7RY1
| human Hsp90_MC domain structure | 分子名称: | Heat shock protein HSP 90-alpha, N-[2-(1-MALEIMIDYL)ETHYL]-7-DIETHYLAMINOCOUMARIN-3-CARBOXAMIDE | 著者 | Peng, S, Deng, J, Matts, R. | 登録日 | 2021-08-24 | 公開日 | 2022-05-11 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.523 Å) | 主引用文献 | Crystal structure of the middle and C-terminal domains of Hsp90 alpha labeled with a coumarin derivative reveals a potential allosteric binding site as a drug target. Acta Crystallogr D Struct Biol, 78, 2022
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6KSQ
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1HK7
| Middle Domain of HSP90 | 分子名称: | CADMIUM ION, HEAT SHOCK PROTEIN HSP82, MAGNESIUM ION | 著者 | Meyer, P, Prodromou, C, Roe, S.M, Pearl, L.H. | 登録日 | 2003-03-06 | 公開日 | 2004-01-29 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural and Functional Analysis of the Middle Segment of Hsp90. Implications for ATP Hydrolysis and Client Protein and Cochaperone Interactions Mol.Cell, 11, 2003
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5HPH
| Structure of TRAP1 fragment | 分子名称: | GLYCEROL, Heat shock protein 75 kDa, mitochondrial, ... | 著者 | Sung, N, Chang, C, Lee, S, Tsai, F.T.F. | 登録日 | 2016-01-20 | 公開日 | 2016-08-10 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.429 Å) | 主引用文献 | 2.4 angstrom resolution crystal structure of human TRAP1NM, the Hsp90 paralog in the mitochondrial matrix. Acta Crystallogr D Struct Biol, 72, 2016
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7C7C
| Crystal structure of human TRAP1 with SJT104 | 分子名称: | 2-azanyl-9-[(4-bromanyl-2-fluoranyl-phenyl)methyl]-6-chloranyl-purin-8-ol, Heat shock protein 75 kDa, mitochondrial | 著者 | Kim, D, Yang, S, Yoon, N.G, Park, E, Kim, S.Y, Kang, B.H, Lee, C, Kang, S. | 登録日 | 2020-05-24 | 公開日 | 2021-05-26 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Design and Synthesis of TRAP1 Selective Inhibitors: H-Bonding with Asn171 Residue in TRAP1 Increases Paralog Selectivity. Acs Med.Chem.Lett., 12, 2021
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2CGE
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7C05
| Crystal structure of human Trap1 with DN203495 | 分子名称: | 1-[(4-bromanyl-2-fluoranyl-phenyl)methyl]-4-chloranyl-pyrazolo[3,4-d]pyrimidin-6-amine, Heat shock protein 75 kDa, mitochondrial | 著者 | Kim, D, Kim, D, Kim, S.Y, Lee, J.H, Kang, B.H, Kang, S, Lee, C. | 登録日 | 2020-04-30 | 公開日 | 2020-07-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | 主引用文献 | Development of pyrazolo[3,4-d]pyrimidine-6-amine-based TRAP1 inhibitors that demonstrate in vivo anticancer activity in mouse xenograft models. Bioorg.Chem., 101, 2020
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5Y3N
| Structure of TRAP1 complexed with DN401 | 分子名称: | 1-[(6-bromanyl-1,3-benzodioxol-5-yl)methyl]-4-chloranyl-pyrazolo[3,4-d]pyrimidin-6-amine, Heat shock protein 75 kDa, mitochondrial | 著者 | Jeong, H, Park, H.K, Kang, S, Kang, B.H, Lee, C. | 登録日 | 2017-07-29 | 公開日 | 2017-08-30 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Paralog Specificity Determines Subcellular Distribution, Action Mechanism, and Anticancer Activity of TRAP1 Inhibitors. J. Med. Chem., 60, 2017
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5Y3O
| Structure of TRAP1 complexed with DN320 | 分子名称: | 4-chloranyl-1-[(4-methoxy-3,5-dimethyl-pyridin-2-yl)methyl]pyrazolo[3,4-d]pyrimidin-6-amine, Heat shock protein 75 kDa, mitochondrial | 著者 | Jeong, H, Park, H.K, Kang, S, Kang, B.H, Lee, C. | 登録日 | 2017-07-29 | 公開日 | 2017-08-30 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Paralog Specificity Determines Subcellular Distribution, Action Mechanism, and Anticancer Activity of TRAP1 Inhibitors. J. Med. Chem., 60, 2017
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3HJC
| Crystal structure of the carboxy-terminal domain of HSP90 from Leishmania major, LmjF33.0312 | 分子名称: | Heat shock protein 83-1, SULFATE ION | 著者 | Wernimont, A.K, Tempel, W, Walker, J, Lin, Y.H, Hutchinson, A, Mackenzie, F, Fairlamb, A, Kozieradzki, I, Cossar, D, Zhao, Y, Schapira, M, Bochkarev, A, Arrowsmith, C.H, Bountra, C, Weigelt, J, Edwards, A.M, Ferguson, M.A.J, Hui, R, Pizarro, J.C, Hills, T, Structural Genomics Consortium (SGC) | 登録日 | 2009-05-21 | 公開日 | 2009-06-02 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal Structure of the middle and carboxy-terminal domain of HSP90 from Leishmania major, LMJF33.0312 To be Published
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3PRY
| Crystal structure of the middle domain of human HSP90-beta refined at 2.3 A resolution | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, Heat shock protein HSP 90-beta, ... | 著者 | Chaikuad, A, Pilka, E, Sharpe, T.D, Cooper, C.D.O, Phillips, C, Berridge, G, Ayinampudi, V, Fedorov, O, Keates, T, Thangaratnarajah, C, Zimmermann, T, Vollmar, M, Yue, W.W, Che, K.H, Krojer, T, Muniz, J.R.C, von Delft, F, Bountra, C, Arrowsmith, C.H, Weigelt, J, Edwards, A, Bullock, A, Structural Genomics Consortium (SGC) | 登録日 | 2010-11-30 | 公開日 | 2010-12-15 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | 主引用文献 | Crystal structure of the middle domain of human HSP90-beta refined at 2.3 A resolution To be Published
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3Q6M
| Crystal Structure of Human MC-HSP90 in C2221 Space Group | 分子名称: | Heat shock protein HSP 90-alpha, SULFATE ION | 著者 | Lee, C.C, Lin, T.W, Ko, T.P, Wang, A.H.-J. | 登録日 | 2011-01-03 | 公開日 | 2011-06-01 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | The hexameric structures of human heat shock protein 90 Plos One, 6, 2011
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3Q6N
| Crystal Structure of Human MC-HSP90 in P21 space group | 分子名称: | Heat shock protein HSP 90-alpha, SULFATE ION | 著者 | Lee, C.C, Lin, T.W, Ko, T.P, Wang, A.H.-J. | 登録日 | 2011-01-03 | 公開日 | 2011-06-01 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | 主引用文献 | The hexameric structures of human heat shock protein 90 Plos One, 6, 2011
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1Y6Z
| Middle domain of Plasmodium falciparum putative heat shock protein PF14_0417 | 分子名称: | heat shock protein, putative | 著者 | Lunin, V.V, Botchkareva, E, Loppnau, P, Amani, M, Bray, J, Vedadi, M, Edwards, A, Arrowsmith, C, Sundstrom, M, Bochkarev, A, Hui, R, Plotnikova, O, Structural Genomics Consortium (SGC) | 登録日 | 2004-12-07 | 公開日 | 2005-02-08 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms. Mol.Biochem.Parasitol., 151, 2007
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2GQ0
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4Z1I
