Loading
PDBj
メニューPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

6X8O
DownloadVisualize
BU of 6x8o by Molmil
BimBH3 peptide tetramer
分子名称: Bcl-2-like protein 11, THIOCYANATE ION
著者Robin, A.Y, Westphal, D, Uson, I, Czabotar, P.E.
登録日2020-06-01
公開日2020-09-09
最終更新日2021-02-17
実験手法X-RAY DIFFRACTION (1.31 Å)
主引用文献Biophysical Characterization of Pro-apoptotic BimBH3 Peptides Reveals an Unexpected Capacity for Self-Association.
Structure, 29, 2021
8T5E
DownloadVisualize
BU of 8t5e by Molmil
De novo design of high-affinity protein binders to bioactive helical peptides
分子名称: Bcl-2-like protein 11, Bim_fulldiff
著者Torres, S.V, Leung, P.J.Y, Bera, A.K, Baker, D, Kang, A.
登録日2023-06-13
公開日2024-01-10
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献De novo design of high-affinity binders of bioactive helical peptides.
Nature, 626, 2024
4UF3
DownloadVisualize
BU of 4uf3 by Molmil
Deerpox virus DPV022 in complex with Bim BH3
分子名称: Antiapoptotic membrane protein, Bcl-2-like protein 11
著者Burton, D.R, Kvansakul, M.
登録日2014-12-23
公開日2015-08-05
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural Basis of Deerpox Virus-Mediated Inhibition of Apoptosis.
Acta Crystallogr.,Sect.D, 71, 2015
4D2M
DownloadVisualize
BU of 4d2m by Molmil
Vaccinia Virus F1L bound to Bim BH3
分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, BCL-2-LIKE PROTEIN 11, CHLORIDE ION, ...
著者Kvansakul, M, Colman, P.M.
登録日2014-05-12
公開日2014-06-04
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural Insight Into Bh3-Domain Binding of Vaccinia Virus Anti-Apoptotic F1L.
J.Virol., 88, 2014
6TQQ
DownloadVisualize
BU of 6tqq by Molmil
Structural insight into tanapoxvirus mediated inhibition of apoptosis
分子名称: 16L protein, Bcl-2-like protein 11, SODIUM ION
著者Suraweera, C.D, Hinds, M.G, Kvansakul, M.
登録日2019-12-17
公開日2020-06-03
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (3.0017972 Å)
主引用文献Structural insight into tanapoxvirus-mediated inhibition of apoptosis.
Febs J., 287, 2020
1PQ1
DownloadVisualize
BU of 1pq1 by Molmil
Crystal structure of Bcl-xl/Bim
分子名称: Apoptosis regulator Bcl-X, BCL2-like protein 11
著者Liu, X, Dai, S, Zhu, Y, Marrack, P, Kappler, J.W.
登録日2003-06-17
公開日2003-09-23
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献The structure of a Bcl-xl/Bim fragment complex: Implications for Bim function
Immunity, 19, 2003
5AGW
DownloadVisualize
BU of 5agw by Molmil
Bcl-2 alpha beta-1 complex
分子名称: APOPTOSIS REGULATOR BCL-2, BCL-2-LIKE PROTEIN 1, BCL-2-LIKE PROTEIN 11
著者Smith, B.J, F Lee, E, Checco, J.W, Gellman, S.H, Fairlie, W.D.
登録日2015-02-04
公開日2015-09-09
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.695 Å)
主引用文献Alpha Beta Peptide Foldamers Targeting Intracellular Protein-Protein Interactions with Activity on Living Cells
J.Am.Chem.Soc., 137, 2015
3FDL
DownloadVisualize
BU of 3fdl by Molmil
Bim BH3 peptide in complex with Bcl-xL
分子名称: Apoptosis regulator Bcl-X, Bcl-2-like protein 11
著者Fairlie, W.D, Lee, E.F, Smith, B.J, Czabotar, P.E, Colman, P.M.
登録日2008-11-26
公開日2009-03-10
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献High-Resolution Structural Characterization of a Helical alpha/beta-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-x(L)
Angew.Chem.Int.Ed.Engl., 48, 2009
2NL9
DownloadVisualize
BU of 2nl9 by Molmil
Crystal structure of the Mcl-1:Bim BH3 complex
分子名称: Bcl-2-like protein 11, CHLORIDE ION, FUSION PROTEIN CONSISTING OF Induced myeloid leukemia cell differentiation protein Mcl-1 homolog, ...
著者Czabotar, P.E, Colman, P.M.
登録日2006-10-19
公開日2007-03-27
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Structural insights into the degradation of Mcl-1 induced by BH3 domains.
Proc.Natl.Acad.Sci.USA, 104, 2007
4QVF
DownloadVisualize
BU of 4qvf by Molmil
