8BTL

Crystal structure of a complex between the E2 conjugating enzyme UBE2A and the E3 ligase module from UBR4

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0000086	biological_process	G2/M transition of mitotic cell cycle
C	0000209	biological_process	protein polyubiquitination
C	0000785	cellular_component	chromatin
C	0004842	molecular_function	ubiquitin-protein transferase activity
C	0005515	molecular_function	protein binding
C	0005654	cellular_component	nucleoplasm
C	0005764	cellular_component	lysosome
C	0005770	cellular_component	late endosome
C	0005829	cellular_component	cytosol
C	0006281	biological_process	DNA repair
C	0006301	biological_process	DNA damage tolerance
C	0006338	biological_process	chromatin remodeling
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0009411	biological_process	response to UV
C	0016567	biological_process	protein ubiquitination
C	0019787	molecular_function	ubiquitin-like protein transferase activity
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0033503	cellular_component	HULC complex
C	0043130	molecular_function	ubiquitin binding
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0061631	molecular_function	ubiquitin conjugating enzyme activity
C	0070936	biological_process	protein K48-linked ubiquitination
C	0070979	biological_process	protein K11-linked ubiquitination
C	1901526	biological_process	positive regulation of mitophagy
D	0000086	biological_process	G2/M transition of mitotic cell cycle
D	0000209	biological_process	protein polyubiquitination
D	0000785	cellular_component	chromatin
D	0004842	molecular_function	ubiquitin-protein transferase activity
D	0005515	molecular_function	protein binding
D	0005654	cellular_component	nucleoplasm
D	0005764	cellular_component	lysosome
D	0005770	cellular_component	late endosome
D	0005829	cellular_component	cytosol
D	0006281	biological_process	DNA repair
D	0006301	biological_process	DNA damage tolerance
D	0006338	biological_process	chromatin remodeling
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0009411	biological_process	response to UV
D	0016567	biological_process	protein ubiquitination
D	0019787	molecular_function	ubiquitin-like protein transferase activity
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0033503	cellular_component	HULC complex
D	0043130	molecular_function	ubiquitin binding
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0061631	molecular_function	ubiquitin conjugating enzyme activity
D	0070936	biological_process	protein K48-linked ubiquitination
D	0070979	biological_process	protein K11-linked ubiquitination
D	1901526	biological_process	positive regulation of mitophagy

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	230
Details	Domain: {"description":"UZI","evidences":[{"source":"PROSITE-ProRule","id":"PRU01388","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"38182926","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40328314","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40875847","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8B5W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8BTL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9D9Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	114
Details	Zinc finger: {"description":"HemiRING-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01388","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"38182926","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40328314","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40875847","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8B5W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8BTL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9D9Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01388","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"38182926","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8B5W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8BTL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	292
Details	Domain: {"description":"UBC core","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Active site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10133","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by CDK9","evidences":[{"source":"PubMed","id":"22592529","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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