7TQL

CryoEM structure of the human 40S small ribosomal subunit in complex with translation initiation factors eIF1A and eIF5B.

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0003924	molecular_function	GTPase activity
1	0005525	molecular_function	GTP binding
4	0003723	molecular_function	RNA binding
4	0003743	molecular_function	translation initiation factor activity
4	0006413	biological_process	translational initiation
B	0003735	molecular_function	structural constituent of ribosome
B	0005840	cellular_component	ribosome
B	0006412	biological_process	translation
B	0015935	cellular_component	small ribosomal subunit
C	0003735	molecular_function	structural constituent of ribosome
C	0005840	cellular_component	ribosome
C	0006412	biological_process	translation
C	0015935	cellular_component	small ribosomal subunit
D	0003723	molecular_function	RNA binding
D	0003735	molecular_function	structural constituent of ribosome
D	0005840	cellular_component	ribosome
D	0006412	biological_process	translation
D	0015935	cellular_component	small ribosomal subunit
E	0002181	biological_process	cytoplasmic translation
E	0003723	molecular_function	RNA binding
E	0003735	molecular_function	structural constituent of ribosome
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005730	cellular_component	nucleolus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005840	cellular_component	ribosome
E	0005925	cellular_component	focal adhesion
E	0006412	biological_process	translation
E	0008284	biological_process	positive regulation of cell population proliferation
E	0015935	cellular_component	small ribosomal subunit
E	0016020	cellular_component	membrane
E	0019843	molecular_function	rRNA binding
E	0022626	cellular_component	cytosolic ribosome
E	0022627	cellular_component	cytosolic small ribosomal subunit
E	0032040	cellular_component	small-subunit processome
E	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
E	0042274	biological_process	ribosomal small subunit biogenesis
E	0045727	biological_process	positive regulation of translation
E	0070062	cellular_component	extracellular exosome
E	1990904	cellular_component	ribonucleoprotein complex
F	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
F	0002181	biological_process	cytoplasmic translation
F	0003677	molecular_function	DNA binding
F	0003684	molecular_function	damaged DNA binding
F	0003723	molecular_function	RNA binding
F	0003729	molecular_function	mRNA binding
F	0003735	molecular_function	structural constituent of ribosome
F	0003906	molecular_function	DNA-(apurinic or apyrimidinic site) endonuclease activity
F	0004520	molecular_function	DNA endonuclease activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005730	cellular_component	nucleolus
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0005759	cellular_component	mitochondrial matrix
F	0005783	cellular_component	endoplasmic reticulum
F	0005819	cellular_component	spindle
F	0005829	cellular_component	cytosol
F	0005840	cellular_component	ribosome
F	0005856	cellular_component	cytoskeleton
F	0005886	cellular_component	plasma membrane
F	0005925	cellular_component	focal adhesion
F	0006281	biological_process	DNA repair
F	0006284	biological_process	base-excision repair
F	0006412	biological_process	translation
F	0006413	biological_process	translational initiation
F	0006417	biological_process	regulation of translation
F	0006915	biological_process	apoptotic process
F	0006974	biological_process	DNA damage response
F	0007059	biological_process	chromosome segregation
F	0008017	molecular_function	microtubule binding
F	0010628	biological_process	positive regulation of gene expression
F	0014069	cellular_component	postsynaptic density
F	0015631	molecular_function	tubulin binding
F	0015935	cellular_component	small ribosomal subunit
F	0016020	cellular_component	membrane
F	0016829	molecular_function	lyase activity
F	0017148	biological_process	negative regulation of translation
F	0019104	molecular_function	DNA N-glycosylase activity
F	0019899	molecular_function	enzyme binding
F	0019900	molecular_function	kinase binding
F	0019901	molecular_function	protein kinase binding
F	0022626	cellular_component	cytosolic ribosome
F	0022627	cellular_component	cytosolic small ribosomal subunit
F	0030544	molecular_function	Hsp70 protein binding
F	0031116	biological_process	positive regulation of microtubule polymerization
F	0031334	biological_process	positive regulation of protein-containing complex assembly
F	0031397	biological_process	negative regulation of protein ubiquitination
F	0032079	biological_process	positive regulation of endodeoxyribonuclease activity
F	0032357	molecular_function	oxidized purine DNA binding
F	0032358	molecular_function	oxidized pyrimidine DNA binding
F	0032587	cellular_component	ruffle membrane
F	0032743	biological_process	positive regulation of interleukin-2 production
F	0034614	biological_process	cellular response to reactive oxygen species
F	0042104	biological_process	positive regulation of activated T cell proliferation
F	0042981	biological_process	regulation of apoptotic process
F	0044390	molecular_function	ubiquitin-like protein conjugating enzyme binding
F	0044877	molecular_function	protein-containing complex binding
F	0045202	cellular_component	synapse
F	0045738	biological_process	negative regulation of DNA repair
F	0045739	biological_process	positive regulation of DNA repair
F	0050862	biological_process	positive regulation of T cell receptor signaling pathway
