8J1N
Structure of human UCP1 in the DNP-bound state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002024 | biological_process | diet induced thermogenesis |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005740 | cellular_component | mitochondrial envelope |
| A | 0005743 | cellular_component | mitochondrial inner membrane |
| A | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006839 | biological_process | mitochondrial transport |
| A | 0009266 | biological_process | response to temperature stimulus |
| A | 0009409 | biological_process | response to cold |
| A | 0015078 | molecular_function | proton transmembrane transporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0017077 | molecular_function | oxidative phosphorylation uncoupler activity |
| A | 0019003 | molecular_function | GDP binding |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0031667 | biological_process | response to nutrient levels |
| A | 0032555 | molecular_function | purine ribonucleotide binding |
| A | 0032870 | biological_process | cellular response to hormone stimulus |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0034614 | biological_process | cellular response to reactive oxygen species |
| A | 0036041 | molecular_function | long-chain fatty acid binding |
| A | 0043168 | molecular_function | anion binding |
| A | 0050873 | biological_process | brown fat cell differentiation |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0070417 | biological_process | cellular response to cold |
| A | 0071398 | biological_process | cellular response to fatty acid |
| A | 0120162 | biological_process | positive regulation of cold-induced thermogenesis |
| A | 1901612 | molecular_function | cardiolipin binding |
| A | 1902600 | biological_process | proton transmembrane transport |
| A | 1903426 | biological_process | regulation of reactive oxygen species biosynthetic process |
| A | 1903495 | biological_process | cellular response to dehydroepiandrosterone |
| A | 1990542 | biological_process | mitochondrial transmembrane transport |
| A | 1990845 | biological_process | adaptive thermogenesis |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 117 |
| Details | Topological domain: {"description":"Mitochondrial matrix","evidences":[{"source":"UniProtKB","id":"P04633","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 35 |
| Details | Topological domain: {"description":"Mitochondrial intermembrane","evidences":[{"source":"UniProtKB","id":"P04633","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 16 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 16 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 91 |
| Details | Repeat: {"description":"Solcar 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 90 |
| Details | Repeat: {"description":"Solcar 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 85 |
| Details | Repeat: {"description":"Solcar 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"28781081","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Cysteine sulfenic acid (-SOH)","evidences":[{"source":"UniProtKB","id":"P12242","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
