8P94

Cryo-EM structure of cortactin stabilized Arp2/3-complex nucleated actin branches

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003779	molecular_function	actin binding
A	0005200	molecular_function	structural constituent of cytoskeleton
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005885	cellular_component	Arp2/3 protein complex
A	0005903	cellular_component	brush border
A	0005911	cellular_component	cell-cell junction
A	0005925	cellular_component	focal adhesion
A	0010592	biological_process	positive regulation of lamellipodium assembly
A	0015629	cellular_component	actin cytoskeleton
A	0016020	cellular_component	membrane
A	0030027	cellular_component	lamellipodium
A	0030030	biological_process	cell projection organization
A	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
A	0035861	cellular_component	site of double-strand break
A	0042995	cellular_component	cell projection
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0051015	molecular_function	actin filament binding
A	0060271	biological_process	cilium assembly
A	0070062	cellular_component	extracellular exosome
A	0070358	biological_process	actin polymerization-dependent cell motility
B	0000166	molecular_function	nucleotide binding
B	0003779	molecular_function	actin binding
B	0005200	molecular_function	structural constituent of cytoskeleton
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005730	cellular_component	nucleolus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0005885	cellular_component	Arp2/3 protein complex
B	0005925	cellular_component	focal adhesion
B	0005938	cellular_component	cell cortex
B	0010592	biological_process	positive regulation of lamellipodium assembly
B	0015629	cellular_component	actin cytoskeleton
B	0016020	cellular_component	membrane
B	0030478	cellular_component	actin cap
B	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
B	0035578	cellular_component	azurophil granule lumen
B	0035861	cellular_component	site of double-strand break
B	0042995	cellular_component	cell projection
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0051015	molecular_function	actin filament binding
B	0060271	biological_process	cilium assembly
B	0070062	cellular_component	extracellular exosome
B	1904813	cellular_component	ficolin-1-rich granule lumen
B	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
B	2001032	biological_process	regulation of double-strand break repair via nonhomologous end joining
C	0003779	molecular_function	actin binding
C	0005200	molecular_function	structural constituent of cytoskeleton
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005885	cellular_component	Arp2/3 protein complex
C	0005925	cellular_component	focal adhesion
C	0015629	cellular_component	actin cytoskeleton
C	0032355	biological_process	response to estradiol
C	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
C	0036284	cellular_component	tubulobulbar complex
C	0043627	biological_process	response to estrogen
C	0044877	molecular_function	protein-containing complex binding
C	0051015	molecular_function	actin filament binding
C	0070062	cellular_component	extracellular exosome
D	0003779	molecular_function	actin binding
D	0005200	molecular_function	structural constituent of cytoskeleton
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005768	cellular_component	endosome
D	0005829	cellular_component	cytosol
D	0005856	cellular_component	cytoskeleton
D	0005885	cellular_component	Arp2/3 protein complex
D	0005886	cellular_component	plasma membrane
D	0005925	cellular_component	focal adhesion
D	0010592	biological_process	positive regulation of lamellipodium assembly
D	0015629	cellular_component	actin cytoskeleton
D	0030027	cellular_component	lamellipodium
D	0030041	biological_process	actin filament polymerization
D	0030672	cellular_component	synaptic vesicle membrane
D	0031252	cellular_component	cell leading edge
D	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
D	0035861	cellular_component	site of double-strand break
D	0036195	cellular_component	muscle cell projection membrane
D	0042995	cellular_component	cell projection
D	0043005	cellular_component	neuron projection
D	0044089	biological_process	positive regulation of cellular component biogenesis
D	0045202	cellular_component	synapse
D	0051015	molecular_function	actin filament binding
D	0051130	biological_process	positive regulation of cellular component organization
D	0070062	cellular_component	extracellular exosome
D	0070358	biological_process	actin polymerization-dependent cell motility
D	0098793	cellular_component	presynapse
D	0098794	cellular_component	postsynapse
D	0098978	cellular_component	glutamatergic synapse
E	0003779	molecular_function	actin binding
E	0005200	molecular_function	structural constituent of cytoskeleton
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005885	cellular_component	Arp2/3 protein complex
E	0005925	cellular_component	focal adhesion
E	0015629	cellular_component	actin cytoskeleton
E	0016020	cellular_component	membrane
E	0030027	cellular_component	lamellipodium
E	0030833	biological_process	regulation of actin filament polymerization
E	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
E	0035861	cellular_component	site of double-strand break
E	0042995	cellular_component	cell projection
E	0051015	molecular_function	actin filament binding
E	0070062	cellular_component	extracellular exosome
E	0070358	biological_process	actin polymerization-dependent cell motility
E	1900242	biological_process	regulation of synaptic vesicle endocytosis
F	0003779	molecular_function	actin binding
F	0005200	molecular_function	structural constituent of cytoskeleton
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005829	cellular_component	cytosol
F	0005856	cellular_component	cytoskeleton
F	0005885	cellular_component	Arp2/3 protein complex
F	0015629	cellular_component	actin cytoskeleton
F	0019899	molecular_function	enzyme binding
F	0030041	biological_process	actin filament polymerization
F	0030674	molecular_function	protein-macromolecule adaptor activity
F	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
F	0035861	cellular_component	site of double-strand break
F	0042995	cellular_component	cell projection
F	0045010	biological_process	actin nucleation
F	0051015	molecular_function	actin filament binding
F	0070062	cellular_component	extracellular exosome
G	0003779	molecular_function	actin binding
G	0005515	molecular_function	protein binding
G	0005856	cellular_component	cytoskeleton
G	0005885	cellular_component	Arp2/3 protein complex
G	0005925	cellular_component	focal adhesion
G	0015629	cellular_component	actin cytoskeleton
G	0016477	biological_process	cell migration
G	0030674	molecular_function	protein-macromolecule adaptor activity
G	0030833	biological_process	regulation of actin filament polymerization
G	0030863	cellular_component	cortical cytoskeleton
G	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
G	0045202	cellular_component	synapse
G	0070062	cellular_component	extracellular exosome
G	0098978	cellular_component	glutamatergic synapse
H	0000166	molecular_function	nucleotide binding
H	0001738	biological_process	morphogenesis of a polarized epithelium
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005856	cellular_component	cytoskeleton
H	0005884	cellular_component	actin filament
H	0005886	cellular_component	plasma membrane
H	0005903	cellular_component	brush border
H	0005911	cellular_component	cell-cell junction
H	0005912	cellular_component	adherens junction
H	0005925	cellular_component	focal adhesion
H	0007017	biological_process	microtubule-based process
H	0007163	biological_process	establishment or maintenance of cell polarity
H	0007409	biological_process	axonogenesis
H	0015629	cellular_component	actin cytoskeleton
H	0016020	cellular_component	membrane
H	0016787	molecular_function	hydrolase activity
H	0016887	molecular_function	ATP hydrolysis activity
H	0019894	molecular_function	kinesin binding
H	0019901	molecular_function	protein kinase binding
H	0030027	cellular_component	lamellipodium
H	0030235	molecular_function	nitric-oxide synthase regulator activity
H	0030424	cellular_component	axon
H	0030863	cellular_component	cortical cytoskeleton
H	0030957	molecular_function	Tat protein binding
H	0032991	cellular_component	protein-containing complex
H	0034333	biological_process	adherens junction assembly
H	0035267	cellular_component	NuA4 histone acetyltransferase complex
H	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
H	0042802	molecular_function	identical protein binding
H	0043296	cellular_component	apical junction complex
H	0044305	cellular_component	calyx of Held
H	0045176	biological_process	apical protein localization
H	0045202	cellular_component	synapse
H	0048870	biological_process	cell motility
H	0050998	molecular_function	nitric-oxide synthase binding
H	0051621	biological_process	regulation of norepinephrine uptake
H	0051726	biological_process	regulation of cell cycle
H	0070160	cellular_component	tight junction
H	0071896	biological_process	protein localization to adherens junction
H	0072749	biological_process	cellular response to cytochalasin B
H	0097433	cellular_component	dense body
H	0098685	cellular_component	Schaffer collateral - CA1 synapse
H	0098871	cellular_component	postsynaptic actin cytoskeleton
H	0098973	molecular_function	structural constituent of postsynaptic actin cytoskeleton
H	0098974	biological_process	postsynaptic actin cytoskeleton organization
H	0098978	cellular_component	glutamatergic synapse
H	0141108	molecular_function	transporter regulator activity
H	0150111	biological_process	regulation of transepithelial transport
H	1900242	biological_process	regulation of synaptic vesicle endocytosis
H	1903076	biological_process	regulation of protein localization to plasma membrane
H	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
H	1990904	cellular_component	ribonucleoprotein complex
I	0001726	cellular_component	ruffle
I	0002102	cellular_component	podosome
I	0005515	molecular_function	protein binding
I	0005522	molecular_function	profilin binding
I	0005737	cellular_component	cytoplasm
I	0005783	cellular_component	endoplasmic reticulum
I	0005794	cellular_component	Golgi apparatus
I	0005829	cellular_component	cytosol
I	0005856	cellular_component	cytoskeleton
I	0005884	cellular_component	actin filament
I	0005886	cellular_component	plasma membrane
I	0005905	cellular_component	clathrin-coated pit
I	0005925	cellular_component	focal adhesion
I	0005938	cellular_component	cell cortex
I	0006886	biological_process	intracellular protein transport
I	0006897	biological_process	endocytosis
I	0006898	biological_process	receptor-mediated endocytosis
I	0006930	biological_process	substrate-dependent cell migration, cell extension
I	0008076	cellular_component	voltage-gated potassium channel complex
I	0016477	biological_process	cell migration
I	0030027	cellular_component	lamellipodium
I	0030036	biological_process	actin cytoskeleton organization
I	0030054	cellular_component	cell junction
I	0030425	cellular_component	dendrite
I	0030426	cellular_component	growth cone
I	0030427	cellular_component	site of polarized growth
I	0030516	biological_process	regulation of axon extension
I	0030833	biological_process	regulation of actin filament polymerization
I	0030838	biological_process	positive regulation of actin filament polymerization
I	0030863	cellular_component	cortical cytoskeleton
I	0030864	cellular_component	cortical actin cytoskeleton
I	0042995	cellular_component	cell projection
I	0043197	cellular_component	dendritic spine
I	0045987	biological_process	positive regulation of smooth muscle contraction
I	0048041	biological_process	focal adhesion assembly
I	0048812	biological_process	neuron projection morphogenesis
I	0048870	biological_process	cell motility
I	0050921	biological_process	positive regulation of chemotaxis
I	0051015	molecular_function	actin filament binding
