PDB: 18 件ウェブページステータス検索Chemie searchBIRD

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2E6I	Solution structure of the BTK motif of tyrosine-protein kinase ITK from human 分子名称: Tyrosine-protein kinase ITK/TSK, ZINC ION 著者 Li, H, Tochio, N, Koshiba, S, Watanabe, S, Harada, T, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2006-12-27 公開日 2007-07-03 最終更新日 2022-03-09 実験手法 SOLUTION NMR 主引用文献 Solution structure of the BTK motif of tyrosine-protein kinase ITK from human To be Published
2YS2	Solution structure of the BTK motif of human Cytoplasmic tyrosine-protein kinase BMX 分子名称: Cytoplasmic tyrosine-protein kinase BMX, ZINC ION 著者 Abe, H, Tochio, N, Tomizawa, T, Koshiba, S, Yoneyama, M, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2007-04-03 公開日 2007-10-09 最終更新日 2022-03-16 実験手法 SOLUTION NMR 主引用文献 Solution structure of the BTK motif of human Cytoplasmic tyrosine-protein kinase BMX To be Published
6TVN	Crystal Structure of 5-bromoindoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase 分子名称: 5-bromanyl-1,3-dihydroindol-2-one, MAGNESIUM ION, Tyrosine-protein kinase BTK, ... 著者 Brear, P, Wagstaff, J, Hyvonen, M. 登録日 2020-01-10 公開日 2020-11-25 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 Crystal Structure of 1-methylindoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C To Be Published
2LUL	Solution NMR Structure of PH Domain of Tyrosine-protein kinase Tec from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR3504C 分子名称: Tyrosine-protein kinase Tec, ZINC ION 著者 Liu, G, Xiao, R, Janjua, H, Hamilton, K, Shastry, R, Kohan, E, Acton, T.B, Everett, J.K, Lee, H, Pederson, K, Huang, Y.J, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) 登録日 2012-06-15 公開日 2012-08-15 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Solution NMR Structure of PH Domain of Tyrosine-protein kinase Tec from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR3504C To be Published
8GMB	Crystal structure of the full-length Bruton's tyrosine kinase (PH-TH domain not visible) 分子名称: 2-[3'-(hydroxymethyl)-1-methyl-5-({5-[(2S)-2-methyl-4-(oxetan-3-yl)piperazin-1-yl]pyridin-2-yl}amino)-6-oxo[1,6-dihydro[3,4'-bipyridine]]-2'-yl]-7,7-dimethyl-3,4,7,8-tetrahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one, Tyrosine-protein kinase BTK 著者 Lin, D.Y, Andreotti, A.H. 登録日 2023-03-24 公開日 2023-08-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states. Elife, 12, 2024
8S93	Crystal structure of the PH-TH/kinase complex of Bruton's tyrosine kinase 分子名称: 2-[3'-(hydroxymethyl)-1-methyl-5-({5-[(2S)-2-methyl-4-(oxetan-3-yl)piperazin-1-yl]pyridin-2-yl}amino)-6-oxo[1,6-dihydro[3,4'-bipyridine]]-2'-yl]-7,7-dimethyl-3,4,7,8-tetrahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one, GLYCEROL, Tyrosine-protein kinase BTK, ... 著者 Lin, D.Y, Andreotti, A.H. 登録日 2023-03-27 公開日 2023-08-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states. Elife, 12, 2024
4Y94	Crystal structure of the PH-TH module of Bruton's tyrosine kinase bound to inositol hexakisphosphate 分子名称: INOSITOL HEXAKISPHOSPHATE, Non-specific protein-tyrosine kinase, ZINC ION 著者 Wang, Q, Kuriyan, J. 登録日 2015-02-16 公開日 2015-03-18 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate. Elife, 4, 2015
4Y93	Crystal structure of the PH-TH-kinase construct of Bruton's tyrosine kinase (Btk) 分子名称: 4-tert-butyl-N-[2-methyl-3-(4-methyl-6-{[4-(morpholin-4-ylcarbonyl)phenyl]amino}-5-oxo-4,5-dihydropyrazin-2-yl)phenyl]benzamide, CALCIUM ION, Non-specific protein-tyrosine kinase,Non-specific protein-tyrosine kinase, ... 著者 Wang, Q, Kuriyan, J. 登録日 2015-02-16 公開日 2015-03-18 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.695 Å) 主引用文献 Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate. Elife, 4, 2015