| Crystal structure of human Trap1 with AMPPNP | 分子名称: | Heat shock protein 75 kDa, mitochondrial, MAGNESIUM ION, ... | 著者 | Lee, C, Park, H.K, Ryu, J.H, Kang, B.H. | 登録日 | 2015-03-27 | 公開日 | 2015-04-29 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Development of a Mitochondria-Targeted Hsp90 Inhibitor Based on the Crystal Structures of Human TRAP1 J.Am.Chem.Soc., 137, 2015
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4Z1G
| Crystal structure of human Trap1 with BIIB-021 | 分子名称: | 6-chloro-9-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-9H-purin-2-amine, Heat shock protein 75 kDa, mitochondrial | 著者 | Lee, C, Park, H.K, Ryu, J.H, Kang, B.H. | 登録日 | 2015-03-27 | 公開日 | 2015-04-22 | 最終更新日 | 2022-10-05 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Development of a Mitochondria-Targeted Hsp90 Inhibitor Based on the Crystal Structures of Human TRAP1 J.Am.Chem.Soc., 137, 2015
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4Z1F
| Crystal structure of human Trap1 with PU-H71 | 分子名称: | 8-[(6-IODO-1,3-BENZODIOXOL-5-YL)THIO]-9-[3-(ISOPROPYLAMINO)PROPYL]-9H-PURIN-6-AMINE, Heat shock protein 75 kDa, mitochondrial | 著者 | Lee, C, Park, H.K, Ryu, J.H, Kang, B.H. | 登録日 | 2015-03-27 | 公開日 | 2015-04-22 | 実験手法 | X-RAY DIFFRACTION (2.703 Å) | 主引用文献 | Development of a Mitochondria-Targeted Hsp90 Inhibitor Based on the Crystal Structures of Human TRAP1 J.Am.Chem.Soc., 137, 2015
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4Z1H
| Crystal structure of human Trap1 with SMTIN-P01 | 分子名称: | 8-[(6-iodo-1,3-benzodioxol-5-yl)sulfanyl]-9-[6-(triphenyl-lambda~5~-phosphanyl)hexyl]-9H-purin-6-amine, Heat shock protein 75 kDa, mitochondrial | 著者 | Lee, C, Park, H.K, Ryu, J.H, Kang, B.H. | 登録日 | 2015-03-27 | 公開日 | 2015-04-22 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Development of a Mitochondria-Targeted Hsp90 Inhibitor Based on the Crystal Structures of Human TRAP1 J.Am.Chem.Soc., 137, 2015
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2O1T
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7KCK
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8K2S
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8OXU
| Crystal Structure of the Hsp90-LA1011 Complex | 分子名称: | ATP-dependent molecular chaperone HSP82, dimethyl 2,6-bis[2-(dimethylamino)ethyl]-1-methyl-4-[4-(trifluoromethyl)phenyl]-4~{H}-pyridine-3,5-dicarboxylate | 著者 | Roe, S.M, Prodromou, C. | 登録日 | 2023-05-02 | 公開日 | 2023-07-12 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.94 Å) | 主引用文献 | The Crystal Structure of the Hsp90-LA1011 Complex and the Mechanism by Which LA1011 May Improve the Prognosis of Alzheimer's Disease. Biomolecules, 13, 2023
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7RXZ
| human Hsp90_MC domain structure | 分子名称: | Heat shock protein HSP 90-alpha | 著者 | Peng, S, Deng, J, Matts, R. | 登録日 | 2021-08-24 | 公開日 | 2022-12-28 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (3.152 Å) | 主引用文献 | Structural basis of the key residue W320 responsible for Hsp90 conformational change. J.Biomol.Struct.Dyn., 2022
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7RY0
| human Hsp90_MC domain structure | 分子名称: | DIMETHYL SULFOXIDE, GLYCEROL, Heat shock protein HSP 90-alpha | 著者 | Peng, S, Deng, J, Matts, R. | 登録日 | 2021-08-24 | 公開日 | 2022-12-28 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural basis of the key residue W320 responsible for Hsp90 conformational change. J.Biomol.Struct.Dyn., 2022
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