I	0060491	biological_process	regulation of cell projection assembly
I	0070064	molecular_function	proline-rich region binding
I	0070161	cellular_component	anchoring junction
I	0071933	molecular_function	Arp2/3 complex binding
I	0097062	biological_process	dendritic spine maintenance
I	0097581	biological_process	lamellipodium organization
I	0098794	cellular_component	postsynapse
I	0098871	cellular_component	postsynaptic actin cytoskeleton
I	0098885	biological_process	modification of postsynaptic actin cytoskeleton
I	0098978	cellular_component	glutamatergic synapse
I	0099010	biological_process	modification of postsynaptic structure
I	1901524	biological_process	regulation of mitophagy
I	1990023	cellular_component	mitotic spindle midzone
I	2001237	biological_process	negative regulation of extrinsic apoptotic signaling pathway
J	0000166	molecular_function	nucleotide binding
J	0001738	biological_process	morphogenesis of a polarized epithelium
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005856	cellular_component	cytoskeleton
J	0005884	cellular_component	actin filament
J	0005886	cellular_component	plasma membrane
J	0005903	cellular_component	brush border
J	0005911	cellular_component	cell-cell junction
J	0005912	cellular_component	adherens junction
J	0005925	cellular_component	focal adhesion
J	0007017	biological_process	microtubule-based process
J	0007163	biological_process	establishment or maintenance of cell polarity
J	0007409	biological_process	axonogenesis
J	0015629	cellular_component	actin cytoskeleton
J	0016020	cellular_component	membrane
J	0016787	molecular_function	hydrolase activity
J	0016887	molecular_function	ATP hydrolysis activity
J	0019894	molecular_function	kinesin binding
J	0019901	molecular_function	protein kinase binding
J	0030027	cellular_component	lamellipodium
J	0030235	molecular_function	nitric-oxide synthase regulator activity
J	0030424	cellular_component	axon
J	0030863	cellular_component	cortical cytoskeleton
J	0030957	molecular_function	Tat protein binding
J	0032991	cellular_component	protein-containing complex
J	0034333	biological_process	adherens junction assembly
J	0035267	cellular_component	NuA4 histone acetyltransferase complex
J	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
J	0042802	molecular_function	identical protein binding
J	0043296	cellular_component	apical junction complex
J	0044305	cellular_component	calyx of Held
J	0045176	biological_process	apical protein localization
J	0045202	cellular_component	synapse
J	0048870	biological_process	cell motility
J	0050998	molecular_function	nitric-oxide synthase binding
J	0051621	biological_process	regulation of norepinephrine uptake
J	0051726	biological_process	regulation of cell cycle
J	0070160	cellular_component	tight junction
J	0071896	biological_process	protein localization to adherens junction
J	0072749	biological_process	cellular response to cytochalasin B
J	0097433	cellular_component	dense body
J	0098685	cellular_component	Schaffer collateral - CA1 synapse
J	0098871	cellular_component	postsynaptic actin cytoskeleton
J	0098973	molecular_function	structural constituent of postsynaptic actin cytoskeleton
J	0098974	biological_process	postsynaptic actin cytoskeleton organization
J	0098978	cellular_component	glutamatergic synapse
J	0141108	molecular_function	transporter regulator activity
J	0150111	biological_process	regulation of transepithelial transport
J	1900242	biological_process	regulation of synaptic vesicle endocytosis
J	1903076	biological_process	regulation of protein localization to plasma membrane
J	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
J	1990904	cellular_component	ribonucleoprotein complex
K	0000166	molecular_function	nucleotide binding
K	0001738	biological_process	morphogenesis of a polarized epithelium
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0005856	cellular_component	cytoskeleton
K	0005884	cellular_component	actin filament
K	0005886	cellular_component	plasma membrane
K	0005903	cellular_component	brush border
K	0005911	cellular_component	cell-cell junction
K	0005912	cellular_component	adherens junction
K	0005925	cellular_component	focal adhesion
K	0007017	biological_process	microtubule-based process
K	0007163	biological_process	establishment or maintenance of cell polarity
K	0007409	biological_process	axonogenesis
K	0015629	cellular_component	actin cytoskeleton
K	0016020	cellular_component	membrane
K	0016787	molecular_function	hydrolase activity
K	0016887	molecular_function	ATP hydrolysis activity
K	0019894	molecular_function	kinesin binding
K	0019901	molecular_function	protein kinase binding
K	0030027	cellular_component	lamellipodium
K	0030235	molecular_function	nitric-oxide synthase regulator activity
K	0030424	cellular_component	axon
K	0030863	cellular_component	cortical cytoskeleton
K	0030957	molecular_function	Tat protein binding
K	0032991	cellular_component	protein-containing complex
K	0034333	biological_process	adherens junction assembly
K	0035267	cellular_component	NuA4 histone acetyltransferase complex
K	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
K	0042802	molecular_function	identical protein binding
K	0043296	cellular_component	apical junction complex
K	0044305	cellular_component	calyx of Held
K	0045176	biological_process	apical protein localization
K	0045202	cellular_component	synapse
K	0048870	biological_process	cell motility
K	0050998	molecular_function	nitric-oxide synthase binding
K	0051621	biological_process	regulation of norepinephrine uptake
K	0051726	biological_process	regulation of cell cycle
K	0070160	cellular_component	tight junction
K	0071896	biological_process	protein localization to adherens junction
K	0072749	biological_process	cellular response to cytochalasin B
K	0097433	cellular_component	dense body
K	0098685	cellular_component	Schaffer collateral - CA1 synapse
K	0098871	cellular_component	postsynaptic actin cytoskeleton
