Al Obaidi, N, Stead, M, Love, J, Gerlt, J.A, Armstrong, R.N, Almo, S.C, Enzyme Function Initiative (EFI)
Deposit date:2014-03-21
Release date:2014-04-09
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structure of glutathione s-transferase zeta from methylobacterium extorquens (TARGET EFI-507068)
To be Published
4CHS
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BU of 4chs by Molmil
Crystal structure of a tau class glutathione transferase 10 from Glycine max
Descriptor: ACETONE, GLUTATHIONE S-TRANSFERASE, S-Hydroxy-Glutathione
Authors:Skopelitou, K, Muleta, A.W, Papageorgiou, A.C, Pavli, O, Flemetakis, E, Chronopoulou, E, Skaracis, G.N, Labrou, N.E.
Deposit date:2013-12-04
Release date:2014-12-17
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Catalytic features and crystal structure of a tau class glutathione transferase from Glycine max specifically upregulated in response to soybean mosaic virus infections.
Biochim. Biophys. Acta, 1854, 2015
6W58
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BU of 6w58 by Molmil
hPGDS complexed with an aza-quinoline
Descriptor: 7-(azetidin-1-yl)-~{N}-[4-(2-oxidanylpropan-2-yl)cyclohexyl]-1,6-naphthyridine-3-carboxamide, GLUTATHIONE, Hematopoietic prostaglandin D synthase
Authors:Elkins, P.A, Ward, P.
Deposit date:2020-03-12
Release date:2020-11-04
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.395 Å)
Cite:The exploration of aza-quinolines as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors with low brain exposure.
Bioorg.Med.Chem., 28, 2020
8C5D
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BU of 8c5d by Molmil
Glutathione transferase P1-1 from Mus musculus
Descriptor: CALCIUM ION, CHLORIDE ION, GLYCEROL, ...
Authors:Papageorgiou, A.C.
Deposit date:2023-01-06
Release date:2023-05-24
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:Inhibition Analysis and High-Resolution Crystal Structure of Mus musculus Glutathione Transferase P1-1.
Biomolecules, 13, 2023
7SO8
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BU of 7so8 by Molmil
Crystal structure of Glutathione S-Transferase from Shrimp Litopenaeus vannamei in complex with silver ions and a molecules of Glutathione binding in G-site and H-site
Descriptor: GLUTATHIONE, Glutathione transferase, PENTAETHYLENE GLYCOL, ...
Authors:Escudero-Garcia, A, Rudino-Pinera, E, Miranda-Blancas, R.
Deposit date:2021-10-29
Release date:2022-11-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Inhibition of GST class Mu of the shrimp Litopenaeus vannamei by binding silver ions in H-site.
To Be Published
8DHB
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BU of 8dhb by Molmil
Active FLCN GAP complex
Descriptor: BERYLLIUM TRIFLUORIDE ION, Folliculin, Folliculin-interacting protein 2, ...
Authors:Jansen, R.M, Hurley, J.H.
Deposit date:2022-06-25
Release date:2022-09-28
Method:ELECTRON MICROSCOPY (3.53 Å)
Cite:Structural basis for FLCN RagC GAP activation in MiT-TFE substrate-selective mTORC1 regulation.
Sci Adv, 8, 2022
6W8H
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BU of 6w8h by Molmil
H-PGDS complexed with inhibitor 1Y
Descriptor: 1,2-ETHANEDIOL, 7-cyclopropyl-N-[trans-4-(2-hydroxypropan-2-yl)cyclohexyl]-1,8-naphthyridine-3-carboxamide, GLUTATHIONE, ...
Authors:Shewchuk, L.M, Ward, P.
Deposit date:2020-03-20
Release date:2020-11-04
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:The exploration of aza-quinolines as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors with low brain exposure.
Bioorg.Med.Chem., 28, 2020
3KMN
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BU of 3kmn by Molmil
Crystal Structure of the Human Apo GST Pi C47S/Y108V Double Mutant
Descriptor: CALCIUM ION, CARBONATE ION, Glutathione S-transferase P, ...
Authors:Parker, L.J.
Deposit date:2009-11-11
Release date:2010-03-23
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Diuretic drug binding to human glutathione transferase P1-1: potential role of CYS101 revealed in the double mutant C47S/Y108V
to be published
3KM6
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BU of 3km6 by Molmil
Crystal Structure of the Human GST Pi C47S/Y108V Double Mutant in Complex with the Ethacrynic Acid-Glutathione Conjugate
Descriptor: CALCIUM ION, ETHACRYNIC ACID, GLUTATHIONE, ...