F	0051018	molecular_function	protein kinase A binding
F	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
F	0051225	biological_process	spindle assembly
F	0051301	biological_process	cell division
F	0051536	molecular_function	iron-sulfur cluster binding
F	0051879	molecular_function	Hsp90 protein binding
F	0061481	biological_process	response to TNF agonist
F	0070062	cellular_component	extracellular exosome
F	0070181	molecular_function	small ribosomal subunit rRNA binding
F	0070301	biological_process	cellular response to hydrogen peroxide
F	0071159	cellular_component	NF-kappaB complex
F	0071356	biological_process	cellular response to tumor necrosis factor
F	0072686	cellular_component	mitotic spindle
F	0097100	molecular_function	supercoiled DNA binding
F	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F	0140297	molecular_function	DNA-binding transcription factor binding
F	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
F	1902231	biological_process	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
F	1905053	biological_process	positive regulation of base-excision repair
F	1990904	cellular_component	ribonucleoprotein complex
F	2001235	biological_process	positive regulation of apoptotic signaling pathway
G	0000028	biological_process	ribosomal small subunit assembly
G	0002181	biological_process	cytoplasmic translation
G	0003723	molecular_function	RNA binding
G	0003729	molecular_function	mRNA binding
G	0003735	molecular_function	structural constituent of ribosome
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005730	cellular_component	nucleolus
G	0005737	cellular_component	cytoplasm
G	0005783	cellular_component	endoplasmic reticulum
G	0005829	cellular_component	cytosol
G	0005840	cellular_component	ribosome
G	0006364	biological_process	rRNA processing
G	0006412	biological_process	translation
G	0008284	biological_process	positive regulation of cell population proliferation
G	0015935	cellular_component	small ribosomal subunit
G	0016020	cellular_component	membrane
G	0019901	molecular_function	protein kinase binding
G	0022626	cellular_component	cytosolic ribosome
G	0022627	cellular_component	cytosolic small ribosomal subunit
G	0030425	cellular_component	dendrite
G	0031929	biological_process	TOR signaling
G	0032040	cellular_component	small-subunit processome
G	0032868	biological_process	response to insulin
G	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
G	0042274	biological_process	ribosomal small subunit biogenesis
G	0042593	biological_process	glucose homeostasis
G	0043065	biological_process	positive regulation of apoptotic process
G	0044297	cellular_component	cell body
G	0071361	biological_process	cellular response to ethanol
G	0098793	cellular_component	presynapse
G	0098982	cellular_component	GABA-ergic synapse
G	1903347	biological_process	negative regulation of bicellular tight junction assembly
G	1990904	cellular_component	ribonucleoprotein complex
H	0001843	biological_process	neural tube closure
H	0002181	biological_process	cytoplasmic translation
H	0003723	molecular_function	RNA binding
H	0003730	molecular_function	mRNA 3'-UTR binding
H	0003735	molecular_function	structural constituent of ribosome
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005730	cellular_component	nucleolus
H	0005737	cellular_component	cytoplasm
H	0005783	cellular_component	endoplasmic reticulum
H	0005813	cellular_component	centrosome
H	0005829	cellular_component	cytosol
H	0005840	cellular_component	ribosome
H	0005856	cellular_component	cytoskeleton
H	0005925	cellular_component	focal adhesion
H	0006364	biological_process	rRNA processing
H	0006412	biological_process	translation
H	0010628	biological_process	positive regulation of gene expression
H	0014033	biological_process	neural crest cell differentiation
H	0016020	cellular_component	membrane
H	0019901	molecular_function	protein kinase binding
H	0022626	cellular_component	cytosolic ribosome
H	0022627	cellular_component	cytosolic small ribosomal subunit
H	0032040	cellular_component	small-subunit processome
H	0032991	cellular_component	protein-containing complex
H	0042274	biological_process	ribosomal small subunit biogenesis
H	0045202	cellular_component	synapse
H	0048027	molecular_function	mRNA 5'-UTR binding
H	0050821	biological_process	protein stabilization
H	1902255	biological_process	positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
H	1904667	biological_process	negative regulation of ubiquitin protein ligase activity
H	1990904	cellular_component	ribonucleoprotein complex
H	1990948	molecular_function	ubiquitin ligase inhibitor activity
H	2000059	biological_process	negative regulation of ubiquitin-dependent protein catabolic process
I	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I	0002181	biological_process	cytoplasmic translation
I	0003723	molecular_function	RNA binding
I	0003735	molecular_function	structural constituent of ribosome
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005730	cellular_component	nucleolus
I	0005737	cellular_component	cytoplasm
I	0005783	cellular_component	endoplasmic reticulum
I	0005829	cellular_component	cytosol
I	0005840	cellular_component	ribosome
I	0005925	cellular_component	focal adhesion
I	0006412	biological_process	translation
I	0016020	cellular_component	membrane
I	0022626	cellular_component	cytosolic ribosome
I	0022627	cellular_component	cytosolic small ribosomal subunit
I	0032040	cellular_component	small-subunit processome
