7YFF
Structure of GluN1a-GluN2D NMDA receptor in complex with agonist glycine and competitive antagonist CPP.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0038023 | molecular_function | signaling receptor activity |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| B | 0016020 | cellular_component | membrane |
| B | 0038023 | molecular_function | signaling receptor activity |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| C | 0016020 | cellular_component | membrane |
| C | 0038023 | molecular_function | signaling receptor activity |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| D | 0016020 | cellular_component | membrane |
| D | 0038023 | molecular_function | signaling receptor activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1452 |
| Details | TOPO_DOM: Extracellular => ECO:0000250|UniProtKB:Q00960 |
| Chain | Residue | Details |
| B | PHE28-ALA584 | |
| B | THR674-ASN844 | |
| D | PHE28-ALA584 | |
| D | THR674-ASN844 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 104 |
| Details | TRANSMEM: Helical => ECO:0000250|UniProtKB:Q00960 |
| Chain | Residue | Details |
| B | VAL585-ILE603 | |
| B | MET658-TYR673 | |
| B | MET845-ALA864 | |
| D | VAL585-ILE603 | |
| D | MET658-TYR673 | |
| D | MET845-ALA864 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 64 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:Q00960 |
| Chain | Residue | Details |
| B | PHE604-GLY630 | |
| B | ARG651-ILE657 | |
| D | PHE604-GLY630 | |
| D | ARG651-ILE657 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 38 |
| Details | INTRAMEM: Discontinuously helical => ECO:0000250|UniProtKB:Q00960 |
| Chain | Residue | Details |
| B | LYS631-PRO650 | |
| D | LYS631-PRO650 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q00959 |
| Chain | Residue | Details |
| B | SER539 | |
| B | SER717 | |
| D | SER539 | |
| D | SER717 | |
| C | PRO516 | |
| C | ARG523 | |
| C | SER688 | |
| C | ASP732 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q00960 |
| Chain | Residue | Details |
| B | THR541 | |
| A | ASN491 | |
| A | ASN674 | |
| A | ASN771 | |
| C | ASN61 | |
| C | ASN203 | |
| C | ASN239 | |
| C | ASN276 | |
| C | ASN300 | |
| C | ASN350 | |
| C | ASN368 | |
| B | ARG546 | |
| C | ASN440 | |
| C | ASN471 | |
| C | ASN491 | |
| C | ASN674 | |
| C | ASN771 | |
| B | ASP759 | |
| D | THR541 | |
| D | ARG546 | |
| D | ASP759 | |
| A | ASN368 | |
| A | ASN440 | |
| A | ASN471 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | SITE: Functional determinant of NMDA receptors => ECO:0000250 |
| Chain | Residue | Details |
| B | ASN642 | |
| D | ASN642 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 14 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| B | ASN92 | |
| D | ASN366 | |
| D | ASN384 | |
| D | ASN467 | |
| D | ASN569 | |
| D | ASN715 | |
| B | ASN352 | |
| B | ASN366 | |
| B | ASN384 | |
| B | ASN467 | |
| B | ASN569 | |
| B | ASN715 | |
| D | ASN92 | |
| D | ASN352 |
