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6VJ8
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BU of 6vj8 by Molmil
Crystal structure of GlpG in complex with peptide chloromethylketone inhibitor
Descriptor: Peptide chloromethylketone inhibitor, Rhomboid family intramembrane serine protease GlpG
Authors:Urban, S, Cho, S.
Deposit date:2020-01-15
Release date:2020-09-16
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Designed Parasite-Selective Rhomboid Inhibitors Block Invasion and Clear Blood-Stage Malaria.
Cell Chem Biol, 27, 2020
8AB5
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BU of 8ab5 by Molmil
Structure of E. coli GlpG in complex with peptide derived inhibitor Ac-VRHA-conh-[4-(4-butyl)-phenoxy-1-phenyl-2-butyl]
Descriptor: Ac-VRHA-conh-[4-(4-butyl)-phenoxy-1-phenyl-2-butyl], Rhomboid protease GlpG
Authors:Skerlova, J, Polovinkin, V, Bach, K, Borshchevskiy, V, Strisovsky, K.
Deposit date:2022-07-04
Release date:2023-10-25
Last modified:2024-07-10
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Extensive targeting of chemical space at the prime side of ketoamide inhibitors of rhomboid proteases by branched substituents empowers their selectivity and potency.
Eur.J.Med.Chem., 275, 2024
3ODJ
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BU of 3odj by Molmil
Crystal structure of H. influenzae rhomboid GlpG with disordered loop 4, helix 5 and loop 5
Descriptor: Rhomboid protease glpG
Authors:Brooks, C.L, Lazareno-Saez, C, Lamoureux, J.S, Mak, M.W, Lemieux, M.J.
Deposit date:2010-08-11
Release date:2011-02-23
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Insights into Substrate Gating in H. influenzae Rhomboid.
J.Mol.Biol., 407, 2011
4H1D
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BU of 4h1d by Molmil
Cocrystal structure of GlpG and DFP
Descriptor: DIISOPROPYL PHOSPHONATE, Rhomboid protease GlpG
Authors:Xue, Y, Ha, Y.
Deposit date:2012-09-10
Release date:2013-05-01
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (2.8975 Å)
Cite:Large lateral movement of transmembrane helix s5 is not required for substrate access to the active site of rhomboid intramembrane protease.
J.Biol.Chem., 288, 2013
3TXT
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BU of 3txt by Molmil
Crystal structure of GlpG in complex with inhibitor DFP
Descriptor: DIISOPROPYL PHOSPHONATE, Rhomboid protease glpG
Authors:Xue, Y, Ha, Y.
Deposit date:2011-09-23
Release date:2011-12-07
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The crystal structure of rhomboid protease GlpG in complex with a mechanism-based inhibitor
To be Published
2IRV
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BU of 2irv by Molmil
Crystal structure of GlpG, a rhomboid intramembrane serine protease
Descriptor: (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, DODECYL-BETA-D-MALTOSIDE, LAURYL DIMETHYLAMINE-N-OXIDE, ...
Authors:Bibi, E, Fass, D, Ben-Shem, A.
Deposit date:2006-10-16
Release date:2006-10-31
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for intramembrane proteolysis by rhomboid serine proteases.
Proc.Natl.Acad.Sci.Usa, 104, 2007
2IC8
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BU of 2ic8 by Molmil
Crystal structure of GlpG
Descriptor: Protein glpG, nonyl beta-D-glucopyranoside
Authors:Ha, Y.
Deposit date:2006-09-12
Release date:2006-10-17
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of a rhomboid family intramembrane protease.
Nature, 444, 2006
4NJN
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BU of 4njn by Molmil
Crystal Structure of E.coli GlpG at pH 4.5
Descriptor: Rhomboid protease GlpG
Authors:Dickey, S.W, Baker, R.P, Cho, S, Urban, S.
Deposit date:2013-11-11
Release date:2013-12-25
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Proteolysis inside the Membrane Is a Rate-Governed Reaction Not Driven by Substrate Affinity.
