8U4R
Structure of REGN7663-Fab bound CXCR4
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| R | 0001618 | molecular_function | virus receptor activity |
| R | 0001666 | biological_process | response to hypoxia |
| R | 0001764 | biological_process | neuron migration |
| R | 0002064 | biological_process | epithelial cell development |
| R | 0002407 | biological_process | dendritic cell chemotaxis |
| R | 0003674 | molecular_function | molecular_function |
| R | 0003779 | molecular_function | actin binding |
| R | 0004930 | molecular_function | G protein-coupled receptor activity |
| R | 0005515 | molecular_function | protein binding |
| R | 0005575 | cellular_component | cellular_component |
| R | 0005737 | cellular_component | cytoplasm |
| R | 0005764 | cellular_component | lysosome |
| R | 0005768 | cellular_component | endosome |
| R | 0005769 | cellular_component | early endosome |
| R | 0005770 | cellular_component | late endosome |
| R | 0005886 | cellular_component | plasma membrane |
| R | 0006091 | biological_process | generation of precursor metabolites and energy |
| R | 0006915 | biological_process | apoptotic process |
| R | 0006954 | biological_process | inflammatory response |
| R | 0006955 | biological_process | immune response |
| R | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| R | 0007204 | biological_process | positive regulation of cytosolic calcium ion concentration |
| R | 0007420 | biological_process | brain development |
| R | 0008038 | biological_process | neuron recognition |
| R | 0008218 | biological_process | bioluminescence |
| R | 0009615 | biological_process | response to virus |
| R | 0009897 | cellular_component | external side of plasma membrane |
| R | 0009986 | cellular_component | cell surface |
| R | 0014070 | biological_process | response to organic cyclic compound |
| R | 0014823 | biological_process | response to activity |
| R | 0015026 | molecular_function | coreceptor activity |
| R | 0016020 | cellular_component | membrane |
| R | 0016477 | biological_process | cell migration |
| R | 0016493 | molecular_function | C-C chemokine receptor activity |
| R | 0016494 | molecular_function | C-X-C chemokine receptor activity |
| R | 0019722 | biological_process | calcium-mediated signaling |
| R | 0019955 | molecular_function | cytokine binding |
| R | 0019957 | molecular_function | C-C chemokine binding |
| R | 0022008 | biological_process | neurogenesis |
| R | 0022029 | biological_process | telencephalon cell migration |
| R | 0030155 | biological_process | regulation of cell adhesion |
| R | 0030335 | biological_process | positive regulation of cell migration |
| R | 0031252 | cellular_component | cell leading edge |
| R | 0031410 | cellular_component | cytoplasmic vesicle |
| R | 0031625 | molecular_function | ubiquitin protein ligase binding |
| R | 0032027 | molecular_function | myosin light chain binding |
| R | 0032991 | cellular_component | protein-containing complex |
| R | 0035470 | biological_process | positive regulation of vascular wound healing |
| R | 0036094 | molecular_function | small molecule binding |
| R | 0038147 | molecular_function | C-X-C motif chemokine 12 receptor activity |
| R | 0038160 | biological_process | CXCL12-activated CXCR4 signaling pathway |
| R | 0043067 | biological_process | regulation of programmed cell death |
| R | 0043130 | molecular_function | ubiquitin binding |
| R | 0043217 | biological_process | myelin maintenance |
| R | 0045446 | biological_process | endothelial cell differentiation |
| R | 0046718 | biological_process | symbiont entry into host cell |
| R | 0048714 | biological_process | positive regulation of oligodendrocyte differentiation |
| R | 0050769 | biological_process | positive regulation of neurogenesis |
| R | 0050792 | biological_process | regulation of viral process |
| R | 0050920 | biological_process | regulation of chemotaxis |
| R | 0050921 | biological_process | positive regulation of chemotaxis |
| R | 0050965 | biological_process | detection of temperature stimulus involved in sensory perception of pain |
| R | 0050966 | biological_process | detection of mechanical stimulus involved in sensory perception of pain |
| R | 0051924 | biological_process | regulation of calcium ion transport |
| R | 0060048 | biological_process | cardiac muscle contraction |
| R | 0060326 | biological_process | cell chemotaxis |
| R | 0061154 | biological_process | endothelial tube morphogenesis |
| R | 0070062 | cellular_component | extracellular exosome |
| R | 0070098 | biological_process | chemokine-mediated signaling pathway |
| R | 0070161 | cellular_component | anchoring junction |
