2VF3

Aquifex aeolicus IspE in complex with ligand

Summary for 2VF3

Entry DOI	10.2210/pdb2vf3/pdb
Related	2V2Q 2V2V 2V2Y 2V2Z 2V34 2V8P
Descriptor	4-DIPHOSPHOCYTIDYL-2C-METHYL-D-ERYTHRITOL KINASE, ethyl {3-[4-amino-5-{3-[(cyclopropylsulfonyl)amino]prop-1-yn-1-yl}-2-oxopyrimidin-1(2H)-yl]oxetan-3-yl}acetate, PYROPHOSPHATE 2-, ... (6 entities in total)
Functional Keywords	ispe, kinase, aquifex, transferase, atp-binding, isoprene biosynthesis, non-mevalonate, nucleotide-binding
Biological source	AQUIFEX AEOLICUS
Total number of polymer chains	2
Total formula weight	61746.09
Authors	Alphey, M.S.,Hunter, W.N. (deposition date: 2007-10-30, release date: 2008-11-25, Last modification date: 2011-07-13)
Primary citation	Hirsch, A.K.,Alphey, M.S.,Lauw, S.,Seet, M.,Barandun, L.,Eisenreich, W.,Rohdich, F.,Hunter, W.N.,Bacher, A.,Diederich, F. Inhibitors of the Kinase Ispe: Structure-Activity Relationships and Co-Crystal Structure Analysis. Org.Biomol.Chem., 6:2719-, 2008 Cited by PubMed: 18633530 DOI: 10.1039/B804375B PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation