8A58

X-ray structure of TRIM21 RING E3 ligase in complex with E2 enzyme Ube2W

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000209	biological_process	protein polyubiquitination
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0006281	biological_process	DNA repair
A	0006513	biological_process	protein monoubiquitination
A	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
A	0006974	biological_process	DNA damage response
A	0016567	biological_process	protein ubiquitination
A	0016740	molecular_function	transferase activity
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0031669	biological_process	cellular response to nutrient levels
A	0038202	biological_process	TORC1 signaling
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0061631	molecular_function	ubiquitin conjugating enzyme activity
A	0070979	biological_process	protein K11-linked ubiquitination
A	0071218	biological_process	cellular response to misfolded protein
A	0140374	biological_process	antiviral innate immune response
A	1904262	biological_process	negative regulation of TORC1 signaling
B	0000166	molecular_function	nucleotide binding
B	0000209	biological_process	protein polyubiquitination
B	0004842	molecular_function	ubiquitin-protein transferase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0006281	biological_process	DNA repair
B	0006513	biological_process	protein monoubiquitination
B	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
B	0006974	biological_process	DNA damage response
B	0016567	biological_process	protein ubiquitination
B	0016740	molecular_function	transferase activity
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0031669	biological_process	cellular response to nutrient levels
B	0038202	biological_process	TORC1 signaling
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0061631	molecular_function	ubiquitin conjugating enzyme activity
B	0070979	biological_process	protein K11-linked ubiquitination
B	0071218	biological_process	cellular response to misfolded protein
B	0140374	biological_process	antiviral innate immune response
B	1904262	biological_process	negative regulation of TORC1 signaling
C	0004842	molecular_function	ubiquitin-protein transferase activity
C	0016567	biological_process	protein ubiquitination
C	0046872	molecular_function	metal ion binding
D	0004842	molecular_function	ubiquitin-protein transferase activity
D	0016567	biological_process	protein ubiquitination
D	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00518
Number of Residues	10
Details	ZF_RING_1 Zinc finger RING-type signature. CgHsFCqeCI

Chain	Residue	Details
C	CYS31-ILE40

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Cross-link: {"description":"Peptide (Met-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23560854","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	78
Details	Zinc finger: {"description":"RING-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00175","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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