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8DYP

Crystal structure of human cystine transporter cystinosin

Functional Information from GO Data
ChainGOidnamespacecontents
A0002088biological_processlens development in camera-type eye
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005769cellular_componentearly endosome
A0005770cellular_componentlate endosome
A0005886cellular_componentplasma membrane
A0006520biological_processamino acid metabolic process
A0006749biological_processglutathione metabolic process
A0006811biological_processmonoatomic ion transport
A0007420biological_processbrain development
A0007616biological_processlong-term memory
A0007625biological_processgrooming behavior
A0007628biological_processadult walking behavior
A0008542biological_processvisual learning
A0010730biological_processnegative regulation of hydrogen peroxide biosynthetic process
A0010918biological_processpositive regulation of mitochondrial membrane potential
A0015031biological_processprotein transport
A0015184molecular_functionL-cystine transmembrane transporter activity
A0015293molecular_functionsymporter activity
A0015295molecular_functionsolute:proton symporter activity
A0015811biological_processL-cystine transport
A0030878biological_processthyroid gland development
A0033162cellular_componentmelanosome membrane
A0035623biological_processrenal glucose absorption
A0042438biological_processmelanin biosynthetic process
A0042470cellular_componentmelanosome
A0043066biological_processnegative regulation of apoptotic process
A0043231cellular_componentintracellular membrane-bounded organelle
A0046034biological_processATP metabolic process
A0048021biological_processregulation of melanin biosynthetic process
A0050890biological_processcognition
A0055085biological_processtransmembrane transport
A0070062cellular_componentextracellular exosome
A0070295biological_processrenal water absorption
A0072158biological_processproximal tubule morphogenesis
A0097018biological_processrenal albumin absorption
A0097291biological_processrenal phosphate ion absorption
A1902600biological_processproton transmembrane transport
A1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
A1903432biological_processregulation of TORC1 signaling
A1904263biological_processpositive regulation of TORC1 signaling
A1904970biological_processbrush border assembly
A2000611biological_processpositive regulation of thyroid hormone generation
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues143
DetailsTRANSMEM: Helical => ECO:0000269|PubMed:36113465, ECO:0007744|PDB:8DKE, ECO:0007744|PDB:8DKI, ECO:0007744|PDB:8DKM, ECO:0007744|PDB:8DKW, ECO:0007744|PDB:8DKX, ECO:0007744|PDB:8DYP
ChainResidueDetails
AILE126-TRP150
APHE160-GLY179
ASER203-LEU225
ATRP235-VAL257
AGLN264-PHE289
AILE299-GLY308
AASP332-PHE354

site_idSWS_FT_FI2
Number of Residues24
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:36113465
ChainResidueDetails
AARG151-SER159
ATYR226-SER234
ATYR290-SER298

site_idSWS_FT_FI3
Number of Residues49
DetailsTOPO_DOM: Lumenal => ECO:0000269|PubMed:36113465
ChainResidueDetails
ALEU180-ASN202
AGLY258-LEU263
AGLY309-GLY331

site_idSWS_FT_FI4
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:36113465, ECO:0007744|PDB:8DKM
ChainResidueDetails
AASN166
AALA301

site_idSWS_FT_FI5
Number of Residues2
DetailsBINDING: BINDING => ECO:0000305|PubMed:36113465
ChainResidueDetails
AASP205
AASP346

site_idSWS_FT_FI6
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:36113465
ChainResidueDetails
ALYS273
ALYS280
ATYR281
AASP305

site_idSWS_FT_FI7
Number of Residues6
DetailsCARBOHYD: N-linked (GlcNAc...) (high mannose) asparagine => ECO:0000255, ECO:0000269|PubMed:28082515
ChainResidueDetails
AALA36
AALA41
AALA51
AALA84
AALA104
AALA107

site_idSWS_FT_FI8
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:28082515
ChainResidueDetails
AALA66

221716

PDB entries from 2024-06-26

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