6NDS
 
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2FTP
 | | Crystal Structure of hydroxymethylglutaryl-CoA lyase from Pseudomonas aeruginosa | | Descriptor: | GLYCEROL, SODIUM ION, hydroxymethylglutaryl-CoA lyase | | Authors: | Xiao, T, Evdokimova, E, Liu, Y, Kudritska, M, Savchenko, A, Pai, E.F, Edwards, A, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2006-01-24 | | Release date: | 2006-03-14 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal Structure of hydroxymethylglutaryl-CoA lyase from Pseudomonas aeruginosa
To be Published
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2CW6
 | | Crystal Structure of Human HMG-CoA Lyase: Insights into Catalysis and the Molecular Basis for Hydroxymethylglutaric Aciduria | | Descriptor: | 3-HYDROXYPENTANEDIOIC ACID, Hydroxymethylglutaryl-CoA lyase, mitochondrial, ... | | Authors: | Fu, Z, Runquist, J.A, Hunt, J.F, Miziorko, H.M, Kim, J.-J.P. | | Deposit date: | 2005-06-17 | | Release date: | 2005-12-06 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal structure of human 3-hydroxy-3-methylglutaryl-CoA Lyase: insights into catalysis and the molecular basis for hydroxymethylglutaric aciduria
J.Biol.Chem., 281, 2006
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1YDN
 | | Crystal Structure of the HMG-CoA Lyase from Brucella melitensis, Northeast Structural Genomics Target LR35. | | Descriptor: | CALCIUM ION, HYDROXYMETHYLGLUTARYL-COA LYASE | | Authors: | Forouhar, F, Abashidze, M, Hussain, M, Vorobiev, S.M, Xiao, R, Ciano, M, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2004-12-24 | | Release date: | 2005-07-05 | | Last modified: | 2017-10-11 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structures of two bacterial 3-hydroxy-3-methylglutaryl-CoA lyases suggest a common catalytic mechanism among a family of TIM barrel metalloenzymes cleaving carbon-carbon bonds.
J.Biol.Chem., 281, 2006
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1YDO
 | | Crystal Structure of the Bacillis subtilis HMG-CoA Lyase, Northeast Structural Genomics Target SR181. | | Descriptor: | HMG-CoA Lyase, IODIDE ION | | Authors: | Forouhar, F, Hussain, M, Edstrom, W, Vorobiev, S.M, Xiao, R, Ciano, M, Shih, L, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2004-12-24 | | Release date: | 2005-07-05 | | Last modified: | 2017-10-11 | | Method: | X-RAY DIFFRACTION (2.71 Å) | | Cite: | Crystal structures of two bacterial 3-hydroxy-3-methylglutaryl-CoA lyases suggest a common catalytic mechanism among a family of TIM barrel metalloenzymes cleaving carbon-carbon bonds.
J.Biol.Chem., 281, 2006
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3MP4
 | | Crystal structure of Human lyase R41M mutant | | Descriptor: | Hydroxymethylglutaryl-CoA lyase | | Authors: | Fu, Z, Runquist, J.A, Montgomery, C, Miziorko, H.M, Kim, J.-J.P. | | Deposit date: | 2010-04-24 | | Release date: | 2010-06-16 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Functional insights into human HMG-CoA lyase from structures of Acyl-CoA-containing ternary complexes.
J.Biol.Chem., 285, 2010
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3MP3
 | | Crystal Structure of Human Lyase in complex with inhibitor HG-CoA | | Descriptor: | (3R,5S,9R,21S)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9,21-tetrahydroxy-8,8-dimethyl-10,14,19-trioxo-2,4,6-trioxa-18-thia-11,15-diaza-3,5-diphosphatricosan-23-oic acid 3,5-dioxide, 3-HYDROXYPENTANEDIOIC ACID, Hydroxymethylglutaryl-CoA lyase, ... | | Authors: | Fu, Z, Runquist, J.A, Montgomery, C, Miziorko, H.M, Kim, J.-J.P. | | Deposit date: | 2010-04-24 | | Release date: | 2010-06-16 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Functional insights into human HMG-CoA lyase from structures of Acyl-CoA-containing ternary complexes.
