8DYP
Crystal structure of human cystine transporter cystinosin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005764 | cellular_component | lysosome |
| A | 0005765 | cellular_component | lysosomal membrane |
| A | 0005769 | cellular_component | early endosome |
| A | 0005770 | cellular_component | late endosome |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0006749 | biological_process | glutathione metabolic process |
| A | 0007420 | biological_process | brain development |
| A | 0015031 | biological_process | protein transport |
| A | 0015184 | molecular_function | L-cystine transmembrane transporter activity |
| A | 0015293 | molecular_function | symporter activity |
| A | 0015295 | molecular_function | solute:proton symporter activity |
| A | 0015811 | biological_process | L-cystine transport |
| A | 0033162 | cellular_component | melanosome membrane |
| A | 0035672 | biological_process | oligopeptide transmembrane transport |
| A | 0042438 | biological_process | melanin biosynthetic process |
| A | 0042470 | cellular_component | melanosome |
| A | 0046034 | biological_process | ATP metabolic process |
| A | 0048021 | biological_process | regulation of melanin biosynthetic process |
| A | 0048513 | biological_process | animal organ development |
| A | 0048731 | biological_process | system development |
| A | 0050890 | biological_process | cognition |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 1902600 | biological_process | proton transmembrane transport |
| A | 1903432 | biological_process | regulation of TORC1 signaling |
| A | 1904263 | biological_process | positive regulation of TORC1 signaling |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 143 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"36113465","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8DKE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DKI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DKM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DKW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DKX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DYP","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"36113465","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 49 |
| Details | Topological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"36113465","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 66 |
| Details | Domain: {"description":"PQ-loop 1","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 65 |
| Details | Domain: {"description":"PQ-loop 2","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"36113465","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8DKM","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"36113465","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"36113465","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (high mannose) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"28082515","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"28082515","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