K	0098973	molecular_function	structural constituent of postsynaptic actin cytoskeleton
K	0098974	biological_process	postsynaptic actin cytoskeleton organization
K	0098978	cellular_component	glutamatergic synapse
K	0141108	molecular_function	transporter regulator activity
K	0150111	biological_process	regulation of transepithelial transport
K	1900242	biological_process	regulation of synaptic vesicle endocytosis
K	1903076	biological_process	regulation of protein localization to plasma membrane
K	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
K	1990904	cellular_component	ribonucleoprotein complex
N	0000166	molecular_function	nucleotide binding
N	0001738	biological_process	morphogenesis of a polarized epithelium
N	0005515	molecular_function	protein binding
N	0005524	molecular_function	ATP binding
N	0005634	cellular_component	nucleus
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0005856	cellular_component	cytoskeleton
N	0005884	cellular_component	actin filament
N	0005886	cellular_component	plasma membrane
N	0005903	cellular_component	brush border
N	0005911	cellular_component	cell-cell junction
N	0005912	cellular_component	adherens junction
N	0005925	cellular_component	focal adhesion
N	0007017	biological_process	microtubule-based process
N	0007163	biological_process	establishment or maintenance of cell polarity
N	0007409	biological_process	axonogenesis
N	0015629	cellular_component	actin cytoskeleton
N	0016020	cellular_component	membrane
N	0016787	molecular_function	hydrolase activity
N	0016887	molecular_function	ATP hydrolysis activity
N	0019894	molecular_function	kinesin binding
N	0019901	molecular_function	protein kinase binding
N	0030027	cellular_component	lamellipodium
N	0030235	molecular_function	nitric-oxide synthase regulator activity
N	0030424	cellular_component	axon
N	0030863	cellular_component	cortical cytoskeleton
N	0030957	molecular_function	Tat protein binding
N	0032991	cellular_component	protein-containing complex
N	0034333	biological_process	adherens junction assembly
N	0035267	cellular_component	NuA4 histone acetyltransferase complex
N	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
N	0042802	molecular_function	identical protein binding
N	0043296	cellular_component	apical junction complex
N	0044305	cellular_component	calyx of Held
N	0045176	biological_process	apical protein localization
N	0045202	cellular_component	synapse
N	0048870	biological_process	cell motility
N	0050998	molecular_function	nitric-oxide synthase binding
N	0051621	biological_process	regulation of norepinephrine uptake
N	0051726	biological_process	regulation of cell cycle
N	0070160	cellular_component	tight junction
N	0071896	biological_process	protein localization to adherens junction
N	0072749	biological_process	cellular response to cytochalasin B
N	0097433	cellular_component	dense body
N	0098685	cellular_component	Schaffer collateral - CA1 synapse
N	0098871	cellular_component	postsynaptic actin cytoskeleton
N	0098973	molecular_function	structural constituent of postsynaptic actin cytoskeleton
N	0098974	biological_process	postsynaptic actin cytoskeleton organization
N	0098978	cellular_component	glutamatergic synapse
N	0141108	molecular_function	transporter regulator activity
N	0150111	biological_process	regulation of transepithelial transport
N	1900242	biological_process	regulation of synaptic vesicle endocytosis
N	1903076	biological_process	regulation of protein localization to plasma membrane
N	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
N	1990904	cellular_component	ribonucleoprotein complex
O	0000166	molecular_function	nucleotide binding
O	0001738	biological_process	morphogenesis of a polarized epithelium
O	0005515	molecular_function	protein binding
O	0005524	molecular_function	ATP binding
O	0005634	cellular_component	nucleus
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0005856	cellular_component	cytoskeleton
O	0005884	cellular_component	actin filament
O	0005886	cellular_component	plasma membrane
O	0005903	cellular_component	brush border
O	0005911	cellular_component	cell-cell junction
O	0005912	cellular_component	adherens junction
O	0005925	cellular_component	focal adhesion
O	0007017	biological_process	microtubule-based process
O	0007163	biological_process	establishment or maintenance of cell polarity
O	0007409	biological_process	axonogenesis
O	0015629	cellular_component	actin cytoskeleton
O	0016020	cellular_component	membrane
O	0016787	molecular_function	hydrolase activity
O	0016887	molecular_function	ATP hydrolysis activity
O	0019894	molecular_function	kinesin binding
O	0019901	molecular_function	protein kinase binding
O	0030027	cellular_component	lamellipodium
O	0030235	molecular_function	nitric-oxide synthase regulator activity
O	0030424	cellular_component	axon
O	0030863	cellular_component	cortical cytoskeleton
O	0030957	molecular_function	Tat protein binding
O	0032991	cellular_component	protein-containing complex
O	0034333	biological_process	adherens junction assembly
O	0035267	cellular_component	NuA4 histone acetyltransferase complex
O	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
O	0042802	molecular_function	identical protein binding
O	0043296	cellular_component	apical junction complex
O	0044305	cellular_component	calyx of Held
O	0045176	biological_process	apical protein localization
O	0045202	cellular_component	synapse
O	0048870	biological_process	cell motility
O	0050998	molecular_function	nitric-oxide synthase binding
O	0051621	biological_process	regulation of norepinephrine uptake
O	0051726	biological_process	regulation of cell cycle
O	0070160	cellular_component	tight junction
O	0071896	biological_process	protein localization to adherens junction
O	0072749	biological_process	cellular response to cytochalasin B
O	0097433	cellular_component	dense body
O	0098685	cellular_component	Schaffer collateral - CA1 synapse
O	0098871	cellular_component	postsynaptic actin cytoskeleton
O	0098973	molecular_function	structural constituent of postsynaptic actin cytoskeleton
O	0098974	biological_process	postsynaptic actin cytoskeleton organization
O	0098978	cellular_component	glutamatergic synapse
O	0141108	molecular_function	transporter regulator activity
O	0150111	biological_process	regulation of transepithelial transport
O	1900242	biological_process	regulation of synaptic vesicle endocytosis
O	1903076	biological_process	regulation of protein localization to plasma membrane
O	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
O	1990904	cellular_component	ribonucleoprotein complex
P	0000166	molecular_function	nucleotide binding
P	0001738	biological_process	morphogenesis of a polarized epithelium
P	0005515	molecular_function	protein binding
P	0005524	molecular_function	ATP binding
P	0005634	cellular_component	nucleus
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0005856	cellular_component	cytoskeleton
P	0005884	cellular_component	actin filament
P	0005886	cellular_component	plasma membrane
P	0005903	cellular_component	brush border
P	0005911	cellular_component	cell-cell junction
P	0005912	cellular_component	adherens junction
P	0005925	cellular_component	focal adhesion
P	0007017	biological_process	microtubule-based process
P	0007163	biological_process	establishment or maintenance of cell polarity
P	0007409	biological_process	axonogenesis
P	0015629	cellular_component	actin cytoskeleton
P	0016020	cellular_component	membrane
P	0016787	molecular_function	hydrolase activity
P	0016887	molecular_function	ATP hydrolysis activity
P	0019894	molecular_function	kinesin binding
P	0019901	molecular_function	protein kinase binding
P	0030027	cellular_component	lamellipodium
P	0030235	molecular_function	nitric-oxide synthase regulator activity
P	0030424	cellular_component	axon
P	0030863	cellular_component	cortical cytoskeleton
P	0030957	molecular_function	Tat protein binding
P	0032991	cellular_component	protein-containing complex
P	0034333	biological_process	adherens junction assembly
P	0035267	cellular_component	NuA4 histone acetyltransferase complex
P	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
P	0042802	molecular_function	identical protein binding
P	0043296	cellular_component	apical junction complex
P	0044305	cellular_component	calyx of Held
P	0045176	biological_process	apical protein localization
P	0045202	cellular_component	synapse
P	0048870	biological_process	cell motility
P	0050998	molecular_function	nitric-oxide synthase binding
P	0051621	biological_process	regulation of norepinephrine uptake
P	0051726	biological_process	regulation of cell cycle
P	0070160	cellular_component	tight junction
P	0071896	biological_process	protein localization to adherens junction
P	0072749	biological_process	cellular response to cytochalasin B
P	0097433	cellular_component	dense body
P	0098685	cellular_component	Schaffer collateral - CA1 synapse
P	0098871	cellular_component	postsynaptic actin cytoskeleton
P	0098973	molecular_function	structural constituent of postsynaptic actin cytoskeleton
P	0098974	biological_process	postsynaptic actin cytoskeleton organization
P	0098978	cellular_component	glutamatergic synapse
P	0141108	molecular_function	transporter regulator activity
P	0150111	biological_process	regulation of transepithelial transport
P	1900242	biological_process	regulation of synaptic vesicle endocytosis
P	1903076	biological_process	regulation of protein localization to plasma membrane
P	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
P	1990904	cellular_component	ribonucleoprotein complex
Q	0000166	molecular_function	nucleotide binding
Q	0001738	biological_process	morphogenesis of a polarized epithelium
Q	0005515	molecular_function	protein binding
Q	0005524	molecular_function	ATP binding
Q	0005634	cellular_component	nucleus
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0005856	cellular_component	cytoskeleton
Q	0005884	cellular_component	actin filament
Q	0005886	cellular_component	plasma membrane
Q	0005903	cellular_component	brush border
Q	0005911	cellular_component	cell-cell junction
Q	0005912	cellular_component	adherens junction
Q	0005925	cellular_component	focal adhesion
Q	0007017	biological_process	microtubule-based process
Q	0007163	biological_process	establishment or maintenance of cell polarity
Q	0007409	biological_process	axonogenesis
Q	0015629	cellular_component	actin cytoskeleton
Q	0016020	cellular_component	membrane
Q	0016787	molecular_function	hydrolase activity
Q	0016887	molecular_function	ATP hydrolysis activity
Q	0019894	molecular_function	kinesin binding
Q	0019901	molecular_function	protein kinase binding
Q	0030027	cellular_component	lamellipodium
Q	0030235	molecular_function	nitric-oxide synthase regulator activity
Q	0030424	cellular_component	axon
Q	0030863	cellular_component	cortical cytoskeleton
Q	0030957	molecular_function	Tat protein binding
Q	0032991	cellular_component	protein-containing complex
Q	0034333	biological_process	adherens junction assembly
Q	0035267	cellular_component	NuA4 histone acetyltransferase complex
Q	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
Q	0042802	molecular_function	identical protein binding
Q	0043296	cellular_component	apical junction complex
Q	0044305	cellular_component	calyx of Held
Q	0045176	biological_process	apical protein localization
Q	0045202	cellular_component	synapse
Q	0048870	biological_process	cell motility
Q	0050998	molecular_function	nitric-oxide synthase binding
Q	0051621	biological_process	regulation of norepinephrine uptake
Q	0051726	biological_process	regulation of cell cycle
Q	0070160	cellular_component	tight junction
Q	0071896	biological_process	protein localization to adherens junction
Q	0072749	biological_process	cellular response to cytochalasin B
Q	0097433	cellular_component	dense body
Q	0098685	cellular_component	Schaffer collateral - CA1 synapse
Q	0098871	cellular_component	postsynaptic actin cytoskeleton
Q	0098973	molecular_function	structural constituent of postsynaptic actin cytoskeleton
Q	0098974	biological_process	postsynaptic actin cytoskeleton organization
Q	0098978	cellular_component	glutamatergic synapse
Q	0141108	molecular_function	transporter regulator activity
Q	0150111	biological_process	regulation of transepithelial transport
Q	1900242	biological_process	regulation of synaptic vesicle endocytosis
Q	1903076	biological_process	regulation of protein localization to plasma membrane
Q	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
Q	1990904	cellular_component	ribonucleoprotein complex
R	0000166	molecular_function	nucleotide binding
R	0001738	biological_process	morphogenesis of a polarized epithelium
R	0005515	molecular_function	protein binding
R	0005524	molecular_function	ATP binding
R	0005634	cellular_component	nucleus
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0005856	cellular_component	cytoskeleton
R	0005884	cellular_component	actin filament
R	0005886	cellular_component	plasma membrane
R	0005903	cellular_component	brush border
R	0005911	cellular_component	cell-cell junction
R	0005912	cellular_component	adherens junction
R	0005925	cellular_component	focal adhesion
R	0007017	biological_process	microtubule-based process
R	0007163	biological_process	establishment or maintenance of cell polarity
R	0007409	biological_process	axonogenesis
R	0015629	cellular_component	actin cytoskeleton
R	0016020	cellular_component	membrane
R	0016787	molecular_function	hydrolase activity
R	0016887	molecular_function	ATP hydrolysis activity
R	0019894	molecular_function	kinesin binding
R	0019901	molecular_function	protein kinase binding
R	0030027	cellular_component	lamellipodium
R	0030235	molecular_function	nitric-oxide synthase regulator activity
R	0030424	cellular_component	axon
R	0030863	cellular_component	cortical cytoskeleton
R	0030957	molecular_function	Tat protein binding
R	0032991	cellular_component	protein-containing complex
R	0034333	biological_process	adherens junction assembly
R	0035267	cellular_component	NuA4 histone acetyltransferase complex
R	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
R	0042802	molecular_function	identical protein binding
R	0043296	cellular_component	apical junction complex
R	0044305	cellular_component	calyx of Held
R	0045176	biological_process	apical protein localization
R	0045202	cellular_component	synapse
R	0048870	biological_process	cell motility
R	0050998	molecular_function	nitric-oxide synthase binding
R	0051621	biological_process	regulation of norepinephrine uptake
R	0051726	biological_process	regulation of cell cycle
R	0070160	cellular_component	tight junction
R	0071896	biological_process	protein localization to adherens junction
R	0072749	biological_process	cellular response to cytochalasin B
R	0097433	cellular_component	dense body
R	0098685	cellular_component	Schaffer collateral - CA1 synapse
R	0098871	cellular_component	postsynaptic actin cytoskeleton
R	0098973	molecular_function	structural constituent of postsynaptic actin cytoskeleton
R	0098974	biological_process	postsynaptic actin cytoskeleton organization
R	0098978	cellular_component	glutamatergic synapse
R	0141108	molecular_function	transporter regulator activity
R	0150111	biological_process	regulation of transepithelial transport
R	1900242	biological_process	regulation of synaptic vesicle endocytosis
R	1903076	biological_process	regulation of protein localization to plasma membrane
R	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
R	1990904	cellular_component	ribonucleoprotein complex
S	0000166	molecular_function	nucleotide binding
S	0001738	biological_process	morphogenesis of a polarized epithelium
S	0005515	molecular_function	protein binding
S	0005524	molecular_function	ATP binding
S	0005634	cellular_component	nucleus
S	0005737	cellular_component	cytoplasm
S	0005829	cellular_component	cytosol
S	0005856	cellular_component	cytoskeleton
S	0005884	cellular_component	actin filament
S	0005886	cellular_component	plasma membrane
S	0005903	cellular_component	brush border
S	0005911	cellular_component	cell-cell junction
S	0005912	cellular_component	adherens junction
S	0005925	cellular_component	focal adhesion
S	0007017	biological_process	microtubule-based process
S	0007163	biological_process	establishment or maintenance of cell polarity
S	0007409	biological_process	axonogenesis
S	0015629	cellular_component	actin cytoskeleton
S	0016020	cellular_component	membrane
S	0016787	molecular_function	hydrolase activity
S	0016887	molecular_function	ATP hydrolysis activity
S	0019894	molecular_function	kinesin binding
S	0019901	molecular_function	protein kinase binding
S	0030027	cellular_component	lamellipodium
S	0030235	molecular_function	nitric-oxide synthase regulator activity
S	0030424	cellular_component	axon
S	0030863	cellular_component	cortical cytoskeleton
S	0030957	molecular_function	Tat protein binding
S	0032991	cellular_component	protein-containing complex
S	0034333	biological_process	adherens junction assembly
S	0035267	cellular_component	NuA4 histone acetyltransferase complex
S	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
S	0042802	molecular_function	identical protein binding
S	0043296	cellular_component	apical junction complex
S	0044305	cellular_component	calyx of Held
S	0045176	biological_process	apical protein localization
S	0045202	cellular_component	synapse
S	0048870	biological_process	cell motility
S	0050998	molecular_function	nitric-oxide synthase binding
S	0051621	biological_process	regulation of norepinephrine uptake
S	0051726	biological_process	regulation of cell cycle
S	0070160	cellular_component	tight junction
S	0071896	biological_process	protein localization to adherens junction
S	0072749	biological_process	cellular response to cytochalasin B
S	0097433	cellular_component	dense body
S	0098685	cellular_component	Schaffer collateral - CA1 synapse
S	0098871	cellular_component	postsynaptic actin cytoskeleton
S	0098973	molecular_function	structural constituent of postsynaptic actin cytoskeleton
S	0098974	biological_process	postsynaptic actin cytoskeleton organization
S	0098978	cellular_component	glutamatergic synapse
S	0141108	molecular_function	transporter regulator activity
S	0150111	biological_process	regulation of transepithelial transport
S	1900242	biological_process	regulation of synaptic vesicle endocytosis
S	1903076	biological_process	regulation of protein localization to plasma membrane
S	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
S	1990904	cellular_component	ribonucleoprotein complex
U	0003779	molecular_function	actin binding
U	0005515	molecular_function	protein binding
U	0005829	cellular_component	cytosol
U	0005856	cellular_component	cytoskeleton
U	0005903	cellular_component	brush border
U	0005911	cellular_component	cell-cell junction
U	0008290	cellular_component	F-actin capping protein complex
U	0016020	cellular_component	membrane
U	0030036	biological_process	actin cytoskeleton organization
U	0030863	cellular_component	cortical cytoskeleton
U	0034329	biological_process	cell junction assembly
U	0051015	molecular_function	actin filament binding
U	0051016	biological_process	barbed-end actin filament capping
U	0051693	biological_process	actin filament capping
U	0071203	cellular_component	WASH complex
V	0000902	biological_process	cell morphogenesis
V	0003779	molecular_function	actin binding
V	0005515	molecular_function	protein binding
V	0005737	cellular_component	cytoplasm
V	0005829	cellular_component	cytosol
V	0005856	cellular_component	cytoskeleton
V	0005903	cellular_component	brush border
V	0007010	biological_process	cytoskeleton organization
V	0008154	biological_process	actin polymerization or depolymerization
V	0008290	cellular_component	F-actin capping protein complex
V	0010591	biological_process	regulation of lamellipodium assembly
V	0014069	cellular_component	postsynaptic density
V	0016020	cellular_component	membrane
V	0022604	biological_process	regulation of cell morphogenesis
V	0030017	cellular_component	sarcomere
V	0030018	cellular_component	Z disc
V	0030027	cellular_component	lamellipodium
V	0030030	biological_process	cell projection organization
V	0030032	biological_process	lamellipodium assembly
V	0030036	biological_process	actin cytoskeleton organization
V	0030863	cellular_component	cortical cytoskeleton
V	0033150	cellular_component	cytoskeletal calyx
V	0043025	cellular_component	neuronal cell body
V	0043197	cellular_component	dendritic spine
V	0051016	biological_process	barbed-end actin filament capping
V	0051490	biological_process	negative regulation of filopodium assembly
V	0051693	biological_process	actin filament capping
V	0071203	cellular_component	WASH complex
V	0098685	cellular_component	Schaffer collateral - CA1 synapse
V	0098686	cellular_component	hippocampal mossy fiber to CA3 synapse
V	0120212	cellular_component	sperm head-tail coupling apparatus
W	0000166	molecular_function	nucleotide binding
W	0001738	biological_process	morphogenesis of a polarized epithelium
W	0005515	molecular_function	protein binding
W	0005524	molecular_function	ATP binding
W	0005634	cellular_component	nucleus
W	0005737	cellular_component	cytoplasm
W	0005829	cellular_component	cytosol
W	0005856	cellular_component	cytoskeleton
W	0005884	cellular_component	actin filament
W	0005886	cellular_component	plasma membrane
W	0005903	cellular_component	brush border
W	0005911	cellular_component	cell-cell junction
W	0005912	cellular_component	adherens junction
W	0005925	cellular_component	focal adhesion
W	0007017	biological_process	microtubule-based process
W	0007163	biological_process	establishment or maintenance of cell polarity
W	0007409	biological_process	axonogenesis
W	0015629	cellular_component	actin cytoskeleton
W	0016020	cellular_component	membrane
W	0016787	molecular_function	hydrolase activity
W	0016887	molecular_function	ATP hydrolysis activity
W	0019894	molecular_function	kinesin binding
W	0019901	molecular_function	protein kinase binding
W	0030027	cellular_component	lamellipodium
W	0030235	molecular_function	nitric-oxide synthase regulator activity
W	0030424	cellular_component	axon
W	0030863	cellular_component	cortical cytoskeleton
W	0030957	molecular_function	Tat protein binding
W	0032991	cellular_component	protein-containing complex
W	0034333	biological_process	adherens junction assembly
W	0035267	cellular_component	NuA4 histone acetyltransferase complex
W	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
W	0042802	molecular_function	identical protein binding
W	0043296	cellular_component	apical junction complex
W	0044305	cellular_component	calyx of Held
W	0045176	biological_process	apical protein localization
W	0045202	cellular_component	synapse
W	0048870	biological_process	cell motility
W	0050998	molecular_function	nitric-oxide synthase binding
W	0051621	biological_process	regulation of norepinephrine uptake
W	0051726	biological_process	regulation of cell cycle
W	0070160	cellular_component	tight junction
W	0071896	biological_process	protein localization to adherens junction
W	0072749	biological_process	cellular response to cytochalasin B
W	0097433	cellular_component	dense body
W	0098685	cellular_component	Schaffer collateral - CA1 synapse
W	0098871	cellular_component	postsynaptic actin cytoskeleton
W	0098973	molecular_function	structural constituent of postsynaptic actin cytoskeleton
W	0098974	biological_process	postsynaptic actin cytoskeleton organization
W	0098978	cellular_component	glutamatergic synapse
W	0141108	molecular_function	transporter regulator activity
W	0150111	biological_process	regulation of transepithelial transport
W	1900242	biological_process	regulation of synaptic vesicle endocytosis
W	1903076	biological_process	regulation of protein localization to plasma membrane
W	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
W	1990904	cellular_component	ribonucleoprotein complex

Functional Information from PROSITE/UniProt

site_id	PS00231
Number of Residues	6
Details	F_ACTIN_CAPPING_BETA F-actin capping protein beta subunit signature. CDYNRD

Chain	Residue	Details
V	CYS62-ASP67

---

site_id	PS00406
Number of Residues	11
Details	ACTINS_1 Actins signature 1. YVGDEAQs.KRG

Chain	Residue	Details
H	TYR53-GLY63

---

site_id	PS00432
Number of Residues	9
Details	ACTINS_2 Actins signature 2. WISKqEYDE

Chain	Residue	Details
H	TRP356-GLU364

---

site_id	PS00748
Number of Residues	9
Details	F_ACTIN_CAPPING_A_1 F-actin capping protein alpha subunit signature 1. VHYYEDGNV

Chain	Residue	Details
U	VAL196-VAL204

---

site_id	PS00749
Number of Residues	11
Details	F_ACTIN_CAPPING_A_2 F-actin capping protein alpha subunit signature 2. KaLRRqLPVTR

Chain	Residue	Details
U	LYS256-ARG266

---

site_id	PS01132
Number of Residues	13
Details	ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR

Chain	Residue	Details
H	LEU104-ARG116
A	LEU111-ARG123
B	LEU108-ARG120

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	11
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"A7MB62","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	39
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	39
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	41
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	39
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	38
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	43
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	Modified residue: {"description":"N-acetylthreonine","evidences":[{"source":"PubMed","id":"12665801","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	20
Details	Modified residue: {"description":"Methionine (R)-sulfoxide","evidences":[{"source":"UniProtKB","id":"P60710","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	10
Details	Modified residue: {"description":"Tele-methylhistidine","evidences":[{"source":"UniProtKB","id":"P60710","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	10
Details	Modified residue: {"description":"N6-methyllysine","evidences":[{"source":"UniProtKB","id":"P60709","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	36
Details	Repeat: {"description":"Cortactin 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	3
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"23806337","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"31600191","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P52907","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P52907","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P47756","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---