I	0042274	biological_process	ribosomal small subunit biogenesis
I	0070062	cellular_component	extracellular exosome
I	1990904	cellular_component	ribonucleoprotein complex
J	0002181	biological_process	cytoplasmic translation
J	0003723	molecular_function	RNA binding
J	0003735	molecular_function	structural constituent of ribosome
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005730	cellular_component	nucleolus
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005840	cellular_component	ribosome
J	0005925	cellular_component	focal adhesion
J	0006412	biological_process	translation
J	0015935	cellular_component	small ribosomal subunit
J	0016020	cellular_component	membrane
J	0019843	molecular_function	rRNA binding
J	0022626	cellular_component	cytosolic ribosome
J	0022627	cellular_component	cytosolic small ribosomal subunit
J	0032040	cellular_component	small-subunit processome
J	0042274	biological_process	ribosomal small subunit biogenesis
J	0045202	cellular_component	synapse
J	0070062	cellular_component	extracellular exosome
J	1990904	cellular_component	ribonucleoprotein complex
K	0002181	biological_process	cytoplasmic translation
K	0003723	molecular_function	RNA binding
K	0003729	molecular_function	mRNA binding
K	0003735	molecular_function	structural constituent of ribosome
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005730	cellular_component	nucleolus
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0005840	cellular_component	ribosome
K	0005925	cellular_component	focal adhesion
K	0006412	biological_process	translation
K	0006413	biological_process	translational initiation
K	0006450	biological_process	regulation of translational fidelity
K	0015935	cellular_component	small ribosomal subunit
K	0016020	cellular_component	membrane
K	0019843	molecular_function	rRNA binding
K	0022626	cellular_component	cytosolic ribosome
K	0022627	cellular_component	cytosolic small ribosomal subunit
K	0032040	cellular_component	small-subunit processome
K	0042274	biological_process	ribosomal small subunit biogenesis
K	0045202	cellular_component	synapse
K	0070062	cellular_component	extracellular exosome
K	1990904	cellular_component	ribonucleoprotein complex
L	0002181	biological_process	cytoplasmic translation
L	0003723	molecular_function	RNA binding
L	0003735	molecular_function	structural constituent of ribosome
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005730	cellular_component	nucleolus
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0005840	cellular_component	ribosome
L	0005925	cellular_component	focal adhesion
L	0006412	biological_process	translation
L	0016020	cellular_component	membrane
L	0019843	molecular_function	rRNA binding
L	0022626	cellular_component	cytosolic ribosome
L	0022627	cellular_component	cytosolic small ribosomal subunit
L	0032040	cellular_component	small-subunit processome
L	0042274	biological_process	ribosomal small subunit biogenesis
L	0045202	cellular_component	synapse
L	0070062	cellular_component	extracellular exosome
L	1990904	cellular_component	ribonucleoprotein complex
N	0002181	biological_process	cytoplasmic translation
N	0003723	molecular_function	RNA binding
N	0003729	molecular_function	mRNA binding
N	0003735	molecular_function	structural constituent of ribosome
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005730	cellular_component	nucleolus
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0005840	cellular_component	ribosome
N	0005925	cellular_component	focal adhesion
N	0006412	biological_process	translation
N	0014069	cellular_component	postsynaptic density
N	0016020	cellular_component	membrane
N	0022626	cellular_component	cytosolic ribosome
N	0022627	cellular_component	cytosolic small ribosomal subunit
N	0032040	cellular_component	small-subunit processome
N	0033119	biological_process	negative regulation of RNA splicing
N	0042274	biological_process	ribosomal small subunit biogenesis
N	0048027	molecular_function	mRNA 5'-UTR binding
N	0070062	cellular_component	extracellular exosome
N	0070181	molecular_function	small ribosomal subunit rRNA binding
N	1990904	cellular_component	ribonucleoprotein complex
O	0002181	biological_process	cytoplasmic translation
O	0003723	molecular_function	RNA binding
O	0003735	molecular_function	structural constituent of ribosome
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005730	cellular_component	nucleolus
O	0005737	cellular_component	cytoplasm
O	0005794	cellular_component	Golgi apparatus
O	0005829	cellular_component	cytosol
O	0005840	cellular_component	ribosome
O	0006412	biological_process	translation
O	0016020	cellular_component	membrane
O	0022626	cellular_component	cytosolic ribosome
O	0022627	cellular_component	cytosolic small ribosomal subunit
O	0032040	cellular_component	small-subunit processome
O	0042274	biological_process	ribosomal small subunit biogenesis
O	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
O	1990145	biological_process	maintenance of translational fidelity
O	1990904	cellular_component	ribonucleoprotein complex
P	0003735	molecular_function	structural constituent of ribosome
P	0005840	cellular_component	ribosome
P	0006412	biological_process	translation
Q	0003723	molecular_function	RNA binding
Q	0003735	molecular_function	structural constituent of ribosome
Q	0005840	cellular_component	ribosome
Q	0006412	biological_process	translation
Q	0015935	cellular_component	small ribosomal subunit
R	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