Authors:Parker, L.J.
Deposit date:2009-11-10
Release date:2010-03-23
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Diuretic drug binding to human glutathione transferase P1-1: potential role of Cys-101 revealed in the double mutant C47S/Y108V.
J.Mol.Recognit., 24
7PKA
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BU of 7pka by Molmil
Synechocystis sp. PCC6803 glutathione transferase Chi 1, GSOH bound
Descriptor: Glutathione S-transferase, POTASSIUM ION, S-Hydroxy-Glutathione
Authors:Didierjean, C, Mocchetti, E, Hecker, A, Favier, F.
Deposit date:2021-08-25
Release date:2022-09-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Structure and functions of glutathione transferase Chi 1 from cyanobacterium Synechocystis sp. PCC 6803
To Be Published
4WR5
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BU of 4wr5 by Molmil
Crystal Structure of GST Mutated with Halogenated Tyrosine (7cGST-1)
Descriptor: GLUTATHIONE, Glutathione S-transferase class-mu 26 kDa isozyme, SULFATE ION
Authors:Akasaka, R, Kawazoe, M, Tomabechi, Y, Ohtake, K, Itagaki, T, Takemoto, C, Shirouzu, M, Yokoyama, S, Sakamoto, K.
Deposit date:2014-10-23
Release date:2015-08-19
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Protein stabilization utilizing a redefined codon
Sci Rep, 5, 2015
4WR4
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BU of 4wr4 by Molmil
Crystal Structure of GST Mutated with Halogenated Tyrosine (7bGST-1)
Descriptor: GLUTATHIONE, Glutathione S-transferase class-mu 26 kDa isozyme, SULFATE ION
Authors:Akasaka, R, Kawazoe, M, Tomabechi, Y, Ohtake, K, Itagaki, T, Takemoto, C, Shirouzu, M, Yokoyama, S, Sakamoto, K.
Deposit date:2014-10-23
Release date:2015-08-19
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Protein stabilization utilizing a redefined codon
Sci Rep, 5, 2015
6RWD
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BU of 6rwd by Molmil
Crystal structure of SjGST in complex with GSH and ellagic acid at 1.53 Angstrom resolution
Descriptor: 2,3,7,8-tetrahydroxychromeno[5,4,3-cde]chromene-5,10-dione, CHLORIDE ION, GLUTATHIONE, ...
Authors:Olfsen, J, Pandian, R, Sayed, Y, Dirr, H.W, Achilonu, I.A.
Deposit date:2019-06-04
Release date:2019-06-19
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Molecular basis of inhibition of Schistosoma japonicum glutathione transferase by ellagic acid: Insights into biophysical and structural studies.
Mol.Biochem.Parasitol., 240, 2020
8GSS
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BU of 8gss by Molmil
Human glutathione S-transferase P1-1, complex with glutathione
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLUTATHIONE, GLUTATHIONE S-TRANSFERASE P1-1, ...
Authors:Oakley, A, Parker, M.
Deposit date:1997-08-14
Release date:1998-09-16
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The structures of human glutathione transferase P1-1 in complex with glutathione and various inhibitors at high resolution.
J.Mol.Biol., 274, 1997
6N4E
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BU of 6n4e by Molmil
hPGDS complexed with a quinoline-3-carboxamide
Descriptor: 7-(difluoromethoxy)-N-[trans-4-(2-hydroxypropan-2-yl)cyclohexyl]quinoline-3-carboxamide, GLUTATHIONE, Hematopoietic prostaglandin D synthase
Authors:Shewchuk, L.M, Ward, P.
Deposit date:2018-11-19
Release date:2019-03-27
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The discovery of quinoline-3-carboxamides as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors.
Bioorg. Med. Chem., 27, 2019
6N69
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BU of 6n69 by Molmil
rat hPGDS complexed with a quinoline
Descriptor: GLUTATHIONE, Hematopoietic prostaglandin D synthase, quinoline-3-carbonitrile
Authors:Shewchuk, L.M, Cleasby, A.
Deposit date:2018-11-26
Release date:2019-03-27
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The discovery of quinoline-3-carboxamides as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors.
Bioorg. Med. Chem., 27, 2019
6N8U
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BU of 6n8u by Molmil
DRAFT model of Schistosoma japonicum Glutathione S-transferase expression tag
Descriptor: Glutathione S-transferase class-mu 26 kDa isozyme
Authors:Tempel, W, Dong, C.
