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6NDS
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BU of 6nds by Molmil
Structure of an HMG-CoA lyase from Acenitobacter baumannii in complex with coenzyme A and 3-methylmalate
Descriptor: 1,2-ETHANEDIOL, 3-hydroxy-3-methylglutaryl-CoA lyase, ACETATE ION, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2018-12-14
Release date:2019-12-18
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure of an HMG-CoA lyase from Acenitobacter baumannii in complex with coenzyme A and 3-methylmalate
to be published
2FTP
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BU of 2ftp by Molmil
Crystal Structure of hydroxymethylglutaryl-CoA lyase from Pseudomonas aeruginosa
Descriptor: GLYCEROL, SODIUM ION, hydroxymethylglutaryl-CoA lyase
Authors:Xiao, T, Evdokimova, E, Liu, Y, Kudritska, M, Savchenko, A, Pai, E.F, Edwards, A, Midwest Center for Structural Genomics (MCSG)
Deposit date:2006-01-24
Release date:2006-03-14
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of hydroxymethylglutaryl-CoA lyase from Pseudomonas aeruginosa
To be Published
2CW6
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BU of 2cw6 by Molmil
Crystal Structure of Human HMG-CoA Lyase: Insights into Catalysis and the Molecular Basis for Hydroxymethylglutaric Aciduria
Descriptor: 3-HYDROXYPENTANEDIOIC ACID, Hydroxymethylglutaryl-CoA lyase, mitochondrial, ...
Authors:Fu, Z, Runquist, J.A, Hunt, J.F, Miziorko, H.M, Kim, J.-J.P.
Deposit date:2005-06-17
Release date:2005-12-06
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of human 3-hydroxy-3-methylglutaryl-CoA Lyase: insights into catalysis and the molecular basis for hydroxymethylglutaric aciduria
J.Biol.Chem., 281, 2006
1YDN
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BU of 1ydn by Molmil
Crystal Structure of the HMG-CoA Lyase from Brucella melitensis, Northeast Structural Genomics Target LR35.
Descriptor: CALCIUM ION, HYDROXYMETHYLGLUTARYL-COA LYASE
Authors:Forouhar, F, Abashidze, M, Hussain, M, Vorobiev, S.M, Xiao, R, Ciano, M, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG)
Deposit date:2004-12-24
Release date:2005-07-05
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of two bacterial 3-hydroxy-3-methylglutaryl-CoA lyases suggest a common catalytic mechanism among a family of TIM barrel metalloenzymes cleaving carbon-carbon bonds.
J.Biol.Chem., 281, 2006
1YDO
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BU of 1ydo by Molmil
Crystal Structure of the Bacillis subtilis HMG-CoA Lyase, Northeast Structural Genomics Target SR181.
Descriptor: HMG-CoA Lyase, IODIDE ION
Authors:Forouhar, F, Hussain, M, Edstrom, W, Vorobiev, S.M, Xiao, R, Ciano, M, Shih, L, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG)
Deposit date:2004-12-24
Release date:2005-07-05
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Crystal structures of two bacterial 3-hydroxy-3-methylglutaryl-CoA lyases suggest a common catalytic mechanism among a family of TIM barrel metalloenzymes cleaving carbon-carbon bonds.
J.Biol.Chem., 281, 2006
3MP4
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BU of 3mp4 by Molmil
Crystal structure of Human lyase R41M mutant
Descriptor: Hydroxymethylglutaryl-CoA lyase
Authors:Fu, Z, Runquist, J.A, Montgomery, C, Miziorko, H.M, Kim, J.-J.P.
Deposit date:2010-04-24
Release date:2010-06-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Functional insights into human HMG-CoA lyase from structures of Acyl-CoA-containing ternary complexes.
J.Biol.Chem., 285, 2010
3MP3
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BU of 3mp3 by Molmil
Crystal Structure of Human Lyase in complex with inhibitor HG-CoA
Descriptor: (3R,5S,9R,21S)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9,21-tetrahydroxy-8,8-dimethyl-10,14,19-trioxo-2,4,6-trioxa-18-thia-11,15-diaza-3,5-diphosphatricosan-23-oic acid 3,5-dioxide, 3-HYDROXYPENTANEDIOIC ACID, Hydroxymethylglutaryl-CoA lyase, ...
Authors:Fu, Z, Runquist, J.A, Montgomery, C, Miziorko, H.M, Kim, J.-J.P.
Deposit date:2010-04-24
Release date:2010-06-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Functional insights into human HMG-CoA lyase from structures of Acyl-CoA-containing ternary complexes.
J.Biol.Chem., 285, 2010
3MP5
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BU of 3mp5 by Molmil
Crystal Structure of Human Lyase R41M in complex with HMG-CoA
Descriptor: 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, Hydroxymethylglutaryl-CoA lyase, MAGNESIUM ION
Authors:Fu, Z, Runquist, J.A, Montgomery, C, Miziorko, H.M, Kim, J.-J.P.