R	0002181	biological_process	cytoplasmic translation
R	0003723	molecular_function	RNA binding
R	0003735	molecular_function	structural constituent of ribosome
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005730	cellular_component	nucleolus
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0005840	cellular_component	ribosome
R	0005925	cellular_component	focal adhesion
R	0006364	biological_process	rRNA processing
R	0006412	biological_process	translation
R	0015935	cellular_component	small ribosomal subunit
R	0016020	cellular_component	membrane
R	0022626	cellular_component	cytosolic ribosome
R	0022627	cellular_component	cytosolic small ribosomal subunit
R	0032040	cellular_component	small-subunit processome
R	0042274	biological_process	ribosomal small subunit biogenesis
R	0045202	cellular_component	synapse
R	0070062	cellular_component	extracellular exosome
R	1990830	biological_process	cellular response to leukemia inhibitory factor
R	1990904	cellular_component	ribonucleoprotein complex
S	0002181	biological_process	cytoplasmic translation
S	0003723	molecular_function	RNA binding
S	0003735	molecular_function	structural constituent of ribosome
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005730	cellular_component	nucleolus
S	0005737	cellular_component	cytoplasm
S	0005829	cellular_component	cytosol
S	0005840	cellular_component	ribosome
S	0005925	cellular_component	focal adhesion
S	0006364	biological_process	rRNA processing
S	0006412	biological_process	translation
S	0006413	biological_process	translational initiation
S	0016020	cellular_component	membrane
S	0022626	cellular_component	cytosolic ribosome
S	0022627	cellular_component	cytosolic small ribosomal subunit
S	0032040	cellular_component	small-subunit processome
S	0034101	biological_process	erythrocyte homeostasis
S	0042274	biological_process	ribosomal small subunit biogenesis
S	1990904	cellular_component	ribonucleoprotein complex
T	0002181	biological_process	cytoplasmic translation
T	0003676	molecular_function	nucleic acid binding
T	0003723	molecular_function	RNA binding
T	0003735	molecular_function	structural constituent of ribosome
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005737	cellular_component	cytoplasm
T	0005829	cellular_component	cytosol
T	0005840	cellular_component	ribosome
T	0005925	cellular_component	focal adhesion
T	0006412	biological_process	translation
T	0014069	cellular_component	postsynaptic density
T	0015935	cellular_component	small ribosomal subunit
T	0016020	cellular_component	membrane
T	0019843	molecular_function	rRNA binding
T	0022626	cellular_component	cytosolic ribosome
T	0022627	cellular_component	cytosolic small ribosomal subunit
T	0045202	cellular_component	synapse
T	0070062	cellular_component	extracellular exosome
T	1990904	cellular_component	ribonucleoprotein complex
U	0000028	biological_process	ribosomal small subunit assembly
U	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
U	0002181	biological_process	cytoplasmic translation
U	0002548	biological_process	monocyte chemotaxis
U	0003723	molecular_function	RNA binding
U	0003735	molecular_function	structural constituent of ribosome
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005730	cellular_component	nucleolus
U	0005737	cellular_component	cytoplasm
U	0005829	cellular_component	cytosol
U	0005840	cellular_component	ribosome
U	0005925	cellular_component	focal adhesion
U	0006364	biological_process	rRNA processing
U	0006412	biological_process	translation
U	0007000	biological_process	nucleolus organization
U	0014069	cellular_component	postsynaptic density
U	0016020	cellular_component	membrane
U	0017134	molecular_function	fibroblast growth factor binding
U	0019901	molecular_function	protein kinase binding
U	0022626	cellular_component	cytosolic ribosome
U	0022627	cellular_component	cytosolic small ribosomal subunit
U	0030218	biological_process	erythrocyte differentiation
U	0030490	biological_process	maturation of SSU-rRNA
U	0031640	biological_process	killing of cells of another organism
U	0032040	cellular_component	small-subunit processome
U	0042274	biological_process	ribosomal small subunit biogenesis
U	0042802	molecular_function	identical protein binding
U	0050829	biological_process	defense response to Gram-negative bacterium
U	0060265	biological_process	positive regulation of respiratory burst involved in inflammatory response
U	0060266	biological_process	negative regulation of respiratory burst involved in inflammatory response
U	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
U	0070062	cellular_component	extracellular exosome
U	1990904	cellular_component	ribonucleoprotein complex
V	0003723	molecular_function	RNA binding
V	0003735	molecular_function	structural constituent of ribosome
V	0005840	cellular_component	ribosome
V	0006412	biological_process	translation
V	0015935	cellular_component	small ribosomal subunit
W	0002181	biological_process	cytoplasmic translation
W	0003723	molecular_function	RNA binding
W	0003735	molecular_function	structural constituent of ribosome
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005730	cellular_component	nucleolus
W	0005737	cellular_component	cytoplasm
W	0005829	cellular_component	cytosol
W	0005840	cellular_component	ribosome
W	0006412	biological_process	translation
W	0008284	biological_process	positive regulation of cell population proliferation
W	0009615	biological_process	response to virus
W	0016020	cellular_component	membrane
