8U4R
Structure of REGN7663-Fab bound CXCR4
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| R | 0001618 | molecular_function | virus receptor activity |
| R | 0001666 | biological_process | response to hypoxia |
| R | 0002407 | biological_process | dendritic cell chemotaxis |
| R | 0003779 | molecular_function | actin binding |
| R | 0004930 | molecular_function | G protein-coupled receptor activity |
| R | 0005515 | molecular_function | protein binding |
| R | 0005737 | cellular_component | cytoplasm |
| R | 0005764 | cellular_component | lysosome |
| R | 0005769 | cellular_component | early endosome |
| R | 0005770 | cellular_component | late endosome |
| R | 0005886 | cellular_component | plasma membrane |
| R | 0006091 | biological_process | generation of precursor metabolites and energy |
| R | 0006915 | biological_process | apoptotic process |
| R | 0006954 | biological_process | inflammatory response |
| R | 0006955 | biological_process | immune response |
| R | 0007165 | biological_process | signal transduction |
| R | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| R | 0007193 | biological_process | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
| R | 0007204 | biological_process | positive regulation of cytosolic calcium ion concentration |
| R | 0007420 | biological_process | brain development |
| R | 0008218 | biological_process | bioluminescence |
| R | 0009615 | biological_process | response to virus |
| R | 0009897 | cellular_component | external side of plasma membrane |
| R | 0009986 | cellular_component | cell surface |
| R | 0015026 | molecular_function | coreceptor activity |
| R | 0016020 | cellular_component | membrane |
| R | 0016477 | biological_process | cell migration |
| R | 0016493 | molecular_function | C-C chemokine receptor activity |
| R | 0016494 | molecular_function | C-X-C chemokine receptor activity |
| R | 0019722 | biological_process | calcium-mediated signaling |
| R | 0019955 | molecular_function | cytokine binding |
| R | 0019957 | molecular_function | C-C chemokine binding |
| R | 0022008 | biological_process | neurogenesis |
| R | 0030155 | biological_process | regulation of cell adhesion |
| R | 0030334 | biological_process | regulation of cell migration |
| R | 0030335 | biological_process | positive regulation of cell migration |
| R | 0031252 | cellular_component | cell leading edge |
| R | 0031410 | cellular_component | cytoplasmic vesicle |
| R | 0031625 | molecular_function | ubiquitin protein ligase binding |
| R | 0032027 | molecular_function | myosin light chain binding |
| R | 0032991 | cellular_component | protein-containing complex |
| R | 0038147 | molecular_function | C-X-C motif chemokine 12 receptor activity |
| R | 0038160 | biological_process | CXCL12-activated CXCR4 signaling pathway |
| R | 0043130 | molecular_function | ubiquitin binding |
| R | 0043217 | biological_process | myelin maintenance |
| R | 0046718 | biological_process | symbiont entry into host cell |
| R | 0048714 | biological_process | positive regulation of oligodendrocyte differentiation |
| R | 0060326 | biological_process | cell chemotaxis |
| R | 0070062 | cellular_component | extracellular exosome |
| R | 0070098 | biological_process | chemokine-mediated signaling pathway |
| R | 0070161 | cellular_component | anchoring junction |
| R | 0071345 | biological_process | cellular response to cytokine stimulus |
| R | 0120162 | biological_process | positive regulation of cold-induced thermogenesis |
| R | 1904018 | biological_process | positive regulation of vasculature development |
| R | 2000448 | biological_process | positive regulation of macrophage migration inhibitory factor signaling pathway |
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. SSVlILAFISLDRYLaI |
| Chain | Residue | Details |
| R | SER122-ILE138 |
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCNVDH |
| Chain | Residue | Details |
| H | TYR207-HIS213 | |
| L | TYR197-HIS203 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 50 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 23 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 3 |
| Details | Region: {"description":"Chemokine binding","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10825158","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 4 |
| Details | Region: {"description":"Chemokine binding"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 12 |
| Details | Region: {"description":"Involved in dimerization; when bound to chemokine"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 4 |
| Details | Region: {"description":"Chemokine binding, important for signaling and HIV-1 coreceptor activity"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 21 |
| Details | Region: {"description":"Involved in dimerization"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 2 |
| Details | Motif: {"description":"Important for signaling"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | Site: {"description":"Chemokine binding"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 1 |
| Details | Site: {"description":"Chemokine binding","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10825158","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
