7Z13

S. cerevisiae CMGE dimer nucleating origin DNA melting

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
2	0003677	molecular_function	DNA binding
2	0005524	molecular_function	ATP binding
2	0005634	cellular_component	nucleus
2	0006260	biological_process	DNA replication
2	0006270	biological_process	DNA replication initiation
2	0032508	biological_process	DNA duplex unwinding
2	0042555	cellular_component	MCM complex
2	1905775	biological_process	negative regulation of DNA helicase activity
3	0000727	biological_process	double-strand break repair via break-induced replication
3	0000781	cellular_component	chromosome, telomeric region
3	0003677	molecular_function	DNA binding
3	0003682	molecular_function	chromatin binding
3	0003688	molecular_function	DNA replication origin binding
3	0003697	molecular_function	single-stranded DNA binding
3	0004386	molecular_function	helicase activity
3	0005515	molecular_function	protein binding
3	0005524	molecular_function	ATP binding
3	0005634	cellular_component	nucleus
3	0005654	cellular_component	nucleoplasm
3	0005656	cellular_component	nuclear pre-replicative complex
3	0005737	cellular_component	cytoplasm
3	0006260	biological_process	DNA replication
3	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
3	0006268	biological_process	DNA unwinding involved in DNA replication
3	0006270	biological_process	DNA replication initiation
3	0006271	biological_process	DNA strand elongation involved in DNA replication
3	0006279	biological_process	premeiotic DNA replication
3	0016787	molecular_function	hydrolase activity
3	0016887	molecular_function	ATP hydrolysis activity
3	0017116	molecular_function	single-stranded DNA helicase activity
3	0030466	biological_process	silent mating-type cassette heterochromatin formation
3	0031261	cellular_component	DNA replication preinitiation complex
3	0031298	cellular_component	replication fork protection complex
3	0031509	biological_process	subtelomeric heterochromatin formation
3	0032508	biological_process	DNA duplex unwinding
3	0042555	cellular_component	MCM complex
3	0043596	cellular_component	nuclear replication fork
3	0071162	cellular_component	CMG complex
3	1902975	biological_process	mitotic DNA replication initiation
3	1904931	molecular_function	MCM complex binding
4	0000727	biological_process	double-strand break repair via break-induced replication
4	0003677	molecular_function	DNA binding
4	0003678	molecular_function	DNA helicase activity
4	0003688	molecular_function	DNA replication origin binding
4	0003697	molecular_function	single-stranded DNA binding
4	0004386	molecular_function	helicase activity
4	0005515	molecular_function	protein binding
4	0005524	molecular_function	ATP binding
4	0005634	cellular_component	nucleus
4	0005654	cellular_component	nucleoplasm
4	0005656	cellular_component	nuclear pre-replicative complex
4	0005737	cellular_component	cytoplasm
4	0006260	biological_process	DNA replication
4	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
4	0006268	biological_process	DNA unwinding involved in DNA replication
4	0006270	biological_process	DNA replication initiation
4	0006271	biological_process	DNA strand elongation involved in DNA replication
4	0006279	biological_process	premeiotic DNA replication
4	0008270	molecular_function	zinc ion binding
4	0009378	molecular_function	four-way junction helicase activity
4	0016787	molecular_function	hydrolase activity
4	0016887	molecular_function	ATP hydrolysis activity
4	0017116	molecular_function	single-stranded DNA helicase activity
4	0031261	cellular_component	DNA replication preinitiation complex
4	0031298	cellular_component	replication fork protection complex
4	0032508	biological_process	DNA duplex unwinding
4	0033260	biological_process	nuclear DNA replication
4	0042555	cellular_component	MCM complex
4	0043138	molecular_function	3'-5' DNA helicase activity
4	0043596	cellular_component	nuclear replication fork
4	0071162	cellular_component	CMG complex
4	0097373	cellular_component	MCM core complex
4	1902975	biological_process	mitotic DNA replication initiation
5	0003677	molecular_function	DNA binding
5	0003688	molecular_function	DNA replication origin binding
5	0005524	molecular_function	ATP binding
5	0005634	cellular_component	nucleus
5	0006260	biological_process	DNA replication
5	0006270	biological_process	DNA replication initiation
5	0032508	biological_process	DNA duplex unwinding
5	0042555	cellular_component	MCM complex
6	0000727	biological_process	double-strand break repair via break-induced replication