W	0022626	cellular_component	cytosolic ribosome
W	0022627	cellular_component	cytosolic small ribosomal subunit
W	0032040	cellular_component	small-subunit processome
W	0042274	biological_process	ribosomal small subunit biogenesis
W	0045787	biological_process	positive regulation of cell cycle
W	0070062	cellular_component	extracellular exosome
W	1990904	cellular_component	ribonucleoprotein complex
X	0002181	biological_process	cytoplasmic translation
X	0003723	molecular_function	RNA binding
X	0003735	molecular_function	structural constituent of ribosome
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005730	cellular_component	nucleolus
X	0005737	cellular_component	cytoplasm
X	0005783	cellular_component	endoplasmic reticulum
X	0005791	cellular_component	rough endoplasmic reticulum
X	0005829	cellular_component	cytosol
X	0005840	cellular_component	ribosome
X	0006412	biological_process	translation
X	0015935	cellular_component	small ribosomal subunit
X	0016020	cellular_component	membrane
X	0022626	cellular_component	cytosolic ribosome
X	0022627	cellular_component	cytosolic small ribosomal subunit
X	0032040	cellular_component	small-subunit processome
X	0034063	biological_process	stress granule assembly
X	0042274	biological_process	ribosomal small subunit biogenesis
X	0045202	cellular_component	synapse
X	1990145	biological_process	maintenance of translational fidelity
X	1990904	cellular_component	ribonucleoprotein complex
Y	0002181	biological_process	cytoplasmic translation
Y	0003723	molecular_function	RNA binding
Y	0003735	molecular_function	structural constituent of ribosome
Y	0005634	cellular_component	nucleus
Y	0005654	cellular_component	nucleoplasm
Y	0005730	cellular_component	nucleolus
Y	0005737	cellular_component	cytoplasm
Y	0005783	cellular_component	endoplasmic reticulum
Y	0005829	cellular_component	cytosol
Y	0005840	cellular_component	ribosome
Y	0006364	biological_process	rRNA processing
Y	0006412	biological_process	translation
Y	0015935	cellular_component	small ribosomal subunit
Y	0016020	cellular_component	membrane
Y	0022626	cellular_component	cytosolic ribosome
Y	0022627	cellular_component	cytosolic small ribosomal subunit
Y	0031369	molecular_function	translation initiation factor binding
Y	0032040	cellular_component	small-subunit processome
Y	0034101	biological_process	erythrocyte homeostasis
Y	0042274	biological_process	ribosomal small subunit biogenesis
Y	1990904	cellular_component	ribonucleoprotein complex
Z	0000447	biological_process	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Z	0000461	biological_process	endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Z	0002181	biological_process	cytoplasmic translation
Z	0003723	molecular_function	RNA binding
Z	0003735	molecular_function	structural constituent of ribosome
Z	0005515	molecular_function	protein binding
Z	0005654	cellular_component	nucleoplasm
Z	0005737	cellular_component	cytoplasm
Z	0005783	cellular_component	endoplasmic reticulum
Z	0005791	cellular_component	rough endoplasmic reticulum
Z	0005829	cellular_component	cytosol
Z	0005840	cellular_component	ribosome
Z	0006412	biological_process	translation
Z	0015935	cellular_component	small ribosomal subunit
Z	0022626	cellular_component	cytosolic ribosome
Z	0022627	cellular_component	cytosolic small ribosomal subunit
Z	0045202	cellular_component	synapse
Z	1990904	cellular_component	ribonucleoprotein complex
b	0000028	biological_process	ribosomal small subunit assembly
b	0002181	biological_process	cytoplasmic translation
b	0003677	molecular_function	DNA binding
b	0003723	molecular_function	RNA binding
b	0003735	molecular_function	structural constituent of ribosome
b	0005515	molecular_function	protein binding
b	0005634	cellular_component	nucleus
b	0005654	cellular_component	nucleoplasm
b	0005730	cellular_component	nucleolus
b	0005737	cellular_component	cytoplasm
b	0005829	cellular_component	cytosol
b	0005840	cellular_component	ribosome
b	0006364	biological_process	rRNA processing
b	0006412	biological_process	translation
b	0008270	molecular_function	zinc ion binding
b	0014069	cellular_component	postsynaptic density
b	0022626	cellular_component	cytosolic ribosome
b	0022627	cellular_component	cytosolic small ribosomal subunit
b	0032040	cellular_component	small-subunit processome
b	0042274	biological_process	ribosomal small subunit biogenesis
b	0046872	molecular_function	metal ion binding
b	0098793	cellular_component	presynapse
b	0098978	cellular_component	glutamatergic synapse
b	0098982	cellular_component	GABA-ergic synapse
b	1990904	cellular_component	ribonucleoprotein complex
c	0003735	molecular_function	structural constituent of ribosome
c	0005840	cellular_component	ribosome
c	0006412	biological_process	translation
d	0003735	molecular_function	structural constituent of ribosome
d	0005840	cellular_component	ribosome
d	0006412	biological_process	translation
e	0003735	molecular_function	structural constituent of ribosome
e	0005840	cellular_component	ribosome
e	0006412	biological_process	translation
f	0002181	biological_process	cytoplasmic translation
f	0003735	molecular_function	structural constituent of ribosome
f	0005654	cellular_component	nucleoplasm
f	0005737	cellular_component	cytoplasm
f	0005783	cellular_component	endoplasmic reticulum
f	0005791	cellular_component	rough endoplasmic reticulum
f	0005829	cellular_component	cytosol
f	0005840	cellular_component	ribosome
f	0005925	cellular_component	focal adhesion
