2Z0P

Crystal structure of PH domain of Bruton's tyrosine kinase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0035556	biological_process	intracellular signal transduction
B	0035556	biological_process	intracellular signal transduction
C	0035556	biological_process	intracellular signal transduction
D	0035556	biological_process	intracellular signal transduction

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 301

Chain	Residue
A	HIS143
A	CYS154
A	CYS155
A	CYS165

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 302

Chain	Residue
B	HIS143
B	CYS154
B	CYS155
B	CYS165

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN C 303

Chain	Residue
C	TYR152
C	CYS154
C	CYS155
C	CYS165
C	HIS143

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 304

Chain	Residue
D	HIS143
D	CYS154
D	CYS155
D	CYS165

---

site_id	AC5
Number of Residues	13
Details	BINDING SITE FOR RESIDUE 4PT A 501

Chain	Residue
A	LYS12
A	SER14
A	GLN15
A	GLN16
A	LYS17
A	LYS18
A	SER21
A	PRO22
A	ASN24
A	LYS26
A	ARG28
A	TYR39
A	LYS53

---

site_id	AC6
Number of Residues	13
Details	BINDING SITE FOR RESIDUE 4PT B 502

Chain	Residue
B	LYS12
B	SER14
B	GLN15
B	GLN16
B	LYS17
B	LYS18
B	THR20
B	SER21
B	PRO22
B	ASN24
B	ARG28
B	TYR39
B	LYS53

---

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE 4PT C 503

Chain	Residue
C	LYS12
C	SER14
C	GLN15
C	GLN16
C	LYS17
C	ASN24
C	ARG28
C	TYR39
C	LYS53

---

site_id	AC8
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 4PT D 504

Chain	Residue
D	LYS12
D	SER14
D	GLN15
D	LYS17
D	LYS18
D	SER21
D	PRO22
D	ASN24
D	ARG28
D	TYR39
D	LYS53

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	36
Details	Region: {"description":"Inositol-(1,3,4,5)-tetrakisphosphate 1-binding"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10196129","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00432","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10196129","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9218782","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAY-2007","submissionDatabase":"PDB data bank","title":"Crystal structure of PH domain of Bruton's tyrosine kinase.","authors":["Murayama K.","Kato-Murayama M.","Mishima C.","Shirouzu M.","Yokoyama S."]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"NOV-2005","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Claeys D."]}},{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	7
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"16644721","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P35991","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---