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6I6Z
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BU of 6i6z by Molmil
Crystal structure of the human CARBOXYPEPTIDASE A1 in complex with the PHOSPHINIC INHIBITOR Acetyl-Tyr-Ala-Y(PO2CH2)-homoPhe-OH
Descriptor: (2S)-2-{[(S)-{(1R)-1-[(N-acetyl-L-tyrosyl)amino]ethyl}(hydroxy)phosphoryl]methyl}-4-phenylbutanoic acid, Carboxypeptidase A1, ZINC ION
Authors:Gallego, P, Reverter, D.
Deposit date:2018-11-15
Release date:2018-12-12
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Synthesis and Structural/Functional Characterization of Selective M14 Metallocarboxypeptidase Inhibitors Based on Phosphinic Pseudopeptide Scaffold: Implications on the Design of Specific Optical Probes.
J. Med. Chem., 62, 2019
3KGQ
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BU of 3kgq by Molmil
Carboxypeptidase A liganded to an organic small-molecule: conformational changes
Descriptor: ACETONE, CITRIC ACID, Carboxypeptidase A1, ...
Authors:Fernandez, D, Boix, E, Pallares, I, Aviles, F.X, Vendrell, J.
Deposit date:2009-10-29
Release date:2010-10-27
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural and Functional Analysis of the Complex between Citrate and the Zinc Peptidase Carboxypeptidase A
Enzyme Res, 2011, 2011
2ABZ
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BU of 2abz by Molmil
Crystal structure of C19A/C43A mutant of leech carboxypeptidase inhibitor in complex with bovine carboxypeptidase A
Descriptor: Carboxypeptidase A1, Metallocarboxypeptidase inhibitor, ZINC ION
Authors:Arolas, J.L, Popowicz, G.M, Bronsoms, S, Aviles, F.X, Huber, R, Holak, T.A, Ventura, S.
Deposit date:2005-07-18
Release date:2006-01-31
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Study of a major intermediate in the oxidative folding of leech carboxypeptidase inhibitor: contribution of the fourth disulfide bond
J.Mol.Biol., 352, 2005
8CPA
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BU of 8cpa by Molmil
COMPARISON OF THE STRUCTURES OF THREE CARBOXYPEPTIDASE A-PHOSPHONATE COMPLEXES DETERMINED BY X-RAY CRYSTALLOGRAPHY
Descriptor: CARBOXYPEPTIDASE A, O-(((1R)-((N-(PHENYL-METHOXY-CARBONYL)-ALANYL)-AMINO)METHYL)HYDROXYPHOSPHINYL)3-L-PHENYLLACTATE, ZINC ION
Authors:Kim, H, Lipscomb, W.N.
Deposit date:1991-05-21
Release date:1994-01-31
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (2 Å)
Cite:Comparison of the structures of three carboxypeptidase A-phosphonate complexes determined by X-ray crystallography.
Biochemistry, 30, 1991
6CPA
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BU of 6cpa by Molmil
CRYSTAL STRUCTURE OF THE COMPLEX OF CARBOXYPEPTIDASE A WITH A STRONGLY BOUND PHOSPHONATE IN A NEW CRYSTALLINE FORM: COMPARISON WITH STRUCTURES OF OTHER COMPLEXES
Descriptor: CARBOXYPEPTIDASE A, O-(((1R)-((N-PHENYLMETHOXYCARBONYL-L-ALANYL)AMINO)ETHYL)HYDROXYPHOSPHONO)-L-BENZYLACETIC ACID, ZINC ION
Authors:Kim, H, Lipscomb, W.N.
Deposit date:1990-02-15
Release date:1991-10-15
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the complex of carboxypeptidase A with a strongly bound phosphonate in a new crystalline form: comparison with structures of other complexes.
Biochemistry, 29, 1990
7Q87
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BU of 7q87 by Molmil
Carboxypeptidase T with (S)-3-phenyllactic acid
Descriptor: ALPHA-HYDROXY-BETA-PHENYL-PROPIONIC ACID, CALCIUM ION, Carboxypeptidase T, ...
