4WA8
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4Q0W
| he catalytic core of Rad2 in complex with DNA substrate (complex II) | 分子名称: | CALCIUM ION, DNA (5'-D(*TP*TP*AP*GP*GP*TP*GP*GP*AP*CP*GP*GP*AP*TP*CP*AP*TP*T)-3'), DNA (5'-D(*TP*TP*TP*GP*AP*TP*CP*CP*GP*TP*CP*CP*AP*CP*CP*TP*TP*T)-3'), ... | 著者 | Mietus, M, Nowak, E, Jaciuk, M, Kustosz, P, Nowotny, M. | 登録日 | 2014-04-02 | 公開日 | 2014-08-27 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structure of the catalytic core of Rad2: insights into the mechanism of substrate binding. Nucleic Acids Res., 42, 2014
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1MC8
| Crystal Structure of Flap Endonuclease-1 R42E mutant from Pyrococcus horikoshii | 分子名称: | Flap Endonuclease-1 | 著者 | Matsui, E, Musti, K.V, Abe, J, Yamazaki, K, Matsui, I, Harata, K. | 登録日 | 2002-08-06 | 公開日 | 2002-10-16 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Molecular Structure and Novel DNA Binding Sites Located in Loops of Flap Endonuclease-1 from Pyrococcus horikoshii J.BIOL.CHEM., 277, 2002
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5K97
| Flap endonuclease 1 (FEN1) D233N with cleaved product fragment and Sm3+ | 分子名称: | 1,2-ETHANEDIOL, DNA (5'-D(*AP*CP*CP*GP*TP*CP*C)-3'), DNA (5'-D(*AP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*T)-3'), ... | 著者 | Tsutakawa, S.E, Arvai, A.S, Tainer, J.A. | 登録日 | 2016-05-31 | 公開日 | 2017-06-28 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.102 Å) | 主引用文献 | Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability. Nat Commun, 8, 2017
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5KSE
| Flap endonuclease 1 (FEN1) R100A with 5'-flap substrate DNA and Sm3+ | 分子名称: | DNA (5'-D(*AP*CP*CP*GP*TP*CP*C)-3'), DNA (5'-D(*AP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*T)-3'), DNA (5'-D(P*TP*AP*AP*TP*TP*GP*AP*GP*GP*CP*AP*GP*AP*GP*T)-3'), ... | 著者 | Tsutakawa, S.E, Arvai, A.S, Tainer, J.A. | 登録日 | 2016-07-08 | 公開日 | 2017-06-28 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.105 Å) | 主引用文献 | Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability. Nat Commun, 8, 2017
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6TUR
| human XPG, Apo1 form | 分子名称: | DNA repair protein complementing XP-G cells,DNA repair protein complementing XP-G cells | 著者 | Ruiz, F.M, Fernandez-Tornero, C. | 登録日 | 2020-01-08 | 公開日 | 2020-09-16 | 最終更新日 | 2020-10-07 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | The crystal structure of human XPG, the xeroderma pigmentosum group G endonuclease, provides insight into nucleotide excision DNA repair. Nucleic Acids Res., 48, 2020
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1RXV
| Crystal Structure of A. Fulgidus FEN-1 bound to DNA | 分子名称: | 5'-d(*T*pA*pG*pC*pA*pT*pC*pG*pG), Flap structure-specific endonuclease | 著者 | Chapados, B.R, Hosfield, D.J, Han, S, Qiu, J, Yelent, B, Shen, B, Tainer, J.A. | 登録日 | 2003-12-18 | 公開日 | 2004-01-27 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural Basis for FEN-1 Substrate Specificity and PCNA-Mediated Activation in DNA Replication and Repair Cell(Cambridge,Mass.), 116, 2004
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1RXW
