7BO7

CRYSTAL STRUCTURE OF THE HUMAN PRMT5:MEP50 COMPLEX with JNJB44355437

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0000387	biological_process	spliceosomal snRNP assembly
AAA	0000785	cellular_component	chromatin
AAA	0002039	molecular_function	p53 binding
AAA	0003714	molecular_function	transcription corepressor activity
AAA	0005515	molecular_function	protein binding
AAA	0005634	cellular_component	nucleus
AAA	0005654	cellular_component	nucleoplasm
AAA	0005694	cellular_component	chromosome
AAA	0005737	cellular_component	cytoplasm
AAA	0005794	cellular_component	Golgi apparatus
AAA	0005829	cellular_component	cytosol
AAA	0006325	biological_process	chromatin organization
AAA	0006338	biological_process	chromatin remodeling
AAA	0006353	biological_process	DNA-templated transcription termination
AAA	0006355	biological_process	regulation of DNA-templated transcription
AAA	0006479	biological_process	protein methylation
AAA	0007088	biological_process	regulation of mitotic nuclear division
AAA	0008168	molecular_function	methyltransferase activity
AAA	0008276	molecular_function	protein methyltransferase activity
AAA	0008327	molecular_function	methyl-CpG binding
AAA	0008469	molecular_function	histone arginine N-methyltransferase activity
AAA	0010468	biological_process	regulation of gene expression
AAA	0016274	molecular_function	protein-arginine N-methyltransferase activity
AAA	0018216	biological_process	peptidyl-arginine methylation
AAA	0032259	biological_process	methylation
AAA	0032922	biological_process	circadian regulation of gene expression
AAA	0032991	cellular_component	protein-containing complex
AAA	0034709	cellular_component	methylosome
AAA	0035097	cellular_component	histone methyltransferase complex
AAA	0035243	molecular_function	protein-arginine omega-N symmetric methyltransferase activity
AAA	0035246	biological_process	peptidyl-arginine N-methylation
AAA	0042054	molecular_function	histone methyltransferase activity
AAA	0042118	biological_process	endothelial cell activation
AAA	0042802	molecular_function	identical protein binding
AAA	0043021	molecular_function	ribonucleoprotein complex binding
AAA	0044020	molecular_function	histone H4R3 methyltransferase activity
AAA	0044027	biological_process	negative regulation of gene expression via chromosomal CpG island methylation
AAA	0044877	molecular_function	protein-containing complex binding
AAA	0045596	biological_process	negative regulation of cell differentiation
AAA	0045892	biological_process	negative regulation of DNA-templated transcription
AAA	0046982	molecular_function	protein heterodimerization activity
AAA	0048026	biological_process	positive regulation of mRNA splicing, via spliceosome
AAA	0048511	biological_process	rhythmic process
AAA	0048714	biological_process	positive regulation of oligodendrocyte differentiation
AAA	0070372	biological_process	regulation of ERK1 and ERK2 cascade
AAA	0070888	molecular_function	E-box binding
AAA	0090161	biological_process	Golgi ribbon formation
AAA	0097421	biological_process	liver regeneration
AAA	0140938	molecular_function	histone H3 methyltransferase activity
AAA	1901796	biological_process	regulation of signal transduction by p53 class mediator
AAA	1904992	biological_process	positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway
BBB	0000209	biological_process	protein polyubiquitination
BBB	0000387	biological_process	spliceosomal snRNP assembly
BBB	0005515	molecular_function	protein binding
BBB	0005634	cellular_component	nucleus
BBB	0005654	cellular_component	nucleoplasm
BBB	0005737	cellular_component	cytoplasm
BBB	0005794	cellular_component	Golgi apparatus
BBB	0005829	cellular_component	cytosol
BBB	0006357	biological_process	regulation of transcription by RNA polymerase II
BBB	0006511	biological_process	ubiquitin-dependent protein catabolic process
BBB	0007309	biological_process	oocyte axis specification
BBB	0008284	biological_process	positive regulation of cell population proliferation
BBB	0008285	biological_process	negative regulation of cell population proliferation
BBB	0008327	molecular_function	methyl-CpG binding
BBB	0030374	molecular_function	nuclear receptor coactivator activity
BBB	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
BBB	0034709	cellular_component	methylosome
BBB	0045893	biological_process	positive regulation of DNA-templated transcription
BBB	0048026	biological_process	positive regulation of mRNA splicing, via spliceosome
BBB	0060528	biological_process	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
BBB	0060767	biological_process	epithelial cell proliferation involved in prostate gland development
BBB	0060770	biological_process	negative regulation of epithelial cell proliferation involved in prostate gland development
BBB	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. AVSGskDiCIKVWDL

Chain	Residue	Details
BBB	ALA140-LEU154

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000269|Ref.8, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
BBB	THR5
AAA	GLU444

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site_id	SWS_FT_FI2
Number of Residues	7
Details	BINDING: BINDING => ECO:0000269|PubMed:23071334

Chain	Residue	Details
AAA	TYR324
AAA	PHE327
AAA	LYS333
AAA	GLU392
AAA	ASP419
AAA	GLU435
AAA	GLU444

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Critical for specifying symmetric addition of methyl groups => ECO:0000250|UniProtKB:P46580

Chain	Residue	Details
AAA	PHE327

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N-acetylalanine; in Protein arginine N-methyltransferase 5, N-terminally processed => ECO:0000269|Ref.15, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378

Chain	Residue	Details
AAA	ALA2

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