J.Biol.Chem., 285, 2010
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3MP5
 | | Crystal Structure of Human Lyase R41M in complex with HMG-CoA | | Descriptor: | 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, Hydroxymethylglutaryl-CoA lyase, MAGNESIUM ION | | Authors: | Fu, Z, Runquist, J.A, Montgomery, C, Miziorko, H.M, Kim, J.-J.P. | | Deposit date: | 2010-04-24 | | Release date: | 2010-06-16 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Functional insights into human HMG-CoA lyase from structures of Acyl-CoA-containing ternary complexes.
J.Biol.Chem., 285, 2010
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3DXI
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3EWB
 | | Crystal structure of N-terminal domain of putative 2-isopropylmalate synthase from Listeria monocytogenes | | Descriptor: | 2-isopropylmalate synthase | | Authors: | Ramagopal, U.A, Toro, R, Gilmore, M, Hu, S, Maletic, M, Rodgers, L, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | | Deposit date: | 2008-10-14 | | Release date: | 2008-12-23 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal structure of N-terminal domain of putative 2-isopropylmalate synthase from Listeria monocytogenes.
To be Published
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4LRS
 | | Crystal and solution structures of the bifunctional enzyme (Aldolase/Aldehyde dehydrogenase) from Thermomonospora curvata, reveal a cofactor-binding domain motion during NAD+ and CoA accommodation whithin the shared cofactor-binding site | | Descriptor: | 4-hydroxy-2-oxovalerate aldolase, Acetaldehyde dehydrogenase, CHLORIDE ION, ... | | Authors: | Fischer, B, Branlant, G, Talfournier, F, Gruez, A. | | Deposit date: | 2013-07-20 | | Release date: | 2013-09-04 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Crystal and solution structures of the bifunctional enzyme (Aldolase/Aldehyde dehydrogenase) from Thermomonospora curvata, reveal a cofactor-binding domain motion during NAD+ and CoA accommodation whithin the shared cofactor-binding site
To be Published
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6KTQ
 | | Crystal structure of catalytic domain of homocitrate synthase from Sulfolobus acidocaldarius (SaHCS(dRAM)) in complex with alpha-ketoglutarate/Zn2+/CoA | | Descriptor: | 2-OXOGLUTARIC ACID, COENZYME A, Homocitrate synthase, ... | | Authors: | Suzuki, T, Tomita, T, Kuzuyama, T, Nishiyama, M. | | Deposit date: | 2019-08-28 | | Release date: | 2020-09-02 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.98 Å) | | Cite: | Involvement of subdomain II in the recognition of acetyl-CoA revealed by the crystal structure of homocitrate synthase from Sulfolobus acidocaldarius.
Febs J., 288, 2021
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6E1J
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2NX9
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1NVM
 | | Crystal structure of a bifunctional aldolase-dehydrogenase : sequestering a reactive and volatile intermediate | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 4-hydroxy-2-oxovalerate aldolase, MANGANESE (II) ION, ... | | Authors: | Manjasetty, A.B, Powlowski, J, Vrielink, A. | | Deposit date: | 2003-02-04 | | Release date: | 2003-06-17 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Crystal structure of a bifunctional aldolase-dehydrogenase: Sequestering a
reactive and volatile intermediate
Proc.Natl.Acad.Sci.USA, 100, 2003
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3RMJ
 | | Crystal structure of truncated alpha-Isopropylmalate Synthase from Neisseria meningitidis | | Descriptor: | 2-isopropylmalate synthase, GLYCEROL, MAGNESIUM ION, ... | | Authors: | Huisman, F.H.A, Baker, H.M, Koon, N, Baker, E.N, Parker, E.J. | | Deposit date: | 2011-04-20 | | Release date: | 2012-03-14 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Removal of the C-terminal regulatory domain of alpha-isopropylmalate synthase disrupts functional substrate binding
Biochemistry, 51, 2012
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8IH7
 | | AmnG-AmnH complex | | Descriptor: | 4-hydroxy-2-oxovalerate aldolase, Acetaldehyde dehydrogenase, OXALATE ION, ... | | Authors: | Su, D, Shi, Q.L. | | Deposit date: | 2023-02-22 | | Release date: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.48 Å) | | Cite: | AmnG-AmnH complex
To Be Published
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3U6W
 | | Truncated M. tuberculosis LeuA (1-425) complexed with KIV | | Descriptor: | 2-isopropylmalate synthase, 3-METHYL-2-OXOBUTANOIC ACID, GLYCEROL, ... | | Authors: | Koon, N, Baker, E.N, Squire, C.J. | | Deposit date: | 2011-10-13 | | Release date: | 2012-03-14 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.21 Å) | | Cite: | Removal of the C-terminal regulatory domain of alpha-isopropylmalate synthase disrupts functional substrate binding.