| Crystal structure of A. fulgidus FEN-1 bound to DNA | 分子名称: | 5'-d(*C*pG*pA*pT*pG*pC*pT*pA)-3', 5'-d(*T*pA*pG*pC*pA*pT*pC*pG*pG)-3', Flap structure-specific endonuclease | 著者 | Chapados, B.R, Hosfield, D.J, Han, S, Qiu, J, Yelent, B, Shen, B, Tainer, J.A. | 登録日 | 2003-12-18 | 公開日 | 2004-01-27 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural Basis for FEN-1 Substrate Specificity and PCNA-Mediated Activation in DNA Replication and Repair Cell(Cambridge,Mass.), 116, 2004
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1A77
| FLAP ENDONUCLEASE-1 FROM METHANOCOCCUS JANNASCHII | 分子名称: | FLAP ENDONUCLEASE-1 PROTEIN, MAGNESIUM ION | 著者 | Hwang, K.Y, Baek, K, Kim, H, Cho, Y. | 登録日 | 1998-03-20 | 公開日 | 1999-08-03 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The crystal structure of flap endonuclease-1 from Methanococcus jannaschii. Nat.Struct.Biol., 5, 1998
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1A76
| FLAP ENDONUCLEASE-1 FROM METHANOCOCCUS JANNASCHII | 分子名称: | FLAP ENDONUCLEASE-1 PROTEIN, MANGANESE (II) ION | 著者 | Hwang, K.Y, Baek, K, Kim, H, Cho, Y. | 登録日 | 1998-03-20 | 公開日 | 1999-08-03 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The crystal structure of flap endonuclease-1 from Methanococcus jannaschii. Nat.Struct.Biol., 5, 1998
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1B43
| FEN-1 FROM P. FURIOSUS | 分子名称: | PROTEIN (FEN-1) | 著者 | Hosfield, D.J, Mol, C.D, Shen, B, Tainer, J.A. | 登録日 | 1999-01-05 | 公開日 | 2000-01-12 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activity. Cell(Cambridge,Mass.), 95, 1998
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5CNQ
| Crystal structure of the Holliday junction-resolving enzyme GEN1 (WT) in complex with product DNA, Mg2+ and Mn2+ ions | 分子名称: | DNA (5'-D(*TP*GP*AP*GP*CP*GP*GP*TP*GP*GP*TP*TP*GP*GP*T)-3'), MANGANESE (II) ION, Nuclease-like protein, ... | 著者 | Liu, Y.J, Freeman, A.D.J, Declais, A.C, Wilson, T.J, Gartner, A, Lilley, D.M.J. | 登録日 | 2015-07-17 | 公開日 | 2015-12-30 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.602 Å) | 主引用文献 | Crystal Structure of a Eukaryotic GEN1 Resolving Enzyme Bound to DNA. Cell Rep, 13, 2015
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5CO8
| Crystal structure of the Holliday junction-resolving enzyme GEN1 (WT) in complex with product DNA and Mg2+ ion | 分子名称: | DNA (31-MER), DNA (5'-D(*AP*GP*AP*CP*TP*GP*CP*AP*GP*TP*TP*GP*AP*GP*TP*C)-3'), DNA (5'-D(*TP*GP*AP*GP*CP*GP*GP*TP*GP*GP*TP*TP*GP*GP*A)-3'), ... | 著者 | Liu, Y.J, Freeman, A.D.J, Declais, A.C, Wilson, T.J, Gartner, A, Lilley, D.M.J. | 登録日 | 2015-07-20 | 公開日 | 2016-01-13 | 最終更新日 | 2018-11-21 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal Structure of a Eukaryotic GEN1 Resolving Enzyme Bound to DNA. Cell Rep, 13, 2015
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6GRC
| eukaryotic junction-resolving enzyme GEN-1 binding with Sodium | 分子名称: | DNA (5'-D(*TP*AP*CP*CP*CP*AP*CP*CP*AP*CP*CP*GP*CP*TP*CP*A)-3'), DNA (5'-D(*TP*GP*AP*GP*CP*GP*GP*TP*GP*GP*TP*TP*GP*GP*T)-3'), MAGNESIUM ION, ... | 著者 | Lilley, D.M.J, Liu, Y, Freeman, D.J. | 登録日 | 2018-06-11 | 公開日 | 2018-09-26 | 最終更新日 | 2019-02-13 | 実験手法 | X-RAY DIFFRACTION (2.452 Å) | 主引用文献 | A monovalent ion in the DNA binding interface of the eukaryotic junction-resolving enzyme GEN1. Nucleic Acids Res., 46, 2018
