PDB: 155 resultsInfo pagesStatus searchChemie searchBIRD

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6I6Z	Crystal structure of the human CARBOXYPEPTIDASE A1 in complex with the PHOSPHINIC INHIBITOR Acetyl-Tyr-Ala-Y(PO2CH2)-homoPhe-OH Descriptor: (2S)-2-{[(S)-{(1R)-1-[(N-acetyl-L-tyrosyl)amino]ethyl}(hydroxy)phosphoryl]methyl}-4-phenylbutanoic acid, Carboxypeptidase A1, ZINC ION Authors: Gallego, P, Reverter, D. Deposit date: 2018-11-15 Release date: 2018-12-12 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.72 Å) Cite: Synthesis and Structural/Functional Characterization of Selective M14 Metallocarboxypeptidase Inhibitors Based on Phosphinic Pseudopeptide Scaffold: Implications on the Design of Specific Optical Probes. J. Med. Chem., 62, 2019
3KGQ	Carboxypeptidase A liganded to an organic small-molecule: conformational changes Descriptor: ACETONE, CITRIC ACID, Carboxypeptidase A1, ... Authors: Fernandez, D, Boix, E, Pallares, I, Aviles, F.X, Vendrell, J. Deposit date: 2009-10-29 Release date: 2010-10-27 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structural and Functional Analysis of the Complex between Citrate and the Zinc Peptidase Carboxypeptidase A Enzyme Res, 2011, 2011
2ABZ	Crystal structure of C19A/C43A mutant of leech carboxypeptidase inhibitor in complex with bovine carboxypeptidase A Descriptor: Carboxypeptidase A1, Metallocarboxypeptidase inhibitor, ZINC ION Authors: Arolas, J.L, Popowicz, G.M, Bronsoms, S, Aviles, F.X, Huber, R, Holak, T.A, Ventura, S. Deposit date: 2005-07-18 Release date: 2006-01-31 Last modified: 2021-11-10 Method: X-RAY DIFFRACTION (2.16 Å) Cite: Study of a major intermediate in the oxidative folding of leech carboxypeptidase inhibitor: contribution of the fourth disulfide bond J.Mol.Biol., 352, 2005
8CPA	COMPARISON OF THE STRUCTURES OF THREE CARBOXYPEPTIDASE A-PHOSPHONATE COMPLEXES DETERMINED BY X-RAY CRYSTALLOGRAPHY Descriptor: CARBOXYPEPTIDASE A, O-(((1R)-((N-(PHENYL-METHOXY-CARBONYL)-ALANYL)-AMINO)METHYL)HYDROXYPHOSPHINYL)3-L-PHENYLLACTATE, ZINC ION Authors: Kim, H, Lipscomb, W.N. Deposit date: 1991-05-21 Release date: 1994-01-31 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2 Å) Cite: Comparison of the structures of three carboxypeptidase A-phosphonate complexes determined by X-ray crystallography. Biochemistry, 30, 1991
6CPA	CRYSTAL STRUCTURE OF THE COMPLEX OF CARBOXYPEPTIDASE A WITH A STRONGLY BOUND PHOSPHONATE IN A NEW CRYSTALLINE FORM: COMPARISON WITH STRUCTURES OF OTHER COMPLEXES Descriptor: CARBOXYPEPTIDASE A, O-(((1R)-((N-PHENYLMETHOXYCARBONYL-L-ALANYL)AMINO)ETHYL)HYDROXYPHOSPHONO)-L-BENZYLACETIC ACID, ZINC ION Authors: Kim, H, Lipscomb, W.N. Deposit date: 1990-02-15 Release date: 1991-10-15 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of the complex of carboxypeptidase A with a strongly bound phosphonate in a new crystalline form: comparison with structures of other complexes. Biochemistry, 29, 1990
