7YFF

Structure of GluN1a-GluN2D NMDA receptor in complex with agonist glycine and competitive antagonist CPP.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
A	0038023	molecular_function	signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
B	0038023	molecular_function	signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane
C	0038023	molecular_function	signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0015276	molecular_function	ligand-gated monoatomic ion channel activity
D	0016020	cellular_component	membrane
D	0038023	molecular_function	signaling receptor activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1444
Details	TOPO_DOM: Extracellular => ECO:0000305|PubMed:36959261

Chain	Residue	Details
B	PHE28-SER582
B	ALA675-ASP843
D	PHE28-SER582
D	ALA675-ASP843

---

site_id	SWS_FT_FI2
Number of Residues	128
Details	TRANSMEM: Helical => ECO:0000269|PubMed:36959261

Chain	Residue	Details
B	PRO583-PHE604
B	THR654-THR674
B	ASN844-HIS867
D	PRO583-PHE604
D	THR654-THR674
D	ASN844-HIS867

---

site_id	SWS_FT_FI3
Number of Residues	70
Details	TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:36959261

Chain	Residue	Details
B	GLU605-ILE629
B	ASN642-THR653
D	GLU605-ILE629
D	ASN642-THR653

---

site_id	SWS_FT_FI4
Number of Residues	22
Details	INTRAMEM: Discontinuously helical => ECO:0000269|PubMed:36959261

Chain	Residue	Details
B	GLY630-PHE641
D	GLY630-PHE641

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q62645

Chain	Residue	Details
B	SER539
B	THR718
D	SER539
D	THR718

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:36959261, ECO:0007744|PDB:7YFR

Chain	Residue	Details
B	THR541
B	ARG546
B	SER717
B	ASP759
D	THR541
D	ARG546
D	SER717
D	ASP759

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	SITE: Functional determinant of NMDA receptors => ECO:0000250

Chain	Residue	Details
B	ASN642
D	ASN642

---

site_id	SWS_FT_FI8
Number of Residues	12
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
B	ASN92
D	ASN384
D	ASN467
D	ASN569
B	ASN352
B	ASN366
B	ASN384
B	ASN467
B	ASN569
D	ASN92
D	ASN352
D	ASN366

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:36309015, ECO:0000312|PDB:8E92, ECO:0000312|PDB:8E93, ECO:0000312|PDB:8E94, ECO:0000312|PDB:8E97, ECO:0000312|PDB:8E98, ECO:0000312|PDB:8E99

Chain	Residue	Details
A	ASN61
C	ASN61

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:36309015, ECO:0000269|PubMed:36959261, ECO:0000312|PDB:8E92, ECO:0000312|PDB:8E93, ECO:0000312|PDB:8E94, ECO:0000312|PDB:8E97, ECO:0007744|PDB:7YFR

Chain	Residue	Details
A	ASN203
C	ASN203

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:36309015, ECO:0000312|PDB:8E93, ECO:0000312|PDB:8E97

Chain	Residue	Details
A	ASN239
C	ASN239

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:34186027, ECO:0000269|PubMed:36309015, ECO:0000312|PDB:8E92, ECO:0000312|PDB:8E93, ECO:0000312|PDB:8E94, ECO:0000312|PDB:8E96, ECO:0000312|PDB:8E97, ECO:0007744|PDB:7EOQ

Chain	Residue	Details
A	ASN276
C	ASN276

---

site_id	SWS_FT_FI13
Number of Residues	8
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN300
A	ASN440
A	ASN491
A	ASN674
C	ASN300
C	ASN440
C	ASN491
C	ASN674

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:36309015, ECO:0000312|PDB:8E93, ECO:0000312|PDB:8E94, ECO:0000312|PDB:8E96, ECO:0000312|PDB:8E97

Chain	Residue	Details
A	ASN350
C	ASN350

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:36309015, ECO:0000312|PDB:8E92, ECO:0000312|PDB:8E94, ECO:0000312|PDB:8E97

Chain	Residue	Details
A	ASN368
C	ASN368

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:34186027, ECO:0000269|PubMed:36309015, ECO:0000269|PubMed:36959261, ECO:0000312|PDB:8E93, ECO:0000312|PDB:8E94, ECO:0000312|PDB:8E97, ECO:0000312|PDB:8E98, ECO:0007744|PDB:7EOQ, ECO:0007744|PDB:7YFR

Chain	Residue	Details
A	ASN471
C	ASN471

---

site_id	SWS_FT_FI17
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:34186027, ECO:0000269|PubMed:36309015, ECO:0000312|PDB:8E92, ECO:0000312|PDB:8E93, ECO:0000312|PDB:8E94, ECO:0000312|PDB:8E96, ECO:0000312|PDB:8E97, ECO:0000312|PDB:8E98, ECO:0000312|PDB:8E99, ECO:0007744|PDB:7EOQ

Chain	Residue	Details
A	ASN771
C	ASN771

---