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6GRD
| eukaryotic junction-resolving enzyme GEN-1 binding with Cesium | 分子名称: | CESIUM ION, DNA (5'-D(*TP*AP*CP*CP*CP*AP*CP*CP*AP*CP*CP*GP*CP*TP*CP*A)-3'), DNA (5'-D(*TP*GP*AP*GP*CP*GP*GP*TP*GP*GP*TP*TP*GP*GP*T)-3'), ... | 著者 | Lilley, D.M.J, Liu, Y, Freeman, D.J. | 登録日 | 2018-06-11 | 公開日 | 2018-09-26 | 最終更新日 | 2018-11-28 | 実験手法 | X-RAY DIFFRACTION (2.66 Å) | 主引用文献 | A monovalent ion in the DNA binding interface of the eukaryotic junction-resolving enzyme GEN1. Nucleic Acids Res., 46, 2018
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6GRB
| eukaryotic junction-resolving enzyme GEN-1 binding with Potassium | 分子名称: | DNA (5'-D(*TP*AP*CP*CP*CP*AP*CP*CP*AP*CP*CP*GP*CP*TP*CP*A)-3'), DNA (5'-D(*TP*GP*AP*GP*CP*GP*GP*TP*GP*GP*TP*TP*GP*GP*T)-3'), MAGNESIUM ION, ... | 著者 | Lilley, D.M.J, Liu, Y, Freeman, D.J. | 登録日 | 2018-06-11 | 公開日 | 2018-09-26 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | A monovalent ion in the DNA binding interface of the eukaryotic junction-resolving enzyme GEN1. Nucleic Acids Res., 46, 2018
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5FV7
| Human Fen1 in complex with an N-hydroxyurea compound | 分子名称: | 1-[(2S)-2,3-dihydro-1,4-benzodioxin-2-ylmethyl]-3-hydroxythieno[3,2-d]pyrimidine-2,4(1H,3H)-dione, FLAP ENDONUCLEASE 1, MAGNESIUM ION | 著者 | Exell, J.C, Thompson, M.J, Finger, L.D, Shaw, S.K, Abbott, W.M, McWhirter, C, Debreczeni, J.E, Jones, C.D, Nissink, J.W.M, Ward, T.A, Sioberg, C.W.L, Molina, D.M, Durant, S.T, Grasby, J.A. | 登録日 | 2016-02-03 | 公開日 | 2016-08-17 | 最終更新日 | 2017-08-23 | 実験手法 | X-RAY DIFFRACTION (2.84 Å) | 主引用文献 | Cellular Active N-Hydroxyurea Fen1 Inhibitors Block Substrate Entry to the Active Site Nat.Chem.Biol., 12, 2016
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4Q10
| The catalytic core of Rad2 in complex with DNA substrate (complex IV) | 分子名称: | CALCIUM ION, DNA (5'-D(*TP*TP*TP*TP*CP*TP*GP*AP*GP*AP*CP*AP*AP*GP*GP*GP*AP*GP*CP*TP*TP*TP*T)-3'), DNA (5'-D(*TP*TP*TP*TP*GP*CP*TP*CP*CP*CP*TP*TP*GP*TP*CP*TP*CP*AP*GP*TP*TP*TP*T)-3'), ... | 著者 | Mietus, M, Nowak, E, Jaciuk, M, Kustosz, P, Nowotny, M. | 登録日 | 2014-04-02 | 公開日 | 2014-08-27 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Crystal structure of the catalytic core of Rad2: insights into the mechanism of substrate binding. Nucleic Acids Res., 42, 2014
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4Q0R
| The catalytic core of Rad2 (complex I) | 分子名称: | DNA (5'-D(*CP*TP*GP*AP*GP*TP*CP*AP*GP*AP*GP*CP*AP*AP*A)-3'), DNA repair protein RAD2 | 著者 | Mietus, M, Nowak, E, Jaciuk, M, Kustosz, P, Nowotny, M. | 登録日 | 2014-04-02 | 公開日 | 2014-08-27 | 最終更新日 | 2017-08-09 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Crystal structure of the catalytic core of Rad2: insights into the mechanism of substrate binding. Nucleic Acids Res., 42, 2014
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4Q0Z