Deposit date:2018-11-30
Release date:2019-01-16
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:DRAFT model of Schistosoma japonicum Glutathione S-transferase expression tag
To Be Published
8GYD
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BU of 8gyd by Molmil
Structure of Schistosoma japonicum Glutathione S-transferase bound with the ligand complex of 16
Descriptor: (2R)-2-[[2-(5-chloranylthiophen-2-yl)-4-oxidanylidene-6-[2-(1H-1,2,3,4-tetrazol-5-yl)phenyl]quinazolin-3-yl]methyl]-3-(4-chlorophenyl)propanoic acid, ETHANOL, Glutathione S-transferase class-mu 26 kDa isozyme
Authors:Wen, X, Jin, R, Hu, H, Zhu, J, Song, W, Lu, X.
Deposit date:2022-09-22
Release date:2023-08-23
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Discovery, SAR Study of GST Inhibitors from a Novel Quinazolin-4(1 H )-one Focused DNA-Encoded Library.
J.Med.Chem., 66, 2023
9GSS
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BU of 9gss by Molmil
HUMAN GLUTATHIONE S-TRANSFERASE P1-1, COMPLEX WITH S-HEXYL GLUTATHIONE
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLUTATHIONE S-TRANSFERASE P1-1, S-HEXYLGLUTATHIONE, ...
Authors:Oakley, A, Parker, M.
Deposit date:1997-08-14
Release date:1998-09-16
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:The structures of human glutathione transferase P1-1 in complex with glutathione and various inhibitors at high resolution.
J.Mol.Biol., 274, 1997
8JHU
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BU of 8jhu by Molmil
Legionella effector protein SidI
Descriptor: Legionella pneumophila effector protein SidI
Authors:Wang, L, Subramanian, A, Mukherjee, S, Walter, P.
Deposit date:2023-05-25
Release date:2023-08-30
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:A Legionella toxin exhibits tRNA mimicry and glycosyl transferase activity to target the translation machinery and trigger a ribotoxic stress response.
Nat.Cell Biol., 25, 2023
7GSS
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BU of 7gss by Molmil
Human glutathione S-transferase P1-1, complex with glutathione
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLUTATHIONE, GLUTATHIONE S-TRANSFERASE P1-1
Authors:Oakley, A, Parker, M.
Deposit date:1997-08-13
Release date:1998-09-16
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The structures of human glutathione transferase P1-1 in complex with glutathione and various inhibitors at high resolution.
J.Mol.Biol., 274, 1997
7JR6
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BU of 7jr6 by Molmil
H-PDGS complexed with a 2-phenylimidazo[1,2-a]pyridine-6-carboxamide inhibitors
Descriptor: 1-(3-fluorophenyl)-N-[trans-4-(2-hydroxypropan-2-yl)cyclohexyl]-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide, GLUTATHIONE, Hematopoietic prostaglandin D synthase, ...
Authors:Nolte, R.T, Somers, D.O, Gampe, R.T.
Deposit date:2020-08-11
Release date:2021-05-26
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:A knowledge-based, structural-aided discovery of a novel class of 2-phenylimidazo[1,2-a]pyridine-6-carboxamide H-PGDS inhibitors.
Bioorg.Med.Chem.Lett., 47, 2021
7JR8
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BU of 7jr8 by Molmil
H-PDGS complexed with a 2-phenylimidazo[1,2-a]pyridine-6-carboxamide inhibitors
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, GLUTATHIONE, ...
Authors:Nolte, R.T, Somers, D.O, Gampe, R.T.
Deposit date:2020-08-11
Release date:2021-05-26
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.13 Å)
Cite:A knowledge-based, structural-aided discovery of a novel class of 2-phenylimidazo[1,2-a]pyridine-6-carboxamide H-PGDS inhibitors.
Bioorg.Med.Chem.Lett., 47, 2021
2A2R
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BU of 2a2r by Molmil
Crystal Structure of Glutathione Transferase Pi in complex with S-nitrosoglutathione
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-AMINO-5-[1-(CARBOXYLATOMETHYLCARBAMOYL)-2-NITROSOSULFANYL-ETHYL]AMINO-5-OXO-PENTANOATE, CALCIUM ION, ...
Authors:Parker, L.J, Morton, C.J, Adams, J.J, Parker, M.W.
Deposit date:2005-06-23
Release date:2006-06-06
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Calorimetric and structural studies of the nitric oxide carrier S-nitrosoglutathione bound to human glutathione transferase P1-1
Protein Sci., 15, 2006

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數據於2024-09-18公開中

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