2VF3
Aquifex aeolicus IspE in complex with ligand
Summary for 2VF3
Entry DOI | 10.2210/pdb2vf3/pdb |
Related | 2V2Q 2V2V 2V2Y 2V2Z 2V34 2V8P |
Descriptor | 4-DIPHOSPHOCYTIDYL-2C-METHYL-D-ERYTHRITOL KINASE, ethyl {3-[4-amino-5-{3-[(cyclopropylsulfonyl)amino]prop-1-yn-1-yl}-2-oxopyrimidin-1(2H)-yl]oxetan-3-yl}acetate, PYROPHOSPHATE 2-, ... (6 entities in total) |
Functional Keywords | ispe, kinase, aquifex, transferase, atp-binding, isoprene biosynthesis, non-mevalonate, nucleotide-binding |
Biological source | AQUIFEX AEOLICUS |
Total number of polymer chains | 2 |
Total formula weight | 61746.09 |
Authors | Alphey, M.S.,Hunter, W.N. (deposition date: 2007-10-30, release date: 2008-11-25, Last modification date: 2024-05-08) |
Primary citation | Hirsch, A.K.,Alphey, M.S.,Lauw, S.,Seet, M.,Barandun, L.,Eisenreich, W.,Rohdich, F.,Hunter, W.N.,Bacher, A.,Diederich, F. Inhibitors of the Kinase Ispe: Structure-Activity Relationships and Co-Crystal Structure Analysis. Org.Biomol.Chem., 6:2719-, 2008 Cited by PubMed: 18633530DOI: 10.1039/B804375B PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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