7T4S
CryoEM structure of the HCMV Pentamer gH/gL/UL128/UL130/UL131A in complex with NRP2 and neutralizing fabs 8I21 and 13H11
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0016032 | biological_process | viral process |
| B | 0019031 | cellular_component | viral envelope |
| C | 0019031 | cellular_component | viral envelope |
| C | 0019062 | biological_process | virion attachment to host cell |
| C | 0044423 | cellular_component | virion component |
| C | 0046718 | biological_process | symbiont entry into host cell |
| C | 0055036 | cellular_component | virion membrane |
| C | 0098670 | biological_process | entry receptor-mediated virion attachment to host cell |
| F | 0001525 | biological_process | angiogenesis |
| F | 0005021 | molecular_function | vascular endothelial growth factor receptor activity |
| F | 0007411 | biological_process | axon guidance |
| F | 0016020 | cellular_component | membrane |
| F | 0017154 | molecular_function | semaphorin receptor activity |
| F | 0038084 | biological_process | vascular endothelial growth factor signaling pathway |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH |
| Chain | Residue | Details |
| I | TYR193-HIS199 | |
| H | TYR203-HIS209 | |
| J | TYR204-HIS210 | |
| K | TYR192-HIS198 |
| site_id | PS01285 |
| Number of Residues | 30 |
| Details | FA58C_1 Coagulation factors 5/8 type C domain (FA58C) signature 1. GWtpnldsnke......YLqVDlrfltmLtaIaTQG |
| Chain | Residue | Details |
| F | GLY317-GLY346 | |
| F | GLY473-GLY505 |
| site_id | PS01286 |
| Number of Residues | 17 |
| Details | FA58C_2 Coagulation factors 5/8 type C domain (FA58C) signature 2. Pqtwhsgia..LRlELfGC |
| Chain | Residue | Details |
| F | PRO411-CYS427 | |
| F | PRO575-CYS592 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 63 |
| Details | Region: {"description":"Interaction with gL","evidences":[{"source":"HAMAP-Rule","id":"MF_04033","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine; by host","evidences":[{"source":"HAMAP-Rule","id":"MF_04033","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17989695","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2QQO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"17989695","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2QQK","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