Cell(Cambridge,Mass.), 155, 2013
3UBB
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BU of 3ubb by Molmil
The crystal structure of GlpG in complex with a phosphonofluoridate inhibitor
Descriptor: Rhomboid protease glpG, propan-2-yl hydrogen (S)-[(1R)-1-{[(benzyloxy)carbonyl]amino}ethyl]phosphonate
Authors:Xue, Y, Ha, Y.
Deposit date:2011-10-24
Release date:2012-06-13
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:Conformational Change in Rhomboid Protease GlpG Induced by Inhibitor Binding to Its S' Subsites.
Biochemistry, 51, 2012
4NJP
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BU of 4njp by Molmil
Proteolysis inside the membrane is a rate-governed reaction not Driven by substrate affinity
Descriptor: Rhomboid protease GlpG
Authors:Dickey, S.W, Baker, R.P, Cho, S, Urban, S.
Deposit date:2013-11-11
Release date:2013-12-25
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Proteolysis inside the Membrane Is a Rate-Governed Reaction Not Driven by Substrate Affinity.
Cell(Cambridge,Mass.), 155, 2013
6VJ9
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BU of 6vj9 by Molmil
Crystal structure of GlpG in complex with peptide boronate inhibitor
Descriptor: ACE-VAL-ARG-MET-B2A, Rhomboid family intramembrane serine protease GlpG
Authors:Urban, S, Cho, S.
Deposit date:2020-01-15
Release date:2020-09-16
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Designed Parasite-Selective Rhomboid Inhibitors Block Invasion and Clear Blood-Stage Malaria.
Cell Chem Biol, 27, 2020
2XOW
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BU of 2xow by Molmil
Structure of GlpG in complex with a mechanism-based isocoumarin inhibitor
Descriptor: 5-AMINO-2-(2-METHOXY-2-OXOETHYL)BENZOIC ACID, RHOMBOID PROTEASE GLPG, nonyl beta-D-glucopyranoside
Authors:Vinothkumar, K.R, Strisovsky, K, Andreeva, A, Christova, Y, Verhelst, S, Freeman, M.
Deposit date:2010-08-24
Release date:2010-10-13
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:The Structural Basis for Catalysis and Substrate Specificity of a Rhomboid Protease
Embo J., 29, 2010
2XOV
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BU of 2xov by Molmil
Crystal Structure of E.coli rhomboid protease GlpG, native enzyme
Descriptor: GLYCEROL, RHOMBOID PROTEASE GLPG, nonyl beta-D-glucopyranoside
Authors:Vinothkumar, K.R, Strisovsky, K, Andreeva, A, Christova, Y, Verhelst, S, Freeman, M.
Deposit date:2010-08-24
Release date:2010-10-13
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The structural basis for catalysis and substrate specificity of a rhomboid protease.
EMBO J., 29, 2010
2XTU
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BU of 2xtu by Molmil
Structure of E.coli rhomboid protease GlpG active site mutant, S201T in trigonal crystal form
Descriptor: RHOMBOID PROTEASE GLPG, nonyl beta-D-glucopyranoside
Authors:Vinothkumar, K.R.
Deposit date:2010-10-12
Release date:2011-02-02
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure of Rhomboid Protease in a Lipid Environment
J.Mol.Biol., 407, 2011
6XRO
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BU of 6xro by Molmil
Crystal structure of GlpG in complex with peptide boronate inhibitor, Ac-KRFRSMQYSA-B(OH)2
Descriptor: CHLORIDE ION, Rhomboid protease GlpG, SODIUM ION, ...
Authors:Urban, S, Cho, S.
Deposit date:2020-07-13
Release date:2020-09-16
Last modified:2024-04-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Designed Parasite-Selective Rhomboid Inhibitors Block Invasion and Clear Blood-Stage Malaria.
Cell Chem Biol, 27, 2020
6XRP
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BU of 6xrp by Molmil
Crystal structure of GlpG in complex with peptide ketoamide inhibitor, Ac-RVWHA-ketoamide-phenylbutyl
Descriptor: N-(4-phenylbutyl)formamide, Rhomboid protease GlpG, peptide ketoamide inhibitor
Authors:Urban, S, Cho, S.
Deposit date:2020-07-13
Release date:2020-09-16
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Designed Parasite-Selective Rhomboid Inhibitors Block Invasion and Clear Blood-Stage Malaria.
