8ASC
Ku70/80 binds to the Ku-binding motif of PAXX
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000723 | biological_process | telomere maintenance |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003678 | molecular_function | DNA helicase activity |
| A | 0003684 | molecular_function | damaged DNA binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0006303 | biological_process | double-strand break repair via nonhomologous end joining |
| A | 0042162 | molecular_function | telomeric DNA binding |
| A | 0043564 | cellular_component | Ku70:Ku80 complex |
| B | 0000723 | biological_process | telomere maintenance |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003678 | molecular_function | DNA helicase activity |
| B | 0003684 | molecular_function | damaged DNA binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0006303 | biological_process | double-strand break repair via nonhomologous end joining |
| B | 0006310 | biological_process | DNA recombination |
| B | 0042162 | molecular_function | telomeric DNA binding |
| B | 0043564 | cellular_component | Ku70:Ku80 complex |
| E | 0000723 | biological_process | telomere maintenance |
| E | 0003677 | molecular_function | DNA binding |
| E | 0003678 | molecular_function | DNA helicase activity |
| E | 0003684 | molecular_function | damaged DNA binding |
| E | 0005634 | cellular_component | nucleus |
| E | 0006303 | biological_process | double-strand break repair via nonhomologous end joining |
| E | 0042162 | molecular_function | telomeric DNA binding |
| E | 0043564 | cellular_component | Ku70:Ku80 complex |
| F | 0000723 | biological_process | telomere maintenance |
| F | 0003677 | molecular_function | DNA binding |
| F | 0003678 | molecular_function | DNA helicase activity |
| F | 0003684 | molecular_function | damaged DNA binding |
| F | 0005634 | cellular_component | nucleus |
| F | 0006303 | biological_process | double-strand break repair via nonhomologous end joining |
| F | 0006310 | biological_process | DNA recombination |
| F | 0042162 | molecular_function | telomeric DNA binding |
| F | 0043564 | cellular_component | Ku70:Ku80 complex |
| J | 0006303 | biological_process | double-strand break repair via nonhomologous end joining |
| K | 0000723 | biological_process | telomere maintenance |
| K | 0003677 | molecular_function | DNA binding |
| K | 0003678 | molecular_function | DNA helicase activity |
| K | 0003684 | molecular_function | damaged DNA binding |
| K | 0005634 | cellular_component | nucleus |
| K | 0006303 | biological_process | double-strand break repair via nonhomologous end joining |
| K | 0042162 | molecular_function | telomeric DNA binding |
| K | 0043564 | cellular_component | Ku70:Ku80 complex |
| L | 0000723 | biological_process | telomere maintenance |
| L | 0003677 | molecular_function | DNA binding |
| L | 0003678 | molecular_function | DNA helicase activity |
| L | 0003684 | molecular_function | damaged DNA binding |
| L | 0005634 | cellular_component | nucleus |
| L | 0006303 | biological_process | double-strand break repair via nonhomologous end joining |
| L | 0006310 | biological_process | DNA recombination |
| L | 0042162 | molecular_function | telomeric DNA binding |
| L | 0043564 | cellular_component | Ku70:Ku80 complex |
| O | 0000723 | biological_process | telomere maintenance |
| O | 0003677 | molecular_function | DNA binding |
| O | 0003678 | molecular_function | DNA helicase activity |
| O | 0003684 | molecular_function | damaged DNA binding |
| O | 0005634 | cellular_component | nucleus |
| O | 0006303 | biological_process | double-strand break repair via nonhomologous end joining |
| O | 0042162 | molecular_function | telomeric DNA binding |
| O | 0043564 | cellular_component | Ku70:Ku80 complex |
| P | 0000723 | biological_process | telomere maintenance |
| P | 0003677 | molecular_function | DNA binding |
| P | 0003678 | molecular_function | DNA helicase activity |
| P | 0003684 | molecular_function | damaged DNA binding |
| P | 0005634 | cellular_component | nucleus |
| P | 0006303 | biological_process | double-strand break repair via nonhomologous end joining |
| P | 0006310 | biological_process | DNA recombination |
| P | 0042162 | molecular_function | telomeric DNA binding |
| P | 0043564 | cellular_component | Ku70:Ku80 complex |
| T | 0006303 | biological_process | double-strand break repair via nonhomologous end joining |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 828 |
| Details | Domain: {"description":"Ku"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 256 |
| Details | Region: {"description":"DNA-binding","evidences":[{"source":"PubMed","id":"15023334","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 436 |
| Details | Region: {"description":"Interaction with XRCC5","evidences":[{"source":"PubMed","id":"15023334","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine; by PRKDC","evidences":[{"source":"PubMed","id":"9362500","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 16 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"15023334","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"15023334","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 16 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 28 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 796 |
| Details | Domain: {"description":"Ku","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 108 |
| Details | Region: {"description":"Leucine-zipper"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 28 |
| Details | Motif: {"description":"XLM","evidences":[{"source":"PubMed","id":"27063109","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