6	0003677	molecular_function	DNA binding
6	0003678	molecular_function	DNA helicase activity
6	0003688	molecular_function	DNA replication origin binding
6	0003697	molecular_function	single-stranded DNA binding
6	0004386	molecular_function	helicase activity
6	0005515	molecular_function	protein binding
6	0005524	molecular_function	ATP binding
6	0005634	cellular_component	nucleus
6	0005654	cellular_component	nucleoplasm
6	0005656	cellular_component	nuclear pre-replicative complex
6	0005737	cellular_component	cytoplasm
6	0006260	biological_process	DNA replication
6	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
6	0006268	biological_process	DNA unwinding involved in DNA replication
6	0006270	biological_process	DNA replication initiation
6	0006271	biological_process	DNA strand elongation involved in DNA replication
6	0006279	biological_process	premeiotic DNA replication
6	0008270	molecular_function	zinc ion binding
6	0009378	molecular_function	four-way junction helicase activity
6	0016787	molecular_function	hydrolase activity
6	0016887	molecular_function	ATP hydrolysis activity
6	0017116	molecular_function	single-stranded DNA helicase activity
6	0031261	cellular_component	DNA replication preinitiation complex
6	0031298	cellular_component	replication fork protection complex
6	0032508	biological_process	DNA duplex unwinding
6	0042555	cellular_component	MCM complex
6	0043138	molecular_function	3'-5' DNA helicase activity
6	0043596	cellular_component	nuclear replication fork
6	0071162	cellular_component	CMG complex
6	0097373	cellular_component	MCM core complex
6	1902969	biological_process	mitotic DNA replication
6	1990518	molecular_function	single-stranded 3'-5' DNA helicase activity
7	0003677	molecular_function	DNA binding
7	0003678	molecular_function	DNA helicase activity
7	0005524	molecular_function	ATP binding
7	0006260	biological_process	DNA replication
7	0006270	biological_process	DNA replication initiation
7	0016887	molecular_function	ATP hydrolysis activity
7	0032508	biological_process	DNA duplex unwinding
7	0042555	cellular_component	MCM complex
a	0003677	molecular_function	DNA binding
a	0005524	molecular_function	ATP binding
a	0005634	cellular_component	nucleus
a	0006260	biological_process	DNA replication
a	0006270	biological_process	DNA replication initiation
a	0032508	biological_process	DNA duplex unwinding
a	0042555	cellular_component	MCM complex
a	1905775	biological_process	negative regulation of DNA helicase activity
b	0000727	biological_process	double-strand break repair via break-induced replication
b	0000781	cellular_component	chromosome, telomeric region
b	0003677	molecular_function	DNA binding
b	0003682	molecular_function	chromatin binding
b	0003688	molecular_function	DNA replication origin binding
b	0003697	molecular_function	single-stranded DNA binding
b	0004386	molecular_function	helicase activity
b	0005515	molecular_function	protein binding
b	0005524	molecular_function	ATP binding
b	0005634	cellular_component	nucleus
b	0005654	cellular_component	nucleoplasm
b	0005656	cellular_component	nuclear pre-replicative complex
b	0005737	cellular_component	cytoplasm
b	0006260	biological_process	DNA replication
b	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
b	0006268	biological_process	DNA unwinding involved in DNA replication
b	0006270	biological_process	DNA replication initiation
b	0006271	biological_process	DNA strand elongation involved in DNA replication
b	0006279	biological_process	premeiotic DNA replication
b	0016787	molecular_function	hydrolase activity
b	0016887	molecular_function	ATP hydrolysis activity
b	0017116	molecular_function	single-stranded DNA helicase activity
b	0030466	biological_process	silent mating-type cassette heterochromatin formation
b	0031261	cellular_component	DNA replication preinitiation complex
b	0031298	cellular_component	replication fork protection complex
b	0031509	biological_process	subtelomeric heterochromatin formation
b	0032508	biological_process	DNA duplex unwinding
b	0042555	cellular_component	MCM complex
b	0043596	cellular_component	nuclear replication fork
b	0071162	cellular_component	CMG complex
b	1902975	biological_process	mitotic DNA replication initiation
b	1904931	molecular_function	MCM complex binding
c	0000727	biological_process	double-strand break repair via break-induced replication
c	0003677	molecular_function	DNA binding
c	0003678	molecular_function	DNA helicase activity
c	0003688	molecular_function	DNA replication origin binding
c	0003697	molecular_function	single-stranded DNA binding
c	0004386	molecular_function	helicase activity
c	0005515	molecular_function	protein binding
c	0005524	molecular_function	ATP binding
c	0005634	cellular_component	nucleus
c	0005654	cellular_component	nucleoplasm
c	0005656	cellular_component	nuclear pre-replicative complex
c	0005737	cellular_component	cytoplasm
c	0006260	biological_process	DNA replication
c	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
c	0006268	biological_process	DNA unwinding involved in DNA replication
c	0006270	biological_process	DNA replication initiation
c	0006271	biological_process	DNA strand elongation involved in DNA replication
c	0006279	biological_process	premeiotic DNA replication
c	0008270	molecular_function	zinc ion binding
c	0009378	molecular_function	four-way junction helicase activity
c	0016787	molecular_function	hydrolase activity
c	0016887	molecular_function	ATP hydrolysis activity
c	0017116	molecular_function	single-stranded DNA helicase activity
c	0031261	cellular_component	DNA replication preinitiation complex
c	0031298	cellular_component	replication fork protection complex
c	0032508	biological_process	DNA duplex unwinding
c	0033260	biological_process	nuclear DNA replication
c	0042555	cellular_component	MCM complex
c	0043138	molecular_function	3'-5' DNA helicase activity
c	0043596	cellular_component	nuclear replication fork
c	0071162	cellular_component	CMG complex
c	0097373	cellular_component	MCM core complex
c	1902975	biological_process	mitotic DNA replication initiation
C	0000727	biological_process	double-strand break repair via break-induced replication
C	0000811	cellular_component	GINS complex
C	0003674	molecular_function	molecular_function
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0006260	biological_process	DNA replication
C	0006261	biological_process	DNA-templated DNA replication
C	0006268	biological_process	DNA unwinding involved in DNA replication
C	0031261	cellular_component	DNA replication preinitiation complex
C	0031298	cellular_component	replication fork protection complex
C	0043596	cellular_component	nuclear replication fork
C	0071162	cellular_component	CMG complex
C	1902975	biological_process	mitotic DNA replication initiation
d	0003677	molecular_function	DNA binding
d	0003688	molecular_function	DNA replication origin binding
d	0005524	molecular_function	ATP binding
d	0005634	cellular_component	nucleus
d	0006260	biological_process	DNA replication
d	0006270	biological_process	DNA replication initiation
d	0032508	biological_process	DNA duplex unwinding
d	0042555	cellular_component	MCM complex
D	0000727	biological_process	double-strand break repair via break-induced replication
D	0000811	cellular_component	GINS complex
D	0003674	molecular_function	molecular_function
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0006260	biological_process	DNA replication
D	0006261	biological_process	DNA-templated DNA replication
D	0006268	biological_process	DNA unwinding involved in DNA replication
D	0031261	cellular_component	DNA replication preinitiation complex
D	0031298	cellular_component	replication fork protection complex
D	0043596	cellular_component	nuclear replication fork
D	0071162	cellular_component	CMG complex
e	0000727	biological_process	double-strand break repair via break-induced replication
e	0003677	molecular_function	DNA binding
e	0003678	molecular_function	DNA helicase activity
e	0003688	molecular_function	DNA replication origin binding
e	0003697	molecular_function	single-stranded DNA binding
e	0004386	molecular_function	helicase activity
e	0005515	molecular_function	protein binding
e	0005524	molecular_function	ATP binding
e	0005634	cellular_component	nucleus
e	0005654	cellular_component	nucleoplasm
e	0005656	cellular_component	nuclear pre-replicative complex
e	0005737	cellular_component	cytoplasm
e	0006260	biological_process	DNA replication
e	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
e	0006268	biological_process	DNA unwinding involved in DNA replication
e	0006270	biological_process	DNA replication initiation
e	0006271	biological_process	DNA strand elongation involved in DNA replication
e	0006279	biological_process	premeiotic DNA replication
e	0008270	molecular_function	zinc ion binding
e	0009378	molecular_function	four-way junction helicase activity
e	0016787	molecular_function	hydrolase activity
e	0016887	molecular_function	ATP hydrolysis activity
e	0017116	molecular_function	single-stranded DNA helicase activity
e	0031261	cellular_component	DNA replication preinitiation complex
e	0031298	cellular_component	replication fork protection complex
e	0032508	biological_process	DNA duplex unwinding
e	0042555	cellular_component	MCM complex
e	0043138	molecular_function	3'-5' DNA helicase activity
e	0043596	cellular_component	nuclear replication fork
e	0071162	cellular_component	CMG complex
e	0097373	cellular_component	MCM core complex
e	1902969	biological_process	mitotic DNA replication
e	1990518	molecular_function	single-stranded 3'-5' DNA helicase activity
E	0006270	biological_process	DNA replication initiation
f	0003677	molecular_function	DNA binding
f	0003678	molecular_function	DNA helicase activity
f	0005524	molecular_function	ATP binding
f	0006260	biological_process	DNA replication
f	0006270	biological_process	DNA replication initiation
f	0016887	molecular_function	ATP hydrolysis activity
f	0032508	biological_process	DNA duplex unwinding
f	0042555	cellular_component	MCM complex
F	0003677	molecular_function	DNA binding
F	0003690	molecular_function	double-stranded DNA binding
F	0003697	molecular_function	single-stranded DNA binding
F	0003887	molecular_function	DNA-directed DNA polymerase activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0006260	biological_process	DNA replication
F	0006261	biological_process	DNA-templated DNA replication
F	0008622	cellular_component	epsilon DNA polymerase complex
F	0030337	molecular_function	DNA polymerase processivity factor activity
F	0042276	biological_process	error-prone translesion synthesis
F	0043596	cellular_component	nuclear replication fork
F	0045005	biological_process	DNA-templated DNA replication maintenance of fidelity
H	0000811	cellular_component	GINS complex
H	0006260	biological_process	DNA replication
I	0005634	cellular_component	nucleus
I	0006260	biological_process	DNA replication
J	0000727	biological_process	double-strand break repair via break-induced replication
J	0000811	cellular_component	GINS complex
J	0003674	molecular_function	molecular_function
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0006260	biological_process	DNA replication
J	0006261	biological_process	DNA-templated DNA replication
J	0006268	biological_process	DNA unwinding involved in DNA replication
J	0031261	cellular_component	DNA replication preinitiation complex
J	0031298	cellular_component	replication fork protection complex
J	0043596	cellular_component	nuclear replication fork
J	0071162	cellular_component	CMG complex
J	1902975	biological_process	mitotic DNA replication initiation
K	0000727	biological_process	double-strand break repair via break-induced replication
K	0000811	cellular_component	GINS complex
K	0003674	molecular_function	molecular_function
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0006260	biological_process	DNA replication
K	0006261	biological_process	DNA-templated DNA replication
K	0006268	biological_process	DNA unwinding involved in DNA replication
K	0031261	cellular_component	DNA replication preinitiation complex
K	0031298	cellular_component	replication fork protection complex
K	0043596	cellular_component	nuclear replication fork
K	0071162	cellular_component	CMG complex
L	0006270	biological_process	DNA replication initiation
M	0003677	molecular_function	DNA binding
M	0003690	molecular_function	double-stranded DNA binding
M	0003697	molecular_function	single-stranded DNA binding
M	0003887	molecular_function	DNA-directed DNA polymerase activity
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005737	cellular_component	cytoplasm
M	0006260	biological_process	DNA replication
M	0006261	biological_process	DNA-templated DNA replication
M	0008622	cellular_component	epsilon DNA polymerase complex
M	0030337	molecular_function	DNA polymerase processivity factor activity
M	0042276	biological_process	error-prone translesion synthesis
M	0043596	cellular_component	nuclear replication fork
M	0045005	biological_process	DNA-templated DNA replication maintenance of fidelity
N	0000166	molecular_function	nucleotide binding
N	0000278	biological_process	mitotic cell cycle
N	0003676	molecular_function	nucleic acid binding
N	0003677	molecular_function	DNA binding
N	0003690	molecular_function	double-stranded DNA binding
N	0003697	molecular_function	single-stranded DNA binding
N	0003729	molecular_function	mRNA binding
N	0003887	molecular_function	DNA-directed DNA polymerase activity
