8GCE
The Extracellular Domain of Integrin AlphaIIbBeta3 in Intermediate State
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Integrin alpha-IIb | polymer | 1039 | 113467.5 | 1 | UniProt (P08514) Pfam (PF01839) Pfam (PF08441) Pfam (PF20805) Pfam (PF20806) Pfam (PF00357) In PDB | Homo sapiens (human) | GPalpha IIb,GPIIb,Platelet membrane glycoprotein IIb |
| 2 | B | Integrin beta-3 | polymer | 788 | 87156.8 | 1 | UniProt (P05106) Pfam (PF07974) Pfam (PF07965) Pfam (PF08725) Pfam (PF17205) Pfam (PF00362) Pfam (PF18372) In PDB | Homo sapiens (human) | Platelet membrane glycoprotein IIIa,GPIIIa |
| 3 | C, D | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
| 4 | E | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 5 | A, B | CALCIUM ION | non-polymer | 40.1 | 6 | Chemie (CA) | |||
| 6 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 7 | B | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) |
Sequence modifications
A: -30 - 1008 (UniProt: P08514)
B: -25 - 762 (UniProt: P05106)
| PDB | External Database | Details |
|---|---|---|
| Cys 959 | Leu 990 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Cys 688 | Pro 714 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 200624.3 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 1597.5 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 707.2 | |
| All* | Total formula weight | 202929.0 |
