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6JBC
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BU of 6jbc by Molmil
Phosphotransferase related to CoA biosynthesis pathway
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, GLYCEROL, ...
Authors:Kita, A, Kishimoto, A, Shimosaka, T, Tomita, H, Yokooji, Y, Imanaka, T, Atomi, H, Miki, K.
Deposit date:2019-01-25
Release date:2020-01-29
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of pantoate kinase from Thermococcus kodakarensis.
Proteins, 88, 2020
6JBD
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BU of 6jbd by Molmil
Phosphotransferase-ATP complex related to CoA biosynthesis pathway
Descriptor: 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, ...
Authors:Kita, A, Kishimoto, A, Shimosaka, T, Tomita, H, Yokooji, Y, Imanaka, T, Atomi, H, Miki, K.
Deposit date:2019-01-25
Release date:2020-01-29
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of pantoate kinase from Thermococcus kodakarensis.
Proteins, 88, 2020
2VF3
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BU of 2vf3 by Molmil
Aquifex aeolicus IspE in complex with ligand
Descriptor: 4-DIPHOSPHOCYTIDYL-2C-METHYL-D-ERYTHRITOL KINASE, BROMIDE ION, CHLORIDE ION, ...
Authors:Alphey, M.S, Hunter, W.N.
Deposit date:2007-10-30
Release date:2008-11-25
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Inhibitors of the Kinase Ispe: Structure-Activity Relationships and Co-Crystal Structure Analysis.
Org.Biomol.Chem., 6, 2008
2V2Z
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BU of 2v2z by Molmil
IspE in complex with ADP and CDPME
Descriptor: 4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL, 4-DIPHOSPHOCYTIDYL-2C-METHYL-D-ERYTHRITOL KINASE, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Sgraja, T, Alphey, M.S, Hunter, W.N.
Deposit date:2007-06-08
Release date:2007-06-19
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Characterization of Aquifex Aeolicus 4-Diphosphocytidyl-2C-Methyl-D-Erythritol Kinase -Ligand Recognition in a Template for Antimicrobial Drug Discovery.
FEBS J., 275, 2008
2V2Q
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BU of 2v2q by Molmil
IspE in complex with ligand
Descriptor: 4-AMINO-1-(5-{[3-(1H-BENZIMIDAZOL-2-YL)PROPANOYL]AMINO}-5-DEOXY-ALPHA-L-LYXOFURANOSYL)PYRIMIDIN-2(1H)-ONE, 4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE, BROMIDE ION, ...
Authors:Alphey, M.S, Hunter, W.N.
Deposit date:2007-06-06
Release date:2007-06-19
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Synthesis and Characterization of Cytidine Derivatives that Inhibit the Kinase Ispe of the Non-Mevalonate Pathway for Isoprenoid Biosynthesis.
Chemmedchem, 3, 2008
2V2V
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BU of 2v2v by Molmil
IspE in complex with ligand
Descriptor: 4-DIPHOSPHOCYTIDYL-2C-METHYL-D-ERYTHRITOL KINASE, 5'-[(1H-BENZIMIDAZOL-2-YLACETYL)AMINO]-5'-DEOXYCYTIDINE, BROMIDE ION, ...
Authors:Alphey, M.S, Hunter, W.N.
Deposit date:2007-06-07
Release date:2007-06-19
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Synthesis and Characterization of Cytidine Derivatives that Inhibit the Kinase Ispe of the Non-Mevalonate Pathway for Isoprenoid Biosynthesis.
Chemmedchem, 3, 2008
2V8P
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BU of 2v8p by Molmil
IspE in complex with ADP and CDP
Descriptor: 4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ...
Authors:Sgraja, T, Alphey, M.S, Hunter, W.N.
Deposit date:2007-08-13
Release date:2007-08-21
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Characterization of Aquifex Aeolicus 4-Diphosphocytidyl-2C-Methyl-D-Erythritol Kinase -Ligand Recognition in a Template for Antimicrobial Drug Discovery.
FEBS J., 275, 2008
2V34
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BU of 2v34 by Molmil
IspE in complex with cytidine and ligand
Descriptor: 4-AMINO-1-BETA-D-RIBOFURANOSYL-2(1H)-PYRIMIDINONE, 4-DIPHOSPHOCYTIDYL-2C-METHYL-D-ERYTHRITOL KINASE, CHLORIDE ION, ...
Authors:Sgraja, T, Alphey, M.S, Hunter, W.N.
Deposit date:2007-06-11
Release date:2007-06-26
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Characterization of Aquifex Aeolicus 4-Diphosphocytidyl-2C-Methyl-D-Erythritol Kinase -Ligand Recognition in a Template for Antimicrobial Drug Discovery.
FEBS J., 275, 2008
8CKH
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BU of 8ckh by Molmil
Crystal structure of IspE from Klebsiella pneumoniae
Descriptor: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Hamid, R.
