1BWN

PH DOMAIN AND BTK MOTIF FROM BRUTON'S TYROSINE KINASE MUTANT E41K IN COMPLEX WITH INS(1,3,4,5)P4

Summary for 1BWN

Entry DOI	10.2210/pdb1bwn/pdb
Descriptor	BRUTON'S TYROSINE KINASE, ZINC ION, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, ... (4 entities in total)
Functional Keywords	transferase, ph domain, btk motif, inositol-(1, 3, 4, 5)-tetrakisphosphate, zinc binding, x-linked agammaglobulinemia, tyrosine-protein kinase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm (By similarity): Q06187
Total number of polymer chains	2
Total formula weight	42097.27
Authors	Djinovic Carugo, K.,Baraldi, E.,Hyvoenen, M.,Lo Surdo, P.,Riley, A.,Potter, B.,Saraste, M. (deposition date: 1998-09-25, release date: 1999-06-15, Last modification date: 2024-04-03)
Primary citation	Baraldi, E.,Carugo, K.D.,Hyvonen, M.,Surdo, P.L.,Riley, A.M.,Potter, B.V.,O'Brien, R.,Ladbury, J.E.,Saraste, M. Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphate. Structure Fold.Des., 7:449-460, 1999 Cited by PubMed: 10196129 DOI: 10.1016/S0969-2126(99)80057-4 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation