8K7C

Outward-facing structure of human ABCB6 W546A mutant (ADP/VO4-bound)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0016020	cellular_component	membrane
A	0016887	molecular_function	ATP hydrolysis activity
A	0055085	biological_process	transmembrane transport
A	0140359	molecular_function	ABC-type transporter activity
B	0005524	molecular_function	ATP binding
B	0016020	cellular_component	membrane
B	0016887	molecular_function	ATP hydrolysis activity
B	0055085	biological_process	transmembrane transport
B	0140359	molecular_function	ABC-type transporter activity

Functional Information from PROSITE/UniProt

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. LSGGEKQRVAIARTI

Chain	Residue	Details
A	LEU727-ILE741

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	240
Details	TRANSMEM: Helical => ECO:0000255, ECO:0000255|PROSITE-ProRule:PRU00441

Chain	Residue	Details
A	VAL264-ILE284
A	LEU292-LEU312
A	GLY376-ALA396
A	ILE398-PHE418
A	THR500-VAL520
A	TYR530-TYR550
B	VAL264-ILE284
B	LEU292-LEU312
B	GLY376-ALA396
B	ILE398-PHE418
B	THR500-VAL520
B	TYR530-TYR550

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site_id	SWS_FT_FI2
Number of Residues	30
Details	TOPO_DOM: Lumenal => ECO:0000305|PubMed:18279659, ECO:0000305|PubMed:21199866

Chain	Residue	Details
A	PHE285-ASN291
A	ASP397
A	THR521-ASP529
B	PHE285-ASN291
B	ASP397
B	THR521-ASP529

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site_id	SWS_FT_FI3
Number of Residues	284
Details	TOPO_DOM: Cytoplasmic => ECO:0000305

Chain	Residue	Details
A	LYS313-ARG375
A	LEU419-GLN499
B	LYS313-ARG375
B	LEU419-GLN499

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site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:20823549, ECO:0007744|PDB:3NH9

Chain	Residue	Details
A	TYR599
A	GLY623
B	TYR599
B	GLY623

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