Crystal structure of Bcl-xL in complex with BIM BH3 domain
分子名称: Bcl-2-like protein 1, Peptide from Bcl-2-like protein 11
著者Sreekanth, R, Yoon, H.S.
登録日2014-07-15
公開日2015-06-10
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.531 Å)
主引用文献Bh3 induced conformational changes in Bcl-Xl revealed by crystal structure and comparative analysis.
Proteins, 83, 2015
2K7W
DownloadVisualize
BU of 2k7w by Molmil
BAX Activation is Initiated at a Novel Interaction Site
分子名称: Apoptosis regulator BAX, Bcl-2-like protein 11
著者Gavathiotis, E, Suzuki, M, Davis, M.L, Pitter, K, Bird, G.H, Katz, S.G, Tu, H.C, Kim, H, Cheng, E.H, Tjandra, N, Walensky, L.D.
登録日2008-08-27
公開日2008-10-21
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献BAX activation is initiated at a novel interaction site.
Nature, 455, 2008
5AGX
DownloadVisualize
BU of 5agx by Molmil
Bcl-2 alpha beta-1 LINEAR complex
分子名称: APOPTOSIS REGULATOR BCL-2, BCL-2-LIKE PROTEIN 1, BCL-2-LIKE PROTEIN 11
著者Smith, B.J, F Lee, E, Checco, J.W, Gellman, S.H, Fairlie, W.D.
登録日2015-02-04
公開日2015-09-09
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.24 Å)
主引用文献Alpha Beta Peptide Foldamers Targeting Intracellular Protein-Protein Interactions with Activity on Living Cells
J.Am.Chem.Soc., 137, 2015
5C3G
DownloadVisualize
BU of 5c3g by Molmil
Crystal structure of Bcl-xl bound to BIM-MM
分子名称: Bcl-2-like protein 1,Bcl-2-like protein 1, Bcl-2-like protein 11
著者Miles, J.A, Yeo, D.J, Rowell, P, Rodriguez-Marin, S, Pask, C.M, Warriner, S.L, Edwards, T.A, Wilson, A.J.
登録日2015-06-17
公開日2016-04-20
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Hydrocarbon constrained peptides - understanding preorganisation and binding affinity.
Chem Sci, 7, 2016
6QFI
DownloadVisualize
BU of 6qfi by Molmil
Structure of human Mcl-1 in complex with BIM BH3 peptide
分子名称: Bcl-2-like protein 11, Induced myeloid leukemia cell differentiation protein Mcl-1, ZINC ION
著者Dokurno, P, Murray, J, Davidson, J, Chen, I, Davis, B, Graham, C.J, Harris, R, Jordan, A.M, Matassova, N, Pedder, C, Ray, S, Roughley, S, Smith, J, Walmsley, C, Wang, Y, Whitehead, N, Williamson, D.S, Casara, P, Le Diguarher, T, Hickman, J, Stark, J, Kotschy, A, Geneste, O, Hubbard, R.E.
登録日2019-01-10
公開日2019-06-12
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1.
Acs Omega, 4, 2019
6RJP
DownloadVisualize
BU of 6rjp by Molmil
Bfl-1 in complex with alpha helical peptide
分子名称: Bcl-2-like protein 11, Bcl-2-related protein A1
著者Baggio, C, Gambini, L, Udompholkul, P, Salem, A.F, Hakansson, M, Jossart, J, Perry, J, Pellecchia, M.
登録日2019-04-29
公開日2019-10-30
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.57 Å)
主引用文献N-locking stabilization of covalent helical peptides: Application to Bfl-1 antagonists.
Chem.Biol.Drug Des., 95, 2020
2V6Q
DownloadVisualize
BU of 2v6q by Molmil
Crystal Structure of a BHRF-1 : Bim BH3 complex
分子名称: BCL-2-LIKE PROTEIN 11, BHRF1 PROTEIN, BROMIDE ION
著者Kvansakul, M, Huang, D.C.S, Colman, P.M.
登録日2007-07-20
公開日2008-08-19
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural Basis for Apoptosis Inhibition by Epstein-Barr Virus Bhrf1.
Plos Pathog., 6, 2010
2YQ7
DownloadVisualize
BU of 2yq7 by Molmil
Structure of Bcl-xL bound to BimLOCK
分子名称: BCL-2-LIKE PROTEIN 1, BCL-2-LIKE PROTEIN 11, GLYCEROL
著者Smith, B.J, Czabotar, P.E.
登録日2012-11-06
公開日2012-11-28
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.901 Å)
主引用文献Stabilizing the Pro-Apoptotic Bimbh3 Helix (Bimsahb) Does not Necessarily Enhance Affinity or Biological Activity.
Acs Chem.Biol., 8, 2013
2WH6
DownloadVisualize
BU of 2wh6 by Molmil
Crystal structure of anti-apoptotic BHRF1 in complex with the Bim BH3 domain
分子名称: BCL-2-LIKE PROTEIN 11, BROMIDE ION, EARLY ANTIGEN PROTEIN R, ...
著者Kvansakul, M, Huang, D.C.S, Colman, P.M.