Biochemistry, 51, 2012
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3BLF
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3MI3
 | | Homocitrate Synthase Lys4 bound to Lysine | | Descriptor: | Homocitrate synthase, mitochondrial, LYSINE, ... | | Authors: | Bulfer, S.L, Scott, E.M, Pillus, L, Trievel, R.C. | | Deposit date: | 2010-04-09 | | Release date: | 2010-04-28 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.38 Å) | | Cite: | Structural Basis for L-lysine Feedback Inhibition of Homocitrate Synthase
J.Biol.Chem., 285, 2010
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3FIG
 | | Crystal Structure of Leucine-bound LeuA from Mycobacterium tuberculosis | | Descriptor: | 2-isopropylmalate synthase, GLYCEROL, LEUCINE, ... | | Authors: | Koon, N, Squire, C.J, Baker, E.N. | | Deposit date: | 2008-12-11 | | Release date: | 2008-12-23 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structure of LeuA from Mycobacterium tuberculosis, a key enzyme in leucine biosynthesis.
Proc.Natl.Acad.Sci.USA, 101, 2004
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1SR9
 | | Crystal Structure of LeuA from Mycobacterium tuberculosis | | Descriptor: | 2-isopropylmalate synthase, 3-METHYL-2-OXOBUTANOIC ACID, CHLORIDE ION, ... | | Authors: | Koon, N, Squire, C.J, Baker, E.N. | | Deposit date: | 2004-03-22 | | Release date: | 2004-05-18 | | Last modified: | 2017-10-11 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of LeuA from Mycobacterium tuberculosis, a key enzyme in leucine biosynthesis
Proc.Natl.Acad.Sci.USA, 101, 2004
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1RR2
 | | Propionibacterium shermanii transcarboxylase 5S subunit bound to 2-ketobutyric acid | | Descriptor: | 2-KETOBUTYRIC ACID, COBALT (II) ION, transcarboxylase 5S subunit | | Authors: | Hall, P.R, Zheng, R, Antony, L, Pusztai-Carey, M, Carey, P.R, Yee, V.C. | | Deposit date: | 2003-12-08 | | Release date: | 2004-09-07 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Transcarboxylase 5S structures: assembly and catalytic mechanism of a multienzyme complex subunit.
Embo J., 23, 2004
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4JX5
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4JN6
 | | Crystal Structure of the Aldolase-Dehydrogenase Complex from Mycobacterium tuberculosis HRv37 | | Descriptor: | 4-hydroxy-2-oxovalerate aldolase, Acetaldehyde dehydrogenase, MANGANESE (II) ION, ... | | Authors: | Carere, J, McKenna, S.E, Kimber, M.S, Seah, S.Y.K. | | Deposit date: | 2013-03-14 | | Release date: | 2013-05-08 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.93 Å) | | Cite: | Characterization of an Aldolase-Dehydrogenase Complex from the Cholesterol Degradation Pathway of Mycobacterium tuberculosis.
Biochemistry, 52, 2013
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