Authors:Timofeev, V.I, Akparov, V.K, Shevtsov, M.B, Kuranova, I.P.
Deposit date:2021-11-10
Release date:2022-01-26
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Carboxypeptidase T with (S)-3-phenyllactic acid
To Be Published
4Z65
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BU of 4z65 by Molmil
Carboxypeptidase B with Sulphamoil Arginine
Descriptor: Carboxypeptidase B, N~2~-sulfamoyl-L-arginine, ZINC ION
Authors:Timofeev, V.I, Akparov, V.K, Kuranova, I.P.
Deposit date:2015-04-03
Release date:2015-10-14
Last modified:2015-10-28
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Structure of the complex of carboxypeptidase B and N-sulfamoyl-L-arginine.
Acta Crystallogr.,Sect.F, 71, 2015
6Z28
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BU of 6z28 by Molmil
Carboxypeptidase T mutant L254N with N-sulfamoyl-L-glutamic acid
Descriptor: CALCIUM ION, Carboxypeptidase T, N-sulfamoyl-L-glutamic acid, ...
Authors:Timofeev, V.I, Akparov, V.K, Kuranova, I.P.
Deposit date:2020-05-15
Release date:2020-05-27
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:CARBOXYPEPTIDASE T MUTANT L254N WITH WITH N-SULFAMOYL-L-GLUT
To Be Published
7CPA
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BU of 7cpa by Molmil
COMPARISON OF THE STRUCTURES OF THREE CARBOXYPEPTIDASE A-PHOSPHONATE COMPLEXES DETERMINED BY X-RAY CRYSTALLOGRAPHY
Descriptor: CARBOXYPEPTIDASE A, O-((((N-PHENYL-METHOXY-CARBONYL)-PHENYL ALANYL-CARBONYL)AMINO)-ISOBUTYL)HYDROXY PHOSPHINYL)-3-PHENYLACETIC ACID, ZINC ION
Authors:Kim, H, Lipscomb, W.N.
Deposit date:1991-05-21
Release date:1994-01-31
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (2 Å)
Cite:Comparison of the structures of three carboxypeptidase A-phosphonate complexes determined by X-ray crystallography.
Biochemistry, 30, 1991
5ZEQ
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BU of 5zeq by Molmil
Carboxypeptidase B in complex with DD28
Descriptor: (2~{S})-2-[(6-azanyl-5-chloranyl-pyridin-3-yl)methyl]-3-selanyl-propanoic acid, CACODYLATE ION, Carboxypeptidase B, ...
Authors:Itoh, T, Yoshimoto, N, Yamamoto, K.
Deposit date:2018-02-27
Release date:2018-06-20
Last modified:2018-07-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for the selective inhibition of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) by a selenium-containing inhibitor with chloro-aminopyridine as a basic group
Bioorg. Med. Chem. Lett., 28, 2018
2JEW
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BU of 2jew by Molmil
Crystal structure of ((2S)-5-amino-2-((1-n-propyl-1H-imidazol-4-yl) methyl)pentanoic acid) UK396,082 a TAFIa inhibitor, Bound to Activated Porcine Pancreatic carboxypeptidaseB
Descriptor: (2S)-5-AMINO-2-[(1-PROPYL-1H-IMIDAZOL-4-YL)METHYL]PENTANOIC ACID, CARBOXYPEPTIDASE B, ZINC ION
Authors:Brown, D.G, Moore, R.S.
Deposit date:2007-01-24
Release date:2007-11-20
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Discovery of potent & selective inhibitors of activated thrombin-activatable fibrinolysis inhibitor for the treatment of thrombosis.
J. Med. Chem., 50, 2007
8QVO
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BU of 8qvo by Molmil
L211Q, L254N, T262G mutant of carboxypeptidase T from Thermoactinomyces vulgaris
Descriptor: CALCIUM ION, Carboxypeptidase T, SULFATE ION, ...
Authors:Timofeev, V.I, Dorovatovskii, P.V, Lazarenko, V.A, Akparov, V.K, Kuranova, I.P.