Deposit date:2010-04-24
Release date:2010-06-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Functional insights into human HMG-CoA lyase from structures of Acyl-CoA-containing ternary complexes.
J.Biol.Chem., 285, 2010
3DXI
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BU of 3dxi by Molmil
Crystal structure of the N-terminal domain of a putative aldolase (BVU_2661) from Bacteroides vulgatus
Descriptor: Putative aldolase
Authors:Eswaramoorthy, S, Pabalan, A.A, Burley, S.K, Swaminathan, S, New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2008-07-24
Release date:2008-08-26
Last modified:2021-02-10
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Crystal structure of the N-terminal domain of a putative aldolase (BVU_2661) from Bacteroides vulgatus
To be Published
3EWB
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BU of 3ewb by Molmil
Crystal structure of N-terminal domain of putative 2-isopropylmalate synthase from Listeria monocytogenes
Descriptor: 2-isopropylmalate synthase
Authors:Ramagopal, U.A, Toro, R, Gilmore, M, Hu, S, Maletic, M, Rodgers, L, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2008-10-14
Release date:2008-12-23
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of N-terminal domain of putative 2-isopropylmalate synthase from Listeria monocytogenes.
To be Published
4LRS
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BU of 4lrs by Molmil
Crystal and solution structures of the bifunctional enzyme (Aldolase/Aldehyde dehydrogenase) from Thermomonospora curvata, reveal a cofactor-binding domain motion during NAD+ and CoA accommodation whithin the shared cofactor-binding site
Descriptor: 4-hydroxy-2-oxovalerate aldolase, Acetaldehyde dehydrogenase, CHLORIDE ION, ...
Authors:Fischer, B, Branlant, G, Talfournier, F, Gruez, A.
Deposit date:2013-07-20
Release date:2013-09-04
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal and solution structures of the bifunctional enzyme (Aldolase/Aldehyde dehydrogenase) from Thermomonospora curvata, reveal a cofactor-binding domain motion during NAD+ and CoA accommodation whithin the shared cofactor-binding site
To be Published
6KTQ
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BU of 6ktq by Molmil
Crystal structure of catalytic domain of homocitrate synthase from Sulfolobus acidocaldarius (SaHCS(dRAM)) in complex with alpha-ketoglutarate/Zn2+/CoA
Descriptor: 2-OXOGLUTARIC ACID, COENZYME A, Homocitrate synthase, ...
Authors:Suzuki, T, Tomita, T, Kuzuyama, T, Nishiyama, M.
Deposit date:2019-08-28
Release date:2020-09-02
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Involvement of subdomain II in the recognition of acetyl-CoA revealed by the crystal structure of homocitrate synthase from Sulfolobus acidocaldarius.
Febs J., 288, 2021
6E1J
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BU of 6e1j by Molmil
Crystal Structure of Methylthioalkylmalate Synthase (BjuMAM1.1) from Brassica juncea
Descriptor: 2-isopropylmalate synthase, A genome specific 1, 4-(METHYLSULFANYL)-2-OXOBUTANOIC ACID, ...
Authors:Lee, S.G, Jez, J.M.
Deposit date:2018-07-09
Release date:2019-05-08
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.096 Å)
Cite:Molecular Basis of the Evolution of Methylthioalkylmalate Synthase and the Diversity of Methionine-Derived Glucosinolates.
Plant Cell, 31, 2019
2NX9
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BU of 2nx9 by Molmil
Crystal structure of the carboxyltransferase domain of the oxaloacetate decarboxylase Na+ pump from Vibrio cholerae
Descriptor: Oxaloacetate decarboxylase 2, subunit alpha, ZINC ION
Authors:Studer, R, Dimroth, P.
Deposit date:2006-11-17
Release date:2006-12-26
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structure of the Carboxyltransferase Domain of the Oxaloacetate Decarboxylase Na(+) Pump from Vibrio cholerae.
J.Mol.Biol., 367, 2007
1NVM
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BU of 1nvm by Molmil
Crystal structure of a bifunctional aldolase-dehydrogenase : sequestering a reactive and volatile intermediate
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 4-hydroxy-2-oxovalerate aldolase, MANGANESE (II) ION, ...
Authors:Manjasetty, A.B, Powlowski, J, Vrielink, A.
Deposit date:2003-02-04
Release date:2003-06-17
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of a bifunctional aldolase-dehydrogenase: Sequestering a reactive and volatile intermediate
Proc.Natl.Acad.Sci.USA, 100, 2003
3RMJ
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BU of 3rmj by Molmil
Crystal structure of truncated alpha-Isopropylmalate Synthase from Neisseria meningitidis
Descriptor: 2-isopropylmalate synthase, GLYCEROL, MAGNESIUM ION, ...
Authors:Huisman, F.H.A, Baker, H.M, Koon, N, Baker, E.N, Parker, E.J.