| R | 0071345 | biological_process | cellular response to cytokine stimulus |
| R | 0071417 | biological_process | cellular response to organonitrogen compound |
| R | 0071466 | biological_process | cellular response to xenobiotic stimulus |
| R | 0120162 | biological_process | positive regulation of cold-induced thermogenesis |
| R | 1901327 | biological_process | response to tacrolimus |
| R | 1903861 | biological_process | positive regulation of dendrite extension |
| R | 1904018 | biological_process | positive regulation of vasculature development |
| R | 1905322 | biological_process | positive regulation of mesenchymal stem cell migration |
| R | 1990478 | biological_process | response to ultrasound |
| R | 2000448 | biological_process | positive regulation of macrophage migration inhibitory factor signaling pathway |
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. SSVlILAFISLDRYLaI |
| Chain | Residue | Details |
| R | SER122-ILE138 |
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCNVDH |
| Chain | Residue | Details |
| H | TYR207-HIS213 | |
| L | TYR197-HIS203 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:20929726 |
| Chain | Residue | Details |
| R | ILE39-MET63 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 109 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:20929726 |
| Chain | Residue | Details |
| R | GLY64-ARG77 | |
| R | SER131-LYS154 | |
| R | SER217-THR241 | |
| R | ALA303-SER352 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:20929726 |
| Chain | Residue | Details |
| R | LEU78-VAL99 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 50 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:20929726 |
| Chain | Residue | Details |
| R | ALA100-LYS110 | |
| R | ALA175-TRP195 | |
| R | ASP262-LYS282 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:20929726 |
| Chain | Residue | Details |
| R | ALA111-ILE130 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:20929726 |
| Chain | Residue | Details |
| R | VAL155-PHE174 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:20929726 |
| Chain | Residue | Details |
| R | VAL196-LEU216 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:20929726 |
| Chain | Residue | Details |
| R | VAL242-ILE261 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:20929726 |
| Chain | Residue | Details |
| R | TRP283-TYR302 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | SITE: Chemokine binding |
| Chain | Residue | Details |
| R | ASP171 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | SITE: Chemokine binding => ECO:0000269|PubMed:20929726, ECO:0000305|PubMed:10825158 |
| Chain | Residue | Details |
| R | GLU288 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | MOD_RES: Sulfotyrosine; partial => ECO:0000269|PubMed:18834145 |
| Chain | Residue | Details |
| R | TYR7 | |
| R | TYR12 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | MOD_RES: Sulfotyrosine => ECO:0000269|PubMed:12034737, ECO:0000269|PubMed:16725153, ECO:0000269|PubMed:18834145 |
| Chain | Residue | Details |
| R | TYR21 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648 |
| Chain | Residue | Details |
| R | SER319 | |
| R | SER348 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:20048153, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| R | SER321 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by PKC and GRK6 => ECO:0000269|PubMed:19116316, ECO:0000269|PubMed:20048153, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| R | SER324 | |
| R | SER325 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by GRK6 => ECO:0000269|PubMed:20048153 |
| Chain | Residue | Details |
| R | SER330 | |
| R | SER339 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:20048153 |
| Chain | Residue | Details |
| R | SER351 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10756055 |
| Chain | Residue | Details |
| R | ASN11 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 1 |
| Details | CARBOHYD: O-linked (Xyl...) (chondroitin sulfate) serine => ECO:0000269|PubMed:12034737 |
| Chain | Residue | Details |
| R | SER18 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| R | ASN176 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:28978524 |
| Chain | Residue | Details |
| R | LYS331 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 1 |
| Details | MOD_RES: (Z)-2,3-didehydrotyrosine => ECO:0000269|PubMed:8448132 |
| Chain | Residue | Details |
| R | TYR434 |
| site_id | SWS_FT_FI24 |
| Number of Residues | 2 |
| Details | CROSSLNK: 5-imidazolinone (Ser-Gly) => ECO:0000269|PubMed:8448132 |
| Chain | Residue | Details |
| R | THR433 | |
| R | GLY435 |