Deposit date:2023-10-18
Release date:2024-01-17
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:L211Q, L254N, T262G mutant of carboxypeptidase T from Thermoactinomyces vulgaris
To Be Published
5CPA
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BU of 5cpa by Molmil
REFINED CRYSTAL STRUCTURE OF CARBOXYPEPTIDASE A AT 1.54 ANGSTROMS RESOLUTION.
Descriptor: CARBOXYPEPTIDASE A, ZINC ION
Authors:Lipscomb, W.N.
Deposit date:1982-05-06
Release date:1982-07-29
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Refined crystal structure of carboxypeptidase A at 1.54 A resolution.
J.Mol.Biol., 168, 1983
4UIB
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BU of 4uib by Molmil
Crystal structure of 3p in complex with tafCPB
Descriptor: (2S)-6-AMINO-2-[[(1R)-1-(CYCLOHEXYLMETHYL)-2-OXO-2-[[(2S)-1,7,7-TRIMETHYLNORBORNAN-2-YL]AMINO]ETHYL]ARBAMOYLAMINO]HEXANOIC ACID, ACETATE ION, CARBOXYPEPTIDASE B, ...
Authors:Halland, N, Broenstrup, M, Czech, J, Czechtizky, W, Evers, A, Follmann, M, Kohlmann, M, Schiell, M, Kurz, M, Schreuder, H.A, Kallus, C.
Deposit date:2015-03-27
Release date:2015-06-03
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Novel Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (Tafia) from Natural Product Anabaenopeptin.
J.Med.Chem., 58, 2015
4UIA
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BU of 4uia by Molmil
Crystal structure of 3a in complex with tafCPB
Descriptor: (2S)-6-azanyl-2-[[(2R)-3-cyclohexyl-1-(3-methylbutylamino)-1-oxidanylidene-propan-2-yl]carbamoylamino]hexanoic acid, CARBOXYPEPTIDASE B, ZINC ION
Authors:Halland, N, Broenstrup, M, Czech, J, Czechtizky, W, Evers, A, Follmann, M, Kohlmann, M, Schiell, M, Kurz, M, Schreuder, H.A, Kallus, C.
Deposit date:2015-03-27
Release date:2015-06-03
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Novel Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (Tafia) from Natural Product Anabaenopeptin.
J.Med.Chem., 58, 2015
6F6Q
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BU of 6f6q by Molmil
Carboxypeptidase T mutant L254N with Sulphamoil Arginine
Descriptor: CALCIUM ION, Carboxypeptidase T, N~2~-sulfamoyl-L-arginine, ...
Authors:Timofeev, V.I, Akparov, V.K, Kuranova, I.P.
Deposit date:2017-12-06
Release date:2018-08-15
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Carboxypeptidase T mutant L254N with Sulphamoil Arginine
To Be Published
7AQP
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BU of 7aqp by Molmil
T262S, A251S, L254S, L211Q mutant of carboxypeptidase T from Thermoactinomyces vulgaris
Descriptor: CALCIUM ION, Carboxypeptidase T, SULFATE ION, ...
Authors:Timofeev, V.I, Akparov, V.K, Kuranova, I.P.
Deposit date:2020-10-22
Release date:2020-12-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:T262S, A251S, L254S, L211Q mutant of carboxypeptidase T from Thermoactinomyces vulgaris
To Be Published
7ARU
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BU of 7aru by Molmil
L254N mutant of carboxypeptidase T from Thermoactinomyces vulgaris N-sulfamoyl-L-valine
Descriptor: (2~{S})-3-methyl-2-(sulfamoylamino)butanoic acid, CALCIUM ION, Carboxypeptidase T, ...
Authors:Timofeev, V.I, Akparov, V.K, Kuranova, I.P.
Deposit date:2020-10-26
Release date:2020-11-11
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:L254N mutant of carboxypeptidase T from Thermoactinomyces vulgaris N-sulfamoyl-L-valine
To Be Published
6F79
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BU of 6f79 by Molmil
Carboxypeptidase T mutant L211Q with Sulphamoil Arginine
Descriptor: CALCIUM ION, Carboxypeptidase T, N~2~-sulfamoyl-L-arginine, ...