7Q87	Carboxypeptidase T with (S)-3-phenyllactic acid Descriptor: ALPHA-HYDROXY-BETA-PHENYL-PROPIONIC ACID, CALCIUM ION, Carboxypeptidase T, ... Authors: Timofeev, V.I, Akparov, V.K, Shevtsov, M.B, Kuranova, I.P. Deposit date: 2021-11-10 Release date: 2022-01-26 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.73 Å) Cite: Carboxypeptidase T with (S)-3-phenyllactic acid To Be Published
4Z65	Carboxypeptidase B with Sulphamoil Arginine Descriptor: Carboxypeptidase B, N~2~-sulfamoyl-L-arginine, ZINC ION Authors: Timofeev, V.I, Akparov, V.K, Kuranova, I.P. Deposit date: 2015-04-03 Release date: 2015-10-14 Last modified: 2015-10-28 Method: X-RAY DIFFRACTION (1.25 Å) Cite: Structure of the complex of carboxypeptidase B and N-sulfamoyl-L-arginine. Acta Crystallogr.,Sect.F, 71, 2015
6Z28	Carboxypeptidase T mutant L254N with N-sulfamoyl-L-glutamic acid Descriptor: CALCIUM ION, Carboxypeptidase T, N-sulfamoyl-L-glutamic acid, ... Authors: Timofeev, V.I, Akparov, V.K, Kuranova, I.P. Deposit date: 2020-05-15 Release date: 2020-05-27 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.3 Å) Cite: CARBOXYPEPTIDASE T MUTANT L254N WITH WITH N-SULFAMOYL-L-GLUT To Be Published
7CPA	COMPARISON OF THE STRUCTURES OF THREE CARBOXYPEPTIDASE A-PHOSPHONATE COMPLEXES DETERMINED BY X-RAY CRYSTALLOGRAPHY Descriptor: CARBOXYPEPTIDASE A, O-((((N-PHENYL-METHOXY-CARBONYL)-PHENYL ALANYL-CARBONYL)AMINO)-ISOBUTYL)HYDROXY PHOSPHINYL)-3-PHENYLACETIC ACID, ZINC ION Authors: Kim, H, Lipscomb, W.N. Deposit date: 1991-05-21 Release date: 1994-01-31 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2 Å) Cite: Comparison of the structures of three carboxypeptidase A-phosphonate complexes determined by X-ray crystallography. Biochemistry, 30, 1991
5ZEQ	Carboxypeptidase B in complex with DD28 Descriptor: (2~{S})-2-[(6-azanyl-5-chloranyl-pyridin-3-yl)methyl]-3-selanyl-propanoic acid, CACODYLATE ION, Carboxypeptidase B, ... Authors: Itoh, T, Yoshimoto, N, Yamamoto, K. Deposit date: 2018-02-27 Release date: 2018-06-20 Last modified: 2018-07-04 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural basis for the selective inhibition of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) by a selenium-containing inhibitor with chloro-aminopyridine as a basic group Bioorg. Med. Chem. Lett., 28, 2018
2JEW	Crystal structure of ((2S)-5-amino-2-((1-n-propyl-1H-imidazol-4-yl) methyl)pentanoic acid) UK396,082 a TAFIa inhibitor, Bound to Activated Porcine Pancreatic carboxypeptidaseB Descriptor: (2S)-5-AMINO-2-[(1-PROPYL-1H-IMIDAZOL-4-YL)METHYL]PENTANOIC ACID, CARBOXYPEPTIDASE B, ZINC ION Authors: Brown, D.G, Moore, R.S. Deposit date: 2007-01-24 Release date: 2007-11-20 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Discovery of potent & selective inhibitors of activated thrombin-activatable fibrinolysis inhibitor for the treatment of thrombosis. J. Med. Chem., 50, 2007
8QVO	L211Q, L254N, T262G mutant of carboxypeptidase T from Thermoactinomyces vulgaris Descriptor: CALCIUM ION, Carboxypeptidase T, SULFATE ION, ... Authors: Timofeev, V.I, Dorovatovskii, P.V, Lazarenko, V.A, Akparov, V.K, Kuranova, I.P. Deposit date: 2023-10-18 Release date: 2024-01-17 Method: X-RAY DIFFRACTION (1.96 Å) Cite: L211Q, L254N, T262G mutant of carboxypeptidase T from Thermoactinomyces vulgaris To Be Published
