1BWN
PH DOMAIN AND BTK MOTIF FROM BRUTON'S TYROSINE KINASE MUTANT E41K IN COMPLEX WITH INS(1,3,4,5)P4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | BRUTON'S TYROSINE KINASE | polymer | 169 | 19983.1 | 2 | UniProt (Q06187) Pfam (PF00169) Pfam (PF00779) | Homo sapiens (human) | BRUTON'S AGAMMAGLOBULINEMIA TYROSINE KINASE, BTK |
| 2 | C, F (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, E, G, H (A, B) | INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE | non-polymer | 500.1 | 4 | Chemie (4IP) | |||
| 4 | I, J (A, B) | water | water | 18.0 | 273 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 170 (UniProt: Q06187)
| PDB | External Database | Details |
|---|---|---|
| Lys 41 | Glu 41 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 39966.2 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 2131.1 | |
| All* | Total formula weight | 42097.3 |