Deposit date:2023-02-15
Release date:2024-02-28
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of IspE from Klebsiella pneumoniae
To Be Published
4N3O
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BU of 4n3o by Molmil
2.4 Angstrom Resolution Crystal Structure of Putative Sugar Kinase from Campylobacter jejuni.
Descriptor: CALCIUM ION, Putative D-glycero-D-manno-heptose 7-phosphate kinase
Authors:Minasov, G, Wawrzak, Z, Gordon, E, Onopriyenko, O, Grimshaw, S, Kwon, K, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2013-10-07
Release date:2013-10-16
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:2.4 Angstrom Resolution Crystal Structure of Putative Sugar Kinase from Campylobacter jejuni.
TO BE PUBLISHED
7OZX
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BU of 7ozx by Molmil
Structure of human galactokinase 1 bound with azepan-1-yl(2,6-difluorophenyl)methanone
Descriptor: (azepan-1-yl)(2,6-difluorophenyl)methanone, 2-(1,3-benzoxazol-2-ylamino)spiro[1,6,7,8-tetrahydroquinazoline-4,1'-cyclohexane]-5-one, Galactokinase, ...
Authors:Mackinnon, S.R, Bezerra, G.A, Zhang, M, Foster, W, Krojer, T, Brandao-Neto, J, Arrowsmith, C, Edwards, A, Bountra, C, Brennan, P, Lai, K, Yue, W.W.
Deposit date:2021-06-29
Release date:2022-05-25
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of human galactokinase 1 bound with azepan-1-yl(2,6-difluorophenyl)methanone
To Be Published
6CYZ
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BU of 6cyz by Molmil
Mycobacterial homoserine kinase ThrB in complex with AMPPNP
Descriptor: CHLORIDE ION, Homoserine kinase, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Li, J, Korotkov, K.V.
Deposit date:2018-04-07
Release date:2018-04-18
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Mycobacterial homoserine kinase ThrB
To Be Published
5YYS
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BU of 5yys by Molmil
Cryo-EM structure of L-fucokinase, GDP-fucose pyrophosphorylase (FKP)in Bacteroides fragilis
Descriptor: L-fucokinase, L-fucose-1-P guanylyltransferase
Authors:Wang, J, Hu, H, Liu, Y, Zhou, Q, Wu, P, Yan, N, Wang, H.W, Wu, J.W, Sun, L.
Deposit date:2017-12-11
Release date:2018-12-12
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Cryo-EM structure of L-fucokinase/GDP-fucose pyrophosphorylase (FKP) in Bacteroides fragilis.
Protein Cell, 10, 2019
4RPF
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BU of 4rpf by Molmil
Crystal structure of homoserine kinase from Yersinia pestis Nepal516, NYSGRC target 032715
Descriptor: CITRIC ACID, Homoserine kinase
Authors:Ptskovsky, Y, Bhosle, R, Toro, R, Hillerich, B, Gizzi, A, Garforth, S, Kar, A, Chan, M.K, Lafluer, J, Patel, H, Matikainen, B, Chamala, S, Lim, S, Celikgil, A, Villegas, G, Evans, B, Love, J, Fiser, A, Seidel, R, Bonanno, J.B, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC)
Deposit date:2014-10-30
Release date:2014-11-12
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of Homoserine Kinase from Yersinia Pestis Nepal516, Nysgrc Target 032715
To be Published
6GR2
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BU of 6gr2 by Molmil
Structure of human galactokinase in complex with galactose and ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Galactokinase, SULFATE ION, ...
Authors:Bezerra, G.A, Mackinnon, S, Williams, E, Zhang, M, Arrowsmith, C, Edwards, A, Bountra, C, Lai, K, Yue, W.W, Structural Genomics Consortium (SGC)
Deposit date:2018-06-08
Release date:2019-06-19
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Structure of human galactokinase in complex with galactose and ADP
To Be Published
3D4J
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BU of 3d4j by Molmil
Crystal structure of Human mevalonate diphosphate decarboxylase
Descriptor: Diphosphomevalonate decarboxylase, SULFATE ION
Authors:Voynova, N.E, Fu, Z, Battaile, K, Herdendorf, T.J, Kim, J.-J.P, Miziorko, H.M.
Deposit date:2008-05-14
Release date:2008-12-16
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Human mevalonate diphosphate decarboxylase: characterization, investigation of the mevalonate diphosphate binding site, and crystal structure.
Arch.Biochem.Biophys., 480, 2008
2OI2
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BU of 2oi2 by Molmil
Streptococcus pneumoniae Mevalonate Kinase in Complex with Diphosphomevalonate
Descriptor: (3R)-3-HYDROXY-5-{[(R)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}-3-METHYLPENTANOIC ACID, MAGNESIUM ION, Mevalonate kinase
Authors:Andreassi, J.L, Bilder, P.W, Vetting, M.W, Roderick, S.L, Leyh, T.S.
Deposit date:2007-01-10
Release date:2007-05-01
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the Streptococcus pneumoniae mevalonate kinase in complex with diphosphomevalonate.
Protein Sci., 16, 2007
4USM
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BU of 4usm by Molmil
WcbL complex with glycerol bound to sugar site
Descriptor: CHLORIDE ION, GLYCEROL, PUTATIVE SUGAR KINASE
Authors:Vivoli, M, Isupov, M.N, Nicholas, R, Hill, A, Scott, A, Kosma, P, Prior, J, Harmer, N.J.
Deposit date:2014-07-10
Release date:2016-01-13
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Unraveling the B.Pseudomallei Heptokinase Wcbl: From Structure to Drug Discovery.
Chem.Biol., 22, 2015
7S49
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BU of 7s49 by Molmil
Crystal Structure of Inhibitor-bound Galactokinase
Descriptor: (4R)-2-[(1,3-benzoxazol-2-yl)amino]-4-(4-chloro-1H-pyrazol-5-yl)-4,6,7,8-tetrahydroquinazolin-5(1H)-one, Galactokinase, PHOSPHATE ION, ...
Authors:Whitby, F.G.
Deposit date:2021-09-08
Release date:2021-09-29
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure-Based Optimization of Small Molecule Human Galactokinase Inhibitors.
J.Med.Chem., 64, 2021
7S4C
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BU of 7s4c by Molmil
Crystal Structure of Inhibitor-bound Galactokinase
Descriptor: 2-({(4R)-4-(2-chlorophenyl)-2-[(6-fluoro-1,3-benzoxazol-2-yl)amino]-6-methyl-1,4-dihydropyrimidine-5-carbonyl}amino)pyridine-4-carboxylic acid, Galactokinase, PHOSPHATE ION, ...
Authors:Whitby, F.G.
Deposit date:2021-09-08
Release date:2021-09-29
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure-Based Optimization of Small Molecule Human Galactokinase Inhibitors.
J.Med.Chem., 64, 2021
1WUU
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BU of 1wuu by Molmil
crystal structure of human galactokinase complexed with MgAMPPNP and galactose
Descriptor: Galactokinase, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Thoden, J.B, Timson, D.J, Reece, R.J, Holden, H.M.
Deposit date:2004-12-08
Release date:2004-12-28
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular Structure of Human Galactokinase: IMPLICATIONS FOR TYPE II GALACTOSEMIA
J.Biol.Chem., 280, 2005
5GMD
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BU of 5gmd by Molmil
Crystal structure of Sulfolobus solfataricus diphosphomevalonate decarboxylase in complex with ATP-gamma-S
Descriptor: (3R)-3-HYDROXY-5-{[(R)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}-3-METHYLPENTANOIC ACID, ADENOSINE MONOPHOSPHATE, Diphosphomevalonate decarboxylase, ...
Authors:Unno, H, Hemmi, H, Hattori, A.
Deposit date:2016-07-13
Release date:2016-12-28
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:A Single Amino Acid Mutation Converts (R)-5-Diphosphomevalonate Decarboxylase into a Kinase
J. Biol. Chem., 292, 2017
4USK
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BU of 4usk by Molmil
Unravelling the B. pseudomallei heptokinase WcbL: from Structure to Drug Discovery.
Descriptor: CHLORIDE ION, DIMETHYL SULFOXIDE, PUTATIVE SUGAR KINASE, ...
Authors:Vivoli, M, Isupov, M.N, Nicholas, R, Hill, A, Scott, A, Kosma, P, Prior, J, Harmer, N.J.
Deposit date:2014-07-09
Release date:2016-01-13
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Unraveling the B.Pseudomallei Heptokinase Wcbl: From Structure to Drug Discovery.
Chem.Biol., 22, 2015
1H72
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BU of 1h72 by Molmil
CRYSTAL STRUCTURE OF HOMOSERINE KINASE COMPLEXED WITH HSE
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, HOMOSERINE KINASE, L-HOMOSERINE, ...
Authors:Krishna, S.S, Zhou, T, Daugherty, M, Osterman, A.L, Zhang, H.
Deposit date:2001-07-02
Release date:2001-09-13
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis for the Catalysis and Substrate Specificity of Homoserine Kinase
Biochemistry, 40, 2001
1H73
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BU of 1h73 by Molmil
CRYSTAL STRUCTURE OF HOMOSERINE KINASE COMPLEXED WITH THREONINE
Descriptor: HOMOSERINE KINASE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, THREONINE
Authors:Krishna, S.S, Zhou, T, Daugherty, M, Osterman, A.L, Zhang, H.
Deposit date:2001-07-02
Release date:2001-09-13
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis for the Catalysis and Substrate Specificity of Homoserine Kinase
Biochemistry, 40, 2001

 

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