登録日2009-05-01
公開日2010-05-26
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural basis for apoptosis inhibition by Epstein-Barr virus BHRF1.
PLoS Pathog., 6, 2010
2YQ6
DownloadVisualize
BU of 2yq6 by Molmil
Structure of Bcl-xL bound to BimSAHB
分子名称: BCL-2-LIKE PROTEIN 1, BIM BETA 5, GLYCEROL
著者Smith, B.J, Czabotar, P.E.
登録日2012-11-06
公開日2012-11-28
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.799 Å)
主引用文献Stabilizing the Pro-Apoptotic Bimbh3 Helix (Bimsahb) Does not Necessarily Enhance Affinity or Biological Activity.
Acs Chem.Biol., 8, 2013
4A1U
DownloadVisualize
BU of 4a1u by Molmil
Crystal structure of alpha-beta-foldamer 2c in complex with Bcl-xL
分子名称: ALPHA-BETA-FOLDAMER 2C, BCL-2-LIKE PROTEIN 1, CHLORIDE ION, ...
著者Boersma, M.D, Haase, H.S, Kaufman, K.J, Horne, W.S, Lee, E.F, Clarke, O.B, Smith, B.J, Colman, P.M, Gellman, S.H, Fairlie, W.D.
登録日2011-09-20
公開日2011-12-28
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.54 Å)
主引用文献Evaluation of Diverse Alpha/Beta-Backbone Patterns for Functional Alpha-Helix Mimicry: Analogues of the Bim Bh3 Domain.
J.Am.Chem.Soc., 134, 2012
4A1W
DownloadVisualize
BU of 4a1w by Molmil
Crystal structure of alpha-beta foldamer 4c in complex with Bcl-xL
分子名称: ALPHA-BETA-FOLDAMER 2C, BCL-2-LIKE PROTEIN 1
著者Boersma, M.D, Haase, H.S, Kaufman, K.J, Horne, W.S, Lee, E.F, Clarke, O.B, Smith, B.J, Colman, P.M, Gellman, S.H, Fairlie, W.D.
登録日2011-09-20
公開日2011-12-28
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.497 Å)
主引用文献Evaluation of Diverse Alpha/Beta-Backbone Patterns for Functional Alpha-Helix Mimicry: Analogues of the Bim Bh3 Domain.
J.Am.Chem.Soc., 134, 2012
2VM6
DownloadVisualize
BU of 2vm6 by Molmil
Human Bcl2-A1 in complex with Bim-BH3 peptide
分子名称: BCL-2-LIKE PROTEIN 11, BCL-2-RELATED PROTEIN A1, SULFATE ION
著者Herman, M.D, Lehtio, L, Arrowsmith, C.H, Berglund, H, Busam, R.D, Collins, R, Dahlgren, L.G, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, I, Kallas, A, Karlberg, T, Kotenyova, T, Moche, M, Nilsson, M.E, Nyman, T, Persson, C, Sagemark, J, Svensson, L, Thorsell, A.G, Tresaugues, L, van den Berg, S, Weigelt, J, Welin, M, Nordlund, P, Structural Genomics Consortium (SGC)
登録日2008-01-23
公開日2008-02-05
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Completing the Family Portrait of the Anti- Apoptotic Bcl-2 Proteins: Crystal Structure of Human Bfl-1 in Complex with Bim.
FEBS Lett., 582, 2008
4B4S
DownloadVisualize
BU of 4b4s by Molmil
Crystal Structure of a pro-survival Bcl-2:Bim BH3 complex
分子名称: BCL-2-LIKE PROTEIN 10, BCL-2-LIKE PROTEIN 11, TETRAETHYLENE GLYCOL
著者Rautureau, G.J.P, Hinds, M.G, Kvansakul, M.
登録日2012-08-01
公開日2013-01-16
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The Restricted Binding Repertoire of Bcl-B Leaves Bim as the Universal Bh3-Only Prosurvival Bcl-2 Protein Antagonist.
Cell Death Dis., 3, 2012
3D7V
DownloadVisualize
BU of 3d7v by Molmil
Crystal structure of Mcl-1 in complex with an Mcl-1 selective BH3 ligand
分子名称: Bcl-2-like protein 11, Induced myeloid leukemia cell differentiation protein Mcl-1, ZINC ION
著者Lee, E.F, Czabotar, P.E, Colman, P.M, Fairlie, W.D.
登録日2008-05-22
公開日2008-06-24
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation.
J.Cell Biol., 180, 2008
6UA3
DownloadVisualize
BU of 6ua3 by Molmil
Human Mcl-1 in complex with a modified Bim BH3 peptide
分子名称: Induced myeloid leukemia cell differentiation protein Mcl-1, modified Bim BH3 peptide
著者Mandal, T, Grant, R.A, Keating, A.E.
登録日2019-09-10
公開日2020-09-16
実験手法X-RAY DIFFRACTION (1.552 Å)
主引用文献Inhibitor peptides against Mcl-1 containing non-natural amino acids show potent apoptotic response.
To Be Published

 

12>

225399

件を2024-09-25に公開中

PDB statisticsPDBj update infoContact PDBjnumon