7LF4
Structure of importin a3 bound to the p50- and p65-NLSs
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001673 | cellular_component | male germ cell nucleus |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005643 | cellular_component | nuclear pore |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006606 | biological_process | protein import into nucleus |
| A | 0006607 | biological_process | NLS-bearing protein import into nucleus |
| A | 0008139 | molecular_function | nuclear localization sequence binding |
| A | 0015031 | biological_process | protein transport |
| A | 0031965 | cellular_component | nuclear membrane |
| A | 0042542 | biological_process | response to hydrogen peroxide |
| A | 0042564 | cellular_component | NLS-dependent protein nuclear import complex |
| A | 0061608 | molecular_function | nuclear import signal receptor activity |
| C | 0001673 | cellular_component | male germ cell nucleus |
| C | 0005515 | molecular_function | protein binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005643 | cellular_component | nuclear pore |
| C | 0005654 | cellular_component | nucleoplasm |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006606 | biological_process | protein import into nucleus |
| C | 0006607 | biological_process | NLS-bearing protein import into nucleus |
| C | 0008139 | molecular_function | nuclear localization sequence binding |
| C | 0015031 | biological_process | protein transport |
| C | 0031965 | cellular_component | nuclear membrane |
| C | 0042542 | biological_process | response to hydrogen peroxide |
| C | 0042564 | cellular_component | NLS-dependent protein nuclear import complex |
| C | 0061608 | molecular_function | nuclear import signal receptor activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 84 |
| Details | Repeat: {"description":"ARM 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 88 |
| Details | Repeat: {"description":"ARM 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 76 |
| Details | Repeat: {"description":"ARM 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 88 |
| Details | Repeat: {"description":"ARM 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 78 |
| Details | Repeat: {"description":"ARM 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 82 |
| Details | Repeat: {"description":"ARM 7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 78 |
| Details | Repeat: {"description":"ARM 8"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 84 |
| Details | Repeat: {"description":"ARM 9"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 76 |
| Details | Repeat: {"description":"ARM 10; atypical"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 184 |
| Details | Region: {"description":"NLS binding site (major)","evidences":[{"source":"PubMed","id":"29042532","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 176 |
| Details | Region: {"description":"NLS binding site (minor)","evidences":[{"source":"PubMed","id":"29042532","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 16 |
| Details | Motif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-methyllysine; by SETD6; alternate","evidences":[{"source":"UniProtKB","id":"Q04207","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC/PRKCZ","evidences":[{"source":"UniProtKB","id":"Q04207","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
