8GCE
The Extracellular Domain of Integrin AlphaIIbBeta3 in Intermediate State
Functional Information from GO Data
Functional Information from PROSITE/UniProt
| site_id | PS00022 |
| Number of Residues | 12 |
| Details | EGF_1 EGF-like domain signature 1. CrCgpGwlGSqC |
| Chain | Residue | Details |
| B | CYS460-CYS471 | |
| B | CYS547-CYS558 |
| site_id | PS00242 |
| Number of Residues | 8 |
| Details | INTEGRIN_ALPHA Integrins alpha chain signature. WKvGFFkR |
| Chain | Residue | Details |
| A | TRP988-ARG995 |
| site_id | PS00243 |
| Number of Residues | 14 |
| Details | INTEGRIN_BETA Integrins beta chain cysteine-rich domain signature. CsQr..GeClCgqCvC |
| Chain | Residue | Details |
| B | CYS495-CYS508 | |
| B | CYS536-CYS549 | |
| B | CYS575-CYS588 |
| site_id | PS01186 |
| Number of Residues | 14 |
| Details | EGF_2 EGF-like domain signature 2. CrCgpGWlgsqce..C |
| Chain | Residue | Details |
| B | CYS460-CYS473 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 691 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| B | GLY1-ASP692 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| B | ILE693-TRP715 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 46 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| B | LYS716-THR762 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: in MIDAS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU |
| Chain | Residue | Details |
| B | SER121 | |
| A | ASP305 | |
| A | ASP365 | |
| A | ASP367 | |
| A | ASP369 | |
| A | TYR371 | |
| A | ASP373 | |
| A | ASP426 | |
| A | ASP428 | |
| A | ASN430 | |
| A | TYR432 | |
| B | GLU220 | |
| A | ASP434 | |
| A | ASP247 | |
| A | THR250 | |
| A | GLU252 | |
| A | ASP297 | |
| A | ASN299 | |
| A | ASP301 | |
| A | ARG303 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: in MIDAS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCU |
| Chain | Residue | Details |
| B | SER123 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | BINDING: in ADMIDAS binding site => ECO:0000269|PubMed:11546839, ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1JV2, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU, ECO:0007744|PDB:3IJE |
| Chain | Residue | Details |
| B | ASP126 | |
| B | ASP127 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | BINDING: in LIMBS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU |
| Chain | Residue | Details |
| B | ASP158 | |
| B | ASN215 | |
| B | ASP217 | |
| B | PRO219 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | BINDING: in LIMBS binding site => ECO:0007744|PDB:4G1M |
| Chain | Residue | Details |
| B | ASP251 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | BINDING: in ADMIDAS binding site and unliganded-closed conformation => ECO:0000269|PubMed:11546839, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1JV2, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3IJE |
| Chain | Residue | Details |
| B | MET335 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:O54890 |
| Chain | Residue | Details |
| B | THR741 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:19141530, ECO:0007744|PubMed:18088087 |
| Chain | Residue | Details |
| B | TYR747 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by PDPK1 and PKB/AKT1; in vitro => ECO:0000269|PubMed:10896934 |
| Chain | Residue | Details |
| B | THR753 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:8631894 |
| Chain | Residue | Details |
| B | TYR759 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:16263699, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3IJE |
| Chain | Residue | Details |
| B | ASN99 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11546839, ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1JV2, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3IJE |
| Chain | Residue | Details |
| B | ASN320 | |
| B | ASN371 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:3IJE |
| Chain | Residue | Details |
| B | ASN452 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11546839, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1JV2, ECO:0007744|PDB:3IJE |
| Chain | Residue | Details |
| B | ASN559 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11546839, ECO:0000269|PubMed:19159218, ECO:0007744|PDB:1JV2 |
| Chain | Residue | Details |
| B | ASN654 |