f	0006412	biological_process	translation
f	0008270	molecular_function	zinc ion binding
f	0015935	cellular_component	small ribosomal subunit
f	0022626	cellular_component	cytosolic ribosome
f	0022627	cellular_component	cytosolic small ribosomal subunit
f	0046872	molecular_function	metal ion binding
f	0070062	cellular_component	extracellular exosome
f	0098556	cellular_component	cytoplasmic side of rough endoplasmic reticulum membrane
f	1990904	cellular_component	ribonucleoprotein complex
g	0003735	molecular_function	structural constituent of ribosome
g	0005840	cellular_component	ribosome
g	0006412	biological_process	translation
h	0003735	molecular_function	structural constituent of ribosome
h	0005840	cellular_component	ribosome
h	0006412	biological_process	translation
j	0001891	cellular_component	phagocytic cup
j	0001934	biological_process	positive regulation of protein phosphorylation
j	0002181	biological_process	cytoplasmic translation
j	0003723	molecular_function	RNA binding
j	0005080	molecular_function	protein kinase C binding
j	0005102	molecular_function	signaling receptor binding
j	0005515	molecular_function	protein binding
j	0005634	cellular_component	nucleus
j	0005654	cellular_component	nucleoplasm
j	0005737	cellular_component	cytoplasm
j	0005739	cellular_component	mitochondrion
j	0005829	cellular_component	cytosol
j	0005840	cellular_component	ribosome
j	0005886	cellular_component	plasma membrane
j	0006412	biological_process	translation
j	0006417	biological_process	regulation of translation
j	0006915	biological_process	apoptotic process
j	0007369	biological_process	gastrulation
j	0008047	molecular_function	enzyme activator activity
j	0008200	molecular_function	ion channel inhibitor activity
j	0008656	molecular_function	cysteine-type endopeptidase activator activity involved in apoptotic process
j	0010629	biological_process	negative regulation of gene expression
j	0015935	cellular_component	small ribosomal subunit
j	0016020	cellular_component	membrane
j	0016567	biological_process	protein ubiquitination
j	0017148	biological_process	negative regulation of translation
j	0019899	molecular_function	enzyme binding
j	0019903	molecular_function	protein phosphatase binding
j	0022627	cellular_component	cytosolic small ribosomal subunit
j	0030178	biological_process	negative regulation of Wnt signaling pathway
j	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
j	0030292	molecular_function	protein tyrosine kinase inhibitor activity
j	0030308	biological_process	negative regulation of cell growth
j	0030332	molecular_function	cyclin binding
j	0030335	biological_process	positive regulation of cell migration
j	0030425	cellular_component	dendrite
j	0030496	cellular_component	midbody
j	0030971	molecular_function	receptor tyrosine kinase binding
j	0031334	biological_process	positive regulation of protein-containing complex assembly
j	0032091	biological_process	negative regulation of protein binding
j	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
j	0032880	biological_process	regulation of protein localization
j	0035591	molecular_function	signaling adaptor activity
j	0042169	molecular_function	SH2 domain binding
j	0042802	molecular_function	identical protein binding
j	0042803	molecular_function	protein homodimerization activity
j	0042995	cellular_component	cell projection
j	0042998	biological_process	positive regulation of Golgi to plasma membrane protein transport
j	0043005	cellular_component	neuron projection
j	0043022	molecular_function	ribosome binding
j	0043025	cellular_component	neuronal cell body
j	0043065	biological_process	positive regulation of apoptotic process
j	0043204	cellular_component	perikaryon
j	0043473	biological_process	pigmentation
j	0043547	biological_process	positive regulation of GTPase activity
j	0044297	cellular_component	cell body
j	0045182	molecular_function	translation regulator activity
j	0045296	molecular_function	cadherin binding
j	0045879	biological_process	negative regulation of smoothened signaling pathway
j	0048471	cellular_component	perinuclear region of cytoplasm
j	0048511	biological_process	rhythmic process
j	0050765	biological_process	negative regulation of phagocytosis
j	0051302	biological_process	regulation of cell division
j	0051434	molecular_function	BH3 domain binding
j	0051726	biological_process	regulation of cell cycle
j	0051898	biological_process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
j	0051901	biological_process	positive regulation of mitochondrial depolarization
j	0060090	molecular_function	molecular adaptor activity
j	0070062	cellular_component	extracellular exosome
j	0071333	biological_process	cellular response to glucose stimulus
j	0071363	biological_process	cellular response to growth factor stimulus
j	0072344	biological_process	rescue of stalled ribosome
j	0106070	biological_process	regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
j	1900102	biological_process	negative regulation of endoplasmic reticulum unfolded protein response
j	1903751	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
j	1990630	cellular_component	IRE1-RACK1-PP2A complex
j	1990904	cellular_component	ribonucleoprotein complex
j	2000114	biological_process	regulation of establishment of cell polarity
j	2000543	biological_process	positive regulation of gastrulation
j	2001125	biological_process	negative regulation of translational frameshifting
j	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway

Functional Information from PROSITE/UniProt

site_id	PS00052
Number of Residues	27
Details	RIBOSOMAL_S7 Ribosomal protein S7 signature. ErLtnsMMmhgrnnGKKlmtvrIVkhA

Chain	Residue	Details
K	GLU70-ALA96

---

site_id	PS00053
Number of Residues	18
Details	RIBOSOMAL_S8 Ribosomal protein S8 signature. GfiVLTTSaGIMdheeAR

Chain	Residue	Details
W	GLY100-ARG117

---

site_id	PS00054
Number of Residues	23
Details	RIBOSOMAL_S11 Ribosomal protein S11 signature. LrALarS.GMkIgrieDvTPiPSD

Chain	Residue	Details
P	LEU116-ASP138

---

site_id	PS00055
Number of Residues	8
Details	RIBOSOMAL_S12 Ribosomal protein S12 signature. KqPNSAiR

Chain	Residue	Details
X	LYS60-ARG67

---

site_id	PS00056
Number of Residues	13
Details	RIBOSOMAL_S17 Ribosomal protein S17 signature. GDiVtVgEcRPLS

Chain	Residue	Details
L	GLY123-SER135

---

site_id	PS00323
Number of Residues	25
Details	RIBOSOMAL_S19 Ribosomal protein S19 signature. NGKtfnqveIkpemIGhyLGEFsiT

Chain	Residue	Details
Q	ASN98-THR122

---

site_id	PS00360
Number of Residues	19
Details	RIBOSOMAL_S9 Ribosomal protein S9 signature. GGGhvAQiyAirqSiSKAL

Chain	Residue	Details
R	GLY74-LEU92

---

site_id	PS00361
Number of Residues	16
Details	RIBOSOMAL_S10 Ribosomal protein S10 signature. AkekNLkvkGPVrMPT

Chain	Residue	Details
V	ALA43-THR58

---

site_id	PS00362
Number of Residues	31
Details	RIBOSOMAL_S15 Ribosomal protein S15 signature. VrkHLernRkDkdAkfrLilIesrihrLarY

Chain	Residue	Details
N	VAL98-TYR128

---

site_id	PS00527
Number of Residues	23
Details	RIBOSOMAL_S14 Ribosomal protein S14 signature. RvCsnrhglirkyg.LNMCRqCFR

Chain	Residue	Details
f	ARG22-ARG44

---

site_id	PS00528
Number of Residues	15
Details	RIBOSOMAL_S4E Ribosomal protein S4e signature. HlKRVAaPkhWmLdK

Chain	Residue	Details
E	HIS8-LYS22

---

site_id	PS00529
Number of Residues	23
Details	RIBOSOMAL_S24E Ribosomal protein S24e signature. FGggKTtGFGmIYDSldyakknE

Chain	Residue	Details
Y	PHE64-GLU86

---

site_id	PS00548
Number of Residues	37
Details	RIBOSOMAL_S3 Ribosomal protein S3 signature. AKsmkfvdGlMihSgdpVnyyVDtavrhvlLrqGvlG

Chain	Residue	Details
F	ALA147-GLY183

---

site_id	PS00578
Number of Residues	12
Details	RIBOSOMAL_S6E Ribosomal protein S6e signature. ISGGnDkqGfPM

Chain	Residue	Details
G	ILE52-MET63

---

site_id	PS00585
Number of Residues	33
Details	RIBOSOMAL_S5 Ribosomal protein S5 signature. GQrtrFkAfvAIGDyn.GhVGlGvkcsk.EVat.AI

