8EBN
Structure of KLHDC2-EloB/C tetrameric assembly
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0016567 | biological_process | protein ubiquitination |
| A | 0016604 | cellular_component | nuclear body |
| A | 0031461 | cellular_component | cullin-RING ubiquitin ligase complex |
| A | 0031462 | cellular_component | Cul2-RING ubiquitin ligase complex |
| A | 0031965 | cellular_component | nuclear membrane |
| A | 0043161 | biological_process | proteasome-mediated ubiquitin-dependent protein catabolic process |
| A | 0140627 | biological_process | ubiquitin-dependent protein catabolic process via the C-end degron rule pathway |
| A | 1990756 | molecular_function | ubiquitin-like ligase-substrate adaptor activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0016567 | biological_process | protein ubiquitination |
| B | 0016604 | cellular_component | nuclear body |
| B | 0031461 | cellular_component | cullin-RING ubiquitin ligase complex |
| B | 0031462 | cellular_component | Cul2-RING ubiquitin ligase complex |
| B | 0031965 | cellular_component | nuclear membrane |
| B | 0043161 | biological_process | proteasome-mediated ubiquitin-dependent protein catabolic process |
| B | 0140627 | biological_process | ubiquitin-dependent protein catabolic process via the C-end degron rule pathway |
| B | 1990756 | molecular_function | ubiquitin-like ligase-substrate adaptor activity |
| C | 0006368 | biological_process | transcription elongation by RNA polymerase II |
| C | 0030891 | cellular_component | VCB complex |
| C | 0070449 | cellular_component | elongin complex |
| D | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| E | 0006368 | biological_process | transcription elongation by RNA polymerase II |
| E | 0030891 | cellular_component | VCB complex |
| E | 0070449 | cellular_component | elongin complex |
| F | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 44 |
| Details | Repeat: {"description":"Kelch 2","evidences":[{"source":"PubMed","id":"36805027","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38177675","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8EBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SH2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 59 |
| Details | Repeat: {"description":"Kelch 3","evidences":[{"source":"PubMed","id":"36805027","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38177675","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8EBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SH2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 38 |
| Details | Repeat: {"description":"Kelch 4","evidences":[{"source":"PubMed","id":"36805027","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38177675","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8EBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SH2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 80 |
| Details | Repeat: {"description":"Kelch 5","evidences":[{"source":"PubMed","id":"36805027","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38177675","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8EBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SH2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 74 |
| Details | Repeat: {"description":"Kelch 6","evidences":[{"source":"PubMed","id":"36805027","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38177675","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8EBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SH2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 54 |
| Details | Repeat: {"description":"Kelch 1","evidences":[{"source":"PubMed","id":"36805027","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38177675","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8EBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SH2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 130 |
| Details | Domain: {"description":"Ubiquitin-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Waridel P.","Quadroni M."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