Authors:Timofeev, V.I, Akparov, V.K, Kuranova, I.P.
Deposit date:2017-12-07
Release date:2018-08-15
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Carboxypeptidase T mutant L211Q with Sulphamoil Arginine
To Be Published
5MRV
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BU of 5mrv by Molmil
Crystal structure of human carboxypeptidase O in complex with NvCI
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Carboxypeptidase O, Metallocarboxypeptidase inhibitor, ...
Authors:Garcia-Pardo, J, Garcia-Guerrero, M.C, Fernandez-Alvarez, R, Lyons, P, Aviles, F.X, Lorenzo, J, Reverter, D.
Deposit date:2016-12-27
Release date:2018-01-17
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.854 Å)
Cite:Crystal structure and mechanism of human carboxypeptidase O: Insights into its specific activity for acidic residues.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6F75
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BU of 6f75 by Molmil
Carboxypeptidase T mutant L254N with Sulphamoil Leucine
Descriptor: CALCIUM ION, Carboxypeptidase T, SULFATE ION, ...
Authors:Timofeev, V.I, Akparov, V.K, Kuranova, I.P.
Deposit date:2017-12-07
Release date:2018-08-15
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Carboxypeptidase T mutant L254N with Sulphamoil Leucine
To Be Published
2V77
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BU of 2v77 by Molmil
Crystal Structure of Human Carboxypeptidase A1
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CARBOXYPEPTIDASE A1, OCTANE-1,3,5,7-TETRACARBOXYLIC ACID, ...
Authors:Pallares, I, Fernandez, D, Comellas-Bigler, M, Fernandez-Recio, J, Ventura, S, Aviles, F.X, Vendrell, J.
Deposit date:2007-07-27
Release date:2008-07-01
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.603 Å)
Cite:Direct interaction between a human digestive protease and the mucoadhesive poly(acrylic acid).
Acta Crystallogr. D Biol. Crystallogr., D64, 2008
6GO2
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BU of 6go2 by Molmil
Carboxypeptidase T with N-sulfamoyl-L-Leucine
Descriptor: CALCIUM ION, Carboxypeptidase T, SULFATE ION, ...
Authors:Timofeev, V.I, Akparov, V.K, Kuranova, I.P.
Deposit date:2018-06-01
Release date:2018-06-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Carboxypeptidase T with N-sulfamoyl-L-Leucine
To Be Published
4UEE
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BU of 4uee by Molmil
Crystal structure of the human CARBOXYPEPTIDASE A1 in complex with the PHOSPHINIC INHIBITOR Acetyl-Leu-Ala-Y(PO2CH2)-homoPhe-OH
Descriptor: (2S)-2-{[(R)-{(1R)-1-[(N-acetyl-L-leucyl)amino]ethyl}(hydroxy)phosphoryl]methyl}-4-phenylbutanoic acid, CARBOXYPEPTIDASE A1, ZINC ION
Authors:Gallego, P, Covaleda, G, Costenaro, L, Devel, L, Dive, V, Aviles, F.X, Reverter, D.
Deposit date:2014-12-17
Release date:2016-01-20
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Crystal Structure of the Human Carboxypeptidase A1 in Complex with Phosphinic Inhibitors
To be Published
4UEZ
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BU of 4uez by Molmil
Crystal structure of the human CARBOXYPEPTIDASE A1 in complex with the PHOSPHINIC INHIBITOR Acetyl-Leu-Phe-Y(PO2CH2)-Phe-OH
Descriptor: (2S)-3-[(R)-{(1R)-1-[(N-acetyl-L-leucyl)amino]-2-phenylethyl}(hydroxy)phosphoryl]-2-benzylpropanoic acid, HUMAN CARBOXYPEPTIDASE A1, ZINC ION
Authors:Gallego, P, Covaleda, G, Costenaro, L, Devel, L, Dive, V, Aviles, F.X, Reverter, D.
Deposit date:2014-12-22
Release date:2016-01-20
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Crystal Structure of the Human Carboxypeptidase A1 in Complex with Phosphinic Inhibitors
To be Published

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