Chain	Residue	Details
D	GLY119-ILE151

---

site_id	PS00628
Number of Residues	20
Details	RIBOSOMAL_S19E Ribosomal protein S19e signature. PshfsrgSksVaRrVLQaLE

Chain	Residue	Details
U	PRO89-GLU108

---

site_id	PS00632
Number of Residues	25
Details	RIBOSOMAL_S4 Ribosomal protein S4 signature. LErRLqtqVFKlglAkSihhARvLI

Chain	Residue	Details
J	LEU106-ILE130

---

site_id	PS00646
Number of Residues	14
Details	RIBOSOMAL_S13_1 Ribosomal protein S13 signature. RGlRHfwGlrVRGQ

Chain	Residue	Details
T	ARG121-GLN134

---

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. ALSGswDgTLRLWDL

Chain	Residue	Details
j	ALA78-LEU92
j	ILE120-THR134
j	ILE165-LEU179
j	CYS207-LEU221

---

site_id	PS00712
Number of Residues	16
Details	RIBOSOMAL_S17E Ribosomal protein S17e signature. IpSKkLRNkIAGYvTH

Chain	Residue	Details
S	ILE41-HIS56

---

site_id	PS00733
Number of Residues	8
Details	RIBOSOMAL_S26E Ribosomal protein S26e signature. YCVSCAIH

Chain	Residue	Details
c	TYR73-HIS80

---

site_id	PS00948
Number of Residues	14
Details	RIBOSOMAL_S7E Ribosomal protein S7e signature. RLvRELEKKFSgKH

Chain	Residue	Details
H	ARG78-HIS91

---

site_id	PS00962
Number of Residues	12
Details	RIBOSOMAL_S2_1 Ribosomal protein S2 signature 1. VlKFLAAGTHLG

Chain	Residue	Details
B	VAL15-GLY26

---

site_id	PS00963
Number of Residues	25
Details	RIBOSOMAL_S2_2 Ribosomal protein S2 signature 2. PrlLVVtDpraDhqpLtEasyvNLP

Chain	Residue	Details
B	PRO119-PRO143

---

site_id	PS00996
Number of Residues	9
Details	RIBOSOMAL_S21E Ribosomal protein S21e signature. LYVPRKCSA

Chain	Residue	Details
Z	LEU11-ALA19

---

site_id	PS01168
Number of Residues	33
Details	RIBOSOMAL_S27E Ribosomal protein S27e signature. KCpgCykittvFShAqtvvlCvgCStvLcqPtG

Chain	Residue	Details
b	LYS36-GLY68

---

site_id	PS01189
Number of Residues	19
Details	RIBOSOMAL_S12E Ribosomal protein S12e signature. ALQevLktAlihDGLarGI

Chain	Residue	Details
O	ALA17-ILE35

---

site_id	PS01191
Number of Residues	13
Details	RIBOSOMAL_S3AE Ribosomal protein S3Ae signature. LkGRVfEvSLaDL

Chain	Residue	Details
B	LEU249-LEU261

---

site_id	PS01193
Number of Residues	20
Details	RIBOSOMAL_S8E Ribosomal protein S8e signature. RrkTGGkrkpy.HkKrKyELG

Chain	Residue	Details
I	ARG11-GLY30

---

site_id	PS01262
Number of Residues	23
Details	IF1A Eukaryotic initiation factor 1A signature. MlGnGRleamCfDGvkRlcHIrG

Chain	Residue	Details
4	MET41-GLY63

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18691976

Chain	Residue	Details
P	THR133
C	ALA-72

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
P	SER139
C	PRO-54
j	THR96
b	CYS59
1	ALA825

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
P	LYS61
C	SER-185
P	LYS63
P	LYS106

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455

Chain	Residue	Details
N	TYR38
C	SER-144
J	LYS139

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36638793

Chain	Residue	Details
N	LYS27
C	LYS-135
I	LYS193

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
B	LYS89
N	LYS43

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
B	THR97
C	THR-90

---

site_id	SWS_FT_FI8
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733

Chain	Residue	Details
B	LYS89
C	LYS-98
B	LYS221
C	LYS34

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861

Chain	Residue	Details
B	LYS221
C	LYS34

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P97351

Chain	Residue	Details
B	LYS243
C	LYS56

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	MOD_RES: ADP-ribosyltyrosine => ECO:0000269|PubMed:29954836

Chain	Residue	Details
B	TYR342
C	TYR155

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

Chain	Residue	Details
F	LYS90
F	LYS202

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:28065601, ECO:0000269|PubMed:28132843, ECO:0000269|PubMed:31981475, ECO:0000269|PubMed:32011234, ECO:0000269|PubMed:34348161, ECO:0000269|PubMed:34469731

Chain	Residue	Details
F	LYS214

---