8PM4

Cryo-EM structure of the Cas12m-crRNA-target DNA complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003723	molecular_function	RNA binding
A	0006351	biological_process	DNA-templated transcription
A	0046872	molecular_function	metal ion binding
A	0051607	biological_process	defense response to virus

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	15
Details	Region: {"description":"Wedge domain (WED-N)","evidences":[{"source":"PubMed","id":"38261981","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	172
Details	Region: {"description":"Recognition domain (REC)","evidences":[{"source":"PubMed","id":"38261981","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	74
Details	Region: {"description":"Roof in REC","evidences":[{"source":"PubMed","id":"38261981","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	20
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	125
Details	Region: {"description":"Wedge domain (WED-C)","evidences":[{"source":"PubMed","id":"38261981","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	243
Details	Region: {"description":"RuvC-I","evidences":[{"source":"PubMed","id":"38261981","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	61
Details	Region: {"description":"RuvC insertion","evidences":[{"source":"PubMed","id":"38261981","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	36
Details	Region: {"description":"Target nucleic-acid binding (TNB)","evidences":[{"source":"UniProtKB","id":"P0DXB1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	9
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P0DXB1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details