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8J1N

Structure of human UCP1 in the DNP-bound state

Functional Information from GO Data
ChainGOidnamespacecontents
A0002024biological_processdiet induced thermogenesis
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005739cellular_componentmitochondrion
A0005740cellular_componentmitochondrial envelope
A0005743cellular_componentmitochondrial inner membrane
A0006357biological_processregulation of transcription by RNA polymerase II
A0006839biological_processmitochondrial transport
A0009266biological_processresponse to temperature stimulus
A0009409biological_processresponse to cold
A0015078molecular_functionproton transmembrane transporter activity
A0017077molecular_functionoxidative phosphorylation uncoupler activity
A0019003molecular_functionGDP binding
A0022857molecular_functiontransmembrane transporter activity
A0031667biological_processresponse to nutrient levels
A0032555molecular_functionpurine ribonucleotide binding
A0032870biological_processcellular response to hormone stimulus
A0034220biological_processmonoatomic ion transmembrane transport
A0034614biological_processcellular response to reactive oxygen species
A0036041molecular_functionlong-chain fatty acid binding
A0050873biological_processbrown fat cell differentiation
A0055085biological_processtransmembrane transport
A0070417biological_processcellular response to cold
A0071398biological_processcellular response to fatty acid
A0120162biological_processpositive regulation of cold-induced thermogenesis
A1901612molecular_functioncardiolipin binding
A1902600biological_processproton transmembrane transport
A1903426biological_processregulation of reactive oxygen species biosynthetic process
A1903495biological_processcellular response to dehydroepiandrosterone
A1990542biological_processmitochondrial transmembrane transport
A1990845biological_processadaptive thermogenesis
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues61
DetailsTOPO_DOM: Mitochondrial intermembrane => ECO:0000250|UniProtKB:P04633
ChainResidueDetails
AMET0-HIS9
AASP96-LYS115
AASP195-VAL211
AGLU289-THR306

site_idSWS_FT_FI2
Number of Residues21
DetailsTRANSMEM: Helical; Name=1 => ECO:0000255
ChainResidueDetails
APRO10-PHE31

site_idSWS_FT_FI3
Number of Residues117
DetailsTOPO_DOM: Mitochondrial matrix => ECO:0000250|UniProtKB:P04633
ChainResidueDetails
APRO32-LYS72
ATHR133-THR177
AVAL232-ALA265

site_idSWS_FT_FI4
Number of Residues22
DetailsTRANSMEM: Helical; Name=2 => ECO:0000255
ChainResidueDetails
ALEU73-TYR95

site_idSWS_FT_FI5
Number of Residues16
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255
ChainResidueDetails
AILE116-PRO132

site_idSWS_FT_FI6
Number of Residues16
DetailsTRANSMEM: Helical; Name=4 => ECO:0000255
ChainResidueDetails
APRO178-TYR194

site_idSWS_FT_FI7
Number of Residues19
DetailsTRANSMEM: Helical; Name=5 => ECO:0000255
ChainResidueDetails
APRO212-PRO231

site_idSWS_FT_FI8
Number of Residues22
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255
ChainResidueDetails
APHE266-PHE288

site_idSWS_FT_FI9
Number of Residues2
DetailsBINDING: BINDING => ECO:0000305|PubMed:28781081
ChainResidueDetails
ALYS55
ALYS268

site_idSWS_FT_FI10
Number of Residues1
DetailsMOD_RES: Cysteine sulfenic acid (-SOH) => ECO:0000250|UniProtKB:P12242
ChainResidueDetails
ACYS253

226707

PDB entries from 2024-10-30

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