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005657	cellular_component	replication fork
N	0006260	biological_process	DNA replication
N	0006261	biological_process	DNA-templated DNA replication
N	0006272	biological_process	leading strand elongation
N	0006281	biological_process	DNA repair
N	0006284	biological_process	base-excision repair
N	0006287	biological_process	base-excision repair, gap-filling
N	0006297	biological_process	nucleotide-excision repair, DNA gap filling
N	0006302	biological_process	double-strand break repair
N	0006303	biological_process	double-strand break repair via nonhomologous end joining
N	0007064	biological_process	mitotic sister chromatid cohesion
N	0008270	molecular_function	zinc ion binding
N	0008310	molecular_function	single-stranded DNA 3'-5' DNA exonuclease activity
N	0008622	cellular_component	epsilon DNA polymerase complex
N	0016787	molecular_function	hydrolase activity
N	0031573	biological_process	mitotic intra-S DNA damage checkpoint signaling
N	0032183	molecular_function	SUMO binding
N	0033314	biological_process	mitotic DNA replication checkpoint signaling
N	0035822	biological_process	gene conversion
N	0042276	biological_process	error-prone translesion synthesis
N	0043231	cellular_component	intracellular membrane-bounded organelle
N	0043596	cellular_component	nuclear replication fork
N	0045004	biological_process	DNA replication proofreading
N	0046872	molecular_function	metal ion binding
N	0051539	molecular_function	4 iron, 4 sulfur cluster binding
O	0000811	cellular_component	GINS complex
O	0006260	biological_process	DNA replication
P	0005634	cellular_component	nucleus
P	0006260	biological_process	DNA replication
Q	0000166	molecular_function	nucleotide binding
Q	0000278	biological_process	mitotic cell cycle
Q	0003676	molecular_function	nucleic acid binding
Q	0003677	molecular_function	DNA binding
Q	0003690	molecular_function	double-stranded DNA binding
Q	0003697	molecular_function	single-stranded DNA binding
Q	0003729	molecular_function	mRNA binding
Q	0003887	molecular_function	DNA-directed DNA polymerase activity
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005657	cellular_component	replication fork
Q	0006260	biological_process	DNA replication
Q	0006261	biological_process	DNA-templated DNA replication
Q	0006272	biological_process	leading strand elongation
Q	0006281	biological_process	DNA repair
Q	0006284	biological_process	base-excision repair
Q	0006287	biological_process	base-excision repair, gap-filling
Q	0006297	biological_process	nucleotide-excision repair, DNA gap filling
Q	0006302	biological_process	double-strand break repair
Q	0006303	biological_process	double-strand break repair via nonhomologous end joining
Q	0007064	biological_process	mitotic sister chromatid cohesion
Q	0008270	molecular_function	zinc ion binding
Q	0008310	molecular_function	single-stranded DNA 3'-5' DNA exonuclease activity
Q	0008622	cellular_component	epsilon DNA polymerase complex
Q	0016787	molecular_function	hydrolase activity
Q	0031573	biological_process	mitotic intra-S DNA damage checkpoint signaling
Q	0032183	molecular_function	SUMO binding
Q	0033314	biological_process	mitotic DNA replication checkpoint signaling
Q	0035822	biological_process	gene conversion
Q	0042276	biological_process	error-prone translesion synthesis
Q	0043231	cellular_component	intracellular membrane-bounded organelle
Q	0043596	cellular_component	nuclear replication fork
Q	0045004	biological_process	DNA replication proofreading
Q	0046872	molecular_function	metal ion binding
Q	0051539	molecular_function	4 iron, 4 sulfur cluster binding

Functional Information from PROSITE/UniProt

site_id	PS00847
Number of Residues	9
Details	MCM_1 MCM family signature. GVVCIDEFD

Chain	Residue	Details
5	GLY475-ASP483
2	GLY602-ASP610
f	GLY519-ASP527
4	GLY627-ASP635
e	GLY634-ASP642
3	GLY468-ASP476

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255

Chain	Residue	Details
6	GLY575
e	GLY575

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956

Chain	Residue	Details
6	SER78
Q	CYS2111
Q	CYS2130
Q	CYS2133
Q	CYS2164
Q	CYS2167
Q	CYS2179
Q	CYS2181
6	SER372
e	SER78
e	SER372
N	CYS2164
N	CYS2167
N	CYS2179
N	CYS2181
Q	CYS2108

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19779198

Chain	Residue	Details
6	SER249
e	SER249

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17330950

Chain	Residue	Details
6	THR766
e	THR766

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17330950

Chain	Residue	Details
3	THR868
b	THR868

---