Deposit date:2011-04-20
Release date:2012-03-14
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Removal of the C-terminal regulatory domain of alpha-isopropylmalate synthase disrupts functional substrate binding
Biochemistry, 51, 2012
8IH7
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BU of 8ih7 by Molmil
AmnG-AmnH complex
Descriptor: 4-hydroxy-2-oxovalerate aldolase, Acetaldehyde dehydrogenase, OXALATE ION, ...
Authors:Su, D, Shi, Q.L.
Deposit date:2023-02-22
Release date:2024-02-28
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:AmnG-AmnH complex
To Be Published
3U6W
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BU of 3u6w by Molmil
Truncated M. tuberculosis LeuA (1-425) complexed with KIV
Descriptor: 2-isopropylmalate synthase, 3-METHYL-2-OXOBUTANOIC ACID, GLYCEROL, ...
Authors:Koon, N, Baker, E.N, Squire, C.J.
Deposit date:2011-10-13
Release date:2012-03-14
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Removal of the C-terminal regulatory domain of alpha-isopropylmalate synthase disrupts functional substrate binding.
Biochemistry, 51, 2012
3BLF
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BU of 3blf by Molmil
Crystal structure of the catalytic domain of LiCMS in complexed with pyruvate
Descriptor: Citramalate synthase from Leptospira interrogans, PYRUVIC ACID, ZINC ION
Authors:Zhang, P, Ma, J.
Deposit date:2007-12-11
Release date:2008-11-11
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular basis of the substrate specificity and the catalytic mechanism of citramalate synthase from Leptospira interrogans.
Biochem.J., 415, 2008
3MI3
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BU of 3mi3 by Molmil
Homocitrate Synthase Lys4 bound to Lysine
Descriptor: Homocitrate synthase, mitochondrial, LYSINE, ...
Authors:Bulfer, S.L, Scott, E.M, Pillus, L, Trievel, R.C.
Deposit date:2010-04-09
Release date:2010-04-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Structural Basis for L-lysine Feedback Inhibition of Homocitrate Synthase
J.Biol.Chem., 285, 2010
3FIG
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BU of 3fig by Molmil
Crystal Structure of Leucine-bound LeuA from Mycobacterium tuberculosis
Descriptor: 2-isopropylmalate synthase, GLYCEROL, LEUCINE, ...
Authors:Koon, N, Squire, C.J, Baker, E.N.
Deposit date:2008-12-11
Release date:2008-12-23
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of LeuA from Mycobacterium tuberculosis, a key enzyme in leucine biosynthesis.
Proc.Natl.Acad.Sci.USA, 101, 2004
1SR9
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BU of 1sr9 by Molmil
Crystal Structure of LeuA from Mycobacterium tuberculosis
Descriptor: 2-isopropylmalate synthase, 3-METHYL-2-OXOBUTANOIC ACID, CHLORIDE ION, ...
Authors:Koon, N, Squire, C.J, Baker, E.N.
Deposit date:2004-03-22
Release date:2004-05-18
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of LeuA from Mycobacterium tuberculosis, a key enzyme in leucine biosynthesis
Proc.Natl.Acad.Sci.USA, 101, 2004
1RR2
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BU of 1rr2 by Molmil
Propionibacterium shermanii transcarboxylase 5S subunit bound to 2-ketobutyric acid
Descriptor: 2-KETOBUTYRIC ACID, COBALT (II) ION, transcarboxylase 5S subunit
Authors:Hall, P.R, Zheng, R, Antony, L, Pusztai-Carey, M, Carey, P.R, Yee, V.C.
Deposit date:2003-12-08
Release date:2004-09-07
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Transcarboxylase 5S structures: assembly and catalytic mechanism of a multienzyme complex subunit.
Embo J., 23, 2004
4JX5
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BU of 4jx5 by Molmil
Structure of the carboxyl transferase domain from Rhizobium etli pyruvate carboxylase with pyruvate
Descriptor: CHLORIDE ION, GLYCEROL, MAGNESIUM ION, ...
Authors:Lietzan, A.D, St Maurice, M.
Deposit date:2013-03-27
Release date:2013-05-29
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:A Substrate-induced Biotin Binding Pocket in the Carboxyltransferase Domain of Pyruvate Carboxylase.
J.Biol.Chem., 288, 2013
4JN6
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BU of 4jn6 by Molmil
Crystal Structure of the Aldolase-Dehydrogenase Complex from Mycobacterium tuberculosis HRv37
Descriptor: 4-hydroxy-2-oxovalerate aldolase, Acetaldehyde dehydrogenase, MANGANESE (II) ION, ...
Authors:Carere, J, McKenna, S.E, Kimber, M.S, Seah, S.Y.K.
Deposit date:2013-03-14
Release date:2013-05-08
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Characterization of an Aldolase-Dehydrogenase Complex from the Cholesterol Degradation Pathway of Mycobacterium tuberculosis.
Biochemistry, 52, 2013

 

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