2Z0P

Crystal structure of PH domain of Bruton's tyrosine kinase

Summary for 2Z0P

DescriptorTyrosine-protein kinase BTK, ZINC ION, (2R)-3-{[(S)-{[(2S,3R,5S,6S)-2,6-DIHYDROXY-3,4,5-TRIS(PHOSPHONOOXY)CYCLOHEXYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-(1-HYDROXYBUTOXY)PROPYL BUTYRATE, ... (4 entities in total)
Functional Keywordsph domain, pip3c4, atp-binding, disease mutation, kinase, membrane, metal-binding, nucleotide-binding, nucleus, phosphorylation, sh2 domain, sh3 domain, transferase, tyrosine-protein kinase, zinc-finger, signaling protein, structural genomics, nppsfa, national project on protein structural and functional analyses, riken structural genomics/proteomics initiative, rsgi
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm Q06187
Total number of polymer chains4
Total molecular weight83059.09
Authors
Murayama, K.,Kato-Murayama, M.,Mishima, C.,Shirouzu, M.,Yokoyama, S.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (deposition date: 2007-05-07, release date: 2008-05-13, Last modification date: 2015-07-08)
Primary citation
Murayama, K.,Kato-Murayama, M.,Mishima, C.,Akasaka, R.,Shirouzu, M.,Fukui, Y.,Yokoyama, S.
Crystal structure of the Bruton's tyrosine kinase PH domain with phosphatidylinositol
Biochem.Biophys.Res.Commun., 377:23-28, 2008
PubMed: 18809383 (PDB entries with the same primary citation)
DOI: 10.1016/j.bbrc.2008.09.055
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.58 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.296221.3%4.2%12.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2z0p
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Molmil generated image of 2z0p
rotated about x axis by 90°
Molmil generated image of 2z0p
rotated about y axis by 90°

More Biological unit images

Molmil generated image of 2z0p
no rotation
Molmil generated image of 2z0p
rotated about x axis by 90°
Molmil generated image of 2z0p
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (2z0p.pdb4.gz [31.42 KB])
Coordinate files for Biological unit (2z0p.pdb1.gz [30.46 KB])
Coordinate files for Biological unit (2z0p.pdb3.gz [29.61 KB])
Coordinate files for Biological unit (2z0p.pdb5.gz [58.73 KB])
Coordinate files for Biological unit (2z0p.pdb2.gz [31.52 KB])
Coordinate files for Biological unit (2z0p.pdb6.gz [57.73 KB])