8Q5U

Endoglycosidase S2 in complex with IgG1 Fc

Functional Information from GO Data

Chain	GOid	namespace	contents
D	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
D	0005509	molecular_function	calcium ion binding
D	0005576	cellular_component	extracellular region
D	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
D	0033925	molecular_function	mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity
D	0042783	biological_process	evasion of host immune response
D	0043655	cellular_component	host extracellular space
D	0046872	molecular_function	metal ion binding
E	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
E	0005509	molecular_function	calcium ion binding
E	0005576	cellular_component	extracellular region
E	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
E	0033925	molecular_function	mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity
E	0042783	biological_process	evasion of host immune response
E	0043655	cellular_component	host extracellular space
E	0046872	molecular_function	metal ion binding
F	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
F	0005509	molecular_function	calcium ion binding
F	0005576	cellular_component	extracellular region
F	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
F	0033925	molecular_function	mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity
F	0042783	biological_process	evasion of host immune response
F	0043655	cellular_component	host extracellular space
F	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. FSCSVMH

Chain	Residue	Details
A	PHE423-HIS429

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Proton donor => ECO:0000255|PROSITE-ProRule:PRU10053, ECO:0000305|PubMed:23865566

Chain	Residue	Details
D	LEU186
E	LEU186
F	LEU186

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site_id	SWS_FT_FI2
Number of Residues	27
Details	BINDING: BINDING => ECO:0000269|PubMed:30937380, ECO:0007744|PDB:6MDS, ECO:0007744|PDB:6MDV

Chain	Residue	Details
D	ARG72
E	ARG72
E	TRP74
E	ASP108
E	HIS109
E	TYR252
E	GLU288
E	GLU289
E	ASN295
E	TYR339
F	ARG72
D	TRP74
F	TRP74
F	ASP108
F	HIS109
F	TYR252
F	GLU288
F	GLU289
F	ASN295
F	TYR339
D	ASP108
D	HIS109
D	TYR252
D	GLU288
D	GLU289
D	ASN295
D	TYR339

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site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:30937380, ECO:0007744|PDB:6MDV

Chain	Residue	Details
D	HIS88
E	HIS88
F	HIS88

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site_id	SWS_FT_FI4
Number of Residues	9
Details	BINDING: BINDING => ECO:0000269|PubMed:30937380, ECO:0007744|PDB:6MDS

Chain	Residue	Details
D	HIS107
D	ALA184
D	GLN250
E	HIS107
E	ALA184
E	GLN250
F	HIS107
F	ALA184
F	GLN250

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site_id	SWS_FT_FI5
Number of Residues	18
Details	BINDING: BINDING => ECO:0000269|PubMed:30937380, ECO:0007744|PDB:6E58, ECO:0007744|PDB:6MDS, ECO:0007744|PDB:6MDV

Chain	Residue	Details
D	LYS699
E	ASP707
E	THR824
E	GLU825
F	LYS699
F	ASP702
F	GLU704
F	ASP707
F	THR824
F	GLU825
D	ASP702
D	GLU704
D	ASP707
D	THR824
D	GLU825
E	LYS699
E	ASP702
E	GLU704

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