5CPA	REFINED CRYSTAL STRUCTURE OF CARBOXYPEPTIDASE A AT 1.54 ANGSTROMS RESOLUTION. Descriptor: CARBOXYPEPTIDASE A, ZINC ION Authors: Lipscomb, W.N. Deposit date: 1982-05-06 Release date: 1982-07-29 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (1.54 Å) Cite: Refined crystal structure of carboxypeptidase A at 1.54 A resolution. J.Mol.Biol., 168, 1983
4UIB	Crystal structure of 3p in complex with tafCPB Descriptor: (2S)-6-AMINO-2-[[(1R)-1-(CYCLOHEXYLMETHYL)-2-OXO-2-[[(2S)-1,7,7-TRIMETHYLNORBORNAN-2-YL]AMINO]ETHYL]ARBAMOYLAMINO]HEXANOIC ACID, ACETATE ION, CARBOXYPEPTIDASE B, ... Authors: Halland, N, Broenstrup, M, Czech, J, Czechtizky, W, Evers, A, Follmann, M, Kohlmann, M, Schiell, M, Kurz, M, Schreuder, H.A, Kallus, C. Deposit date: 2015-03-27 Release date: 2015-06-03 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (1.94 Å) Cite: Novel Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (Tafia) from Natural Product Anabaenopeptin. J.Med.Chem., 58, 2015
4UIA	Crystal structure of 3a in complex with tafCPB Descriptor: (2S)-6-azanyl-2-[[(2R)-3-cyclohexyl-1-(3-methylbutylamino)-1-oxidanylidene-propan-2-yl]carbamoylamino]hexanoic acid, CARBOXYPEPTIDASE B, ZINC ION Authors: Halland, N, Broenstrup, M, Czech, J, Czechtizky, W, Evers, A, Follmann, M, Kohlmann, M, Schiell, M, Kurz, M, Schreuder, H.A, Kallus, C. Deposit date: 2015-03-27 Release date: 2015-06-03 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (2.18 Å) Cite: Novel Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (Tafia) from Natural Product Anabaenopeptin. J.Med.Chem., 58, 2015
6F6Q	Carboxypeptidase T mutant L254N with Sulphamoil Arginine Descriptor: CALCIUM ION, Carboxypeptidase T, N~2~-sulfamoyl-L-arginine, ... Authors: Timofeev, V.I, Akparov, V.K, Kuranova, I.P. Deposit date: 2017-12-06 Release date: 2018-08-15 Method: X-RAY DIFFRACTION (1.79 Å) Cite: Carboxypeptidase T mutant L254N with Sulphamoil Arginine To Be Published
7AQP	T262S, A251S, L254S, L211Q mutant of carboxypeptidase T from Thermoactinomyces vulgaris Descriptor: CALCIUM ION, Carboxypeptidase T, SULFATE ION, ... Authors: Timofeev, V.I, Akparov, V.K, Kuranova, I.P. Deposit date: 2020-10-22 Release date: 2020-12-02 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.6 Å) Cite: T262S, A251S, L254S, L211Q mutant of carboxypeptidase T from Thermoactinomyces vulgaris To Be Published
7ARU	L254N mutant of carboxypeptidase T from Thermoactinomyces vulgaris N-sulfamoyl-L-valine Descriptor: (2~{S})-3-methyl-2-(sulfamoylamino)butanoic acid, CALCIUM ION, Carboxypeptidase T, ... Authors: Timofeev, V.I, Akparov, V.K, Kuranova, I.P. Deposit date: 2020-10-26 Release date: 2020-11-11 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.05 Å) Cite: L254N mutant of carboxypeptidase T from Thermoactinomyces vulgaris N-sulfamoyl-L-valine To Be Published
6F79	Carboxypeptidase T mutant L211Q with Sulphamoil Arginine Descriptor: CALCIUM ION, Carboxypeptidase T, N~2~-sulfamoyl-L-arginine, ... Authors: Timofeev, V.I, Akparov, V.K, Kuranova, I.P. Deposit date: 2017-12-07 Release date: 2018-08-15 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Carboxypeptidase T mutant L211Q with Sulphamoil Arginine To Be Published
