6N69

rat hPGDS complexed with a quinoline

Summary for 6N69

• Entry DOI: 10.2210/pdb6n69/pdb
• Related: 6N4E
• Descriptor: Hematopoietic prostaglandin D synthase, GLUTATHIONE, quinoline-3-carbonitrile, ... (4 entities in total)
• Functional Keywords: pgd2 synthase, hydrolase
• Biological source: Rattus norvegicus (Rat)
• Total number of polymer chains: 2
• Total formula weight: 48135.43

Authors

Shewchuk, L.M.,Cleasby, A. (deposition date: 2018-11-26, release date: 2019-03-27, Last modification date: 2024-03-13)

• Primary citation: Deaton, D.N.,Do, Y.,Holt, J.,Jeune, M.R.,Kramer, H.F.,Larkin, A.L.,Orband-Miller, L.A.,Peckham, G.E.,Poole, C.,Price, D.J.,Schaller, L.T.,Shen, Y.,Shewchuk, L.M.,Stewart, E.L.,Stuart, J.D.,Thomson, S.A.,Ward, P.,Wilson, J.W.,Xu, T.,Guss, J.H.,Musetti, C.,Rendina, A.R.,Affleck, K.,Anders, D.,Hancock, A.P.,Hobbs, H.,Hodgson, S.T.,Hutchinson, J.,Leveridge, M.V.,Nicholls, H.,Smith, I.E.D.,Somers, D.O.,Sneddon, H.F.,Uddin, S.,Cleasby, A.,Mortenson, P.N.,Richardson, C.,Saxty, G.; The discovery of quinoline-3-carboxamides as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors.; Bioorg. Med. Chem., 27:1456-1478, 2019; PubMed: 30858025; DOI: 10.1016/j.bmc.2019.02.017

Experimental method

X-RAY DIFFRACTION (2 Å)