Cell Chem Biol, 27, 2020
2O7L
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BU of 2o7l by Molmil
The open-cap conformation of GlpG
Descriptor: Protein glpG, nonyl beta-D-glucopyranoside
Authors:Ha, Y.
Deposit date:2006-12-11
Release date:2006-12-26
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Open-cap conformation of intramembrane protease GlpG.
Proc.Natl.Acad.Sci.Usa, 104, 2007
2XTV
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BU of 2xtv by Molmil
Structure of E.coli rhomboid protease GlpG, active site mutant, S201T, orthorhombic crystal form
Descriptor: 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, RHOMBOID PROTEASE GLPG
Authors:Vinothkumar, K.R.
Deposit date:2010-10-12
Release date:2011-02-02
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of rhomboid protease in a lipid environment.
J. Mol. Biol., 407, 2011
2NR9
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BU of 2nr9 by Molmil
Crystal structure of GlpG, Rhomboid Peptidase from Haemophilus influenzae
Descriptor: (R)-2-(FORMYLOXY)-3-(PHOSPHONOOXY)PROPYL PENTANOATE, 3,6,12,15,18,21,24-HEPTAOXAHEXATRIACONTAN-1-OL, Protein glpG homolog
Authors:Lemieux, M.J, Fischer, S.J, Cherney, M.M, Bateman, K.S, James, M.N.G.
Deposit date:2006-11-01
Release date:2006-11-14
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The crystal structure of the rhomboid peptidase from Haemophilus influenzae provides insight into intramembrane proteolysis.
Proc.Natl.Acad.Sci.USA, 104, 2007
3B44
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BU of 3b44 by Molmil
Crystal structure of GlpG W136A mutant
Descriptor: glpG, nonyl beta-D-glucopyranoside
Authors:Wang, Y, Maegawa, S, Akiyama, Y, Ha, Y.
Deposit date:2007-10-23
Release date:2008-01-22
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The role of L1 loop in the mechanism of rhomboid intramembrane protease GlpG.
J.Mol.Biol., 374, 2007
3B45
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BU of 3b45 by Molmil
Crystal structure of GlpG at 1.9A resolution
Descriptor: glpG, nonyl beta-D-glucopyranoside
Authors:Wang, Y, Maegawa, S, Akiyama, Y, Ha, Y.
Deposit date:2007-10-23
Release date:2008-01-22
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The role of L1 loop in the mechanism of rhomboid intramembrane protease GlpG.
J.Mol.Biol., 374, 2007
2NRF
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BU of 2nrf by Molmil
Crystal Structure of GlpG, a Rhomboid family intramembrane protease
Descriptor: Protein GlpG
Authors:Wu, Z, Yan, N, Feng, L, Yan, H, Gu, L, Shi, Y.
Deposit date:2006-11-02
Release date:2006-11-14
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry.
Nat.Struct.Mol.Biol., 13, 2006
6PJQ
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BU of 6pjq by Molmil
Time-resolved structural snapshot of proteolysis by GlpG inside the membrane
Descriptor: Peptide aldehyde inhibitor, Rhomboid protease GlpG
Authors:Urban, S, Cho, S.
Deposit date:2019-06-28
Release date:2019-11-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release.
Nat.Struct.Mol.Biol., 26, 2019
5MT7
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BU of 5mt7 by Molmil
Structure of E.coli GlpG in complex with peptide derived inhibitor Ac-VRHA-cmk
Descriptor: ACE-VAL-ARG-HIS-ALA-0QE, Rhomboid protease GlpG
Authors:Vinothkumar, K.R.
Deposit date:2017-01-06
Release date:2017-11-15
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases.
Cell Chem Biol, 24, 2017
5MT6
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BU of 5mt6 by Molmil
Structure of E.coli GlpG in complex with peptide derived inhibitor Ac-RVRHA-phenylethyl-ketoamide
Descriptor: ACE-ARG-VAL-ARG-HIS-ALA-V9C, Rhomboid protease GlpG, nonyl beta-D-glucopyranoside
Authors:Vinothkumar, K.R.
Deposit date:2017-01-06
Release date:2017-11-15
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases.
Cell Chem Biol, 24, 2017

 

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