5MRV	Crystal structure of human carboxypeptidase O in complex with NvCI Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Carboxypeptidase O, Metallocarboxypeptidase inhibitor, ... Authors: Garcia-Pardo, J, Garcia-Guerrero, M.C, Fernandez-Alvarez, R, Lyons, P, Aviles, F.X, Lorenzo, J, Reverter, D. Deposit date: 2016-12-27 Release date: 2018-01-17 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.854 Å) Cite: Crystal structure and mechanism of human carboxypeptidase O: Insights into its specific activity for acidic residues. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6F75	Carboxypeptidase T mutant L254N with Sulphamoil Leucine Descriptor: CALCIUM ION, Carboxypeptidase T, SULFATE ION, ... Authors: Timofeev, V.I, Akparov, V.K, Kuranova, I.P. Deposit date: 2017-12-07 Release date: 2018-08-15 Method: X-RAY DIFFRACTION (1.89 Å) Cite: Carboxypeptidase T mutant L254N with Sulphamoil Leucine To Be Published
2V77	Crystal Structure of Human Carboxypeptidase A1 Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CARBOXYPEPTIDASE A1, OCTANE-1,3,5,7-TETRACARBOXYLIC ACID, ... Authors: Pallares, I, Fernandez, D, Comellas-Bigler, M, Fernandez-Recio, J, Ventura, S, Aviles, F.X, Vendrell, J. Deposit date: 2007-07-27 Release date: 2008-07-01 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.603 Å) Cite: Direct interaction between a human digestive protease and the mucoadhesive poly(acrylic acid). Acta Crystallogr. D Biol. Crystallogr., D64, 2008
6GO2	Carboxypeptidase T with N-sulfamoyl-L-Leucine Descriptor: CALCIUM ION, Carboxypeptidase T, SULFATE ION, ... Authors: Timofeev, V.I, Akparov, V.K, Kuranova, I.P. Deposit date: 2018-06-01 Release date: 2018-06-13 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Carboxypeptidase T with N-sulfamoyl-L-Leucine To Be Published
4UEE	Crystal structure of the human CARBOXYPEPTIDASE A1 in complex with the PHOSPHINIC INHIBITOR Acetyl-Leu-Ala-Y(PO2CH2)-homoPhe-OH Descriptor: (2S)-2-{[(R)-{(1R)-1-[(N-acetyl-L-leucyl)amino]ethyl}(hydroxy)phosphoryl]methyl}-4-phenylbutanoic acid, CARBOXYPEPTIDASE A1, ZINC ION Authors: Gallego, P, Covaleda, G, Costenaro, L, Devel, L, Dive, V, Aviles, F.X, Reverter, D. Deposit date: 2014-12-17 Release date: 2016-01-20 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.27 Å) Cite: Crystal Structure of the Human Carboxypeptidase A1 in Complex with Phosphinic Inhibitors To be Published
4UEZ	Crystal structure of the human CARBOXYPEPTIDASE A1 in complex with the PHOSPHINIC INHIBITOR Acetyl-Leu-Phe-Y(PO2CH2)-Phe-OH Descriptor: (2S)-3-[(R)-{(1R)-1-[(N-acetyl-L-leucyl)amino]-2-phenylethyl}(hydroxy)phosphoryl]-2-benzylpropanoic acid, HUMAN CARBOXYPEPTIDASE A1, ZINC ION Authors: Gallego, P, Covaleda, G, Costenaro, L, Devel, L, Dive, V, Aviles, F.X, Reverter, D. Deposit date: 2014-12-22 Release date: 2016-01-20 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.29 Å) Cite: Crystal Structure of the Human Carboxypeptidase A1 in Complex with Phosphinic Inhibitors To be Published

 

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