2Z0P	Crystal structure of PH domain of Bruton's tyrosine kinase 分子名称: (2R)-3-{[(S)-{[(2S,3R,5S,6S)-2,6-DIHYDROXY-3,4,5-TRIS(PHOSPHONOOXY)CYCLOHEXYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-(1-HYDROXY BUTOXY)PROPYL BUTYRATE, Tyrosine-protein kinase BTK, ZINC ION 著者 Murayama, K, Kato-Murayama, M, Mishima, C, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2007-05-07 公開日 2008-05-13 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.58 Å) 主引用文献 Crystal structure of the Bruton's tyrosine kinase PH domain with phosphatidylinositol Biochem.Biophys.Res.Commun., 377, 2008
1B55	PH DOMAIN FROM BRUTON'S TYROSINE KINASE IN COMPLEX WITH INOSITOL 1,3,4,5-TETRAKISPHOSPHATE 分子名称: INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, TYROSINE-PROTEIN KINASE BTK, ZINC ION 著者 Djinovic Carugo, K, Baraldi, E, Hyvoenen, M, Lo Surdo, P, Riley, A.M, Potter, B.V.L, O'Brien, R, Ladbury, J.E, Saraste, M. 登録日 1999-01-12 公開日 1999-06-15 最終更新日 2023-08-02 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphate. Structure Fold.Des., 7, 1999
1BWN	PH DOMAIN AND BTK MOTIF FROM BRUTON'S TYROSINE KINASE MUTANT E41K IN COMPLEX WITH INS(1,3,4,5)P4 分子名称: BRUTON'S TYROSINE KINASE, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, ZINC ION 著者 Djinovic Carugo, K, Baraldi, E, Hyvoenen, M, Lo Surdo, P, Riley, A, Potter, B, Saraste, M. 登録日 1998-09-25 公開日 1999-06-15 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphate. Structure Fold.Des., 7, 1999
1BTK	PH DOMAIN AND BTK MOTIF FROM BRUTON'S TYROSINE KINASE MUTANT R28C 分子名称: BRUTON'S TYROSINE KINASE, SODIUM ION, ZINC ION 著者 Hyvonen, M, Saraste, M. 登録日 1997-07-01 公開日 1997-09-17 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structure of the PH domain and Btk motif from Bruton's tyrosine kinase: molecular explanations for X-linked agammaglobulinaemia. EMBO J., 16, 1997
6YYK	Crystal Structure of 1,5-dimethylindoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C 分子名称: 1,5-dimethyl-3~{H}-indol-2-one, MAGNESIUM ION, Tyrosine-protein kinase BTK, ... 著者 Brear, P, Wagstaff, J, Hyvonen, M. 登録日 2020-05-05 公開日 2021-05-12 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 Optimising crystallographic systems for structure-guided drug discovery To Be Published
6YYF	Crystal Structure of 5-chloroindoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C 分子名称: 5-chloranyl-1,3-dihydroindol-2-one, MAGNESIUM ION, Tyrosine-protein kinase BTK, ... 著者 Brear, P, Wagstaff, J, Hyvonen, M. 登録日 2020-05-05 公開日 2021-05-12 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Optimising crystallographic systems for structure-guided drug discovery To Be Published
6YYG	Crystal Structure of 5-(trifluoromethoxy)indoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C 分子名称: 5-(trifluoromethyloxy)-1,3-dihydroindol-2-one, MAGNESIUM ION, Tyrosine-protein kinase BTK, ... 著者 Brear, P, Wagstaff, J, Hyvonen, M. 登録日 2020-05-05 公開日 2021-05-12 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Optimising crystallographic systems for structure-guided drug discovery To Be Published
6TT2	The PH domain of Bruton's tyrosine kinase mutant R28C 分子名称: MAGNESIUM ION, Tyrosine-protein kinase BTK, ZINC ION 著者 Brear, P, Wagstaff, J, Hyvonen, M. 登録日 2019-12-23 公開日 2020-11-25 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.36 Å) 主引用文献 Crystal Structure of 1-methylindoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C To Be Published
6TSE	Crystal Structure of 1-methylindoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C 分子名称: 1-methylindole-2,3-dione, MAGNESIUM ION, Tyrosine-protein kinase BTK, ... 著者 Brear, P, Wagstaff, J, Hyvonen, M. 登録日 2019-12-20 公開日 2020-11-25 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.41 Å) 主引用文献 Crystal Structure of 1-methylindoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C To Be Published
6TUH	The PH domain of Bruton's tyrosine kinase mutant R28C 分子名称: 4,5,6,7-tetrahydro-1-benzofuran-3-carboxylic acid, MAGNESIUM ION, Tyrosine-protein kinase BTK, ... 著者 Brear, P, Wagstaff, J, Hyvonen, M. 登録日 2020-01-07 公開日 2020-11-25 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Crystal Structure of 1-methylindoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C To Be Published