| The catalytic core of Rad2 in complex with DNA substrate (complex III) | 分子名称: | CALCIUM ION, DNA (5'-D(*TP*CP*TP*GP*AP*GP*AP*CP*AP*AP*GP*GP*GP*AP*GP*CP*T)-3'), DNA (5'-D(*TP*GP*CP*TP*CP*CP*CP*TP*TP*GP*TP*CP*TP*CP*AP*GP*T)-3'), ... | 著者 | Mietus, M, Nowak, E, Jaciuk, M, Kustosz, P, Nowotny, M. | 登録日 | 2014-04-02 | 公開日 | 2014-08-27 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.398 Å) | 主引用文献 | Crystal structure of the catalytic core of Rad2: insights into the mechanism of substrate binding. Nucleic Acids Res., 42, 2014
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6TUX
| human XPG-DNA, Complex 2 | 分子名称: | DNA (5'-D(P*AP*AP*CP*TP*CP*TP*GP*C)-3'), DNA (5'-D(P*GP*CP*AP*GP*AP*GP*TP*T)-3'), DNA repair protein complementing XP-G cells,DNA repair protein complementing XP-G cells | 著者 | Ruiz, F.M, Fernandez-Tornero, C. | 登録日 | 2020-01-08 | 公開日 | 2020-09-16 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | The crystal structure of human XPG, the xeroderma pigmentosum group G endonuclease, provides insight into nucleotide excision DNA repair. Nucleic Acids Res., 48, 2020
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6TUW
| human XPG-DNA, Complex 1 | 分子名称: | DNA (5'-D(P*GP*AP*AP*CP*TP*CP*TP*G)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*AP*GP*TP*TP*C)-3'), DNA repair protein complementing XP-G cells,DNA repair protein complementing XP-G cells | 著者 | Ruiz, F.M, Fernandez-Tornero, C. | 登録日 | 2020-01-08 | 公開日 | 2020-09-16 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | The crystal structure of human XPG, the xeroderma pigmentosum group G endonuclease, provides insight into nucleotide excision DNA repair. Nucleic Acids Res., 48, 2020
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6TUS
| human XPG, Apo2 form | 分子名称: | DNA repair protein complementing XP-G cells,DNA repair protein complementing XP-G cells, GLYCEROL, SULFATE ION | 著者 | Ruiz, F.M, Fernandez-Tornero, C. | 登録日 | 2020-01-08 | 公開日 | 2020-09-16 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | The crystal structure of human XPG, the xeroderma pigmentosum group G endonuclease, provides insight into nucleotide excision DNA repair. Nucleic Acids Res., 48, 2020
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6VBH
| Human XPG endonuclease catalytic domain | 分子名称: | DNA repair protein complementing XP-G cells,Flap endonuclease 1, SULFATE ION | 著者 | Tsutakawa, S.E, Arvai, A.S, Tainer, J.A. | 登録日 | 2019-12-18 | 公開日 | 2020-06-17 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.995 Å) | 主引用文献 | Human XPG nuclease structure, assembly, and activities with insights for neurodegeneration and cancer from pathogenic mutations. Proc.Natl.Acad.Sci.USA, 117, 2020
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5ZOF
| Crystal Structure of D181A/R192F hFen1 in complex with DNA | 分子名称: | DNA (5'-D(*AP*CP*TP*TP*TP*GP*AP*GP*GP*CP*AP*GP*AP*G)-3'), DNA (5'-D(*CP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*G)-3'), DNA (5'-D(*GP*CP*CP*CP*GP*TP*CP*C)-3'), ... | 著者 | Han, W, Hua, Y, Zhao, Y. | 登録日 | 2018-04-13 | 公開日 | 2019-01-30 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.249 Å) | 主引用文献 | Structural basis of 5' flap recognition and protein-protein interactions of human flap endonuclease 1. Nucleic Acids Res., 46, 2018
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