7KIU

Structure of recombinant human DNase1L3 in complex with Mg2+

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002283	biological_process	neutrophil activation involved in immune response
A	0002673	biological_process	regulation of acute inflammatory response
A	0003677	molecular_function	DNA binding
A	0003824	molecular_function	catalytic activity
A	0004518	molecular_function	nuclease activity
A	0004519	molecular_function	endonuclease activity
A	0004520	molecular_function	DNA endonuclease activity
A	0004530	molecular_function	deoxyribonuclease I activity
A	0004536	molecular_function	DNA nuclease activity
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005783	cellular_component	endoplasmic reticulum
A	0006259	biological_process	DNA metabolic process
A	0006308	biological_process	DNA catabolic process
A	0006309	biological_process	apoptotic DNA fragmentation
A	0006915	biological_process	apoptotic process
A	0010623	biological_process	programmed cell death involved in cell development
A	0012501	biological_process	programmed cell death
A	0016787	molecular_function	hydrolase activity
A	0070948	biological_process	regulation of neutrophil mediated cytotoxicity
B	0002283	biological_process	neutrophil activation involved in immune response
B	0002673	biological_process	regulation of acute inflammatory response
B	0003677	molecular_function	DNA binding
B	0003824	molecular_function	catalytic activity
B	0004518	molecular_function	nuclease activity
B	0004519	molecular_function	endonuclease activity
B	0004520	molecular_function	DNA endonuclease activity
B	0004530	molecular_function	deoxyribonuclease I activity
B	0004536	molecular_function	DNA nuclease activity
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005783	cellular_component	endoplasmic reticulum
B	0006259	biological_process	DNA metabolic process
B	0006308	biological_process	DNA catabolic process
B	0006309	biological_process	apoptotic DNA fragmentation
B	0006915	biological_process	apoptotic process
B	0010623	biological_process	programmed cell death involved in cell development
B	0012501	biological_process	programmed cell death
B	0016787	molecular_function	hydrolase activity
B	0070948	biological_process	regulation of neutrophil mediated cytotoxicity
C	0002283	biological_process	neutrophil activation involved in immune response
C	0002673	biological_process	regulation of acute inflammatory response
C	0003677	molecular_function	DNA binding
C	0003824	molecular_function	catalytic activity
C	0004518	molecular_function	nuclease activity
C	0004519	molecular_function	endonuclease activity
C	0004520	molecular_function	DNA endonuclease activity
C	0004530	molecular_function	deoxyribonuclease I activity
C	0004536	molecular_function	DNA nuclease activity
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005634	cellular_component	nucleus
C	0005783	cellular_component	endoplasmic reticulum
C	0006259	biological_process	DNA metabolic process
C	0006308	biological_process	DNA catabolic process
C	0006309	biological_process	apoptotic DNA fragmentation
C	0006915	biological_process	apoptotic process
C	0010623	biological_process	programmed cell death involved in cell development
C	0012501	biological_process	programmed cell death
C	0016787	molecular_function	hydrolase activity
C	0070948	biological_process	regulation of neutrophil mediated cytotoxicity
D	0002283	biological_process	neutrophil activation involved in immune response
D	0002673	biological_process	regulation of acute inflammatory response
D	0003677	molecular_function	DNA binding
D	0003824	molecular_function	catalytic activity
D	0004518	molecular_function	nuclease activity
D	0004519	molecular_function	endonuclease activity
D	0004520	molecular_function	DNA endonuclease activity
D	0004530	molecular_function	deoxyribonuclease I activity
D	0004536	molecular_function	DNA nuclease activity
D	0005509	molecular_function	calcium ion binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005634	cellular_component	nucleus
D	0005783	cellular_component	endoplasmic reticulum
D	0006259	biological_process	DNA metabolic process
D	0006308	biological_process	DNA catabolic process
D	0006309	biological_process	apoptotic DNA fragmentation
D	0006915	biological_process	apoptotic process
D	0010623	biological_process	programmed cell death involved in cell development
D	0012501	biological_process	programmed cell death
D	0016787	molecular_function	hydrolase activity
D	0070948	biological_process	regulation of neutrophil mediated cytotoxicity

Functional Information from PROSITE/UniProt

site_id	PS00918
Number of Residues	8
Details	DNASE_I_2 Deoxyribonuclease I signature 2. GDFNAgCS

Chain	Residue	Details
A	GLY188-SER195

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site_id	PS00919
Number of Residues	21
Details	DNASE_I_1 Deoxyribonuclease I signature 1. IIPLHTTPetsvkEIDeLvEV

Chain	Residue	Details
A	ILE151-VAL171

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	64
Details	Motif: {"description":"Bipartite nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	8
Details	Active site: {"evidences":[{"source":"UniProtKB","id":"P00639","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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