PDB: 12 件ウェブページステータス検索Chemie searchBIRD

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6OUG	Structure of drug-resistant V27A mutant of the influenza M2 proton channel bound to spiroadamantyl amine inhibitor, TM + cytosolic helix construct 分子名称: (1r,1'S,3'S,5'S,7'S)-spiro[cyclohexane-1,2'-tricyclo[3.3.1.1~3,7~]decan]-4-amine, Matrix protein 2 著者 Thomaston, J.L, Liu, L, DeGrado, W.F. 登録日 2019-05-04 公開日 2020-01-15 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.01 Å) 主引用文献 X-ray Crystal Structures of the Influenza M2 Proton Channel Drug-Resistant V27A Mutant Bound to a Spiro-Adamantyl Amine Inhibitor Reveal the Mechanism of Adamantane Resistance. Biochemistry, 59, 2020
6US9	Influenza A M2 proton channel wild type TM domain bound to R-rimantadine 分子名称: CHLORIDE ION, Matrix protein 2, RIMANTADINE 著者 Thomaston, J.L, DeGrado, W.F. 登録日 2019-10-25 公開日 2020-10-28 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Rimantadine Binds to and Inhibits the Influenza A M2 Proton Channel without Enantiomeric Specificity. Biochemistry, 2021
6US8	Influenza A M2 proton channel wild type TM domain bound to S-rimantadine 分子名称: (1S)-1-[(3R,5R,7R)-tricyclo[3.3.1.1~3,7~]decan-1-yl]ethan-1-amine, CHLORIDE ION, Matrix protein 2 著者 Thomaston, J.L, DeGrado, W.F. 登録日 2019-10-25 公開日 2020-10-28 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Rimantadine Binds to and Inhibits the Influenza A M2 Proton Channel without Enantiomeric Specificity. Biochemistry, 2021
2H95	Structure of the Amantadine-Blocked Influenza A M2 Proton Channel Trans-membrane Domain by Solid-state NMR spectroscopy 分子名称: Matrix protein 2 著者 Hu, J, Asbury, T, Cross, T.A. 登録日 2006-06-08 公開日 2007-04-24 最終更新日 2022-03-09 実験手法 SOLID-STATE NMR 主引用文献 Backbone structure of the amantadine-blocked trans-membrane domain m2 proton channel from influenza a virus. Biophys.J., 92, 2007
2KIH	S31N mutant of M2 proton channel 分子名称: Matrix protein 2 著者 Pielak, R.M. 登録日 2009-05-05 公開日 2009-05-19 最終更新日 2021-10-13 実験手法 SOLUTION NMR 主引用文献 Mechanism of drug inhibition and drug resistance of influenza A M2 channel. Proc.Natl.Acad.Sci.USA, 106, 2009
2KWX	The V27A mutant of influenza A M2 proton channel 分子名称: Matrix protein 2 著者 Pielak, R.M, Chou, J.J. 登録日 2010-04-20 公開日 2010-09-29 最終更新日 2021-10-06 実験手法 SOLUTION NMR 主引用文献 Solution NMR structure of the V27A drug resistant mutant of influenza A M2 channel. Biochem.Biophys.Res.Commun., 401, 2010
2L0J	Solid State NMR structure of the M2 proton channel from Influenza A Virus in hydrated lipid bilayer 分子名称: Matrix protein 2 著者 Sharma, M, Yi, M, Dong, H, Qin, H, Peterson, E, Busath, D.D, Zhou, H.X, Cross, T.A. 登録日 2010-07-08 公開日 2010-11-03 最終更新日 2011-07-13 実験手法 SOLID-STATE NMR 主引用文献 Insight into the mechanism of the influenza a proton channel from a structure in a lipid bilayer. Science, 330, 2010
2LY0	Solution NMR structure of the influenza A virus S31N mutant (19-49) in presence of drug M2WJ332 分子名称: (3S,5S,7S)-N-{[5-(thiophen-2-yl)-1,2-oxazol-3-yl]methyl}tricyclo[3.3.1.1~3,7~]decan-1-aminium, Membrane ion channel M2 著者 Wu, Y, Wang, J, DeGrado, W. 登録日 2012-09-10 公開日 2013-01-09 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus. Proc.Natl.Acad.Sci.USA, 110, 2013
2MUV	NOE-based model of the influenza A virus M2 (19-49) bound to drug 11 分子名称: (3s,5s,7s)-N-[(5-bromothiophen-2-yl)methyl]tricyclo[3.3.1.1~3,7~]decan-1-aminium, Matrix protein 2 著者 Wu, Y, Wang, J, DeGrado, W. 登録日 2014-09-18 公開日 2014-12-24 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Flipping in the Pore: Discovery of Dual Inhibitors That Bind in Different Orientations to the Wild-Type versus the Amantadine-Resistant S31N Mutant of the Influenza A Virus M2 Proton Channel. J.Am.Chem.Soc., 136, 2014
2MUW	NOE-based model of the influenza A virus N31S mutant (19-49) bound to drug 11 分子名称: (3s,5s,7s)-N-[(5-bromothiophen-2-yl)methyl]tricyclo[3.3.1.1~3,7~]decan-1-aminium, Matrix protein 2 著者 Wu, Y, Wang, J, DeGrado, W. 登録日 2014-09-18 公開日 2014-12-24 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Flipping in the Pore: Discovery of Dual Inhibitors That Bind in Different Orientations to the Wild-Type versus the Amantadine-Resistant S31N Mutant of the Influenza A Virus M2 Proton Channel. J.Am.Chem.Soc., 136, 2014
2N70	Two-fold symmetric structure of the 18-60 construct of S31N M2 from Influenza A in lipid bilayers 分子名称: Matrix protein 2 著者 Andreas, L.B, Reese, M, Eddy, M.T, Gelev, V, Ni, Q, Miller, E.A, Emsley, L, Pintacuda, G, Chou, J.J, Griffin, R.G. 登録日 2015-09-01 公開日 2015-09-23 最終更新日 2023-06-14 実験手法 SOLID-STATE NMR 主引用文献 Structure and Mechanism of the Influenza A M218-60 Dimer of Dimers. J.Am.Chem.Soc., 137, 2015
2RLF	Proton Channel M2 from Influenza A in complex with inhibitor rimantadine 分子名称: Matrix protein 2, RIMANTADINE 著者 Chou, J.J, Schnell, J.R. 登録日 2007-07-11 公開日 2008-01-29 最終更新日 2021-11-10 実験手法 SOLUTION NMR 主引用文献 Structure and mechanism of the M2 proton channel of influenza A virus. Nature, 451, 2008